m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03328
 [1], [2]
Histone modification H3K4me3 KDM5A hsa-miR-495 Indirect Enhancement m6A modification AKT1 AKT1 YTHDF2 : m6A sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
m6A Target RAC-alpha serine/threonine-protein kinase (AKT1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Lysine-specific demethylase 5A (KDM5A) ERASER View Details
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3) View Details
Downstream Gene hsa-miR-495 View Details
Crosstalk Relationship Histone modification  →  m6A Enhancement
Crosstalk Mechanism histone modification indirectly regulates m6A modification through downstream signaling pathways
Crosstalk Summary KDM5A, as a Histone H3 lysine 4 trimethylation (H3K4me3) demethylase, bound to the hsa-miR-495 promoter, which led to inhibition of its transcription and expression. As a target of miR-495, YTHDF2 could inhibit MOB3B expression by recognizing m6A modification of MOB3B mRNA and inducing mRNA degradation. Knock-down of YTHDF2 or METTL3 significantly induced the expression of LHPP and NKX3-1 at both mRNA and protein level with inhibited phosphorylated RAC-alpha serine/threonine-protein kinase (AKT1). YTHDF2 mediates the mRNA degradation of the tumor suppressors LHPP and NKX3-1 in m6A-dependent way to regulate AKT phosphorylation-induced tumor progression in prostate cancer.
Responsed Disease Prostate cancer ICD-11: 2C82
 Disease Info 
Pathway Response Oxidative phosphorylation hsa00190
Cell Process Cell proliferation
Cell migration
Cell invasion
Cell apoptosis
In-vitro Model
 RWPE-1 Normal Homo sapiens CVCL_3791
DU145 Prostate carcinoma Homo sapiens CVCL_0105
PC-3 Prostate carcinoma Homo sapiens CVCL_0035
22Rv1 Prostate carcinoma Homo sapiens CVCL_1045
VCaP Prostate carcinoma Homo sapiens CVCL_2235
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Lysine-specific demethylase 5A (KDM5A) 21 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name 6EP Patented [3]
Synonyms
2-{5-[(4-Chloro-2-Methylphenyl)methoxy]-1h-Pyrazol-1-Yl}pyridine-4-Carboxylic Acid; 1613410-75-5; CHEMBL3786952; SCHEMBL15778339; BDBM191600; NCGC00390881-02; QC3611,QC-3611,QC 3611; 2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl)isonicotinic acid (N19)
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 74766595
TTD: D00SUC
 Compound Name BDBM50158803 Patented [4]
Synonyms
CHEMBL3787438; SCHEMBL15792889
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 90216982
TTD: D01WHH
 Compound Name US10022354, Example 151 Patented [5]
Synonyms
SCHEMBL19513974; CHEMBL4060968; BDBM281211
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.065 nM
External Link
CID: 132054530
TTD: D03POM
 Compound Name US9714230, 12 Patented [3]
Synonyms
SCHEMBL15778399; LKBZHRSAENXIOI-UHFFFAOYSA-N; BDBM263942; 2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid; 2-(5-p-tolyl-1H-pyrazol-1-yl)isonicotinic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 550 nM
External Link
CID: 76901247
TTD: D03TKM
 Compound Name BDBM50158791 Patented [6]
Synonyms
CHEMBL3786596; SCHEMBL15818867; SCHEMBL19646964
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 550 nM
External Link
CID: 77106319
TTD: D05CCY
 Compound Name US10040779, Example 4 Patented [7]
Synonyms
SCHEMBL15792083; BDBM277707; 3-[(5-chloro-1-methyl-1H-indazol-3-yl)amino]pyridine-4-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 0.1nM
External Link
CID: 75202257
TTD: D06TKT
 Compound Name US9611221, Example 9 Patented [8]
Synonyms
3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxylic acid; SCHEMBL15286753; RNBCOBWQQCESLL-UHFFFAOYSA-N; BDBM314105
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 71766727
TTD: D09CWB
 Compound Name US9714230, 46 Patented [9]
Synonyms
SCHEMBL15778753; MITOFELVTHNBGA-UHFFFAOYSA-N; BDBM263981; 2-(5-(4-bromophenyl)-1H-pyrazol- 1-yl)isonicotinic acid; 2-[5-(4-bromophenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 10nM
External Link
CID: 86725517
TTD: D0F3TL
 Compound Name BDBM50158794 Patented [7]
Synonyms
CHEMBL3785470; SCHEMBL15792416
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MOA Inhibitor
