Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05221
[1]
Non-coding RNA Circ_0066715 WTAP  lncRNA       miRNA   circRNA Direct Inhibition m6A modification ETS1 ETS1 WTAP Methylation : m6A sites
m6A Modification:
m6A Regulator Wilms tumor 1-associating protein (WTAP) WRITER
m6A Target Protein C-ets-1 (ETS1)
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator hsa_circ_0066715 (Circ_CBLB) circRNA View Details
Regulated Target Pre-mRNA-splicing regulator WTAP (WTAP) View Details
Crosstalk Relationship ncRNA  →  m6A Inhibition
Crosstalk Mechanism ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator
Crosstalk Summary WTAP may be involved in the methylation process of Protein C-ets-1 (ETS1) in RA. ETS1 m6A methylation levels were altered upon WTAP intervention. The overexpression or interference of Circ_CBLB decreased or increased WTAP expression.
Responsed Disease Rheumatoid arthritis ICD-11: FA20
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
FA20: Rheumatoid arthritis 434 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Sarilumab Approved [2]
Synonyms
Kevzara
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 Compound Name Sulindac Approved [3]
Synonyms
Aclin; Aflodac; Arthrobid; Arthrocine; Chibret; Clinoril; Copal; Copals; Kenalin; Klinoril; Mobilin; Sulindaco; Sulindacum; Sulindal; Alphapharm Brand of Sulindac; Apo Sulin; Apotex Brand of Sulindac; Cahill May Roberts Brand of Sulindac; Chemia Brand of Sulindac; Copal resin; Copal rosin varnish; Gum copal; KendrickBrand of Sulindac; Merck Brand of Sulindac; Novo Sundac; Novopharm Brand of Sulindac; Nu Pharm Brand of Sulindac; Nu Sulindac; Resin copal; Sulindac sulfoxide; MK 231; MK231; S 8139; Apo-Sulin; Clinoril (TN); MK-231; Merck Sharp & Dohme Brand of Sulindac; Novo-Sundac; Nu-Pharm Brand of Sulindac; Nu-Sulindac; Sulindaco [INN-Spanish]; Sulindacum [INN-Latin]; Sulindac (JAN/USP/INN); Sulindac [USAN:BAN:INN:JAN]; Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benzylidene]indene-3-acetic acid; Cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; {5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1h-inden-3-yl}acetic acid; Cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; [(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfinyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid; {(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; (E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[[4-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; 2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid; 5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
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 Compound Name Ofatumumab Phase 3 [4]
Synonyms
Arzerra (TN)
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 Compound Name Baricitinib Approved [5]
Synonyms
Baricitinib (LY3009104, INCB028050); Baricitinib [USAN:INN]; C16H17N7O2S; INCB 028050; INCB-028050; INCB028050; ISP4442I3Y; J-503551; LY-3009104; LY3009104; Olumiant (TN); UNII-ISP4442I3Y; olumiant
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 Compound Name Felbinac Approved [6]
Synonyms
Felbinac); Felbinac, Takeda Chemical Industries Ltd; Seltouch, Takeda
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 Compound Name Salsalate Approved [6]
Synonyms
Diacesal; Diplosal; Disalcid; Disalicylsaeure; Disalyl; Nobacid; Salflex; Salical; Salina; Saloxium; Salsalato; Salsalatum;Salysal; Sasapirin; Sasapyrin; Sasapyrine; Sasapyrinum; Disalicylic acid; Sal Ester Sal; Salicylic Acid Salicylate; Salicyloylsalicylic acid; Salicylsalicylic acid; Disalcid (TN); O-Salicylcylsalicylsaeure; O-Salicyloylsalicylic Acid; O-Salicylsalicylic acid; Salflex (TN); Salicylic acid, bimolecular ester; Salicylic acid, salicylate; Salsalato [INN-Spanish]; Salsalatum [INN-Latin]; Salsitab (TN); Sasapyrine (JAN); Mono-Gesic (TN); Salsalate (USP/INN); Salsalate [USAN:INN:BAN]; Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; 2-((2-Hydroxybenzoyl)oxy)benzoic acid; 2-(2-hydroxybenzoyl)oxybenzoic acid; 2-Carboxyphenyl salicylate; 2-Salicyloyloxybenzoic Acid; 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
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 Compound Name Fostamatinib Phase 3 [7]
Synonyms
901119-35-5; R788; Tavalisse; UNII-SQ8A3S5101; R-788 Free acid; R 788; R-788; R-935788 Free acid; SQ8A3S5101; R7935788; Fostamatinib [USAN:INN]
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 Compound Name Belumosudil Approved [8]
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 Compound Name Canakinumab Approved [9]
Synonyms
Ilaris (TN)
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 Compound Name Methotrexate Phase 3 [10]
Synonyms
Rheumatrex; Amethopterin; Metatrexan; Hdmtx; Abitrexate; Mexate; Methylaminopterinum; Methotrexatum; Antifolan; Metotrexato; Methylaminopterin; MTX; (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid; Methotrexat; Amethopterine; Maxtrex; Rasuvo; L-Amethopterin; A-Methopterin; A-Methpterin; Amethopterin L-; Folex-Pfs; Methotrexat-Ebewe; N-Bismethylpteroylglutamic acid; Methotrexate, L-; Metotressato [DCIT]; Methotextrate; Mexate-Aq; [3H]methotrexate
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 Compound Name IPI-145 Phase 3 [11]
Synonyms
Duvelisib; 1201438-56-3; INK-1197; UNII-610V23S0JI;
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 Compound Name Indomethacin Approved [6]
Synonyms
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
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 Compound Name Inosine pranobex Approved [6]
Synonyms
Imunovir (TN)
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 Compound Name Secukinumab Phase 2 [12]
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 Compound Name Infliximab Approved [13]
Synonyms
Remicade (TN)
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 Compound Name Citrofen Approved [6]
Synonyms
Citrofen (TN)
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 Compound Name Meclofenamate Sodium Approved [6]
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 Compound Name Oxaprozin Approved [6]
Synonyms
Actirin; Alvo; Danoprox; Daypro; Dayrun; Deflam; Oxaprozina; Oxaprozine; Oxaprozinum; Voir; Xopane; Apotex brand of oxaprozin; CSC brand of oxaprozin; Pfizer brand of oxaprozin; Rhoxalpharma brand of oxaprozin; TRB brand of oxaprozin; Lyl)propenoic acid; NCI310839; O 9637; WY 21743; Apo-Oxaprozin; Daypro (TN); Duraprox (TN); Oxaprozina [INN-Spanish]; Oxaprozine [INN-French]; Oxaprozinum [INN-Latin]; Rhoxal-oxaprozin; WY-21743; WY-21,743; Oxaprozin (JP15/USAN/INN); Oxaprozin [USAN:BAN:INN:JAN]; Beta-(4,5-Diphenyloxazol-2-yl)propionic acid; 3-(4, 5-Diphenyl-2-oxazo; 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid; 3-(4,5-Diphenyl-2-oxazolyl)propenoic acid; 4, 5-Diphenyl-2-oxazolepropionic acid; 4,5-Diphenyl-2-oxazolepropanoic acid; 4,5-Diphenyl-2-oxazolepropionic acid
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 Compound Name Zinc salts Approved [6]
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 Compound Name Adalimumab Approved [14]
Synonyms
Humira; Adalimumab (genetical recombination); Humira (TN); Adalimumab (USAN/INN); Adalimumab (genetical recombination) (JAN)
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 Compound Name Orthokine Approved [6]
Synonyms
Orthokine (TN)
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 Compound Name Dexamethasone Approved [15]
Synonyms
Adexone; Anaflogistico; Aphtasolon; Aphthasolone; Auxiron; Azium; Calonat; Corson; Corsone; Cortisumman; DXM; Decacort; Decacortin; Decaderm; Decadron; Decagel; Decaject; Decalix; Decameth; Decasone; Decaspray; Dectancyl; Dekacort; Deltafluorene; Dergramin; Deronil; Desadrene; Desametasone; Desamethasone; Desameton; Deseronil; Dexacort; Dexacortal; Dexacortin; Dexadeltone; Dexafarma; Dexair; Dexalona; Dexaltin; Dexametasona; Dexameth; Dexamethansone; Dexamethasonum; Dexamethazone; Dexamonozon; Dexapolcort; Dexaprol; Dexason; Dexasone; Dexinolon; Dexinoral; Dexone; Dexonium; Dexpak; Dextelan; Dezone; Dinormon; Dxms; Fluormethylprednisolone; Fluormone; Fluorocort; Fortecortin; Gammacorten; Hexadecadrol; Hexadrol; IontoDex; Loverine; Luxazone; Maxidex; Mediamethasone; Methylfluorprednisolone; Mexidex; Millicorten; Mymethasone; Oradexon; Policort; Posurdex; Prodex; Spoloven; Superprednol; Turbinaire; Visumetazone; Alcon Brand of Dexamethasone; Bisu DS; Desametasone [DCIT]; Dexa Mamallet; Dexamethasone Base; Dexamethasone Intensol; Dexamethasone alcohol; ECR Brand of Dexamethasone; Foy Brand of Dexamethasone; Hexadrol Elixir; Hexadrol Tablets; ICN Brand of Dexamethasone; Lokalison F; Merck Brand of Dexamethasone; Pet Derm III; Prednisolon F; Prednisolone F; Sunia Sol D; Dexone 4; MK 125; Merz Brand 1 of Dexamethasone; Merz Brand 2 of Dexamethasone; Aeroseb-D; Aeroseb-Dex; Azium (Veterinary); Decadron (TN); Decadron Tablets, Elixir; Decadron, Dexamethasone; Decadron-LA; Dex-ide; Dexa-Cortidelt;Dexa-Cortisyl; Dexa-Mamallet; Dexa-Scheroson; Dexa-sine; Dexacen-4; Dexametasona [INN-Spanish]; Dexamethasonum [INN-Latin]; Dexone 0.5; Dexone 0.75; Dexone 1.5; Hl-dex; Isopto-Dex; OTO-104; Ocu-trol;Pet-Derm Iii; SK-Dexamethasone; Decaject L.A.; Dexamethasone [INN:BAN:JAN]; Decaject-L.A.; Dexamethasone (JP15/USP/INN); Delta1-9alpha-Fluoro-16alpha-methylcortisol; Delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol; (3H)-Dexamethasone; 1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol; 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoroprednisolone; 16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol; 16.alpha.-Methyl-9.alpha.-fluoroprednisolone; 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol; 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone; 16alpha-Methyl-9alpha-fluoroprednisolone; 9-alpha-Fluoro-16-alpha-methylprednisolone; 9.alpha.-Fluoro-16.alpha.-methylprednisolone; 9A-FLUORO-16BETA-METHYLPREDNISOLONE; 9alpha-Fluoro-16alpha-methylprednisolone
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 Compound Name SK-1306X Approved [6]
Synonyms
Cararthron; Joins
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 Compound Name Tenoxicam Approved [16]
Synonyms
Artriunic; Liman; Mobiflex; Reutenox; Tenoxicamum; Tilcotil; Apotex brand of tenoxicam; Novag brand of tenoxicam; Novopharm brand of tenoxicam; Roche brand of tenoxicam; Solvay brand of tenoxicam; Apo-Tenoxicam; Mobiflex (TN); Novo-Tenoxicam; Ro 12-0068; Ro-120068; Tenoxicamum [INN-Latin]; Tilcotil (TN); Ro 12-0068/000; Ro-12-0068; Tenoxicam (JAN/USAN/INN); Tenoxicam [USAN:BAN:INN:JAN]; (3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one; (3Z)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; 3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one; 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE; 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide1,1-dioxide; 4-Hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide; 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
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 Compound Name Etanercept Approved [17]
Synonyms
Etanercept (sciatica); Etanercept (sciatica), BioAssets Development; Etanercept (sciatica), Cephalon
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 Compound Name Meloxicam Approved [18]
Synonyms
Meloxicam (SoluMatrix/arthritis); Meloxicam nanoformulation capsules (arthritis), iCeutica; Meloxicam (SoluMatrix/arthritis), iCeutica
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 Compound Name Gold sodium thiomalate Approved [6]
Synonyms
Sodium aurothiomalate
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 Compound Name Vamorolone Approved [19]
Synonyms
vamorolone; 13209-41-1; UNII-8XP29XMB43; VBP-15; 8XP29XMB43; CHEMBL2348780; 17,21-Dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione; A-Methyl-9,11-dehydro Prednisolone; (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one; Vamorolone [USAN]; VBP-15 free alcohol; VBP 15; EINECS 236-177-8; AC1MHYKY; Vamorolone (USAN/INN); SCHEMBL143459; GTPL9247; A)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; ZINC33650317
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 Compound Name Abatacept Approved [20]
Synonyms
Orencia (TN)
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 Compound Name Tofacitinib Approved [21]
Synonyms
Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)
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 Compound Name OM-89 Approved [6]
Synonyms
Subreum; UroVaxom; UroVaxon; OM-8980
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 Compound Name Rimexolone Approved [22]
Synonyms
Rimexolone (sustained release intra-articular steroid suspension, Plexis, arthritis)
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 Compound Name Certolizumab Approved [23]
Synonyms
CDP-870; Cimzia; PHA-738144; Simziya
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 Compound Name Alclofenac Approved [6]
Synonyms
22131-79-9; Alclophenac; Prinalgin; Medifenac; Reufenac; Allopydin; Mervan; Alclofenacum; Alclofenaco; Zumaril; Neoston; Neosten; 2-(4-(Allyloxy)-3-chlorophenyl)acetic acid; [4-(Allyloxy)-3-chlorophenyl]acetic acid; Desinflam; Marvan Forte; 3-Chloro-4-(2-propenyloxy)benzeneacetic acid; (4-Allyloxy-3-chlorphenyl)essigsaeure; MY 101; Epinal; Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-; Alclofenacum [INN-Latin]; Alclofenaco [INN-Spanish]; UNII-M9CP5H21N8; W 7320; CHEBI:31183; EINECS 244-795-4
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 Compound Name Careram Approved [24]
Synonyms
Iguratimod
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 Compound Name Flurbiprofen Approved [25]
Synonyms
Adfeed; Adofeed; Anmetarin; Ansaid; Anside; Antadys; Cebutid; FLP; Flubiprofen; Flugalin; Flurbiprofene; Flurbiprofeno; Flurbiprofenum; Fluriproben; Flurofen; Froben; Ocufen; Ocuflur; Stayban; Yakuban; Zepolas; FLURBIPROFEN SODIUM; Froben Sr; BTS 18322; F0371; FP 70; IN1332; U 27182; Ansaid (TN); Apo-Flurbiprofen; BTS-18322; Flurbiprofene [INN-French]; Flurbiprofeno [INN-Spanish]; Flurbiprofenum [INN-Latin]; Froben (TN); MKS-11; Novo-Flurprofen; Nu-Flurbiprofen; U 27,182; U-27182; L-790,330; Flurbiprofen (JP15/USP/INN); Flurbiprofen [USAN:INN:BAN:JAN]; [+/-]-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+-)-2-(2-Fluoro-4-biphenylyl)propionic acid; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+/-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+/-)-2-Fluoro-alpha-methyl[1,1′ -biphenyl]-4-acetic Acid; (1)-2-Fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid; 2-(2-Fluorobiphenyl-4-yl)propionic Acid; 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid; 2-(2-fluorobiphenyl-4-yl)propanoic acid; 2-(3-fluoro-4-phenylphenyl)propanoic acid; 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid; 2-Fluoro-alpha-methyl-4-biphenylacetic acid; 3-Fluoro-4-phenylhydratropic acid
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 Compound Name Nafcillin Approved [26]
Synonyms
