m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT03196				[1]
m⁶A modification TEX41 TEX41 WTAP Methylation : m⁶A sites Indirect Enhancement Histone modification H3K27me3 SUZ12 HDAC1
m6A Regulator	Wilms tumor 1-associating protein (WTAP)			WRITER	Regulator Info
m6A Target	testis expressed 41 (TEX41)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Histone modification (HistMod)
Epigenetic Regulator	Polycomb protein SUZ12 (SUZ12)			WRITER	View Details
Regulated Target	Histone H3 lysine 27 trimethylation (H3K27me3)				View Details
Downstream Gene	HDAC1				View Details
Crosstalk Relationship	m6A → Histone modification			Enhancement
Crosstalk Mechanism	m6A modification indirectly regulates histone modification through downstream signaling pathways
Crosstalk Summary	WTAP act as an N6-methyladenosine transferase to regulate the m6A modification of long noncoding RNA testis expressed 41 (TEX41). Then, the upregulated m6A modification destabilized TEX41 in a YTHDF2-dependent manner. Furthermore, TEX41 interacted with the SUZ12 protein and increased the histone methyltransferase activity of SUZ12, resulting in HDAC1 silencing by Histone H3 lysine 27 trimethylation (H3K27me3).
Responsed Disease	Renal cell carcinoma		ICD-11: 2C90		Disease Info
In-vitro Model	786-O	Renal cell carcinoma	Homo sapiens		CVCL_1051
	769-P	Renal cell carcinoma	Homo sapiens		CVCL_1050
	OS-RC-2	Clear cell renal cell carcinoma	Homo sapiens		CVCL_1626
	ACHN	Papillary renal cell carcinoma	Homo sapiens		CVCL_1067
	HK-2 [Human kidney]	Normal	Homo sapiens		CVCL_0302
In-vivo Model	For xenograft mice model, 110⁶ 769-P stably transfected cells were subcutaneously injected into the 4-weeks nude mice. For tail vein mice metastasis model, 210⁶ 769-P stably transfected cells were injected into the 4-weeks nude mice via tail vein.

Full List of Potential Compound(s) Related to This m6A-centered Crosstalk

Histone deacetylase 1 (HDAC1)		250 Compound(s) Regulating the Target	Click to Show/Hide the Full List
Compound Name	Panobinostat		Approved	[2]
Synonyms	Faridak; LBH 589; LBH589; LBH-589; LBH-589B; NVP-LBH589; NVP-LBH-589; Panobinostat, NVP-LBH589, LBH589; (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE; (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 0.54 nM
External Link	CID: 6918837 TTD: D0E3SH DrugBank: DB06603
Compound Name	Vorinostat		Approved	[2]
Synonyms	NHNPODA; SAHA; SHH; Zolinza; Merck brand of Vorinostat; OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE; SAHA cpd; Suberanilohydroxamic acid; Suberoylanilide hydroxamic acid; Vorinostat MSD; Vorinostat [USAN]; M344; MK0683; SKI390; WIN64652; MK-0683; SAHA, Suberoylanilide hydroxamic acid; SW-064652; Zolinza (TN); Vorinostat (JAN/USAN); N1-hydroxy-N8-phenyloctanediamide; Zolinza, MK-0683, SAHA; N'-hydroxy-N-phenyloctanediamide; N-Hydroxy-N'-phenyl octanediamide; N-Hyrdroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide; Vorinostat (HDAC inhibitor) Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 1.3 nM
External Link	CID: 5311 TTD: D0E7PQ DrugBank: DB02546
Compound Name	Romidepsin		Approved	[3]
Synonyms	Chromadax; Istodax; Antibiotic FR 901228; FK 228; FK228; FR 901228; FR901228; HDInhib_000006; Chromadax (TN); FK-228; FK-901228; FR-901228; Istodax (TN); Romidepsin (USAN); Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (35)-disulfide; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide; (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 0.0015 nM
External Link	CID: 5352062 TTD: D0L7LC DrugBank: DB06176
Compound Name	HBI-8000		Phase 1/2	[4]
Synonyms	CS055; SCHEMBL5500152; GTPL8305; AKOS026750315; N-(2-amino-5-fluorophenyl)-4-{[3-(pyridin-3-yl)prop-2-enamido]methyl}benzamide Click to Show/Hide
MOA	Modulator
Activity	IC50 = 167 nM
External Link	CID: 12136798 TTD: D00SQN DrugBank: DB06334
Compound Name	NVP-LAQ824		Phase 3	[5]
Synonyms	Dacinostat; 404951-53-7; LAQ824; LAQ-824; LAQ824 (Dacinostat); UNII-V10P524501; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; CHEMBL356066; V10P524501; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Dacinostat [INN]; (E)-N-Hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide; (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide; NVP-LAQ 824; NVP-LAQ824, Dacinostat, LAQ824; LBH539 Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 0.55 nM
External Link	CID: 6445533 TTD: D0B3FV
