m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05063
|
[1] | |||
Non-coding RNA
AK311120
YTHDC2
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
MAP2K7
MAP2K7
YTHDC2
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | YTH domain-containing protein 2 (YTHDC2) | READER | |||
| m6A Target | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Lnc-AK311120 | LncRNA | View Details | ||
| Regulated Target | YTH N6-methyladenosine RNA binding protein C2 (YTHDC2) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | Lnc-AK311120 interacted with the RNA-binding proteins DExH-Box helicase 9 (DHX9) and YTHDC2 to form a ternary complex, while Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) served as the shared downstream target gene of DHX9 and YTHDC2. | ||||