Nafcilina; Nafcilline; Nafcillinum; Nallpen; Naphcillin; Naphthamidopenicillin; Unipen; NAFCILLIN SODIUM; Nafcillin sodium for injection; Nallpen In Plastic Container; Nafcilin-1; Nafcilina [INN-Spanish]; Nafcillin & VRC3375; Nafcillin (INN); Nafcillin [INN:BAN]; Nafcilline [INN-French]; Nafcillinum [INN-Latin]; Nafcillin, Monosodium Salt, Anhydrous; (2-Ethoxy-1-naphthyl)penicillin; (2-ethoxy-1-naphthalenyl)penicillin; (2S,5R,6R)-6-({[2-(ethyloxy)naphthalen-1-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(2-ethoxy-1-naphthamido)penicillanic acid; 6-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion; 6beta-(2-ethoxynaphthalene-1-carboxamido)-2,2-dimethylpenam-3alpha-carboxylic acid
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 Compound Name Etofenamate Approved [6]
Synonyms
30544-47-9; Rheumon; Bayrogel; Rheumon gel; UNII-KZF0XM66JC; Etofenamatum [INN-Latin]; Etofenamato [INN-Spanish]; Bay d 1107; C18H18F3NO4; TVX 485; WHR 5020; EINECS 250-231-8; KZF0XM66JC; BRN 2953263; 2-(2-Hydroxyethoxy)ethyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate; 2-(2-hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate; WHR-5020; NCGC00016804-01; 2-(2-Hydroxyaethoxy)aethylester der flutenaminsaeure [German]; CAS-30544-47-9; 2-(2-hydroxyethoxy)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}benzoate
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 Compound Name Etoricoxib Approved [27]
Synonyms
Algix; Arcoxia; Etoricoxibe; Nucoxia; Tauxib; L791456; MK 0663; MK 663; Algix (TN); Arcoxia (TN); L-791456; MK-0663; MK-663; Merck Sharp & Dohme brand of etoricoxib; Tauxib (TN); Etoricoxib (USAN/INN); Etoricoxib [USAN:INN:BAN]; 5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine; 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine; 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine; 5CH
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 Compound Name Golimumab Approved [28]
Synonyms
Simponi (TN); Golimumab (USAN/INN)
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 Compound Name Rilonacept Approved [29]
Synonyms
Rilonacept (USAN/INN)
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 Compound Name Tolmetin Approved [30]
Synonyms
Tolectin; Tolmetina; Tolmetine; Tolmetino; Tolmetinum; Tolmetina [DCIT]; MCN 2559; McN-2559; Tolectin (TN); Tolmetin Sodium, Dihydrate; Tolmetine [INN-French]; Tolmetino [INN-Spanish]; Tolmetinum [INN-Latin]; Tolmetin (USAN/INN); Tolmetin [USAN:BAN:INN]; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico [Spanish]; 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid; 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid; 1-Methyl-5-p-toluoylpyrrole-2-acetic acid; 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid; 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid
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 Compound Name Denosumab Phase 2 [31]
Synonyms
Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
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 Compound Name Leflunomide Approved [32]
Synonyms
Arava; Leflunomid; Leflunomida; Leflunomidum; Lefunamide; Aventis Behring Brand of Leflunomide; Aventis Brand of Leflunomide; Aventis Pharma Brand of Leflunomide; Hoechst Brand of Leflunomide; HWA 486; L 5025; SU 101; SU101; Arava (TN); Arava, Leflunomide; HWA-486; Leflunomida [INN-Spanish]; Leflunomide [USAN:INN]; Leflunomidum [INN-Latin]; Lefunomide [Inn-Spanish]; RS-34821; SU 101 (pharmaceutical); SU-101; AP-501/42475599; Leflunomide (JAN/USAN/INN); N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide; N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide; Alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide; 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl; 4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl); 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide; 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide; 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide); 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
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 Compound Name Penicillamine Approved [33]
Synonyms
D-Penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine; 3-Mercapto-D-valine; Depen; Cuprenil; D-Penamine; (-)-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; D-Mercaptovaline; Mercaptovaline; Perdolat; Penicillamin; Pendramine; Kuprenil; Depamine; Mercaptyl; Trolovol; Metalcaptase; Artamine; Cupripen; (S)-3,3-Dimethylcysteine; D-Valine, 3-mercapto-; Penicillaminum; Penicilamina; Sufirtan; beta-Thiovaline; Dimethylcysteine; D-beta,beta-Dimethylcysteine; D-3-Mercaptovaline; beta,beta-Dimethylcysteine; Penicillamina; Penicilllamine; Sufortan; Copper penicillaminate; D Penicillamine; Penicillamina [DCIT]; Reduced penicillamine; D 3 Mercaptovaline; TBB068824; Beta,beta Dimethylcysteine; Cuprimine (TN); D-Penicilamine; D-Penicyllamine; Depen (TN); P-1280; Penicilamina [INN-Spanish]; Penicillaminate, Copper; Penicillaminum [INN-Latin]; Reduced D-penicillamine; D,3-Mercaptovaline; D-beta-Mercaptovaline; Distamine (*Hydrochloride*); Metalcaptase (*Hydrochloride*); Penicillamine (JAN/USP/INN); Penicillamine [USAN:INN:BAN:JAN]; Alpha-Amino-beta-methyl-beta-mercaptobutyric acid; D-(-)-2-Amino-3-mercapto-3-methylbutanoic acid; (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid; (D)-PENICILLAMINE; (S)-Penicillamin; (S)-Penicillamine; 2-Amino-3-mercapto-3-methylbutanoic acid; 3,3-Dimethyl-D-cysteine; 3-Mercaptovaline; 3-sulfanyl-D-valine
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 Compound Name Dimethyl Sulfoxide Approved [6]
Synonyms
Rimso-50
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 Compound Name Tocilizumab Approved [34]
Synonyms
Actemra; Actemra (TN); Tocilizumab (USAN/INN); Tocilizumab (genetical recombination); Tocilizumab (genetical recombination) (JAN); humanized IgG1 monoclonal antibody
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 Compound Name Benorilate Approved [6]
Synonyms
5003-48-5; BENORYLATE; 4-acetamidophenyl 2-acetoxybenzoate; Benoral; Salipran; Benortan; Fenasprate; Fenasparate; Aspirin acetaminophen ester; Benorilato; Benorilato [Spanish]; p-Acetamidophenyl acetylsalicylate; Benorilatum [INN-Latin]; Benorilato [INN-Spanish]; UNII-W1QX9DV96G; p-N-Acetylaminophenylacetylsalicylate; TO 125; WIN 11450; 4'-(Acetamido)phenyl-2-acetoxybenzoate; 2-Acetoxy-4'-(acetamino)phenylbenzoate; CCRIS 1739; Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester; 4-Acetamidophenyl salicylate acet
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 Compound Name Halopredone acetate Approved [6]
Synonyms
Haloart (TN)
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 Compound Name Teriflunomide Approved [35]
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 Compound Name Upadacitinib Approved [36]
Synonyms
ABT-494
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External Link
 Compound Name Siponimod Phase 2 [19]
Synonyms
BAF312
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External Link
 Compound Name Oxyphenbutazone Approved [6]
Synonyms
Tandearil
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External Link
 Compound Name FENBUFEN Approved [6]
Synonyms
36330-85-5; Lederfen; Cinopal; Napanol; Bufemid; 4-(4-Biphenylyl)-4-oxobutyric acid; 3-(4-Phenylbenzoyl)propionic acid; 3-(4-Biphenylylcarbonyl)propionic acid; 4-(biphenyl-4-yl)-4-oxobutanoic acid; gamma-Oxo(1,1'-biphenyl)-4-butanoic acid; 3-(4-Biphenylcarbonyl)propionic acid; Cinopol; Fenbufenum [INN-Latin]; Fenbufene [INN-French]; 4-([1,1'-biphenyl]-4-yl)-4-oxobutanoic acid; CL-82204; CL 82204; 4-biphenyl-4-yl-4-oxobutanoic acid; Butyric acid 4-(4-biphenyl)-4-oxo-; UNII-9815R1WR9B; 4-oxo-4-(4-phenylphenyl)butanoic a
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 Compound Name Dexchlorpheniramine Maleate Approved [6]
Synonyms
Polaramine
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 Compound Name Enbrel Approved [37]
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 Compound Name Fenoprofen Approved [38]
Synonyms
Fenoprofene; Fenoprofeno; Fenoprofenum; Feprona; Nalfon; Nalgesic; Feneprofen calcium salt dihydrate; Fenoprofen calcium; Fenoprofen calcium hydrate; Lilly 53838; Fenoprofen Dihydrate, Calcium Salt; Fenoprofene [INN-French]; Fenoprofeno [INN-Spanish]; Fenoprofenum [INN-Latin]; Fenopron (TN); Fenoprofen (USAN/INN); Fenoprofen [USAN:BAN:INN]; Alpha-(m-phenoxyphenyl)propionic acid; Alpha-Methyl-3-phenoxybenzeneacetic acid; (+-)-2-(3-Phenoxyphenyl)propionic acid; (+-)-m-Phenoxyhydratropic acid; 2-(3-Phenoxyphenyl)propanoic acid; 2-(3-Phenoxyphenyl)propionic acid; 2-(m-phenoxyphenyl)propionic acid; 2-[3-(phenyloxy)phenyl]propanoic acid
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 Compound Name Celecoxib Approved [39]
Synonyms
CEL; Celebra; Celebrex; Celecox; Celecoxi; Celocoxib; Eurocox; Medicoxib; Onsenal; Solexa; Xilebao; Celecoxib [Old RN]; Celecoxib [USAN]; Pfizer brand of celecoxib; SC 58635; SC58635; YM 177; YM177; AI-525; CEP-33222; Celebra (TN); Celebrex (TN); SC-58635; TPI-336; YM-177; Celebrex, Celebra, Celecoxib; Celecoxib (SC-58635); Celecoxib (JAN/USAN/INN); SC-58553, SC-58635; P-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide; Benzenesulfonamide,4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl); 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE; 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl] benzenesulfonamide; 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
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 Compound Name Sodium Succinate Approved [6]
Synonyms
Disodium succinate; 150-90-3; Disodium butanedioate; Butanedioic acid, disodium salt; Succinic acid disodium salt; Soduxin; Jantaran sodny [Czech]; UNII-V8ZGC8ISR3; Succinic acid, disodium salt; FEMA No. 3277; CCRIS 3700; Sodium succinate dibasic; EINECS 205-778-7; V8ZGC8ISR3; Butanedioic acid, sodium salt (1:2); Succinic acid disodium salt anhydrous; Butanedioic acid disodium salt; sodium succinate (anhydrous); Jantaran sodny; Butanedioic acid disodium hexahydrate; Succinic acid, disodium salt, 99%, anhydrous
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 Compound Name Sulfasalazine Approved [40]
Synonyms
599-79-1; Salicylazosulfapyridine; Salazosulfapyridine; Azulfidine; Asulfidine; Salazopyridin; Sulcolon; Azopyrin; Accucol; Colo-Pleon; Salazopiridazin; Salisulf; Reupirin; Benzosulfa; Azopyrine; Salazosulfapyridin; Sulfasalazina; w-t Sasp oral; Sulfasalazinum; Sulfasalazin; Azulfidine EN; Sulfazalazine; Azulfidine EN-tabs; Salazosulfapiridina; Sas-500; Salazosulfapyridinum; Azosulfidin; SASP; Salazo-sulfapyridinum; 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid; Sulfasalizine
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 Compound Name Anakinra Approved [41]
Synonyms
Kineret; Kineret (TN); Anakinra (USAN/INN)
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 Compound Name Cyproheptadine Approved [6]
Synonyms
Ciproheptadina; Ciprovit; Cypoheptadine; Cyproheptadiene; Cyproheptadinum; Dihexazin; Dronactin; Eiproheptadine; Periactin; Periactine; Periactinol; Viternum; Cyproheptadine Hcl; MK 141; Ciproheptadina [INN-Spanish]; Ciprovit (TN); Cyproheptadine (INN); Cyproheptadine [INN:BAN]; Cyproheptadinum [INN-Latin]; Dibenzosuberonone/Cyproheptadine; Periactin (TN); 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine; 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine; 4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine; 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
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 Compound Name Niflumic Acid Approved [42]
Synonyms
Actol; Donalgin; Flunir; Forenol; Landruma; NFL; Niflactol; Niflam; Niflugel; Niflumate; Nifluril; Acide niflumique; Acide niflumique [French]; Acido niflumico; Acido niflumico [Italian]; Acidum niflumicum; Nifluminic acid; UPSA Conseil Brand of Niflumic Acid; Upsamedica Brand of Niflumic Acid; N 0630; SC 1332; UP 83; UPSA Brand 1 of Niflumic Acid; UPSA Brand 2 of Niflumic Acid; Acid, Niflumic; Acide niflumique [INN-French]; Acido niflumico [INN-Spanish]; Acidum niflumicum [INN-Latin]; Niflugel (TN); Niflumic acid (INN); Niflumic acid [INN:DCF]; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-Trifluoromethylanilino)nicotinic Acid; 2-(3-[Trifluoromethyl]anilino)nicotinic acid; 2-(A,A,A-Trifluoro-m-toluidino)nicotinic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID; 2-[(3-Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid; 2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid; 2-[alpha,alpha,alpha-trifluoro-m-toluidino]-nicotinic acid; 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 39690A
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 Compound Name Nipocalimab Phase 2 [43]
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 Compound Name Nipocalimab? Phase 3 [43]
External Link
 Compound Name BI 695501 Phase 3 [44]
Synonyms
BI-695501)
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 Compound Name PF-06410293 Phase 3 [19]
External Link
 Compound Name IB-MECA Phase 3 [19]
Synonyms
152918-18-8; piclidenoson; CF-101; 3-IB-Meca; N(6)-Ibamu; CF 101; Cf101; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine; UNII-30679UMI0N; N(6)-(3-Iodobenzyl)adenosine-5'-N-methyluronamide; 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide; CHEMBL119709; CHEBI:73286; 30679UMI0N; RPR-113090; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; N(6)-(3-iodo-benzyl)adenosine-5'-N-methyluronamide
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 Compound Name SA-237 Phase 3 [45]
Synonyms
Second generation IL-6 antagonist (mAb, inflammatory disease), Chugai
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 Compound Name Flobufen Phase 3 [46]
Synonyms
VUFB-16066; VUFB-17203
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 Compound Name BI-695500 Application submitted [19]
Synonyms
Rituximab biosimilar
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External Link
 Compound Name GS-5745 Phase 3 [19]
External Link
 Compound Name CG-100649 Phase 3 [47]
Synonyms
Polmacoxib; 301692-76-2; UNII-IJ34D6YPAO; CG100649; IJ34D6YPAO; 4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide; 4-[3-(3-Fluorophenyl)-5,5-Dimethyl-4-Oxidanylidene-Furan-2-Yl]benzenesulfonamide; 4-(3-(3-Fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-benzenesulfonamide; Polmacoxib [USAN:INN]; Acelex (S. Korea); CG 100649; Polmacoxib (USAN/INN); SCHEMBL3233093; CHEMBL166863; GTPL8316; EX-A601; IJWPAFMIFNSIGD-UHFFFAOYSA-N; ZINC589683; BCP15550; AKOS025149767; SB17177; DB12399
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 Compound Name Resveratrol Phase 3 [19]
Synonyms
Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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 Compound Name GP-2017 Phase 3 [19]
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 Compound Name RAVAX Phase 3 [48]
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 Compound Name Cartistem Phase 3 [49]
Synonyms
Stem cell therapy (cartilage disease/rheumatoid arthritis), Medipost
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 Compound Name IR-201 Phase 3 [50]
Synonyms
Seryl-glutaminyl-isoleucyl-valyl-asparaginyl-aspartyl-phenylalanyl-glutaminyl-lysyl-glycyl-aspartyl-isoleucyl-alanyl-glutamyl-glycyl-tyrosyl-serine