Compound Name	SNDX-275		Phase 3	[6]
Synonyms	Entinostat; Histone Deacetylase Inhibitor I; IN1470; MS 275; SNDX 275; MS 27-275; Ms-275; Entinostat (USAN/INN); MS-27-275; Pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate; Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate; Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Pyridin-3-ylmethyl{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester; Carbamic acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl ester; Entinostat, SNDX-275, MS-27-275, MS-275; N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide; N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide; Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl ester; 3-Pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 22 nM
External Link	CID: 4261 TTD: D0M8FD DrugBank: DB11841
Compound Name	ITF2357		Phase 3	[7]
Synonyms	Givinostat; Carbamic acid, N-(4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl ester, hydrochloride (1:1) Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 2 nM
External Link	CID: 9804992 TTD: D0GH3Q DrugBank: DB12645
Compound Name	Resminostat		Phase 2	[8]
Synonyms	864814-88-0; 4SC-201; RAS2410; Resminostat (RAS2410); UNII-1578EUB98L; (E)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide; BYK408740; 1578EUB98L; Resminostat [INN]; 4SC 201; Resminostat 4SC-201; Resminostat (4SC-201); SCHEMBL295541; SCHEMBL295540; GTPL7502; EX-A542; DTXSID50235587; MolPort-027-720-936; AOB87187; BCP02538; 4SC201; ZINC13983495; s2693; AKOS030526945; SB16667; DB12392; CS-1521; API0013984; BC261895 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11609955 TTD: D01UXJ DrugBank: DB12392
Compound Name	Sodium butyrate		Phase 2	[9]
Synonyms	Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA) Click to Show/Hide
MOA	Inhibitor
External Link	CID: 5222465 TTD: D0I7IB
Compound Name	SB-623		Phase 2	[10]
Synonyms	(E)-3-[1-(2-diethylaminoethyl)-2-phenethylbenzimidazol-5-yl]-N-hydroxyprop-2-enamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 52 nM
External Link	CID: 6918876 TTD: D0VE1W
Compound Name	MGCD-0103		Phase 2	[2]
Synonyms	Mocetinostat; MG 0103; MG 4230; MG 4915; MG 5026; MG0103; MG4230; MG4915; MG5206; MGCD 0103; MGCD0103; MG-0103; MG-4230; MG-4915; MG-5026; Mocetinostat, MGCD0103; N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide; N-(2-Aminophenyl)-4-((4-pyridin-3-ylpyrimidin-2-ylamino)methyl)benzamide Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 9 nM
External Link	CID: 9865515 TTD: D00FHR DrugBank: DB11830
Compound Name	Phenylbutyrate		Phase 2	[11]
Synonyms	Benzenebutyric acid; Phenyl butanoate; Phenyl butyrate; HDInhib_000004; Butanoic acid, phenyl ester; Butyric acid, phenyl ester; FR-2080; Gamma-Phenylbutyric acid; Omega-Phenylbutanoic acid; GAMMA-PHENYL-BUTYRIC ACID; Butyric acid, 4-phenyl-(8CI); 1-Phenylbutyric acid; 4-PHENYL-BUTANOIC ACID; 4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 4-phenylbutans; 4-phenylbutyrate Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 64000 nM
External Link	CID: 4775 TTD: D0B7CH DrugBank: DB06819
Compound Name	CHR-3996		Phase 1/2	[12]
Synonyms	CCT-075453; CHR-2504; HDAC inhibitors, Chroma Therapeutics; Histone deacetylase inhibitors, Chroma Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3 nM
External Link	CID: 49857317 TTD: D06TKI DrugBank: DB15419
Compound Name	SB-639		Phase 1	[10]
Synonyms	CHEMBL491316; AC1OCG09; SCHEMBL13118363; BDBM50248476; US8551988, 72; N-hydroxy-3-(2-phenethyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-5-yl)acrylamide; (E)-N-hydroxy-3-[2-phenethyl-1-(2-pyrrolidin-1-ylethyl)benzimidazol-5-yl]prop-2-enamide Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 11 nM
External Link	CID: 6918877 TTD: D07FPY
Compound Name	RG-2833		Phase 1	[4]
Synonyms	RG-FA; HDAC-1 inhibtors (Friedreich ataxia), RepliGen Click to Show/Hide
MOA	Modulator
Activity	Ki = 32 nM
External Link	CID: 56654642 TTD: D0GE5B
Compound Name	OBP-801		Phase 1	[13]
MOA	Inhibitor
Activity	IC50 = 3.3 nM
External Link	CID: 11178958 TTD: D00SSZ DrugBank: DB12279
Compound Name	PMID29671355-Compound-42		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 10 to 100 nM
External Link	CID: 118366974 TTD: D0YT8O
Compound Name	PMID28092474-Compound-33d		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	CID: 117703486 TTD: D00ACL
Compound Name	PMID28092474-Compound-32u		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D00GLJ