Activity IC50 < 0.1nM
External Link
CID: 76282772
TTD: D0G8QR
 Compound Name BDBM50158703 Patented [3]
Synonyms
CHEMBL3785832; SCHEMBL15777940
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MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 90204862
TTD: D0GH8J
 Compound Name AKOS020330656 Patented [10]
Synonyms
CHEMBL3774545; SCHEMBL15820618; RFUZGPWCXINBNW-UHFFFAOYSA-N; BDBM50153334; ZINC123452149; 3-{[(5-methylthiophen-2-yl)methyl]amino}pyridine-4-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 77106317
TTD: D0HT9Q
 Compound Name BDBM50158755 Patented [11]
Synonyms
CHEMBL3786579; SCHEMBL15778210
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 90205053
TTD: D0K4LW
 Compound Name US10174026, Example 99 Patented [12]
Synonyms
SCHEMBL16157351; BDBM320432; 2-(pyrrolidin-1-ylcarbonyl)-1H- pyrrolo[3,2-b]pyridine-7- carboxylic acid
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MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 85469291
TTD: D0N9JZ
 Compound Name AKOS020330481 Patented [8]
Synonyms
3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic acid; SCHEMBL4855920; US9611221, Example 7; XKZFNTZMCLZYHZ-UHFFFAOYSA-N; BDBM314103; 3[(4-methoxybenzyl)amino]pyridine-4-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 550 nM
External Link
CID: 59699608
TTD: D0NG8M
 Compound Name US10022354, Example 5 Patented [5]
Synonyms
SCHEMBL17682496; CHEMBL4062756; BDBM281065
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7.4 nM
External Link
CID: 121279569
TTD: D0NM3B
 Compound Name NCGC00381656-01 Patented [13]
Synonyms
CHEMBL4100530; SCHEMBL16157407; BDBM320423; US10174026, Example 88; 2-[(2-chlorophenyl)-propoxy- methyl]-1H-pyrrolo[3,2-b]- pyridine-7-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 100nM
External Link
CID: 117637389
TTD: D0PQ5P
 Compound Name US10174026, Example 2 Patented [12]
Synonyms
SCHEMBL16149258; FEZIKLVLFANZBD-UHFFFAOYSA-N; BDBM320362; 2-phenyl-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid; 2-phenyl-1H-pyrrolo[3,2-b] pyridine-7-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 550 nM
External Link
CID: 86280871
TTD: D0R2GT
 Compound Name US10022354, Example 152 Patented [5]
Synonyms
CHEMBL4059597; SCHEMBL17682668; BDBM281212
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.083 nM
External Link
CID: 121279737
TTD: D0T8YT
 Compound Name US10040779, Example 1 Patented [7]
Synonyms
SCHEMBL15792304; BDBM277704; 3-[(1-methyl-1H-indazol-3-yl)amino]pyridine-4-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 0.1nM
External Link
CID: 76282043
TTD: D0VZ5E
 Compound Name 1190312-92-5 Patented [12]
Synonyms
3-chloro-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid; 3-CHLORO-4-AZAINDOLE-7-CARBOXYLIC ACID; SCHEMBL16157363; US10174026, Example 1; UAFNSWUBMGTOQA-UHFFFAOYSA-N; BDBM320361; ZINC44713035; 3-chloro-1H-pyrrolo[3,2-b] pyridine-7-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5500 nM
External Link
CID: 53412620
TTD: D0ZJ0Z
 Compound Name PBIT Investigative [14]
Synonyms
2514-30-9; 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-methylphenyl)-1,2-benzothiazol-3-one; MLS000583746; 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one; 2-(p-tolyl)-1,2-benzothiazol-3-one; SMR000200989; 2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one; 1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)-; 2-(4-methylphenyl)-2,3-dihydro-1,2-benzothiazol-3-one; ChemDiv3_007090; AC1LIP69; cid_935415; SCHEMBL2443755; GTPL7026; CHEMBL1336959; CTK0J4356; BDBM34737; AOB6896; DTXSID10359056; MolPort-002-285-696; HMS2576N21
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 935415
TTD: D0IQ7Y
RAC-alpha serine/threonine-protein kinase (AKT1) 40 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Capivasertib Approved [15]
Synonyms
1143532-39-1; AZD-5363; capivasertib; AZD 5363; UNII-WFR23M21IE; WFR23M21IE; cc-638; 4-Amino-N-[(1s)-1-(4-Chlorophenyl)-3-Hydroxypropyl]-1-(7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)piperidine-4-Carboxamide; C21H25ClN6O2; (S)-4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE; 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide; 4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1