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 Compound Name Esonarimod Phase 3 [51]
Synonyms
Sonatimod; KE-298; KE-749; KE-758; NE-298; (R)-KE-298; (S)-KE-298
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 Compound Name CIPEMASTAT Phase 3 [52]
Synonyms
Trocade; Ro 32-3555; 190648-49-8; UNII-02HQ4TYQ60; 02HQ4TYQ60; GFUITADOEPNRML-SJORKVTESA-N; Cipemastat [USAN:INN]; Ro 32-3555/000; Trocade (TN); Cipemastat (USAN/INN); GTPL6466; CHEMBL115653; SCHEMBL7088217; CTK8F1312; BDBM30344; MolPort-023-276-601; ZINC600699; (alphaR,betaR)-beta-(Cyclopentylmethyl)-gamma-oxo-alpha-((3,4,4-piperidinebutyrohydroxamic acid; AKOS024457333; HY-19677; Ro-32-03555; Ro-323555000; RT-015421; RO32-3555; CS-0016192; D03517; J-012306
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 Compound Name Methylprednisolone Approved [6]
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 Compound Name STI-002 Phase 3 [19]
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 Compound Name ABT-874 Discontinued in Phase 2 [23]
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 Compound Name MK-8808 Phase 1 [53]
External Link
 Compound Name Sivelestat Application submitted [19]
Synonyms
127373-66-4; UNII-DWI62G0P59; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; Elastase Inhibitor IV; C20H22N2O7S; N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid; Sivelestat (ONO-5046); LY544349; CHEMBL76688; LY 544349; DWI62G0P59; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-; N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine
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 Compound Name ABP 798 Phase 3 [19]
External Link
 Compound Name TG-C Phase 3 [54]
Synonyms
3-Thiaglutaryl-Coa; S-[[(2-Hydroxy-2-oxoethyl)thio]acetyl]coenzyme A; (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18,21-dithia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide; TGC
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 Compound Name PF-06438179 Phase 3 [19]
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 Compound Name Baricitinib Approved [6]
External Link
 Compound Name Cilengitide Phase 3 [55]
Synonyms
188968-51-6; EMD-121974; Cilengitide [USAN:INN]; UNII-4EDF46E4GI; EMD121974; EMD-12192; EMD 121974; 4EDF46E4GI; CHEMBL429876; 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid; Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cilengitide (TFA salt)
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 Compound Name CEP-41750 Phase 3 [56]
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 Compound Name Sarilumab Approved [6]
External Link
 Compound Name Andolast Phase 3 [57]
Synonyms
Dizolast; CR-2039; Calcium-activated potassium channel opener (inhaled powder, asthma), Rottapharm
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 Compound Name Vanadate Phase 3 [19]
Synonyms
Ammonium metavanadate; 7803-55-6; Ammonium vanadate(V); UNII-FL85PX638G; FL85PX638G; Ammonium metavanadate, ACS reagent; Ammoniummetavanadate; Ammonium metavanadate, 99.5%, for analysis; Ammonium metavanadate, 99.996%, (trace metal basis); Ammonium meta-Vanadate; Vanadate (VO31-), ammonium (1:1); AC1LANGP; ammonium vanadiumoylolate; H4NO3V; EC 232-261-3; azanium oxido(dioxo)vanadium; KS-00000WUM; UNTBPXHCXVWYOI-UHFFFAOYSA-O; MolPort-044-723-987; MolPort-003-925-733; MFCD00011430; AKOS030228605; AMMONIUM VANADATE (META), NH4VO3
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 Compound Name CPL-7075 Phase 3 [19]
Synonyms
Ajulemic acid; Lenabasum; IP-751; CT-3; 137945-48-3; IP 751; UNII-OGN7X90BT8; CPL7075; JBT-101; OGN7X90BT8; Resunab; (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid; (6ar,10ar)-3-(1,1-Dimethylheptyl)-1-Hydroxy-6,6-Dimethyl-6a,7,10,10a-Tetrahydro-6h-Benzo[c]chromene-9-Carboxylic Acid; DMH-THC-11-OIC; AB-III-56; CT 3; CPL 7075; Lenabasum [USAN]; HU-239; AC1MJ0SY; SCHEMBL26441; CHEMBL456341; GTPL9772; IP751; Mixed CB agonist/sodim channel blocker (pain), Cervelo
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 Compound Name Spermidine Phase 3 [19]
Synonyms
Spermidin; UNII-U87FK77H25; BRN 1698591; AI3-26636; EINECS 204-689-0; CHEMBL19612; CHEBI:16610; ATHGHQPFGPMSJY-UHFFFAOYSA-N; U87FK77H25; MFCD00008229; Spermidine hydrochloride; NSC528399; 1pot; Aminopropylbutandiamine; N-(4-Aminobutyl)-1,3-diaminopropane; Spectrum_000005; Tocris-0959; ACMC-20ajn3; AC1L1AQB; Spectrum2_000874; Spectrum3_000977; Spectrum4_001101; Spectrum5_001561; Lopac-S-2501; Biomol-NT_000212; bmse000116; bmse000951; bmse000955; Spermidine 0.1 M solution; Lopac0_001047; SCHEMBL15618; BSPBio_002613; KBioGR_001542; KBioSS_000345; 4-04-00-01300 (Beilstein Handbook Reference); DivK1c_001007; SPBio_000947; Spermidine, > =99% (GC); Spermidine, analytical standard; BPBio1_001276; GTPL2390; DTXSID4036645; CTK3J1693; KBio1_001007; KBio2_000345; KBio2_002913; KBio2_005481; KBio3_001833; MolPort-001-761-230; NINDS_001007; HY-B1776; ZINC1532612; BDBM50009353; PA(34); N-(3-Aminopropyl)-4-aminobutylamine; AKOS006222987; CCG-205124; DB03566; MCULE-8096530192; RTR-003757; SDCCGMLS-0066822.P001; IDI1_001007; NCGC00015937-01; NCGC00015937-02; NCGC00015937-03; NCGC00015937-04; NCGC00015937-05; NCGC00024903-01; NCGC00024903-02; NCGC00024903-03; AJ-26792; AN-22947; LS-45643; M923; NCI60_004294; SC-69371; DB-026892; TR-003757; CS-0013804; FT-0629162; ST24048721; ST45025991; C00315; 124S209; SR0
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External Link
 Compound Name Varespladib methyl Phase 3 [58]
Synonyms
A-002; LY-333013; S-3013; Varespladib methyl (oral formulation, coronary artery disease); PLA2 inhibitors (inflammation), Lilly/Shionogi; Varespladib (oral formulation, coronary artery disease), Anthera; Varespladib methyl (oral formulation, coronary artery disease), Anthera
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External Link
 Compound Name GP2013 Phase 3 [19]
External Link
 Compound Name ABP 501 Phase 3 [59]
External Link
 Compound Name ASP-015K Phase 3 [19]
Synonyms
Peficitinib; ASP015K; UNII-HPH1166CKX; 944118-01-8; HPH1166CKX; 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; Peficitinib [USAN:INN]; ASP 015K; JNJ-54781532; 9T6; Peficitinib (USAN/INN); SCHEMBL1154421; SCHEMBL9990248; SCHEMBL4447032; GTPL8315; SCHEMBL9990240; SCHEMBL1154418; CHEMBL3137308; SCHEMBL17645135; BCP18465; BDBM50124208; SB16834; DB11708; SC-17960; D10653; Peficitinib pound A
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External Link
 Compound Name Anakinra Approved [60]
External Link
 Compound Name CHS-0214 Phase 3 [19]
External Link
 Compound Name Atacicept Phase 2 [61]
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 Compound Name Tenidap Phase 3 [62]
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 Compound Name Sirukumab Phase 3 [63]
External Link
 Compound Name Olokizumab Phase 3 [19]
External Link
 Compound Name LY3090106 Phase 1 [64]
Synonyms
Tibulizumab
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External Link
 Compound Name VX-509 Phase 2/3 [65]
Synonyms
Decernotinib; Adelatinib; 944842-54-0; UNII-MZK2GP0RHK; Decernotinib(VX-509); VX509; MZK2GP0RHK; VRT-831509; VX 509; (2r)-2-Methyl-2-[[2-(1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-4-Yl]amino]-N-[2,2,2-Tris(Fluoranyl)ethyl]butanamide; (R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide; Decernotinib [USAN:INN]; VRT 831509; Decernotinib,VX-509; Decernotinib (USAN/INN); Decernotinib (VX-509); VX-509 (Decernotinib); SCHEMBL2630387; GTPL8309; CHEMBL3039513; KS-00001CYK
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 Compound Name Olokizumab Phase 3 [66]
External Link
 Compound Name CreaVax-RA Phase 2a [67]
Synonyms
Autologous DC therapy (injectable, rheumatoid arthritis), CreaGene; Autologous dendritic cell therapy (injectable, rheumatoid arthritis), CreaGene
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 Compound Name RhuDex Phase 2a [61]
External Link
 Compound Name VX-702 Phase 2a [68]
Synonyms
ST51054128; I14-1965; EC-000.2363; 6-[carbamoyl-(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)pyridine-3-carboxamide
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External Link
 Compound Name Cevidoplenib Phase 2 [69]
Synonyms
(S)-cyclopropyl(5-(4-(4-((4-hydroxyisoxazolidin-2-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-ylamino)-1-methyl-1H-indol-3-yl)methanone; 1703788-21-9; 3N3H8BX897; AKOS040748110; BDBM196772; Cevidoplenib; Cevidoplenib [INN]; Cevidoplenib [WHO-DD]; CHEMBL3921923; CS-0039259; cyclopropyl-[5-[[4-[4-[[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]methyl]-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]-1-methylindol-3-yl]methanone; EX-A5914; HY-109082; Methanone, cyclopropyl(5-((4-(4-(((4S)-4-hydroxy-2-isoxazolidinyl)methyl)-3-methyl-1H-pyrazol-1-yl)-2-pyrimidinyl)amino)-1-methyl-1H-indol-3-yl)-; MS-28778; SCHEMBL16653204; UNII-3N3H8BX897; US9212178, 1; YCZUBLQESBVOSH-IBGZPJMESA-N
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External Link
 Compound Name Zunsemetinib Phase 2 [70]
Synonyms
(-)-3-Chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl[1(2H),4'-bipyridin]-2-one; (1(2H),4'-Bipyridin)-2-one, 3-chloro-4-((3,5-difluoro-2-pyridinyl)methoxy)-2'-(2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl)-5',6-dimethyl-, (-)-; (2'S)-3-Chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl[1(2H),4'-bipyridin]-2-one; (P)-(3-chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2H-[1,4'-bipyridin]-2-one); (p)-3-Chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2H-(1,4'-bipyridin)-2-one; (R)-Zunsemetinib; [1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (2'S)-; 1639791-42-6; 1640282-42-3; 1640282-44-5; 3-Chloro-4-((3,5-difluoropyridin-2-yl)methoxy)-2'-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-5',6-dimethyl-2H-[1,4'-bipyridin]-2-one; 3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-[2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl]-6-methylpyridin-2-one; 3-chloro-4-[(3,5-difluoropyridin-2-yl)methoxy]-1-{2-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]-5-methylpyridin-4-yl}-6-methylpyridin-2-one; AKOS040756965; Ati 450; ATI 450 [WHO-DD]; ATI450; ATI-450; AX2VWG0ZCR; BDBM175242; CDD450; CDD-450; CHEMBL3704901; CS-0204147; CS-0374185; EX-A6292; GTPL11681; HY-139553; HY-139553A; MS-29543; SCHEMBL16279876; UNII-AX2VWG0ZCR; US9115089, 49; WHO 11983; zunsemetinib; Zunsemetinib [INN]; Zunsemetinib [USAN:INN]; Zunsemetinib [USAN]; Zunsemetinib M-atropisomer
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 Compound Name Dazodalibep Phase 2 [71]
Synonyms
VIB4920
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 Compound Name Natrunix Phase 2 [72]
External Link
 Compound Name A223 Phase 2 [73]
External Link
 Compound Name GS-5718 Phase 2 [74]
Synonyms
1-BOC-3-IODO-1H-PYRAZOLO[3,4-B]PYRIDINE; 1H-PYRAZOLO[3,4-B]PYRIDINE-1-CARBOXYLIC ACID, 3-IODO-, 1,1-DIMETHYLETHYLESTER; 1H-Pyrazolo[3,4-b]pyridine-1-carboxylicacid,3-iodo-,1,1-diMethylethylester; 920036-34-6; A860172; AKOS022178093; AMY21637; CS-0048281; FT-0702852; GS-5718; MFCD13183727; OKKLWSNHFSFXEM-UHFFFAOYSA-N; PB26872; SCHEMBL3606964; tert-Butyl 3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; tert-butyl 3-iodopyrazolo[3,4-b]pyridine-1-carboxylate; tert-Butyl3-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate
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External Link
 Compound Name Branebrutinib Phase 2 [75]
Synonyms
(S)-4-(3-(2-BUTYNOYLAMINO)PIPERIDIN-1-YL)-5-FLUORO-2,3-DIMETHYL-1H-INDOLE-7-CARBOXAMIDE; (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 1912445-55-6; 1H-Indole-7-carboxamide, 5-fluoro-2,3-dimethyl-4-((3S)-3-((1-oxo-2-butyn-1-yl)amino)-1-piperidinyl)-; 4-((3S)-3-(2-BUTYNOYLAMINO)-1-PIPERIDINYL)-5-FLUORO-2,3-DIMETHYL-1HINDOLE-7-CARBOXAMIDE; 4-((3S)-3-(2-Butynoylamino)-1-piperidinyl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 4-((3S)-3-(But-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 4-[(3S)-3-(but-2-ynamido)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide; 7LBRZUYSHU; AC-31535; AKOS037649047; BCP29496; BDBM164638; BDBM166759; BMS986195; BMS986195; BMS986195; BMS-986195; Branebrutinib; Branebrutinib (BMS-986195); Branebrutinib (USAN); BRANEBRUTINIB [INN]; Branebrutinib [USAN]; BRANEBRUTINIB [WHO-DD]; BS-16393; C20H23FN4O2; CHEMBL4297674; CS-0043577; D11478; DB15347; EN300-2007801; EX-A2720; Example 223 [US20160115126A1]; GTPL9869; HY-112161; MFCD31631584; NSC807627; NSC-807627; Q50825082; s8832; SCHEMBL17699728; UNII-7LBRZUYSHU; US9688629, 123; US9688629, 223; VJPPLCNBDLZIFG-ZDUSSCGKSA-N; WHO 11026
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 Compound Name EQ121 Phase 2 [76]
External Link
 Compound Name Vobarilizumab Phase 2 [77]
Synonyms
ALX-0061
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External Link
 Compound Name IRL201805 Phase 2 [78]
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 Compound Name KPL-404 Phase 2 [79]
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 Compound Name ABBV-154 Phase 2 [80]
External Link
 Compound Name FK-3311 Phase 2 [81]
Synonyms
116686-15-8; FK 3311; FK3311; COX-2 Inhibitor V, FK3311; N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide; N-(4-Acetyl-2-(2,4-difluorophenoxy)phenyl)methanesulfonamide; 4'-Acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide; Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-; C15H13F2NO4S; Methanesulfonamide, N-(4-acetyl-2-(2,4-difluorophenoxy)phenyl)-; DIIYLGZNZGPXRR-UHFFFAOYSA-N; AC1L4U0O; AC1Q6W4K; SCHEMBL441676; ZINC3880; DIIYLGZNZGPXRR-UHFFFAOYSA-; CTK8E9207; EX-A545; DTXSID90151474
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 Compound Name TAK-783 Phase 2 [82]
Synonyms
Rheumatoid arthritis therapy (oral), Takeda Pharmaceutical
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 Compound Name Piclamilast Phase 2 [83]
Synonyms
144035-83-6; Cpodpmb; RP 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide; UNII-WM58D7C3ZT; RP 73-401; RP-73401; RP-73-401; RPR 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; WM58D7C3ZT; Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-; CHEMBL42126; CHEBI:47619; RRRUXBQSQLKHEL-UHFFFAOYSA-N; RPR-73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide; PIL
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 Compound Name ADL-5859 Phase 2 [84]
Synonyms
PF-04856880
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External Link
 Compound Name SBI-087 Phase 2 [85]
Synonyms
PF-05230895
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External Link
 Compound Name SB-705498 Phase 2 [86]
Synonyms
501951-42-4; SB705498; SB 705498; UNII-T74V9O0Y2W; (R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea; T74V9O0Y2W; 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea; N-(2-Bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]urea; 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]urea; JYILLRHXRVTRSH-GFCCVEGCSA-N; MLS006011113; SCHEMBL1350298; GTPL4311; CHEMBL207433; BMCL163287 Compound 15; BDBM20504
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 Compound Name BMS-817399 Phase 2 [87]