Compound Name	PMID28092474-Compound-33a		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D00LLN
Compound Name	PMID28092474-Compound-32a		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D00XWZ
Compound Name	PMID28092474-Compound-32j		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D01LCZ
Compound Name	PMID28092474-Compound-32z		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D02YDG
Compound Name	PMID28092474-Compound-32g		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D03EUD
Compound Name	PMID28092474-Compound-34c		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D04AMI
Compound Name	PMID28092474-Compound-32x		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 117703583 TTD: D04KQU
Compound Name	PMID28092474-Compound-33b		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D04MVN
Compound Name	PMID28092474-Compound-32b		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	CID: 86282589 TTD: D04VQE
Compound Name	PMID28092474-Compound-32o		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282321 TTD: D06IIL
Compound Name	PMID28092474-Compound-33g		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	CID: 117703541 TTD: D08GBR
Compound Name	PMID28092474-Compound-33j		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 117703439 TTD: D08GQL
Compound Name	PMID28092474-Compound-33p		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D08SNJ
Compound Name	PMID28092474-Compound-33m		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D08XLK
Compound Name	PMID28092474-Compound-32v		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D08ZJZ
Compound Name	PMID29671355-Compound-24		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 382 nM
External Link	TTD: D09PVH
Compound Name	PMID28092474-Compound-34b		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0BY1R
Compound Name	PMID28092474-Compound-33e		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0CH4M
Compound Name	PMID28092474-Compound-32t		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282179 TTD: D0CX1Y
Compound Name	PMID28092474-Compound-32c		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0DH7R
Compound Name	PMID28092474-Compound-33i		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0E5CO
Compound Name	PMID28092474-Compound-32r		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282178 TTD: D0ET4U
Compound Name	PMID28092474-Compound-32h		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0EU5A
Compound Name	PMID29671355-Compound-65a		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 13800 nM
External Link	CID: 126720707 TTD: D0F3TB
Compound Name	PMID28092474-Compound-32y		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0HM6Y
Compound Name	PMID28092474-Compound-33h		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0JN0A
Compound Name	PMID29671355-Compound-38a		Patented	[14]
MOA	Inhibitor
Activity	IC50 > 1000 nM
External Link	CID: 121304883 TTD: D0JR9L
Compound Name	PMID28092474-Compound-33f		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0K2UF
Compound Name	Diaryl amine derivative 3		Patented	[15]
Synonyms	PMID28092474-Compound-11 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 460 nM
External Link	TTD: D0KA3X
Compound Name	PMID28092474-Compound-33c		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0L3CU
Compound Name	PMID29671355-Compound-39		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 3840 nM
External Link	CID: 124093354 TTD: D0L7HG
Compound Name	PMID29671355-Compound-19		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 500 to 1000 nM
External Link	TTD: D0LV6K
Compound Name	PMID28092474-Compound-32e		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0M7XL
Compound Name	PMID28092474-Compound-32m		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 117703481 TTD: D0MQ2D
Compound Name	PMID28092474-Compound-32p		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282322 TTD: D0MR7U
Compound Name	PMID28092474-Compound-32d		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282452 TTD: D0N1RX
Compound Name	PMID28092474-Compound-32n		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282455 TTD: D0O6SJ
Compound Name	PMID28092474-Compound-33k		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0Q9XK
Compound Name	PMID28092474-Compound-32k		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0QF0Y
