m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05089				[1]
Non-coding RNA Dubr YTHDF1 lncRNA miRNA circRNA Direct Enhancement m⁶A modification Calmodulin Calmodulin YTHDF1 : m⁶A sites
m6A Regulator	YTH domain-containing family protein 1 (YTHDF1)			READER	Regulator Info
m6A Target	Calmodulin-1 (CALM1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	DPPA2 upstream binding RNA (DUBR)			LncRNA	View Details
Regulated Target	YTH domain-containing family protein 1 (YTHDF1)				View Details
Crosstalk Relationship	ncRNA → m6A			Enhancement
Crosstalk Mechanism	ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary	m6A-modified lincRNA DUBR is required for neuronal development by stabilizing YTHDF1 and facilitating mRNA translation.Dubr interacts with m6A-binding proteins, the YTHDF1/3 complex, through its m6A motifs to protect YTHDF1/3 from degradation via the proteasome pathway. Furthermore, Tau and Calmodulin-1 (CALM1) are regulated by YTHDF1/3 and m6A-modified Dubr.
In-vitro Model	Neuro-2a	Mouse neuroblastoma	Mus musculus		CVCL_0470
In-vitro Model	ND7/23	N.A.	Mus musculus		CVCL_4259

References

Ref 1	m(6)A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Rep. 2022 Nov 22;41(8):111693. doi: 10.1016/j.celrep.2022.111693.