External Link
 Compound Name PRALNACASAN Phase 2 [88]
Synonyms
VX-740; UNII-N986NI319S; 192755-52-5; N986NI319S; HMR3480/VX-740; Pralnacasan [USAN:INN]; HMR 3480; VX 470; Pralnacasan (USAN/INN); AC1L4A1A; SCHEMBL142187; GTPL6467; CHEMBL437526; DTXSID60172873; HMR3480; HMR-3480; BDBM50189360; AKOS030230853; DB04875; D08978; (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide
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External Link
 Compound Name F-8-IL-10 fusion protein Phase 2 [19]
Synonyms
Dekavil; F-8-IL-10; F-8-IL-10 fusion protein (rheumatoid arthritis/endometriosis); F-8-IL-10 fusion protein (rheumatoid arthritis/endometriosis), Philogen
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 Compound Name GLPG-0634 Phase 2 [89]
Synonyms
Small molecule, JAK1/JAK2 inhibitor (rheumatoid arthritis), Galapagos/GSK
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 Compound Name CFZ533 Phase 2 [90]
External Link
 Compound Name PD-360324 Phase 2 [91]
Synonyms
PD-0360324; MCSF mAb (RA), Pfizer; Macrophage colony stimulating factor monoclonal antibody (rheumatoid arthritis), Pfizer
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 Compound Name MGCD-290 Phase 2 [92]
Synonyms
MG-1; MG-3290; Histone deacetylase inhibitors (cardiovascular diseases), MethylGene; Histone deacetylase inhibitors (diabetes), MethylGene; Histone deacetylase inhibitors (fungal infection), MethylGene; Histone deacetylase inhibitors (inflammation), MethylGene; HDAC inhibitors (non-oncology), MethylGene; Histone deacetylase inhibitors (non-oncology), MethylGene
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 Compound Name Prednisone/ dipyridamole Phase 2 [93]
Synonyms
Synavive (TN)
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 Compound Name QAL964 Phase 2 [94]
External Link
 Compound Name M2951 Phase 2 [19]
Synonyms
evobrutinib; UNII-ZA45457L1K; ZA45457L1K; 1415823-73-2; 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one; 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one; Evobrutinib [INN]; GTPL9752; SCHEMBL14165673; QUIWHXQETADMGN-UHFFFAOYSA-N; MSC2364447C; MSC-2364447C; ZINC205623965; AKOS032954004; CS-6303; MSC 2364447; HY-101215; A250 [WO2012170976]; N-[(1-acryloylpiperidin-4-yl)methyl]-5-(4-phenoxyphenyl)pyrimidine-4,6-diamine; 1-(4-((6-Amin
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 Compound Name AK-106-001616 Phase 2 [95]
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 Compound Name ABT-122 Phase 2 [96]
External Link
 Compound Name ETIPREDNOL DICLOACETATE Phase 2 [97]
Synonyms
BNP-166; Cronaze (Ivax); Ethinase (Ivax); Etiprednol dicloacetate < USAN; Respicort (Ivax); (11beta,17alpha)-17-(2,2-Dichloroacetoxy)-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid ethyl ester
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 Compound Name Meninge ACYW Phase 2 [98]
External Link
 Compound Name TAK-715 Phase 2 [99]
Synonyms
P38 MAP kinase inhibitor (rheumatoid arthritis), Takeda
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 Compound Name ALD-518 Phase 2 [100]
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 Compound Name MPC-300-IV Phase 2 [19]
External Link
 Compound Name GSK2982772 Phase 1 [19]
Synonyms
LYPAFUINURXJSG-AWEZNQCLSA-N; 1622848-92-3; UNII-T5W3M0VO9B; T5W3M0VO9B; GSK-2982772; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide; GTPL9554; SCHEMBL15956219; MolPort-044-830-634; s8484; AKOS030528033; compound 5 [PMID: 28151659]; ACN-041458; CS-6899; GSK 2982772; AS-35128; AC-29894; HY-101760; J3.650.802G; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide; 3-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydr
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 Compound Name Anti-LT alpha Phase 2 [101]
External Link
 Compound Name NNC-0151-0000-0000 Phase 2 [102]
Synonyms
Neutrazumab; Anti-C5aR monoclonal antibodies (rheumatoid arthritis/SLE), G2/Novo Nordisk
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 Compound Name BMS-945429 Phase 2 [103]
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 Compound Name ONO-4641 Phase 2 [104]
Synonyms
Sphingosine-1-phosphate agonist (tablet, mutiple sclerosis), Ono
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 Compound Name IMO-8400 Phase 2 [19]
Synonyms
Bazlitoran; Bazlitoran [INN]; Bazlitoran [USAN]; UNII-2U46M95B5M; 2U46M95B5M
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 Compound Name CNT0-1959 Phase 2 [105]
External Link
 Compound Name Apratastat Phase 2 [106]
Synonyms
TMI-005; TMI-05; UNII-C6BZ5263BJ; 287405-51-0; C6BZ5263BJ; CHEMBL206815; TMI 005; Apratastat [USAN:INN]; Apratastat (USAN/INN); MLS006010301; SCHEMBL2834310; GTPL6482; TMI005; Apratastat, &gt; MolPort-021-805-014; BCPP000041; ZINC28571311; BDBM50181008; DB13020; API0013699; compound 5h [PMID: 16426848]; SMR004701369; 4CA-0170; D08859; 3-Thiomorpholinecarboxamide,N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-,(3S)-; TMI-1; Dual TACE/MMP-13 inhibitors (inflammation), Wyeth; Dual TACE/MMP-13 inhibitors (rheumatoid arthritis), Wyeth; Dual TACE/MMP-13 inhibitors, Wyeth-Ayerst
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 Compound Name FLUASTERONE Phase 2 [107]
Synonyms
HE-2500; 16alpha-Fluoroandrost-5-en-17-one
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External Link
 Compound Name GS-4059 Phase 2 [19]
Synonyms
tirabrutinib; 1351636-18-4; UNII-LXG44NDL2T; LXG44NDL2T; Tirabrutinib [INN]; ONO-4059(Free base); SCHEMBL14798454; MolPort-044-728-902; BDBM194087; ZINC72318699; AKOS030526437; CS-5676; HY-15771; US9199997, 9; F10085; (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one; 6-Amino-9-((3R)-1-(2-butynoyl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one; 8H-Purin-8-one,6-amino-7,9-dihydro-9-((3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl); 6-Amino-9-[(3R)-1-(2-butyno
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 Compound Name VVZ-149 Phase 2 [108]
Synonyms
VVZ-000149
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 Compound Name MRC-375 Phase 2 [109]
Synonyms
Tetracycline (enteric-coated oral tablet, rheumatoid arthritis), Molecular Research Center Inc
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 Compound Name AWD-12-281 Phase 2 [110]
Synonyms
GW-842470; AWD-12-343; AWD-12-281 (COPD), elbion/GlaxoSmithKline; AWD-12-281 (allergic rhinitis), elbion/GlaxoSmithKline; AWD-12-281 (asthma), elbion/GlaxoSmithKline; AWD-12-281 (inhaled), elbion/GlaxoSmithKline; AWD-12-281 (intranasal), elbion/GlaxoSmithKline
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 Compound Name APX-001 Investigative [111]
Synonyms
EPI-0010; SSS-07; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Apexigen; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Epitomics
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External Link
 Compound Name SR-31747 Phase 2 [112]
Synonyms
SR-317417A
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External Link
 Compound Name STA-5326 Phase 2 [113]
Synonyms
Apilimod; STA 5326; STA5326; N-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
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 Compound Name BI 655064 Phase 2 [114]
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 Compound Name GSK3196165 Phase 2 [19]
External Link
 Compound Name GSK315234 Phase 2 [115]
Synonyms
Oncostatin M mAb
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External Link
 Compound Name GS-9876 Phase 1 [19]
Synonyms
XCIGZBVOUQVIPI-UHFFFAOYSA-N; lanraplenib; UNII-A6U64OU57E; A6U64OU57E; 6-(6-aminopyrazin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine; 6-(6-Aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine; Lanraplenib [INN]; GTPL9764; SCHEMBL16820581; CHEMBL3986824; example 2 [US9290505]; BDBM212271; GS9876; US9290505, Ex.-2; Ex.-2, US9290505; Imidazo(1,2-a)pyrazin-8-amine, 6-(6-amino-2-pyrazinyl)-N-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)-; 6-(6-Aminopyr
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External Link
 Compound Name TZI-41078 Phase 2 [116]
Synonyms
3,5-Di-tert-butyl-4-hydroxybenzophenone oxime
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External Link
 Compound Name SAN-300 Phase 2 [117]
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 Compound Name CNTO-6785 Phase 2 [118]
External Link
 Compound Name AMG-714 Discontinued in Phase 1 [23]
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 Compound Name LX2931 Phase 2 [119]
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 Compound Name VAY736 Phase 2 [19]
External Link
 Compound Name KB002/003 Phase 2 [120]
External Link
 Compound Name SSR-180575 Phase 2 [121]
Synonyms
2-(7-Chloro-5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyridazino[4,5-b]indol-1-yl)-N,N-dimethylacetamide
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External Link
 Compound Name Rabeximod Phase 2 [122]
Synonyms
Rob-803; B-220 analog (RA), OxyPharma; B-220 analog (rheumatoid arthritis), OxyPharma
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 Compound Name BIIB 023 Phase 2 [123]
External Link
 Compound Name Baminercept Phase 2 [124]
Synonyms
BG-9924; Soluble lymphotoxin beta receptor, Biogen; Soluble lymphotoxin beta receptor, Biogen Idec
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External Link
 Compound Name PF-06823859 Phase 2 [125]
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 Compound Name MK-8457 Phase 2 [126]
External Link
 Compound Name CDP323 Phase 2 [23]
Synonyms
Zaurategrast; 455264-31-0; (S)-3-(4-((2,7-Naphthyridin-1-yl)amino)phenyl)-2-((2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino)propanoic acid; UNII-06A0IC74I3; 06A0IC74I3; C26H25BrN4O3; Zaurategrast [INN]; SCHEMBL2976322; CTK8C0588; DTXSID90196547; MolPort-023-332-826; KS-00001DY0; ANW-64932; 6274AB; ZINC100041912; AKOS016005046; CS-0322; N-(2-Bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylamino)-L-phenylalanine; NCGC00378753-01
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 Compound Name Tofacitinib Approved [127]
External Link
 Compound Name BMS-986142 Phase 2 [19]
Synonyms
Unii-pjx9GH268R; PJX9GH268R; CHEMBL3900554; 1643368-58-4; GTPL9857; SCHEMBL16319712; BMS986142; BDBM50194720; AKOS032954006; compound 14f [PMID: 27583770]; J3.563.199B; 73T; 6-Fluoro-5-(R)-(3-(S)-(8-Fluoro-1-Methyl-2,4-Dioxo-1,2-Dihydroquinazolin-3(4h)-Yl)-2-Methylphenyl)-2-(S)-(2-Hydroxypropan-2-Yl)-2,3,4,9-Tetrahydro-1h-Carbazole-8-Carboxamide; (7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide
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External Link
 Compound Name NN8765 Phase 2 [128]
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 Compound Name CDP-6038 Phase 2 [100]
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 Compound Name DE-098 Phase 2 [129]
Synonyms
ARG-098; Anti-Fas antibody, Santen; Anti-APO-1 antibody, Santen
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 Compound Name AMG0714 Phase 2 [130]
Synonyms
HuMax-IL15
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External Link
 Compound Name Fosbretabulin Phase 2 [131]
Synonyms
Zybrestat (TN)
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External Link
 Compound Name Rimacalib Phase 2 [132]
Synonyms
SMP-114
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External Link
 Compound Name Mavrilimumab Phase 2 [133]
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 Compound Name NN8555 Phase 2 [134]
External Link
 Compound Name GSK2586184 Phase 2 [135]
Synonyms
GSK-2586184
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External Link
 Compound Name PTC299 Phase 2 [136]
Synonyms
6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole; skf-86002; 72873-74-6; Skf 86002; F 86002; F 86002-A(2); UNII-9R6QDF1UO7; 9R6QDF1UO7; CHEMBL313417; 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b)-thiazole; 4-[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]pyridine; 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]thiazole; 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole; Imidazo(2,1-b)thiazole,; SK&F 86002
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External Link
 Compound Name CCX-354 Phase 2 [19]
Synonyms
CCX-354-C; GSK2941266
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External Link
 Compound Name [L/D]-aminopterin Phase 2 [137]
External Link
 Compound Name ALX-0061 Phase 2 [19]
Synonyms
Nanobody therapeutic (autoimmune/inflammatory disease), Ablynx; Anti-IL-6R nanobody therapeutic (autoimmune/inflammatory disease), Ablynx
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External Link
 Compound Name Ozoralizumab Phase 2 [138]
Synonyms
ATN-103
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External Link
 Compound Name JNJ-38518168 Phase 2 [139]
External Link
 Compound Name Clazakizumab Phase 2 [19]
External Link
 Compound Name UCB-35440 Phase 2 [140]
Synonyms
5-[4-(N-Carbamoyl-N-hydroxyamino)-1-butynyl]-2-[2-[4-[1(R)-(4-chlorophenyl)-1-phenylmethyl]piperazin-1-yl]ethoxy]benzamide
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External Link
 Compound Name Otilimab Phase 3 [141]
External Link
 Compound Name Pegsunercept Phase 2 [142]
Synonyms
STNF-R1
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External Link
 Compound Name AD-452 Phase 2 [143]
Synonyms
RS(+)-mefloquine; (+)-erythro-mefloquine
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External Link
 Compound Name SSR-240612 Phase 2 [144]
Synonyms
N2-[3(R)-(1,3-Benzodioxol-5-yl)-3-(6-methoxynaphthalen-2-ylsulfonamido)propionyl]-4-[2(R),6(S)-dimethylpiperidin-1-ylmethyl]-N1-isopropyl-N1-methyl-D-phenylalaninamide hydrochloride
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External Link
 Compound Name TOK-8801 Phase 2 [145]
Synonyms
105963-46-0; Imidazo[2,1-b]thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-; N-(2-Phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo(2,1-b)thiazole-2-carboxamide; Imidazo[2,1-b]thiazole-2-carboxamide,5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-; Tok 8801; N-(2-Phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2-carboxamide; Imidazo(2,1-b)thiazole-2-carboxamide, 5,6-dihydro-3,6,6-trimethyl-N-(2-phenylethyl)-; AC1L3UYM; ACMC-20m9c6; SCHEMBL9774378; CTK4A4247; AKOS030604802
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External Link
 Compound Name Sirukumab Phase 3 [146]
External Link
 Compound Name PG-760564 Phase 2 [147]
Synonyms
Rheumatoid arthritis therapy, Procter & Gamble
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External Link
 Compound Name Peresolimab Phase 2 [148]
External Link
 Compound Name CH-4051 Phase 2 [149]
External Link
 Compound Name VX-745 Phase 2 [150]
Synonyms
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one; 209410-46-8; Neflamapimod; VX 745; VX745; VRT-031745; UNII-TYL52QM320; TYL52QM320; CHEBI:90528; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one; 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one; Neflamapimod (USAN); Neflamapimod [USAN]; AK-44905; C19H9Cl2F2N3OS; 5-(2,6-Dichlorophenyl)-2-[(2,4-Difluorophenyl)sulfanyl]-6h-Pyrimido[1,6-B]pyridazin-6-One; VX745, VX-745; 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one; Vertex 745 (VX745)
