m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05188
|
[1] | |||
Non-coding RNA
MetBil
METTL3
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
COL1A2
COL1A2
METTL3
Methylation
 : m6A sites
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Collagen alpha-2(I) chain (COL1A2) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | METTL3 binding lncRNA (MetBil) | LncRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | METBIL as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification of Collagen alpha-2(I) chain (COL1A2). | ||||
| Responsed Disease | Vascular disorders of the liver | ICD-11: DB98.8 | |||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Collagen alpha-2(I) chain (COL1A2) | 1 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
 Compound Name |
Solubilized type 1 native bovine collagen | Phase 2 | [2] | |
|---|---|---|---|---|
| Synonyms |
Solubilized type 1 native bovine collagen (oral, scleroderma); Solubilized type 1 native bovine collagen (oral, scleroderma), arGentis/University of Tennessee
Click to Show/Hide
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| MOA | Modulator | |||
| External Link | ||||