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MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 25227436
TTD: D01ZAQ
DrugBank: DB12218
 Compound Name GDC-0068 Phase 3 [16]
Synonyms
RG7440
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MOA Inhibitor
Activity IC50 = 157 nM
External Link
CID: 24788740
TTD: D0I4TH
DrugBank: DB11743
 Compound Name Enzastaurin Phase 3 [16]
Synonyms
LY317615; LE-0014; LY317615, Enzastaurin; 3-(1-methyl-1H-indol-3-yl)-4-{1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione; 3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 176167
TTD: D0I6VU
DrugBank: DB06486
 Compound Name GSK2110183 Phase 2 [17]
MOA Modulator
External Link
CID: 46843057
TTD: D02NXM
DrugBank: DB11648
 Compound Name RX-0201 Phase 2 [18]
MOA Inhibitor
External Link
TTD: D07SYZ
 Compound Name Trametinib + 2141795 Phase 2 [17]
MOA Modulator
External Link
CID: 11707110
TTD: D0S5WP
DrugBank: DB08911
 Compound Name PTX-200 Phase 2 [16]
Synonyms
Plant-derived antiparkinsonian, Phytrix
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0X7CV
 Compound Name CMX-2043 Phase 2 [19]
MOA Modulator
External Link
CID: 49802864
TTD: D01TBJ
DrugBank: DB12795
 Compound Name ARQ 092 Phase 2 [20]
Synonyms
Miransertib
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MOA Inhibitor
External Link
CID: 53262401
TTD: D07DWF
DrugBank: DB14982
 Compound Name CI-1033 Phase 2 [21]
Synonyms
Canertinib; Canertinib HCl; Canertinib dihydrochloride; Canertinib dihydrochloride [USAN]; CI1033; PD 183805; Canertinib dihydrochloride (USAN); PD-0183805; PD-183805; Canertinib, PD-183805, CI1033, PD183805; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride; N-(4-(3-chloro-4-fluorophenyl)amino)-7-(3-morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide dihydrochloride; N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl) amino)-7-(3-(4-morpholinyl) propoxy)-6-quinazolinyl)-, dihydrochloride; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-morpholinyl)propoxy)-6-quinazolinyl)-, dihydrochloride
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 156414
TTD: D0YB3W
DrugBank: DB05424
 Compound Name Triciribine prodrug Phase 1/2 [17]
Synonyms
TSR-826; Triciribine prodrug (oral, cancer); Triciribine prodrug (oral, cancer), TSRL
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MOA Inhibitor
External Link
TTD: D09CCZ
 Compound Name BMS-754807 Phase 1 [22]
Synonyms
1001350-96-4; BMS 754807; BMS754807; UNII-W9E3353E8J; CHEMBL575448; CHEBI:88339; W9E3353E8J; 1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide; W-204348; J-501009; 2-Pyrrolidinecarboxamide, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-, (2S)-;2-Pyrrolidinecarboxamide, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridin
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MOA Inhibitor
External Link
CID: 24785538
TTD: D02QWY
DrugBank: DB15399
 Compound Name ARQ 751 Phase 1 [16]
MOA Inhibitor
External Link
TTD: D0L8PZ
 Compound Name M2698 Phase 1 [16]
Synonyms
HXAUJHZZPCBFPN-QGZVFWFLSA-N; 1379545-95-5; SCHEMBL15262358; EX-A1187; AKOS030627134; M2698(MSC-2363318A)
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MOA Inhibitor
External Link
CID: 89808643
TTD: D06HYF
DrugBank: DB15431
 Compound Name PMID28460551-Compound-6 Patented [23]
MOA Inhibitor
External Link
TTD: D07QBF
 Compound Name Squalestatin 1 Terminated [24]
Synonyms
Zaragozic acid A; Squalestatin; 142561-96-4; ZARAGOZIC ACIDS A; UNII-1117HVX02L; CHEMBL280978; CHEBI:75170; 1117HVX02L; 1S-((4S-acetoxy-5R-methyl-3-methylene-6-phenylhexyl)-6-(E)-4S,6S-dimethyloct-2-enoyloxy)-4,7S-dihydroxy-2,8-dioxabicyclo[321]octane-3S,4S,5R-tricarboxylic acid; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-(4,6-dimethyl-2-octenoate), (5(2E,4S,6S),7S)-; Squalestatin 1, Glaxo; Zaragozic acid A, Glaxo
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MOA Inhibitor
External Link
CID: 6438355
TTD: D0O1AV
 Compound Name MYRIOCIN Investigative [24]
Synonyms