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External Link
 Compound Name PF-04171327 Phase 2 [151]
Synonyms
Fosdagrocorat; UNII-HPI19004QS; 1044535-58-1; HPI19004QS; 2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-N-(2-methyl-3-pyridinyl)-4b-(phenylmethyl)-7-(phosphonooxy)-7-(trifluoromethyl)-, (4bS,7R,8aR)-;2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-N-(2-methyl-3-pyridinyl)-4b-(phenylmethyl)-7-(phosphonooxy)-7-(trifluoromethyl)-, (4bS,7R,8aR)-; Fosdagrocorat [USAN:INN]; PF 04171327; Fosdagrocorat (USAN/INN); SCHEMBL1707427; GTPL9649; US8901310, Example 2; CHEMBL3137316; BDBM140010; SB17317
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External Link
 Compound Name MANOALIDE Phase 2 [152]
Synonyms
UNII-E1DK0157K9; 75088-80-1; CHEMBL463914; CHEBI:66666; E1DK0157K9; 2(5H)-Furanone, 4-(3,6-dihydro-6-hydroxy-5-(4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-; 2(5H)-Furanone, 4-((2R,6R)-3,6-dihydro-6-hydroxy-5-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-, (5R)-; AC1O5NJS; SCHEMBL20551728; MolPort-020-000-975
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External Link
 Compound Name Cenplacel-L Phase 2 [153]
Synonyms
PDA-001
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External Link
 Compound Name BT-016 Phase 2 [154]
Synonyms
Tregalizumab
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External Link
 Compound Name Xmab 5871 Phase 1/2 [155]
Synonyms
XmAb 5871 (TN)
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External Link
 Compound Name Vidofludimus Phase 2 [156]
Synonyms
717824-30-1; 4SC-101; UNII-8Y1PJ3VG81; SC12267; Vidofludimus(4SC-101; SC12267); CHEMBL197194; 8Y1PJ3VG81; 2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic Acid; 2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}cyclopent-1-ene-1-carboxylic acid; 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid; Vidofludimus [INN]; SC 12267; SCHEMBL247888; GTPL9860; KS-00000TTT; BDBM16111; EX-A546; DTXSID50431325; MolPort-039-193-851; BCP14555; AOB87354; s7262; ZINC14960644
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External Link
 Compound Name K-832 Phase 2 [23]
Synonyms
10465-81-3; 1,1'-(Azodicarbonyl)-dipiperidine; AdDP; 1,1-(Azodicarbonyl)dipiperidine; 1,1'-(Azodicarbonyl)dipiperidine; diazene-1,2-diylbis(piperidin-1-ylmethanone); NSC356027; NSC 356027; (NE)-N-(piperidine-1-carbonylimino)piperidine-1-carboxamide; azodicarboxylic acid dipiperidine; (E)-diazene-1,2-diylbis(piperidin-1-ylmethanone); Azodicarboxylic acid dipiperidide; J-503690; SR-4077; (E)-diazene-1,2-diylbis(piperidin-1-yl methanone); SR 4077; PubChem19605; piperidyl (piperidylcarbonyl)diazenyl ketone; AC1Q5JWC; AC1NWBQ9
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External Link
 Compound Name PRTX-100 Phase 1/2 [157]
Synonyms
Staphylococcal protein A
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External Link
 Compound Name Cx-611 Phase 1/2 [158]
Synonyms
Allogeneic adipose-derived stem cell therapy (intravenous, rheumatoid arthritis), Cellerix; Allogeneic adipose-derived stem cell therapy (intravenous, rheumatoid arthritis), TiGenix
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External Link
 Compound Name BIO-300 Phase 1/2 [159]
Synonyms
Radioprotective therapy, Humanetics
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External Link
 Compound Name Chondrogen Phase 1/2 [160]
Synonyms
Chondrogen (TN)
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 Compound Name ART621 Phase 1/2 [161]
External Link
 Compound Name Indomethacin Approved [162]
External Link
 Compound Name HM71224 Phase 1 [163]
Synonyms
Poseltinib; 1353552-97-2; UNII-D01E4B1U35; D01E4B1U35; LY3337641; N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; Poseltinib [INN]; GTPL9862; CHEMBL4163691; SCHEMBL14915064; BDBM50369724; BS-15248; HM-71224; LY333764; Example 228 [WO2011162515A2]; HY-109010; CS-0030508; Q27275916; 2-Propenamide, N-(3-((2-((4-(4-methyl-1-piperazinyl)phenyl)amino)furo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-; N-(3-((2-(4-(4-Methylpiperazin-1-yl)anilino)furo(3,2-d)pyrimidin-4-yl)oxy)phenyl)prop-2-enamide; N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
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External Link
 Compound Name LABP-104 Phase 1 [164]
Synonyms
NIM-1324
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External Link
 Compound Name ORTD-1 Phase 1 [165]
Synonyms
.theta.-Defensin 1; 1-[3-[benzyl-tetrakis(3-guanidinopropyl)-[(1R)-1-hydroxyethyl]-isobutyl-isopropyl-[(1S)-1-methylpropyl]-octadecaoxo-[?]yl]propyl]guanidine; 251442-64-5; BDBM50236198; CHEMBL4073105; Cyclic-(GVCRCICTRGFCRCLCRR); DTXSID60179822; oRTD-1; RTD-1; theta-Defensin 1; theta-Defensin RTD-1
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External Link
 Compound Name JNJ-67484703 Phase 1 [166]
Synonyms
JNJ-4703
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External Link
 Compound Name IA-14069 Phase 1 [167]
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 Compound Name BX-U001 Phase 1 [168]
External Link
 Compound Name KPE-06001 Phase 1 [169]
Synonyms
Asthma/arthritis therapy, Kemin
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External Link
 Compound Name PF-05230905 Phase 1 [170]
Synonyms
ATN-192
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External Link
 Compound Name RG6125 Phase 1 [19]
External Link
 Compound Name TAK-020 Phase 1 [19]
External Link
 Compound Name AXS-06 Phase 1 [171]
External Link
 Compound Name Aminoguanidine Discontinued in Phase 2 [172]
Synonyms
Pimagedine; Hydrazinecarboximidamide; Guanyl hydrazine; Monoaminoguanidine; 2-aminoguanidine; 79-17-4; Imino semicarbazide; Aminate base; 2-azanylguanidine; Pimagedine [INN]; GUANIDINE, AMINO-; 1-aminoguanidine; UNII-SCQ4EZQ113; Hydrazinecarboximidamide(9CI); CCRIS 3511; EINECS 201-183-1; Aminoguanidine, Hemisulfate; SCQ4EZQ113; CHEMBL225304; CHEBI:40618; HAMNKKUPIHEESI-UHFFFAOYSA-N; guanylhydrazine; GER-11; AGU; amino guanidine; 1-amino-guanidine; Aminoguanidine (AG); Tocris-0787; Carbonohydrazonic diamide; INCB3284
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External Link
 Compound Name OPL-CCL2-LPM Phase 1 [173]
Synonyms
CCR2 targeting agent (arthritis/nephritis/cardiovascular/pulmonaryl/CNS); Leukocyte population modulator (arthritis/nephritis/cardiovascular/pulmonary/CNS), Osprey
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External Link
 Compound Name AZD9567 Phase 1 [19]
Synonyms
ZQFNDBISEYQVRR-LOSJGSFVSA-N; AZD-9567; GTPL9812; SCHEMBL17643955; AZD 9567; example 1 [WO2016046260A1]; compound 15 [PMID: 29424542]; B9W; 2,2-difluoro-N-[(1R,2S)-3-methyl-1-[1-(1-methyl-6-oxopyridin-3-yl)indazol-5-yl]oxy-1-phenylbutan-2-yl]propanamide; 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide
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External Link
 Compound Name AVE1701 Phase 1 [23]
External Link
 Compound Name AVP-13358 Phase 1 [174]
Synonyms
IgE inhibitors, AVANIR; Allergy/asthma therapeutic, AVANIR
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External Link
 Compound Name Cadherin-11 Phase 1 [175]
Synonyms
SDP051
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External Link
 Compound Name NCX-1015 Phase 1 [176]
Synonyms
Nitroprednisolone; NCX-1004; NCX-1016; NO-prednisolone
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External Link
 Compound Name ONS-3010 Phase 1 [19]
External Link
 Compound Name BF-389 Phase 1 [177]
Synonyms
Biofor 389; UNII-MGJ3XBS5KD; MGJ3XBS5KD; BF 389; 127245-22-1; 4-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-2-methyl-5,6-dihydro-2H-1,2-oxazin-3(4H)-one; Dihydro-4-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-methyl-2H-1,2-oxazin-3(4H)-one; 2H-1,2-Oxazin-3(4H)-one, dihydro-4-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-2-methyl-; 2H-1,2-Oxazin-3(4H)-one, 4-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)dihydro-2-methyl-; Biofor-389; AC1O5RBB; SCHEMBL8291651; LS-100029
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External Link
 Compound Name HMR-1031 Phase 1 [178]
Synonyms
MDL-819767; 3(S)-[2(S)-[4,4-Dimethyl-3-[4-[3-(2-methylphenyl)ureido]benzyl]-2,5-dioxoimidazolidin-1-yl]-4-methylpentanoylamino]-3-phenylpropionic acid
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External Link
 Compound Name VI7734 Phase 1 [125]
External Link
 Compound Name BMS-986104 Phase 1 [19]
Synonyms
Unii-KJ9D084FO4; KJ9D084FO4; 1622180-31-7; CHEMBL3806158; SCHEMBL15953811; BPMMYKAHRIEVDH-VOQZNFBZSA-N; J3.582.853B; ((1R,3 S)-1-amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol; ((1R,3S)-1-amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol; Cyclopentanemethanol, 1-amino-3-((6R)-6-hexyl-5,6,7,8-tetrahydro-2-naphthalenyl)-, (1R,3S)-
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External Link
 Compound Name AMAP-102 Phase 1 [179]
Synonyms
5-HT antagonist (rheumatism), AnaMar
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External Link
 Compound Name MEDI5117 Phase 1 [180]
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 Compound Name Sc Veltuzumab Phase 1 [181]
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 Compound Name MORAb-022 Phase 1 [19]
Synonyms
Antibody (inflammation/autoimmune disease), Morphotek
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External Link
 Compound Name ARG301 Phase 1 [182]
External Link
 Compound Name SCH-900117 Phase 1 [183]
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 Compound Name DWP-422 Phase 1 [184]
External Link
 Compound Name Gerilimzumab Phase 1 [19]
External Link
 Compound Name VEL-0230 Phase 1 [185]
Synonyms
NC-2300; Osteoporosis therapy (oral), Velcura/Nippon Chemiphar
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External Link
 Compound Name Synthetic neutrophil inhibitor peptide Phase 1 [186]
Synonyms
SNIP; Nalpha-Acetyl-L-arginyl-L-glutamyl-glycyl-L-seryl-L-tyrosyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-aspartyl-L-asparaginyl-L-alaninamide
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External Link
 Compound Name RWJ-67657 Phase 1 [187]
Synonyms
215303-72-3; RWJ 67657; RWJ67657; 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol; CHEMBL190333; 4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol; 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-Phenylpropyl)-5-(4-Pyridyl)imidazole; 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridyl)imidazol-2-yl]but-3-yn-1-ol; 4-(4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-3-butyn-1-ol
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External Link
 Compound Name MEDI4920 Phase 1 [19]
External Link
 Compound Name RPI-78M Discontinued in Phase 1 [188]
Synonyms
Antiviral agent, Receptogen; Receptin (injectable), ReceptoPharm; Receptin (oral), ReceptoPharm; RPI-78M (injectable), ReceptoPharm; RPI-78M (oral), ReceptoPharm
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External Link
 Compound Name RX-10001 Phase 1 [189]
External Link
 Compound Name ASP2408 Phase 1 [190]
Synonyms
CTLA4-Ig fusion protein
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External Link
 Compound Name GSK3117391 Phase 1 [191]
External Link
 Compound Name ABBV-257 Phase 1 [19]
External Link
 Compound Name VGX-1027 Phase 1 [192]
Synonyms
6501-72-0; GIT 27; git-27; 2-(3-phenyl-4,5-dihydroisoxazol-5-yl)acetic acid; 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID; 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic Acid; GIT27; SCHEMBL1404343; CHEMBL1320667; CTK5C2027; VGX-127; EX-A366; DTXSID50445023; AOB1858; MUFJHYRCIHHATF-UHFFFAOYSA-N; MolPort-022-917-316; HMS3653J11; BCP09284; VGX 1027; VGX-1027(GIT 27); MFCD08696167; s7515; 2792AH; GIT-27 (VGX-1027); AKOS022538967; AKOS000282755; CS-2737; NCGC00186000-02; NCGC00186000-01; AK175225; HY-15507; AB0279943; KB-272590
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External Link
 Compound Name GSK-1827771 Phase 1 [193]
Synonyms
IL-1 antagonist (antibody, rheumatoid arthritis), GSK
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External Link
 Compound Name ASP5094 Phase 1 [19]
External Link
 Compound Name EVT 401 Phase 1 [194]
External Link
 Compound Name SKI-O-703 Phase 1 [19]
External Link
 Compound Name AZ-4217 Clinical trial [195]
Synonyms
AZ4217; AZ 4217
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External Link
 Compound Name PMID27998201-Compound-9 Patented [196]
External Link
 Compound Name Floctafenine Withdrawn from market [6]
Synonyms
23779-99-9; Idarac; Novodolan; Diralgan; Idalon; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)quinolin-4-yl)amino)benzoate; RU 15750; R 4318; Floctafeninum [INN-Latin]; Floctafenina [INN-Spanish]; 8-Trifluoromethyl-7-deschloroglafenine; C20H17F3N2O4; EINECS 245-881-4; BRN 0457808; 2,3-Dihydroxypropyl 2-((8-(trifluoromethyl)-quinolin-4-yl)amino)benzoate; 2,3-Dihydroxypropyl N-(8-(trifluoromethyl)-4-quinolyl)anthranilate; 4-(o-(2',3'-Dihydroxypropyloxycarbonyl)phenyl)-amino-8-trifluoromethylquinoline
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External Link
 Compound Name Aurothioglucose Withdrawn from market [6]
Synonyms
HMS3262I11; LP00685
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External Link
 Compound Name Amiprilose Discontinued in Preregistration [197]
Synonyms
Therafectin; Amiprilose hydrochloride; KAP-690; SM-1213
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External Link
 Compound Name Nerelimomab Discontinued in Phase 3 [198]
Synonyms
BAY-X-1351
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External Link
 Compound Name M-5010 Discontinued in Phase 3 [199]
Synonyms
M-5011; T-3788; 2(R)-[4-(3-Methyl-2-thienyl)phenyl]propionic acid
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External Link
 Compound Name BR3-Fc Discontinued in Phase 2 [200]
External Link
 Compound Name KC706 Discontinued in Phase 2 [201]
External Link
 Compound Name EFLETIRIZINE Discontinued in Phase 2 [202]
Synonyms
Efletirizine < Rec INN; Ucb-28754; 2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid
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External Link
 Compound Name IX207-887 Discontinued in Phase 2 [203]
External Link
 Compound Name AMG 108 Discontinued in Phase 2 [204]
External Link
 Compound Name HR325 Discontinued in Phase 2 [205]
External Link
 Compound Name Apricoxib Discontinued in Phase 2 [206]
Synonyms
TG01
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External Link
 Compound Name TA-383 Discontinued in Phase 2 [207]
Synonyms
Cis-2-(4-Chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride; Cis-2-(4-Chlorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride
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External Link
 Compound Name Camobucol Discontinued in Phase 2 [208]
Synonyms
AGIX-4207; AGIX-4207 IV; V-protectant (rheumatoid arthritis), AtheroGenics
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External Link
 Compound Name SM-8849 Discontinued in Phase 2 [209]
Synonyms
