m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05282
|
[1] | |||
Non-coding RNA
piRNA-36741
METTL3
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
BMP2
BMP2
METTL3
Methylation
 : m6A sites
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Bone morphogenetic protein 2 (BMP2) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | piR-36741 | piRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | piR-36741 regulates Bone morphogenetic protein 2 (BMP2)-mediated osteoblast differentiation via METTL3 controlled m6A modification | ||||
| Responsed Disease | Osteoporosis | ICD-11: FB83.1 | |||
| In-vivo Model | Female C57BL/6 mice were fed under pathogen-free conditions and kept in a controlled environment (temperature 23 ± 1°C; humidity 50-60%), and subjected to a 12-hour light/dark cycle artificial simulation. Eight-week-old mice were selected for surgery and randomly divided into sham group (n = 6) and ovariectomized model group (OVX, n = 24). | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Bone morphogenetic protein 2 (BMP2) | 1 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
 Compound Name |
DWP-431 | Phase 3 | [2] | |
|---|---|---|---|---|
| Synonyms |
Recombinant bone morphogenetic protein 2 (bone synthesis), Daewoong; RBMP-2 (bone synthesis), Daewoong
Click to Show/Hide
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| MOA | Modulator | |||
| External Link | ||||
References