thermozymocidin; 35891-70-4; ISP-I; ISP-1; UNII-YRM4E8R9ST; (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; YRM4E8R9ST; Myriocin, Mycelia sterilia; Myriocin from Mycelia sterilia; CHEBI:582124; NCGC00163597-02; NCGC00163597-03; DSSTox_CID_26360; DSSTox_RID_81561; (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid; DSSTox_GSID_46360; [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
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MOA Inhibitor
External Link
CID: 6438394
TTD: D07MQF
 Compound Name LD-101 Investigative [17]
Synonyms
AKT-SI-1
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MOA Inhibitor
External Link
CID: 24773090
TTD: D09DGE
 Compound Name A-674563 Investigative [25]
Synonyms
A 674563; A674563
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MOA Inhibitor
Activity Ki = 11 nM
External Link
CID: 11314340
TTD: D0CM6T
DrugBank: DB08568
 Compound Name Lactoquinomycin Investigative [26]
Synonyms
SCHEMBL12324296
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 149 nM
External Link
CID: 12967404
TTD: D0F8HX
 Compound Name VLI-27 Investigative [17]
Synonyms
AKT inhibitor (pancreatic cancer), NovaLead Pharma
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0N7CY
 Compound Name A-443654 Investigative [27]
Synonyms
A-4436554
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.16 nM
External Link
CID: 10172943
TTD: D0OX1T
DrugBank: DB08073
 Compound Name NU-1001-41 Investigative [17]
Synonyms
Anti-phospho-AKT monoclonal antibodies (cancer), Nuclea Biotechnologies
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External Link
TTD: D0PX5F
 Compound Name 4,5,6-trihydroxy-3-methylphthalide Investigative [28]
Synonyms
CHEMBL486813; AGUVVAYMPQDJDX-UHFFFAOYSA-; BDBM50242174; 3-methyl-4,5,6-trihydroxy-phthalide; 4,5,6-Trihydroxy-3-methylisobenzofuran-1(3H)-one
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MOA Inhibitor
Activity IC50 = 19700 nM
External Link
CID: 11424128
TTD: D0RZ1H
 Compound Name ALM-301 Investigative [17]
Synonyms
Akt inhibitors (cancer), Almac
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MOA Inhibitor
External Link
TTD: D0V1ES
 Compound Name BX-517 Investigative [29]
Synonyms
BX517; 850717-64-5; UNII-SYV8VN8W5K; SYV8VN8W5K; pdk-1 inhibitors; BX517(PDK1 inhibitor2); Indolinone based inhibitor, 4i; SCHEMBL5567818; CHEMBL228654; 5-Ureido-3-(1-(pyrrol-2-yl)ethylidene)indolin-2-one; BDBM17004; MolPort-046-033-615; BCP16225; EX-A2243; ZINC14962724; AKOS032945106; CS-6066; Urea, N-(2,3-dihydro-2-oxo-3-((3Z)-1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-; Urea, N-(2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-; Urea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-
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MOA Inhibitor
External Link
CID: 11161844
TTD: D0L5AB
 Compound Name Inositol 1,3,4,5-Tetrakisphosphate Investigative [30]
Synonyms
Inositol-1,3,4,5-tetraphosphate; Ins-1,3,4,5-P4; 1D-myo-inositol 1,3,4,5-tetrakisphosphate; Inositol-1,3,4,5-tetrakisphosphate; inositol-(1,3,4,5)-tetrakisphosphate; Inositol 1,3,4,5-tetraphosphate; myo-Inositol-1,3,4,5-tetrakisphosphate; CHEMBL23552; D-myo-inositol 1,3,4,5-tetrakisphosphate; CHEBI:16783; myo-Inositol, 1,3,4,5-tetrakis(dihydrogen phosphate); 1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate); Ins(1,3,4,5)P4; 1bwn; 4IP; 102850-29-3; myo-Inositol 1,3,4,5-tetraphosphate
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MOA Inhibitor
External Link
CID: 107758
TTD: D0MH9X
DrugBank: DB01863
 Compound Name (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one Investigative [29]
Synonyms
oxindole i; CHEMBL86755; 3-(1H-Pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one; oxindole 1; AC1NZGXV; K00027; Indolinone based inhibitor, 1; SCHEMBL1162655; SCHEMBL13819612; BDBM17015; MolPort-023-197-743; SEZFNTZQMWJIAI-FLIBITNWSA-N; ZINC3874586; HSCI1_000049; NCGC00343760-01; BRD-K51816706-001-01-7; (3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; 3-[(1H-Pyrrole-2-yl)methylene]-1H-indole-2(3H)-one; Z-(1H-Pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
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MOA Inhibitor
Activity IC50 = 2300 nM
External Link
CID: 5908088
TTD: D00ATA
 Compound Name Akt inhibitor VIII Investigative [31]