113759-19-6; 4-(1-(2-fluoro-4-biphenylyl)ethyl)-2-methylaminothiazole; 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole; ZTFDMDJGJVUYQE-UHFFFAOYSA-N; AC1L3Y3S; SCHEMBL5078854; 4-(1-(2-Fluoro-4-biphenyl)ethyl)-2-methylaminothiazole; (+)-2-methylamino-4-(1-(2-fluoro-4-biphenylyl)ethyl)thiazole; 4-[1-(3-fluoro-4-phenylphenyl)ethyl]-N-methyl-1,3-thiazol-2-amine; 2-Thiazolamine, 4-(1-(2-fluoro(1,1'-biphenyl)-4-yl)ethyl)-N-methyl-
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External Link
 Compound Name Zolimomab aritox Discontinued in Phase 2 [210]
Synonyms
XomaZyme-CD5 Plus; XomaZyme-H65; XomaZyme-lym; OrthoZyme-CD5+; Xmmly-h65-rta; XomaZyme-H65-rta
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External Link
 Compound Name Fontolizumab Discontinued in Phase 2 [23]
Synonyms
Fontolizumab (USAN/INN)
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External Link
 Compound Name CP-195543 Discontinued in Phase 2 [211]
Synonyms
LB4 antagonist (RA), Pfizer; LB4 antagonist (inflammation), Pfizer; Leukotriene B4 antagonist (inflammation), Pfizer; Leukotriene B4 antagonist (rheumatoid arthritis), Pfizer
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External Link
 Compound Name MLN3897 Discontinued in Phase 2 [23]
External Link
 Compound Name S-5751 Discontinued in Phase 2 [212]
Synonyms
AC1NSK82; GTPL1898; S5751; (Z)-7-[(1R,2R,3R,5S)-2-[(5-hydroxy1-benzothiophene-3-carbonyl)amino]-7,7-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid; (Z)-7-[(1S,3R,4R,5R)-4-[(5-hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid
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External Link
 Compound Name INCB47986 Discontinued in Phase 2 [213]
External Link
 Compound Name MP-435 Discontinued in Phase 2 [214]
Synonyms
C5a antagonist (rheumatoid arthritis), Mitsubishi Tanabe
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External Link
 Compound Name CPA-926 Discontinued in Phase 2 [215]
Synonyms
6-(2-Acetamido-2-deoxy-beta-D-glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
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External Link
 Compound Name ISIS 104838 Discontinued in Phase 2 [216]
External Link
 Compound Name SINOMENINE Discontinued in Phase 2 [217]
Synonyms
Cucoline; Kukoline; (9alpha,13alpha,14alpha)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one
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External Link
 Compound Name Linetastine Discontinued in Phase 2 [218]
Synonyms
Tmk688; UNII-7U248Z56LA; 110501-66-1; TMK-688; 159776-68-8; 7U248Z56LA; Linetastine [INN]; Tmk 688; Linazolast; CCRIS 6902; Linazolast (JAN); YM-257; AC1O5R98; CHEMBL314338; SCHEMBL1614484; [4-[(1E,3E)-5-[2-(4-benzhydryloxypiperidin-1-yl)ethylamino]-5-oxopenta-1,3-dienyl]-2-methoxyphenyl] ethyl carbonate; Carbonic acid, 4-(5-((2-(4-(diphenylmethoxy)-1-piperidinyl)ethyl)amino)-5-oxo-1,3-pentadienyl)-2-methoxyphenyl ethyl ester; D09850; Molecule 26
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External Link
 Compound Name SC-106 Discontinued in Phase 2 [219]
Synonyms
AC1LAPZA; SCHEMBL6773940; IABCGGIFHPDBCJ-JTQLQIEISA-N; (3R)-3-[[2-[(3-guanidinobenzoyl)amino]acetyl]amino]pent-4-ynoic acid; (R)-3-(2-{[1-(3-Guanidino-phenyl)-methanoyl]-amino}-ethanoylamino)-pent-4-ynoic acid; (3R)-3-[[2-[[3-(diaminomethylideneamino)benzoyl]amino]acetyl]amino]pent-4-ynoic acid
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External Link
 Compound Name PRO-515 Discontinued in Phase 2 [220]
External Link
 Compound Name GW-215864 Discontinued in Phase 2 [221]
Synonyms
GR-215864; GR-215864X; GW-215864X
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External Link
 Compound Name HSR-609 Discontinued in Phase 2 [222]
Synonyms
FY-609; 3-[4-(8-Fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]propionic acid dihydrate
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External Link
 Compound Name AnergiX.RA Discontinued in Phase 2 [223]
Synonyms
AG-4263; RA-AnergiX; Antigen specific therapy (rheumatoid arthritis, AnergiX), Corixa/ Organon
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External Link
 Compound Name GLPG-0259 Discontinued in Phase 2 [224]
Synonyms
G-13919, GT-146, GT-1498, GT-1704, GT-314, GT-416, GT-514, GT-562
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External Link
 Compound Name CBF-BS2 Discontinued in Phase 2 [225]
Synonyms
KSB-302
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External Link
 Compound Name NN8209 Discontinued in Phase 2 [226]
External Link
 Compound Name IDEC-151 Discontinued in Phase 2 [227]
Synonyms
Clenoliximab
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External Link
 Compound Name PAMAPIMOD Discontinued in Phase 2 [228]
Synonyms
449811-01-2; RO 4402257; UNII-8S2C9V11K4; Pamapimod (R-1503, Ro4402257); CHEMBL1090089; CHEBI:90685; 8S2C9V11K4; Ro4402257; Ro-4402257; R1503; R 1503; R-1503; 6-(2,4-Difluorophenoxy)-2-{[3-Hydroxy-1-(2-Hydroxyethyl)propyl]amino}-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; Pamapimod [USAN:INN]; 6-(2,4-Difluorophenoxy)-2-((3-hydroxy-1-(2-hydroxyethyl)propyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one; 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
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External Link
 Compound Name S-2474 Discontinued in Phase 2 [229]
Synonyms
158089-95-3; CTK4C9584; DTXSID20724630; PHENOL, 2,6-BIS(1,1-DIMETHYLETHYL)-4-[(E)-(2-ETHYL-1,1-DIOXIDO-5-ISOTHIAZOLIDINYLIDENE)METHYL]-
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External Link
 Compound Name NPC-567 Discontinued in Phase 2 [230]
Synonyms
Npc 567; Arg-3-hyp-7-phe-bradykinin; UNII-DV64B0PLEH; 109333-26-8; Bradykinin, arg-hyp(3)-phe(7)-; DV64B0PLEH; Bradykinin, arg(0)-hyp(3)-phe(7)-; CHEMBL446325; CHEBI:73294; arg(0)-hyp(3)-phe(7)-bradykinin; Bradykinin, arginyl-hydroxyprolyl(3)-phenylalanine(7)-; [D-Arg(0),Hyp(3),D-Phe(7)]bradykinin; Bradykinin, N2-D-arginyl-3-(trans-4-hydroxy-L-proline)-7-D-phenylalanine-
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External Link
 Compound Name T-5224 Discontinued in Phase 2 [231]
Synonyms
AKOS003047196; T5224
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External Link
 Compound Name AD-121 Discontinued in Phase 1/2 [232]
Synonyms
PW-9101; Rheumatoid arthritis therapeutic (oral controlled release, Syncrodose), Arakis/Penwest; Rheumatoid arthritis therapeutic (oral controlled release, TIMERx), Arakis/Penwest
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External Link
 Compound Name AME-527 Discontinued in Phase 1/2 [233]
External Link
 Compound Name AZD-7140 Discontinued in Phase 1 [234]
External Link
 Compound Name PF-4629991 Discontinued in Phase 1 [235]
Synonyms
PF-991; S1P1 receptor agonist (autoimmune disease), Pfizer
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External Link
 Compound Name NN8210 Discontinued in Phase 1 [236]
External Link
 Compound Name ARRY-614 Discontinued in Phase 1 [237]
Synonyms
Pexmetinib; 945614-12-0; Pexmetinib (ARRY-614); UNII-3750D0U8B5; 3750D0U8B5; Pexmetinib [INN]; Pexmetinib;ARRY-614; Pexmetinib(ARRY-614); ARRY614; SCHEMBL379035; GTPL9917; MolPort-039-193-822; LNMRSSIMGCDUTP-UHFFFAOYSA-N; BCP28410; EX-A1421; s7799; ZINC41747181; AKOS032945154; SB16914; Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-((5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)phenyl)methyl)-
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External Link
 Compound Name Oncolysin CD6 Discontinued in Phase 1 [238]
Synonyms
Anti-CD6-bR; Anti-T12-bR
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External Link
 Compound Name Eltenac Discontinued in Phase 1 [239]
Synonyms
BY-820; B-788-20
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External Link
 Compound Name RG-4934 Discontinued in Phase 1 [240]
Synonyms
IL-17 huMAb (psoriatic arthritis), Roche
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External Link
 Compound Name AC-100 Discontinued in Phase 1 [241]
Synonyms
Bicyclo[4.2.0]octa-1,3,5-trien-3-ylboronic acid; BENZOCYCLOBUTANE-4-BORONIC ACID; Boronic acid, bicyclo[4.2.0]octa-1,3,5-trien-3-yl-; SCHEMBL12759201; KS-00000SRU; MolPort-005-942-889; ZINC196051840; AKOS025146995; DS-8536; BC225113; AK164312; 1,2-Dihydrobenzocyclobutene-4-ylboranic acid; CS-0043999; J3.522.588I; 4-bbcb benzocyclobutene-4-boronic acid
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External Link
 Compound Name IL-18BP Discontinued in Phase 1 [242]
External Link
 Compound Name Roquinimex Discontinued in Phase 1 [243]
Synonyms
Linomide
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External Link
 Compound Name D-1367 Discontinued in Phase 1 [244]
Synonyms
167692-94-6; 2-(3,3-dimethylbutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; SCHEMBL15923700; DTXSID80570615; ZINC196470483; SC-92964; 2-(3,3-dimethylbutyl)-4,4,5,5,-tetramethyl-1,3,2-d; 1,3,2-Dioxaborolane, 2-(3,3-dimethylbutyl)-4,4,5,5-tetramethyl-
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External Link
 Compound Name SB-242235 Discontinued in Phase 1 [245]
Synonyms
193746-75-7; SB242235; SB 242235; 4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine; CHEMBL95692; 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine; 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine; Kinome_3169; SCHEMBL2267209; BDBM15458; SYN1076; PDTYLGXVBIWRIM-UHFFFAOYSA-N; MolPort-028-720-427; HMS3244I18; HMS3244J17; HMS3244I17; EX-A1881; BCP05992; ZINC1487129; 3254AH; RS0056; AKOS027323444; CS-2097; NCGC00345831-01; NCGC00345831-03
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External Link
 Compound Name AZD-2315 Discontinued in Phase 1 [246]
Synonyms
ZD-2315
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External Link
 Compound Name AVE-9940 Discontinued in Phase 1 [247]
External Link
 Compound Name AZD-8309 Discontinued in Phase 1 [248]
External Link
 Compound Name MLN0415 Discontinued in Phase 1 [249]
Synonyms
SCHEMBL3805703
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External Link
 Compound Name AZD8566 Discontinued in Phase 1 [250]
External Link
 Compound Name LY-231617 Discontinued in Phase 1 [251]
Synonyms
2,6-Di-tert-butyl-4-(ethylaminomethyl)phenol hydrochloride
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External Link
 Compound Name CI-972 Discontinued in Phase 1 [252]
External Link
 Compound Name R-1487 Discontinued in Phase 1 [253]
Synonyms
449811-92-1; 6-(2,4-difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; UNII-IO0DCY55NQ; IO0DCY55NQ; CHEMBL1230122; 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-Pyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2h-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8h)-one; Kinome_3762; SCHEMBL5120612; KKKRKRMVJRHDMG-UHFFFAOYSA-N; HMS3401C13; BDBM50341342; ZINC58633224; AKOS027420928; NCGC00262195-02; KB-80224; ACM449811921
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External Link
 Compound Name R1295 Discontinued in Phase 1 [23]
Synonyms
CHEMBL2146615
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External Link
 Compound Name KB-2683 Discontinued in Phase 1 [254]
External Link
 Compound Name AZD-6703 Discontinued in Phase 1 [255]
Synonyms
P38 MAP kinase inhibitors (rheumatoid arthritis), AstraZeneca
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External Link
 Compound Name PF-251802 Discontinued in Phase 1 [256]
Synonyms
PF-00251802; Selective glucocorticoid receptor agonist (1), Pfizer
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External Link
 Compound Name SC-57666 Discontinued in Phase 1 [257]
Synonyms
CHEMBL274893; AC1L9EJK; SC57666; CHEBI:8982; 1-fluoro-4-[2-(4-methylsulfonylphenyl)cyclopenten-1-yl]benzene; SureCN213008; SCHEMBL213008; ZINC18527; GJGZQTGPOKPFES-UHFFFAOYSA-N; HY-U00129; BDBM50029614; DNC003789; CS-7166; C11706; 1-[2(4-Flurophenyl)-1-cyclopentyl]4-methylsulfonylbenzene; 1-[2-(4-fluorophenyl)cyclopenten-1-yl]-4-(methylsulfonyl)benzene; 1-[2-(4-fluorophenyl) cyclopenten-1-yl]-4- (methylsulfonyl)benzene; 1-fluoro-4-[2-(4-methylsulfonylphenyl)-1-cyclopentenyl]benzene
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External Link
 Compound Name C-5997 Discontinued in Phase 1 [258]
Synonyms
7709-58-2; 4-(Chloromethyl)thiazole hydrochloride; 4-(chloromethyl)-1,3-thiazole Hydrochloride; 4-(chloromethyl)thiazole hcl; 4-chloromethylthiazole hydrochloride; 4-chloromethylthiazole hcl; 4-(chloromethyl)thiazolehcl; C4H4ClNS.ClH; ACMC-1BBSC; chloromethylthiazole-4 hcl; AC1Q3BH9; AC1MC82W; SCHEMBL122926; 4-(Chloromethyl)thiazole, HCl; CTK6H6834; DTXSID60376874; NVTBASMQHFMANH-UHFFFAOYSA-N; MolPort-000-139-475; 4-(chloromethyl)thiazole HCl salt; ACT02312; KS-000004ND; ANW-36949; 4-chloromethyl thiazole hydrochloride
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External Link
 Compound Name PF-755616 Discontinued in Phase 1 [259]
External Link
 Compound Name GP2015 Application submitted [19]
External Link
 Compound Name CLIK-181 Preclinical [260]
Synonyms
J3.633.044I
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External Link
 Compound Name SR1555 Preclinical [261]
Synonyms
CHEMBL3218917; SR-1555; 1386439-51-5; 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethan-1-one; 1-[4-[[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]methyl]piperazin-1-yl]ethanone; SCHEMBL13974905; GTPL10145; BDBM50044227; ZINC95537675
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External Link
 Compound Name CLIK-148 Preclinical [260]
Synonyms
SCHEMBL7207304
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External Link
 Compound Name MCP-1 Preclinical [262]
External Link
 Compound Name Romazarit Preclinical [263]
Synonyms
ORE-5007; Metabolic modulator (obesity/hyperlipidemia), Ore Pharmaceuticals
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External Link
 Compound Name NPC-17923 Terminated [264]
Synonyms
147960-65-4; N-(9H-(2,7-Dichlorofluorenyl)-9-ethoxycarbonyl)-4-aminobenzoic acid; Benzoic acid, 4-((3-((2,7-dichloro-9H-fluoren-9-yl)oxy)-1-oxopropyl)amino)-
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External Link
 Compound Name TM-31 Terminated [265]
External Link
 Compound Name BCX-25 Terminated [266]
Synonyms
BCX-14
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External Link
 Compound Name BB-1433 Terminated [267]
Synonyms
BB-2014; BB-2116; BB-2284; BB-2633; BB-3029; BB-3050; BB-3103; BB-3241
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External Link
 Compound Name ZK-90695 Terminated [268]
External Link
 Compound Name RP-54745 Terminated [269]
Synonyms
RP 54745; 135330-08-4; AC1L2PX8; SCHEMBL4362761; rp54745; CS-6750; 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one; HY-101716; 4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one; 3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
    Click to Show/Hide
External Link
 Compound Name FR-123826 Terminated [270]
Synonyms
COX-2 inhibitor, Fujisawa
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External Link
 Compound Name Seprilose Terminated [271]
Synonyms
GW-80126
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External Link
 Compound Name NOX-200 Terminated [272]
Synonyms
