m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05118
 [1]
Non-coding RNA SNHG7 KHSRP  lncRNA       miRNA   circRNA Direct Enhancement m6A modification MKL1 MKL1 KHSRP : m6A sites
m6A Modification:
m6A Regulator Far upstream element-binding protein 2 (KHSRP) READER
 Regulator Info 
m6A Target Myocardin-related transcription factor A (MKL1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Small nucleolar RNA host gene (SNHG7) LncRNA View Details
Regulated Target KH-type splicing regulatory protein (KHSRP) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator
Crosstalk Summary m6A transferase METTL3 regulates endothelial-mesenchymal transition in diabetic retinopathy via lncRNA SNHG7/KHSRP/Myocardin-related transcription factor A (MKL1) axis
Responsed Disease Diabetic retinopathy ICD-11: 9B71.0
 Disease Info 
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
9B71: Retinopathy 12 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name SHP607 Phase 2 [2]
External Link
TTD: D0R1JO
 Compound Name RST-001 Phase 1/2 [3]
Synonyms
ChR2 gene therapy (retinopathy), RetroSense; AAV-based ChR2 gene therapy (retinopathy), RetroSense; Channelrhodopsin-2 gene therapy (retinopathy), RetroSense
    Click to Show/Hide
External Link
TTD: D0RM6A
 Compound Name ReN-003 Phase 1/2 [4]
Synonyms
Stem cell therapy (retinal diseases), ReNeuron
    Click to Show/Hide
External Link
TTD: D03OVN
 Compound Name PMID28621580-Compound-WO2015089220C70 Patented [5]
External Link
TTD: D07AVU
 Compound Name SIR-1076 Preclinical [6]
Synonyms
Antioxidants (topical, retinal oxidative stress), Sirion Therapeutics
    Click to Show/Hide
External Link
TTD: D06RVY
 Compound Name CytoRet Investigative [4]
Synonyms
Retinal cell therapy (retinal disease), International Stem Cell; Retinal layers (parthenogenetic stem-cell derived), ISCO
    Click to Show/Hide
External Link
TTD: D0V4YT
 Compound Name LPO-1010CSR Investigative [4]
External Link
TTD: D0MH8K
 Compound Name INDUS-815C Investigative [7]
Synonyms
VEGF modulator (age related macular degeneration/retinopathy), Indus Biotech; INDUS-815C (Huntington's disease), Indus Biotech; INDUS-815C (age related macular degeneration/retinopathy), Indus Biotech; SIRT2 inhibtior (Parkinson's disease/dementia/Huntington's disease), Indus Biotech; NAD-dependent deacetylase sirtuin-2inhibitor (Parkinson's disease/dementia/Huntington's disease), Indus Biotech
    Click to Show/Hide
External Link
TTD: D0IR8J
 Compound Name SF-113 Investigative [4]
External Link
TTD: D0I2AD
 Compound Name SF-106 Investigative [4]
External Link
TTD: D07DRO
 Compound Name Gene therapy, retinopathy, Investigative [4]
Synonyms
Gene therapy (retinopathy)
    Click to Show/Hide
External Link
TTD: D04ENF
 Compound Name Superoxide dismutase mimetics Investigative [4]
Synonyms
INO-6001; INO-6002; Superoxide dismutase mimetics (retinal disease); Superoxide dismutase mimetics (retinal disease), Inotek; Superoxide dismutase mimetics (age-related macular degeneration/diabetic retinopathy/diabetic macular edema), Inotek
    Click to Show/Hide
External Link
TTD: D03KRF
References
Ref 1 m(6)A transferase METTL3 regulates endothelial-mesenchymal transition in diabetic retinopathy via lncRNA SNHG7/KHSRP/MKL1 axis. Genomics. 2022 Nov;114(6):110498. doi: 10.1016/j.ygeno.2022.110498. Epub 2022 Sep 26.
Ref 2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 3 ClinicalTrials.gov (NCT02556736) RST-001 Phase I/II Trial for Retinitis Pigmentosa.
Ref 4 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Ref 5 VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016). Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. doi: 10.1080/13543776.2017.1344215. Epub 2017 Jun 23.
Ref 6 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028168)
Ref 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2708).