Synonyms
isozyme-selective, Akti-1/2
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MOA Inhibitor
Activity IC50 = 58 nM
External Link
CID: 135398501
TTD: D05APZ
 Compound Name SB-747651A Investigative [32]
Synonyms
CHEMBL188434; compound 26; SCHEMBL4719834; GTPL8130; BDBM24996; oxadiazole-containing compound, 9; MBCJUIJWPYUEBX-UHFFFAOYSA-N; ZINC13998530; NCGC00273984-05; NCGC00273984-03; SB-747651; 4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imidazo[4,5-c]pyridin-2-yl}-1,2,5-oxadiazol-3-amine; [2-(4-Amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ylmethyl]-piperidin-4-yl-amine
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MOA Inhibitor
Activity IC50 = 200 nM
External Link
CID: 11393719
TTD: D0I1FJ
 Compound Name PMID20005102C1 Investigative [33]
Synonyms
GTPL8181; BDBM50305878; B99
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MOA Inhibitor
Activity IC50 = 1 nM
External Link
CID: 46225540
TTD: D0L2WP
 Compound Name STAUROSPORINONE Investigative [34]
MOA Inhibitor
External Link
TTD: D0GB4V
 Compound Name Ro31-8220 Investigative [34]
Synonyms
Bisindolylmaleimide IX; ro 31-8220; 125314-64-9; Ro 31 8220; Ro 318220; UNII-W9A0B5E78O; Ro-318220; Ro-31-8220; CHEMBL6291; W9A0B5E78O; CHEBI:38912; 3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate; 3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl imidothiocarbamate; CHEMBL1591531; Carbamimidothioic acid, 3-(3-(2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl; bisindolymaleimide IX
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MOA Inhibitor
External Link
CID: 5083
TTD: D0M5FF
 Compound Name BMS-536924 Investigative [35]
MOA Inhibitor
External Link
CID: 135440466
TTD: D0M4SY
 Compound Name KN-62 Investigative [34]
Synonyms
KN-62 (non-isomeric); GTPL6001; HMS3229A04; CCG-206863
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MOA Inhibitor
External Link
CID: 5312126
TTD: D0N6ES
 Compound Name CI-1040 Investigative [34]
MOA Inhibitor
External Link
CID: 6918454
TTD: D0B9BU
DrugBank: DB12429
 Compound Name 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole Investigative [36]
Synonyms
4,5,6,7-tetrabromobenzotriazole
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MOA Inhibitor
External Link
CID: 1694
TTD: D0O1YH
DrugBank: DB04462
 Compound Name 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol Investigative [37]
MOA Inhibitor
External Link
CID: 9859248
TTD: D0A5RM
 Compound Name Bisindolylmaleimide-I Investigative [34]
Synonyms
Bisindolylmaleimide i; 133052-90-1; GF 109203X; GF109203X; Go 6850; GF-109203X; RBT205 INHIBITOR; Go-6850; UNII-L79H6N0V6C; Bisindolylmaleimide I (GF 109203X); CHEMBL7463; 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE; 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; L79H6N0V6C; QMGUOJYZJKLOLH-UHFFFAOYSA-N; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide; GF-109203; Go6850
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MOA Inhibitor
External Link
CID: 2396
TTD: D0TO6S
DrugBank: DB03777
 Compound Name RO-316233 Investigative [34]
Synonyms
119139-23-0; bisindolylmaleimide iv; 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Arcyriarubin A; 3,4-Bis(3-indolyl)maleimide; 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione; UNII-MBK3OO5K8T; BIM IV; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; MBK3OO5K8T; CHEMBL266487; 3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; DQYBRTASHMYDJG-UHFFFAOYSA-N; 2,3-bis(1H-Indol-3-yl)maleimide; 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-; Ro-31-6233; AK-15401; 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione; Bisindoylmaleimide; Bisindolyl deriv. 3
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MOA Inhibitor
External Link
CID: 2399
TTD: D0L8HO
2C82: Prostate cancer 1 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name CC-94676 Phase 1 [38]
External Link
TTD: DNY63Z
References
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Ref 38 ClinicalTrials.gov (NCT04428788) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CC-94676 in Subjects With Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health.