2-Amino-3-(1H-indol-3-yl)-2-methylpropanoic acid; alpha-Methyl-DL-tryptophan; 153-91-3; NSC9948; 13510-08-2; alpha-Methyl-L-tryptophan; M-5098; Tryptophan, alpha-methyl-; 16709-25-4; DL-alpha-Methyltryptophan; alpha-methyl-D,L-tryptophan; NSC-9948; NSC 9948; Tryptophan,a-methyl-; ACMC-1BNRO; alpha-Methyltryptophan; AC1L3UBI; AC1Q5S1L; (S)-alpha-Methyl pryptophan; SCHEMBL343309; CHEMBL559578; GTPL4693; CTK4C8033; ZTTWHZHBPDYSQB-UHFFFAOYSA-N; MolPort-003-958-850; KS-000001AA; ANW-21478
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External Link
 Compound Name SAN-18 Terminated [273]
External Link
 Compound Name CI-986 Terminated [274]
Synonyms
CI 986; 5-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione; 5-(3,5-Bis(1,1-dimethylethyl)-4-(hydroxyphenyl))-1,3,4-thiadiazole-2(3H)-thione choline salt; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 5-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione (1:1); 130116-16-4; AC1MI25H; C16H22N2OS2.C5H14NO; LS-172752; 2,6-ditert-butyl-4-(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)phenolate
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External Link
 Compound Name SDZ-224-015 Terminated [275]
Synonyms
VE-13045
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External Link
 Compound Name AZD-6942 Terminated [276]
Synonyms
CCR2b antagonists, AstraZeneca; CCR2b, AstraZeneca
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External Link
 Compound Name 3-DEAZAADENOSINE Terminated [277]
Synonyms
Cc3Ado; BW-91Y78; 3DZA; 4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine
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External Link
 Compound Name WY-28342 Terminated [278]
External Link
 Compound Name AG-2024 Terminated [279]
External Link
 Compound Name AZD-0902 Terminated [280]
External Link
 Compound Name Ro-31-4724 Terminated [281]
Synonyms
CHEMBL92608; [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER; RO4; 112105-54-1; Ro 314724; ro 31-4724; AC1NUPD6; ZINC3801503; ro-314724; BDBM50146631; DB08482; RO314724; (R)-N-(N-(2-(2-(Hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)-L-leucyl)-L-alanine ethyl ester; ethyl N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-L-leucyl-L-alaninate; ethyl (2S)-2-[[(2S)-2-[[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoate
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External Link
 Compound Name RO-319790 Terminated [282]
Synonyms
Ro-31-9790; CHEMBL16520; Ro 31-9790; (R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide; SCHEMBL4633699; QRXOZHSEEGNRFC-ZYHUDNBSSA-N; ZINC1534591; BDBM50063920; CS-6682; HY-101703
    Click to Show/Hide
External Link
 Compound Name S-33516 Terminated [283]
External Link
 Compound Name VE-16084 Terminated [284]
Synonyms
ICE inhibitors, Sanofi Winthrop; WIN-67694
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External Link
 Compound Name D-5410 Terminated [285]
Synonyms
CH-138; CH-263
    Click to Show/Hide
External Link
 Compound Name SKF-104351 Terminated [286]
Synonyms
111908-94-2; Skf 104351; F 104351; 5H-Pyrrolo[1,2-a]imidazole,2-(4-fluorophenyl)-6,7-dihydro-3-(4-pyridinyl)-; 2-(4-fluorophenyl)-3-(4-pyridyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole; F-104351; AC1L3V0R; SCHEMBL7378515; DTXSID90149775; GJFVAEMLAFFGDZ-UHFFFAOYSA-N; ZINC3815711; 5H-Pyrrolo(1,2-a)imidazole, 2-(4-fluorophenyl)-6,7-dihydro-3-(4-pyridinyl)-; KB-292516; 2-p-Fluorophenyl-3-(4-pyridyl)-6,7-dihydro[5H]-pyrrolo[1,2-a]imidazole
    Click to Show/Hide
External Link
 Compound Name SB220025 Terminated [287]
Synonyms
3erk; sb 220025; SB-220025; CHEMBL274064; 165806-53-1; CHEBI:82713; 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine; 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE; SB4; 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole; 4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine; SB-220025-A; 1-(4-piperidinyl)-4-(4-fluorophenyl)-5-(2-(amino)-4-pyrimidinyl)imidazole
    Click to Show/Hide
External Link
 Compound Name RWJ-63556 Terminated [288]
External Link
 Compound Name YM-26734 Terminated [289]
Synonyms
YM 26734; 144337-18-8; CHEMBL444450; 1-Dodecanone,1,1'-[5-[3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-; 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone; ACMC-20n3vr; CTK4C4039; AOB2291; SYN5086; MolPort-023-276-467; BDBM50274336; AKOS024457146; 4-(3,5-Didodecanoyl-2,4,6-trihydroxyphenyl)-7-hydroxy-2-(4-hydroxyphenyl)chroman; KB-276131; YM-26734, &gt; J-007943; 1-Dodecanone, 1
    Click to Show/Hide
External Link
 Compound Name AZD5672 Terminated [290]
Synonyms
CHEMBL1951914; SCHEMBL2767780; GTPL7686; QOSMEMHKXNNIGG-SSEXGKCCSA-N; AZD 5672; BDBM50364743; N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
    Click to Show/Hide
External Link
 Compound Name S-16276-1 Terminated [291]
External Link
 Compound Name FR-111142 Terminated [292]
Synonyms
WF-2015A
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External Link
 Compound Name BW A4C Terminated [293]
Synonyms
BW4C; Bwa-4C; Bwa 4C; 106328-57-8; BW-A4C; BWA4C; CHEMBL314360; C17H17NO3; N-(E)-3-(3-Phenoxyphenyl)prop-2-enylacetohydroxamine acid; Acetamide, N-hydroxy-N-(3-(3-phenoxyphenyl)-2-propenyl)-; N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid; Acetohydroxamine acid, N-(E)-3-(3-phenoxyphenyl)prop-2-enyl-; Acetamide, N-hydroxy-N-(3-(3-phenoxyphenyl)-2-propenyl)-, (E)-; BW-4AC; AC1O5PJ5; BW-A-4C; BW-A 4C; JMC515449 Compound 7; BDBM22334; ZINC5138195; MFCD00869694; N-(3-phenoxycinnamyl)-N-hydroxyacetamide
    Click to Show/Hide
External Link
 Compound Name WY-48989 Terminated [294]
Synonyms
WY 48989; 136917-40-3; 4-((2-(7-Chloro-2-phenyl-2H-pyrazolo(4,3-c)quinolin-4-yl)ethyl)amino)benzonitrile; 4-[[2-(7-chloro-2-phenyl-2h-pyrazolo[4,3-c]quinolin-4-yl)ethyl]amino]benzonitrile; WY-48,989; AC1L307T; SCHEMBL10625720; DTXSID90160006; GYVYUQVVKBZPRY-UHFFFAOYSA-N; 4[[2-(7-Chloro-2-phenyl-2H-pyrazolo[4,3-c]quinolin-4-yl)ethyl]amino]benzonitrile
    Click to Show/Hide
External Link
 Compound Name FR-133605 Terminated [295]
External Link
 Compound Name SR-26831 Terminated [296]
Synonyms
SR 26831; AC1L30OS; ((5-(2-Chlorobenzyl-2-tert-butyloxycarbonyl))-4,5,6,7-tetrahydrothieno(3,2-c)pyridine)-N-oxide; Thieno(3,2-c)pyridinium, 5-((2-chlorophenyl)methyl)-2-(2,2-dimethyl-1-oxopropoxy)-4,5,6,7-tetrahydro-5-hydroxy-; [5-[(2-chlorophenyl)methyl]-5-hydroxy-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ium-2-yl] 2,2-dimethylpropanoate
    Click to Show/Hide
External Link
 Compound Name GDC-0834 Terminated [297]
Synonyms
1133432-49-1; UNII-FM7JG3L4SR; FM7JG3L4SR; CHEMBL2057915; N-{3-[6-({4-[(2r)-1,4-Dimethyl-3-Oxopiperazin-2-Yl]phenyl}amino)-4-Methyl-5-Oxo-4,5-Dihydropyrazin-2-Yl]-2-Methylphenyl}-4,5,6,7-Tetrahydro-1-Benzothiophene-2-Carboxamide; GDC0834; CDOOFZZILLRUQH-GDLZYMKVSA-N; 2VL; GTPL9263; SCHEMBL1205333; GDC 0834; GDC 0834;GDC0834; ZINC59185874; BDBM50388183; AKOS030526267; SB18925; CS-3123; Benzo(b)thiophene-2-carboxamide, N-(3-(6-((4-((2R)-1,4-dimethyl-3-oxo-2-piperazinyl)phenyl)amino)-4,5-dihydro-4-methyl-5-oxo-2-pyraz
    Click to Show/Hide
External Link
 Compound Name AZD-0275 Terminated [298]
External Link
 Compound Name RPR 200765A Terminated [299]
Synonyms
CHEMBL68211; SCHEMBL5770288; SCHEMBL13819552; SCHEMBL20555598; SCHEMBL18797648
    Click to Show/Hide
External Link
 Compound Name LY-221068 Terminated [300]
Synonyms
LY 221068; 132392-39-3; AC1O5RGH; SCHEMBL2746042; ly221068; 5-((3,5-Bis(1,1,-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-4-thiazolidinone; 4-Thiazolidinone, 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-
    Click to Show/Hide
External Link
 Compound Name DPC-333 Terminated [301]
Synonyms
BMS-561392; UNII-2X066A8676; BMS 561392; CHEMBL489100; BMS561392; 2X066A8676; DPC 333; 611227-74-8; SCHEMBL6350418; GTPL6509; BDBM50247606; C476910000; (2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hydroxy-4-methylpentanamide
    Click to Show/Hide
External Link
 Compound Name PXS-2076 Terminated [302]
Synonyms
PXS-2000; PXS-2030; Cannabinoid CB2 agonist (rheumatoid arthritis), Pharmaxis; TNFrelease inhibitor (rheumatoid arthritis), Pharmaxis
    Click to Show/Hide
External Link
 Compound Name ETP-46321 Investigative [303]
Synonyms
1252594-99-2; CHEMBL2087474; 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-8-morpholinoimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-amine; 5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine; SCHEMBL10100315; BCP19935; ETP46321; EX-A1284; BDBM50420714; ZINC68247289; CS-3350; ETP 46321;ETP46321; HY-12340; 5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-yl-imidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
    Click to Show/Hide
External Link
 Compound Name ODN-1411 Investigative [304]
External Link
 Compound Name PAC-10649 Investigative [305]
Synonyms
PAC-10549; COX-2 inhibitors (pain/inflammation), Pacific Corp
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External Link
 Compound Name Silicon-modified indomethacin Investigative [306]
Synonyms
Silexsyn; RND-100; SiM-100; Silicon-modified indomethacin (cancer); Silicon-modified indometacin (cancer), Silamed; Silicon-modified indomethacin (cancer), Silamed
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External Link
 Compound Name BFPT-16864 Investigative [111]
Synonyms
BFPT-6864; BRFD-104
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External Link
 Compound Name Arthromir Investigative [111]
External Link
 Compound Name NM-2014 Investigative [307]
External Link
 Compound Name SPX-601 Investigative [111]
External Link
 Compound Name CIGB-814 Investigative [111]
Synonyms
Hsp60 peptide (juvenile idiopathic arthritis), CIGB
    Click to Show/Hide
External Link
 Compound Name Anti-CD40-XTEN Investigative [308]
Synonyms
CD40 ligand receptor antagonist (XTEN, rheumatoid arthritis/transplant rejection), Amunix
    Click to Show/Hide
External Link
 Compound Name TNFcept Investigative [309]
Synonyms
TNFcept (rheumatoid arthritis)
    Click to Show/Hide
External Link
 Compound Name X-071-NAB Investigative [111]
Synonyms
NATHMAB (systemic lupus erythematosus/multiple myeloma/arthritis), XBiotech; Natural/true human monoclonal antibody (systemic lupus erythematosus/multiple myeloma/arthritis), XBiotech
    Click to Show/Hide
External Link
 Compound Name TENOSAL Investigative [310]
Synonyms
MR-Y134; 2-(2-Thienoyloxy)benzoic acid; 2-Thiophenecarboxylic acid salicyl ester
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External Link
 Compound Name DW-908 Investigative [111]
Synonyms
DW-0908
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External Link
 Compound Name Recombinant human TNF receptor Investigative [309]
Synonyms
Recombinant human TNF receptor (arthritis); RhTNFR (arthritis), Shanghai/Taizhou; Recombinant human TNFreceptor (arthritis), Taizhou Fudan-Zhangjiang Pharmaceutical/ Shanghai Pharmaceuticals
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External Link
 Compound Name XGP-110 Investigative [306]
Synonyms
Synoviocyte/tumor cell inhibitor + COX-2 inhibitor (arthritis/cancer/cancer pain), Xaragen
    Click to Show/Hide
External Link
 Compound Name MDDR 217769 Investigative [111]
Synonyms
(E)-2-(4,6-Difluoroindan-1-ylidene)acetamide
    Click to Show/Hide
External Link
 Compound Name FKB327 Investigative [19]
External Link
 Compound Name DMARDs Investigative [111]
Synonyms
DMARDs (oral, rheumatoid arthritis); DMARDs (oral, rheumatoid arthritis), Abbott; Disease-modifying antirheumatic drugs (oral, rheumatoid arthritis), Abbott
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External Link
 Compound Name TX-RAD Investigative [111]
Synonyms
RA1-TX; RA1-TX (ankylosing spondylitis), TxCell; RA1-TX (rheumatoid arthritis), TxCell; RA1-TX (psoriatic arthritis,inflammatory disease), TxCell
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External Link
 Compound Name UR-5269 Investigative [111]
Synonyms
Rheumatoid arthritis therapy, UBE Industries
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External Link
 Compound Name AVX-002 Investigative [111]
External Link
 Compound Name XGP-125 Investigative [111]
Synonyms
Synoviocyte inhibitor + glucocorticoid (arthritis), Xaragen
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External Link
 Compound Name DWJ-425 Investigative [111]
Synonyms
DW-Ab2; MAb (RA), Daewoong; Monoclonal antibody (rheumatoid arthritis), Daewoong
    Click to Show/Hide
External Link
 Compound Name HL-1020 Investigative [111]
Synonyms
Grape seed proanthocyanidin extract (rheumatoid arthritis), Hanlim
    Click to Show/Hide
External Link
 Compound Name XGP-120 Investigative [111]
Synonyms
Synoviocyte inhibitor + DMARD (arthritis), Xaragen
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External Link
 Compound Name XGP-115 Investigative [111]
Synonyms
Synoviocyte inhibitor + NSAID (arthritis), Xaragen
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External Link
 Compound Name CTLA-4-XTEN Investigative [311]
Synonyms
Cytotoxic T-lymphocyte protein 4 modulator (XTEN, rheumatoid arthritis/transplant rejection), Amunix
    Click to Show/Hide
External Link
 Compound Name Nano-steroid Investigative [111]
Synonyms
Steroidal anti-inflammatory (slow release nanoparticle formulation), LTT Bio-Pharma; Steroids (sustained release nanoparticles), LTT Bio-Pharma/Cipra; Steroidal anti-inflammatory (rheumatoid arthritis/collagen disease), LTT Bio-Pharma
    Click to Show/Hide
External Link
 Compound Name TNFmab Investigative [309]
Synonyms
TNFmab (rheumatoid arthritis)
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External Link
 Compound Name YD-101 Investigative [111]
External Link
 Compound Name KI-0906 Investigative [111]
External Link
 Compound Name FHT-401 Investigative [111]
Synonyms
PTD-conjugated methotrexate (transdermal, rheumatoid arthritis), ForHumanTech/Hyundai
    Click to Show/Hide
External Link
 Compound Name TCH-013 Investigative [111]
Synonyms
NF-kB inhibitors (rheumatoid arthritis); NF-kB inhibitors (rheumatoid arthritis), TCH Pharmaceuticals
    Click to Show/Hide
External Link
 Compound Name Anti-CD97 mab Investigative [111]
Synonyms
Anti-CD97 monoclonal antibody (rheumatoid arthritis); Anti-CD97 mAb (RA), Organon/AMC; Anti-CD97 monoclonal antibody (rheumatoid arthritis), Organon/AMC; Anti-CD97 mAb (RA), Schering-Plough/AMC; Anti-CD97 monoclonal antibody (rheumatoid arthritis), Merck & Co/AMC; Anti-CD97 monoclonal antibody (rheumatoid arthritis), Schering-Plough/AMC
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External Link
 Compound Name CIGB-55 Investigative [111]
External Link
 Compound Name NM-9405 Investigative [307]
Synonyms
Humanized Yalciomab (rheumatoid arthritis), Novelmed Therapeutics Inc; H-Yalciomab (rheumatoid arthritis), NovelmedTherapeutics Inc
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External Link
 Compound Name Dendritic cell-based immunotherapy Investigative [111]
Synonyms
Dendritic cell-based immunotherapy (rheumatoid arthritis); Dendritic cell-based immunotherapy (rheumatoid arthritis), Dendright; Dendritic cell-based immunotherapy (rheumatoid arthritis, injectable formulation), Dendright