Compound Name	PMID28092474-Compound-34a		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0QN8W
Compound Name	Isosteric imidazolyl pyrimidine derivative 1		Patented	[16]
Synonyms	PMID26161698-Compound-37 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 656 nM
External Link	CID: 44555024 TTD: D0QR1Z
Compound Name	PMID29671355-Compound-22		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 2100 nM
External Link	CID: 71532921 TTD: D0QX3G
Compound Name	PMID29671355-Compound-26		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 8750 nM
External Link	CID: 130361892 TTD: D0R3RJ
Compound Name	PMID28092474-Compound-33o		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0RD7T
Compound Name	PMID28092474-Compound-32f		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0S3ZB
Compound Name	Diaryl amine derivative 2		Patented	[15]
Synonyms	PMID28092474-Compound-10 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 240 nM
External Link	TTD: D0S7NE
Compound Name	PMID28092474-Compound-33l		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0SF8N
Compound Name	PMID28092474-Compound-32i		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	TTD: D0SK9K
Compound Name	PMID28092474-Compound-32q		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 86282451 TTD: D0TH3L
Compound Name	PMID29671355-Compound-18		Patented	[14]
MOA	Inhibitor
Activity	IC50 > 10000 nM
External Link	CID: 86302675 TTD: D0TN6E
Compound Name	PMID29671355-Compound-57		Patented	[14]
MOA	Inhibitor
Activity	IC50 < 1000 nM
External Link	TTD: D0UD9R
Compound Name	PMID29671355-Compound-27		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 187 nM
External Link	CID: 130227480 TTD: D0V5IQ
Compound Name	PMID28092474-Compound-32l		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 1000 nM; IC50 <= 10000 nM
External Link	TTD: D0W1AX
Compound Name	PMID28092474-Compound-32s		Patented	[15]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 117703493 TTD: D0YC2M
Compound Name	PMID29671355-Compound-38b		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 226 nM
External Link	CID: 73774655 TTD: D0YD7B
Compound Name	PMID29671355-Compound-28		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 28 nM
External Link	TTD: D0Z7QI
Compound Name	PMID29671355-Compound-59		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 3 nM
External Link	CID: 130319551 TTD: D0C9NX
Compound Name	PMID29671355-Compound-55		Patented	[14]
MOA	Inhibitor
Activity	IC50 < 1000 nM
External Link	CID: 60198673 TTD: D0OU0J
Compound Name	PMID29671355-Compound-73		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 1000 nM
External Link	CID: 124194015 TTD: D0T7OQ
Compound Name	PMID29671355-Compound-13		Patented	[14]
MOA	Inhibitor
Activity	IC50 >= 10000 nM
External Link	CID: 71811260 TTD: D0ZG5X
Compound Name	PMID29671355-Compound-11		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 21 nM
External Link	CID: 118005782 TTD: D0EH2K
Compound Name	PMID29671355-Compound-9		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 94 nM
External Link	CID: 57381425 TTD: D0Q1QY
Compound Name	PMID29671355-Compound-8		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 16900 nM
External Link	TTD: D0LN1T
Compound Name	PMID29671355-Compound-61		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 2.6 nM
External Link	TTD: D0JB4S
Compound Name	PMID29671355-Compound-23		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 3620 nM
External Link	CID: 118884610 TTD: D00HXJ
Compound Name	PMID29671355-Compound-44		Patented	[14]
MOA	Inhibitor
Activity	IC50 < 150 nM
External Link	CID: 72710871 TTD: D0N2DK
Compound Name	PMID29671355-Compound-56		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 8700 nM
External Link	CID: 56965342 TTD: D0CH8Q
Compound Name	PMID29671355-Compound-67		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 2900 nM
External Link	CID: 60201048 TTD: D0M0RE
Compound Name	PMID29671355-Compound-31		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 0.3 nM
External Link	CID: 90479372 TTD: D0DI9S DrugBank: DB14979
Compound Name	PMID29671355-Compound-21		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 2120 nM
External Link	CID: 86295624 TTD: D0LP1K
Compound Name	PMID29671355-Compound-62		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 100 to 500 nM
External Link	TTD: D07WAT
Compound Name	PMID29671355-Compound-43		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 23 nM
