m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05124
|
[1] | |||
Non-coding RNA
MIR22HG
YTHDC1
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
Angptl4
Angptl4
YTHDC1
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing protein 1 (YTHDC1) | READER | |||
| m6A Target | Angiopoietin-related protein 4 (ANGPTL4) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MIR22 host gene (MIR22HG) | LncRNA | View Details | ||
| Regulated Target | YTH N6-methyladenosine RNA binding protein C1 (YTHDC1) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | MIR22HG facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angiopoietin-related protein 4 (ANGPTL4) mRNA stability | ||||
In-vitro Model |
MLE-12
|
N.A. | Mus musculus | CVCL_3751 | |
| In-vivo Model | Male C57BL/6J mice (6-8 weeks old and 18-21 g weight) were randomly divided into 3 groups, including ctrl + ad-NC, LPS + ad-NC and LPS + ad-sh-Mir22hg. | ||||