    Click to Show/Hide
External Link
 Compound Name RT-401 Investigative [111]
Synonyms
BoNTA protein (topical, rhinitis), Revance
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External Link
 Compound Name VVZ-138 Investigative [111]
Synonyms
VVZ-000138
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External Link
 Compound Name IG-AI-025 Investigative [111]
External Link
 Compound Name CHR-4487 Investigative [111]
Synonyms
Esterase-sensitive motif compounds (inflammatory disease); Esterase-sensitive motif compounds (inflammatory disease), Chroma Therapeutics
    Click to Show/Hide
External Link
 Compound Name Ankinara Investigative [262]
External Link
 Compound Name ROSMARINIC ACID Investigative [312]
Synonyms
20283-92-5; Rosemary acid; (R)-rosmarinic acid; UNII-MQE6XG29YI; Rosmarinate; MQE6XG29YI; CHEMBL324842; CHEBI:50371; Labiatenic acid; C18H16O8; (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester; (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid; 537-15-5; Rosemaric acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid
    Click to Show/Hide
External Link
 Compound Name CT-340 Investigative [111]
Synonyms
TrkA kinase inhibitor (polyoxyethylene conjugated, LSE, arthritis, scarring, pain), Creabilis
    Click to Show/Hide
External Link
 Compound Name ADR58 Investigative [313]
External Link
 Compound Name CEL-2000 Investigative [111]
Synonyms
T-cell modulating vaccine (LEAPS, rheumatoid arthritis), CEL-SCI
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External Link
 Compound Name FM-201 Investigative [111]
External Link
 Compound Name BMS-345541 Investigative [314]
Synonyms
445430-58-0; BMS345541; BMS-345541 free base; BMS-345541 (free base); UNII-26SU0NEF5F; N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; 26SU0NEF5F; IKK Inhibitor III, BMS-345541; C14H17N5; 4-(2&amp; -Aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline; BMS-345541(free base); IKK Inhibitor III; Kinome_3215; SCHEMBL118886; GTPL5669; CHEMBL249697; CTK8E9618; KS-00001CRN; CHEBI:91340; BDBM25919; DTXSID60196216; PSPFQEBFYXJZEV-UHFFFAOYSA-N; MolPort-035-395-836; HMS3653F06; HMS2043P05
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External Link
 Compound Name CAT-2200 Investigative [315]
Synonyms
MEDI-571; Anti-IL-17 antibody (rheumatoid arthritis/systemic lupus erythematosus (SLE)), MedImmune; Anti-IL-17 antibody (rheumatoid arthritis/systemic lupus erythematosus (SLE)), Cambridge Antibody Technology (CAT)
    Click to Show/Hide
External Link
 Compound Name OCT-SG815 Investigative [111]
Synonyms
OPG secretagogues (osteoporosis/arthritis), Oscotec; Osteoprotegerin secretagogues (osteoporosis/arthritis), Oscotec; OPG secretagogues (osteoporosis/arthritis), KT&G; Osteoprotegerin secretagogues (osteoporosis/arthritis), KT&G
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External Link
References
Ref 1 Role of m6A modification and novel circ_0066715/ miR-486-5p/ ETS1 axis in rheumatoid arthritis macrophage polarization progression. Aging (Albany NY). 2022 Dec 20;14(24):10009-10026. doi: 10.18632/aging.204439. Epub 2022 Dec 20.
Ref 2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018
Ref 3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5425).
Ref 4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6778).
Ref 5 2018 FDA drug approvals. Nat Rev Drug Discov. 2019 Feb;18(2):85-89. doi: 10.1038/d41573-019-00014-x.
Ref 6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7796).
Ref 8 ClinicalTrials.gov (NCT02317627) Study of of KD025 in Subjects With Psoriasis Vulgaris Who Failed First-Line Therapy. U.S. National Institutes of Health.
Ref 9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6773).
Ref 10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034238)
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Ref 12 ClinicalTrials.gov (NCT01359943) Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate
Ref 13 ClinicalTrials.gov (NCT00029042) Infliximab to Treat Children With Juvenile Rheumatoid Arthritis
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Ref 15 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3447).
Ref 16 In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis. Ann Clin Lab Sci. 2005 Spring;35(2):137-43.
Ref 17 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 18 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7220).
Ref 19 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Ref 21 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5677).
Ref 22 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7099).
Ref 23 Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. doi: 10.1517/14728214.13.1.175.
Ref 24 Clinical pipeline report, company report or official report of Eisai.
Ref 25 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4194).
Ref 26 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 062527.
Ref 27 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2896).
Ref 28 ClinicalTrials.gov (NCT02390700) Observational Study of Golimumab Intravenous Infusion
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Ref 181 Subcutaneous injections of low doses of humanized anti-CD20 veltuzumab: a phase I study in chronic lymphocytic leukemia. Leuk Lymphoma. 2015 Oct 19:1-9.
Ref 182 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031251)
Ref 183 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029914)
Ref 184 ClinicalTrials.gov (NCT01635686) Comparison the Safety and Pharmacokinetic Characteristics of DWP422 25 mg With Those of ENBREL 25MG PFS INJ. After Subcutaneous Injection in Healthy Male Volunteers. U.S. National Institutes of Health.
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Ref 189 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030399)
Ref 190 ClinicalTrials.gov (NCT02052375) A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With RheumatoidArthritis on Methotrexate. U.S. National Institutes of Health.
Ref 191 Clinical pipeline report, company report or official report of GlaxoSmithKline.
Ref 192 Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats. Br J Pharmacol. 2008 Nov;155(5):722-30.
Ref 193 ClinicalTrials.gov (NCT00539760) A Phase I Rheumatoid Arthritis Study in Healthy Volunteers. U.S. National Institutes of Health.
Ref 194 Clinical pipeline report, company report or official report of Evotec.
Ref 195 AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. J Neurosci. 2013 Jun 12;33(24):10075-84.
Ref 196 Cathepsin B and L inhibitors: a patent review (2010 - present). Expert Opin Ther Pat. 2017 Jun;27(6):643-656. doi: 10.1080/13543776.2017.1272572. Epub 2016 Dec 23.
Ref 197 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000926)
Ref 198 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002733)
Ref 199 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003093)
Ref 200 Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
Ref 201 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023346)
Ref 202 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005395)
Ref 203 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002363)
Ref 204 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020487)
Ref 205 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005016)
Ref 206 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026002)
Ref 207 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002178)
Ref 208 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015375)
Ref 209 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002351)
Ref 210 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000006)
Ref 211 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6155).
Ref 212 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1898).
Ref 213 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038032)
Ref 214 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027730)
Ref 215 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018063)
Ref 216 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013426)
Ref 217 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008290)
Ref 218 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002311)
Ref 219 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007225)
Ref 220 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030380)
Ref 221 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010130)
Ref 222 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005369)
Ref 223 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001452)
Ref 224 Clinical pipeline report, company report or official report of Galapagos.
Ref 225 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279)
Ref 226 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022053)
Ref 227 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007359)
Ref 228 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018538)
Ref 229 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010176)
Ref 230 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 676).
Ref 231 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016746)
Ref 232 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015041)
Ref 233 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019215)
Ref 234 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017126)
Ref 235 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030004)
Ref 236 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036376)
Ref 237 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026289)
Ref 238 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002825)
Ref 239 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003785)
Ref 240 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032677)
Ref 241 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018196)
Ref 242 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013227)
Ref 243 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001478)
Ref 244 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005889)
Ref 245 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010787)
Ref 246 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009741)
Ref 247 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023206)
Ref 248 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017125)
Ref 249 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025030)
Ref 250 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027710)
Ref 251 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005273)
Ref 252 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002367)
Ref 253 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017105)
Ref 254 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003045)
Ref 255 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7687).
Ref 256 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029003)
Ref 257 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006813)
Ref 258 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020402)
Ref 259 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025504)
Ref 260 Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. doi: 10.1038/s41573-019-0036-1. Epub 2019 Sep 2.
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Ref 262 Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 263 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000969)
Ref 264 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002734)
Ref 265 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007333)
Ref 266 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004493)
Ref 267 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012928)
Ref 268 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002767)
Ref 269 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001772)
Ref 270 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007983)
Ref 271 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003766)
Ref 272 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010855)
Ref 273 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029797)
Ref 274 Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60(1):41-6.
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Ref 277 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5115).
Ref 278 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005582)
Ref 279 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009040)
Ref 280 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019129)
Ref 281 Effects of the hydroxamic acid derivate Ro 31-4724 on the metabolism and morphology of interleukin-1-treated cartilage explants. Pharmacology. 1997 Aug;55(2):95-108.
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Ref 283 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013022)
Ref 284 Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine. 1996 May;8(5):377-86.
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Ref 287 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6038).
Ref 288 Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.
Ref 289 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005488)
Ref 290 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7686).
Ref 291 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005018)
Ref 292 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004415)
Ref 293 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000230)
Ref 294 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003820)
Ref 295 Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83.
Ref 296 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001260)
Ref 297 Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. J Pharmacol Exp Ther. 2011 Jul;338(1):154-63.
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Ref 299 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013076)
Ref 300 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002348)
Ref 301 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6509).
Ref 302 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021746)
Ref 303 ETP-46321, a dual p110Alpha/Delta class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis. Biochem Pharmacol. 2016 Apr 15;106:56-69. doi: 10.1016/j.bcp.2016.02.005. Epub 2016 Feb 13.
Ref 304 Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model. Eur J Immunol. 2016 Mar;46(3):772-81.
Ref 305 PAC 10649 Pacific licensing offer, Worldwide excluding South Korea. R & D Focus Drug News. September 22, 2003.
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Ref 307 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870).
Ref 308 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874).
Ref 309 Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.
Ref 310 US patent application no. 6,274,627, Conjugates of dithiocarbamate disulfides with pharmacologically active agents and uses therefor.
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Ref 312 A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antio... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7393-6.
Ref 313 Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60.
Ref 314 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5669).
Ref 315 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294).