m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05433			[1]
m⁶A modification hsa-miR-25-3p hsa-miR-25-3p METTL3 Methylation : m⁶A sites Direct Enhancement Non-coding RNA miR-25-3p PTEN lncRNA miRNA circRNA
m6A Regulator	Methyltransferase-like 3 (METTL3)		WRITER	Regulator Info
m6A Target	hsa-miR-25-3p			Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	hsa-miR-25-3p		microRNA	View Details
Regulated Target	Mutated in multiple advanced cancers 1 (PTEN)			View Details
Crosstalk Relationship	m6A → ncRNA		Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	METTL3 involves in the pathogenesis of diabetic retinopathy (DR). Both METTL3 mRNA and hsa-miR-25-3p were low-expressed in the peripheral venous blood samples of diabetes mellitus (DM) patients compared to normal volunteers, and high-glucose inhibited METTL3 and miR-25-3p expressions in RPE cells. Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/Mutated in multiple advanced cancers 1 (PTEN)/Akt signaling cascade through DGCR8.
Responsed Disease	Diabetes	ICD-11: 5A10-5A14		Disease Info
Pathway Response	PI3K-Akt signaling pathway			hsa04151
Cell Process	Cell viability
Cell Process	Cell apoptosis

References

Ref 1	Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8. Aging (Albany NY). 2020 May 4;12(9):8137-8150. doi: 10.18632/aging.103130. Epub 2020 May 4.