m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05086
|
[1] | |||
Non-coding RNA
CHAPIR
METTL3
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
Parp10
Parp10
METTL3
Methylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Protein mono-ADP-ribosyltransferase PARP10 (PARP10) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Cardiac-hypertrophy-associated piRNA | piRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Protein mono-ADP-ribosyltransferase PARP10 (PARP10) mRNA | ||||
| Responsed Disease | Cardiomegaly | ICD-11: BC45 | |||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| BC45: Cardiomegaly | 1 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
UK-356202 | Clinical trial | [2] | |
|---|---|---|---|---|
| Synonyms |
compound 13j [PMID: 15149680]; UK-356,202
Click to Show/Hide
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| External Link | ||||
References