m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05336
 [1]
Non-coding RNA SLERT METTL3  lncRNA       miRNA   circRNA Direct Enhancement m6A modification BDNF BDNF METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Neurotrophic factor BDNF precursor form (BDNF)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator SnoRNA-ended lncRNA Enhances pre-Ribosomal RNA Transcription (SLERT) LncRNA View Details
Regulated Target Methyltransferase-like protein 3 (METTL3) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary SLERT directly binds to METTL3, increasing the m6A levels of Neurotrophic factor BDNF precursor form (BDNF) mRNA; then, the m6A sites were read by IGF2BP1, enhancing BDNF mRNA stability,
Responsed Disease Endometrial cancer ICD-11: 2C76
 Disease Info 
In-vivo Model The mice were randomly divided into four groups (n=5 per group), labeled as OE-vector (caudal vein injection of 2×106 AN3CA cells), OE-SLERT (caudal vein injection of 2×106 SLERT-overexpressing AN3CA cells), OE-SLERT+ASO-BDNF (caudal vein injection of 2×106 SLERT-overexpressing AN3CA cells transfected with ASO-BDNF), and OE-SLERT+k252a (caudal vein injection of 2×106 SLERT-overexpressing AN3CA cells and intraperitoneal injection of 25μg/kg k252a).
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Neurotrophic factor BDNF precursor form (BDNF) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PYM-50028 Phase 2 [2]
Synonyms
Cogane; Smilagenin; P-58; P-63
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MOA Agonist
External Link
TTD: D0M2TG
2C76: Endometrial cancer 18 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Dostarlimab Approved [3]
External Link
TTD: DGQU43
 Compound Name Lurbinectedin Phase 3 [4]
Synonyms
UNII-2CN60TN6ZS; 497871-47-3; 2CN60TN6ZS; Lurbinectedin [INN]; SCHEMBL16152477; DTXSID30198065; DB12674; CS-6323; HY-16293; J3.652.626B
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External Link
CID: 57327016
TTD: D0V6OA
DrugBank: DB12674
 Compound Name Mirvetuximab soravtansine Approved [4]
Synonyms
ZOHXWSHGANNQGO-QRVRWUFNSA-N; DB12489
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External Link
CID: 91810695
TTD: D0RP2W
 Compound Name AL3818 Phase 1/2 [4]
Synonyms
Anlotinib; 1058156-90-3; UNII-GKF8S4C432; GKF8S4C432; AL-3818; SCHEMBL2063386; GTPL9601; KSMZEXLVHXZPEF-UHFFFAOYSA-N; MolPort-044-567-604; ZINC117924202; AKOS030526233; DB11885; CS-5396; AL 3818; HY-19716; 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinolin-7-yl]oxymethyl]cyclopropan-1-amine; 1-((4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropan-amine; Cyclopropanamine, 1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-quinolinyl)oxy)methyl)-
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External Link
CID: 25017411
TTD: D0G2CG
DrugBank: DB11885
 Compound Name TKI258 Phase 3 [5]
Synonyms
Dovitinib; 405169-16-6; CHIR-258; TKI-258; Chir 258; 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one; CHIR258; Dovitinib (TKI-258, CHIR-258); UNII-I35H55G906; CHEMBL522892; 804551-71-1; I35H55G906; TKI 258; 1027263-12-2; (3Z)-4-Amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]-2(3H)-quinolinone; C21H21FN6O; 4-Amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one
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External Link
CID: 135611162
TTD: D07OZR
 Compound Name DKN-01 Phase 2 [4]
External Link
TTD: DMF73Z
 Compound Name FP-1039 Phase 2 [6]
Synonyms
FPT-039; HGS-1036; Modified growth factor receptor (cancer), FivePrime Therapeutics; FGFR-1c antagonist (protein fusion/iv,cancer), FivePrime Therapeutics; FGFR-1c antagonist (protein fusion/iv, cancer), FivePrime Therapeutics/ Human Genome Sciences
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External Link
TTD: D0U2DO
 Compound Name XBIO-101 Phase 2 [4]
Synonyms
sodium cridanimod; cridanimod; 38609-97-1; 9-Oxo-10(9H)-acridineacetic acid; 10-Carboxymethyl-9-acridanone; N-(Carboxymethyl)acridone; (9-oxoacridin-10(9H)-yl)acetic acid; 10(9H)-ACRIDINEACETIC ACID, 9-OXO-; Cridanimod [INN]; 2-(9-oxoacridin-10(9H)-yl)acetic acid; (9-Oxo-9H-acridin-10-yl)-acetic acid; UNII-X91E9EME19; 10-Carboxymeth-9-acridanone; Cycloferon; BRN 0227508; 9-Oxo-10-acridanacetic acid; X91E9EME19; C15H11NO3; Cridanimod (INN); 2-(9-oxoacridin-10-yl)acetic acid; 10(9H)-Acridineaceticacid, 9-oxo-; (9-Oxo-10(9H)-acrid
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External Link
CID: 38072
TTD: D0OS6P
DrugBank: DB13674
 Compound Name PF-04691502 Phase 2 [7]
Synonyms
1013101-36-4; PF 04691502; UNII-4W39NS61KI; 4W39NS61KI; 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one; CHEMBL1234354; PF04691502; 2-Amino-8-[trans-4-(2-Hydroxyethoxy)cyclohexyl]-6-(6-Methoxypyridin-3-Yl)-4-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; 2-Amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
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External Link
CID: 25033539
TTD: D0N5JZ
DrugBank: DB11974
 Compound Name Folate binding protein vaccine Phase 2 [8]
External Link
TTD: D0M7YU
 Compound Name Virexxa Phase 2 [9]
External Link
TTD: D0J0EM
 Compound Name ONC201 Phase 2 [4]
Synonyms
Onc-201; TIC10; 1616632-77-9; UNII-9U35A31JAI; 9U35A31JAI; TIC10(ONC-201); 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5(4H)-one; TIC 10 active isomer; ONC201(TIC10 isomer); TIC 10; GTPL9978; SCHEMBL16227974; EX-A669; ONC 201; AOB2892; MolPort-039-137-731; HY-15615A; 3388AH; s7963; ZINC169620396; AKOS025404904; NSC 350625; CS-3564; AS-16735; AK174891; KB-335104; FT-0700231; J-690224; 1342897-86-2; 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimid
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External Link
CID: 73777259
TTD: D07XQS
DrugBank: DB14844
 Compound Name Folate binding protein-E39 Phase 1/2 [10]
External Link
TTD: D0OT3L
 Compound Name GALE-301 Phase 2 [11]
External Link
TTD: D02DEZ
 Compound Name COTI-2 Phase 1 [4]
Synonyms
UNII-2BTA1O65BR; 2BTA1O65BR; 1039455-84-9; ZINC114475331; CS-8156; HY-19896; 1-Piperazinecarbothioic acid, 4-(2-pyridinyl)-, 2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide
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External Link
CID: 91810660
TTD: D0G8CU
 Compound Name Anti-meso-CAR vector transduced T cells Phase 1 [12]
External Link
TTD: D0G4GY
 Compound Name GSK1059615 Discontinued in Phase 1 [13]
Synonyms
KS-00001CUQ; CTK8F0346; HMS3654N17; BCP02498; AKOS026750445; NCGC00346509-01; FT-0669060
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External Link
CID: 23582824
TTD: D0L0ZC
DrugBank: DB11962
 Compound Name RU-46556 Terminated [14]
External Link
TTD: D0N4PC
References
Ref 1 SLERT, as a novel biomarker, orchestrates endometrial cancer metastasis via regulation of BDNF/TRKB signaling. World J Surg Oncol. 2023 Jan 31;21(1):27. doi: 10.1186/s12957-022-02821-w.
Ref 2 PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J. 2008 Jul;22(7):2488-97.
Ref 3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
Ref 4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 5 Phase 2 study of dovitinib in patients with metastatic or unresectable adenoid cystic carcinoma. Cancer. 2015 Aug 1;121(15):2612-7.
Ref 6 ClinicalTrials.gov (NCT01244438) Study of FP-1039 in Subjects With Endometrial Cancers. U.S. National Institutes of Health.
Ref 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7936).
Ref 8 Clinical pipeline report, company report or official report of Galena Biopharma.
Ref 9 ClinicalTrials.gov (NCT02064725) Virexxa (Sodium Cridanimod) w/Progestin Therapy in Pts w/Progesterone Receptor Neg Recurrent/Persistent Endometrial CA. U.S. National Institutes of Health.
Ref 10 Clinical pipeline report, company report or official report of Galena biopharma.
Ref 11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035004)
Ref 12 ClinicalTrials.gov (NCT02580747) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso
Ref 13 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028447)
Ref 14 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003252)