External Link	CID: 118515590 TTD: D0BP8I
Compound Name	PMID29671355-Compound-25		Patented	[14]
MOA	Inhibitor
Activity	IC50 = 175 nM
External Link	CID: 126569528 TTD: D0RA0D
Compound Name	AN-9		Discontinued in Phase 2	[9]
Synonyms	Pivanex; Pivalyloxymethyl butyrate; AN 9; AN9; AN 9 (ion exchanger); Butanoyloxymethyl 2,2-dimethylpropanoate; Butanoicacid, (2,2-dimethyl-1-oxopropoxy)methyl ester; N-(5-amino-9,10-dioxoanthracen-1-yl)acetamide; N-(5-amino-9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide; ((2,2-Dimethylpropanoyl)oxy)methyl butanoate;1,5-BIS[3-(DIETHYLAMINO)PROPIONAMIDO]ANTHRACENE-9,10-DIONE Click to Show/Hide
MOA	Inhibitor
External Link	CID: 60748 TTD: D0MP2U DrugBank: DB05103
Compound Name	Tacedinaline		Discontinued in Phase 2	[10]
Synonyms	Acetyldinaline; Tacedinalina; Goe 5549; PD 123654; Ci-994; Goe-5549; PD-123654; Tacedinalina [INN-Spanish]; Tacedinaline [USAN:INN]; C.I. 994; Tacedinaline (USAN/INN); 4-(Acetylamino)-N-(2-aminophenyl)benzamide; 4-acetamido-N-(2-aminophenyl)benzamide; 4-acetamido-n-(2-aminophenyl)benzamid; 4-acetylamino-N-(2'-aminophenyl)benzamide Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 50 nM
External Link	CID: 2746 TTD: D0W9NH DrugBank: DB12291
Compound Name	Pyroxamide		Discontinued in Phase 1	[10]
Synonyms	POLAR HYBRID COMPOUND; Suberoyl-3-aminopyridineamide hydroxamic acid; N-Hydroxy-N'-3-pyridinyloctanediamide; N'-hydroxy-N-pyridin-3-yloctanediamide; N-hydroxy-n'-(pyridin-3-yl)octanediamide; N-Hydroxy-N'-(3-pyridyl)-1,8-octanediamide Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 2.7 nM
External Link	CID: 4996 TTD: D0N3SH DrugBank: DB12847
Compound Name	M-carboxycinnamic acid bishydroxamide		Preclinical	[10]
Synonyms	Cbha; Histone Deacetylase Inhibitor II; HDInhib_000062; M-Carboxycinnamic Acid bis-Hydroxamide; N-hydroxy-3-[(E)-3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 10 nM
External Link	CID: 5353484 TTD: D03SZR
Compound Name	HC-Toxin		Preclinical	[10]
Synonyms	HC Toxin; Cyclo(aoe-pro-ala-ala); Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine); Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl); Cyclo(L-alanyl-D-alanyl-(alphaS,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl); (3S,6R,9S,12R)-6,9-dimethyl-3-[6-(oxiran-2-yl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone Click to Show/Hide
MOA	Inhibitor
External Link	CID: 107864 TTD: D06RQU
Compound Name	SK-7068		Preclinical	[10]
Synonyms	N-[[4-[(E)-2-(hydroxycarbamoyl)ethenyl]phenyl]methyl]-4-pyrrolidin-1-yl-benzamide Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9799221 TTD: D0DO5U
Compound Name	Scriptaid		Preclinical	[10]
Synonyms	CGK1026; IN1099; SB-556629; GNF-PF-2024; N-Hydroxy-1,3-dioxo-1H-benz(de)isoquinoline-2(3H)-hexan amide; 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide; 6-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide; 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 1.5 nM
External Link	CID: 5186 TTD: D0J8OC
Compound Name	4SC-202		Preclinical	[8]
MOA	Inhibitor
External Link	CID: 44217246 TTD: D0L5DZ
Compound Name	Chlamydocin		Preclinical	[10]
Synonyms	HDInhib_000038; Cyclic(2-methylalanyl-L-phenylalanyl-D-propyl-L-alpha-amino-eta-oxooxiraneoctanoyl); (3S,9S,12R)-3-benzyl-6,6-dimethyl-9-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone; (3s,9s,14ar)-9-benzyl-6,6-dimethyl-3-{6-[(2s)-oxiran-2-yl]-6-oxohexyl}decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone Click to Show/Hide
MOA	Inhibitor
External Link	CID: 124134 TTD: D0UC6H
Compound Name	SK-7041		Preclinical	[10]
Synonyms	IN-2001; 4-(dimethylamino)-N-[[4-[(E)-3-(hydroxyamino)-3-oxoprop-1-enyl]phenyl]methyl]benzamide Click to Show/Hide
MOA	Inhibitor
External Link	CID: 6918714 TTD: D0UL5X
Compound Name	Depudecin		Preclinical	[10]
Synonyms	(1R)-1-[(2S,3S)-3-[(E)-2-[(3S)-3-[(1R)-1-hydroxyethyl]oxiran-2-yl]ethenyl]oxiran-2-yl]prop-2-en-1-ol; 139508-73-9 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 16219259 TTD: D0W8JE
Compound Name	Oxamflatin		Terminated	[10]
Synonyms	NSC729360; CHEBI:258842; I14-11718; NCGC00165855-01; (2E)-5-(3-(phenylsulfonylamino)phenyl)pent-2-ene-4-ynohydroxamic acid; (2E)-5-[3-(Phenylsulfonylamino)phenyl]pent-2-en-4-ynohydroxamic Acid; (E)-5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide; 151720-43-3 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 5353852 TTD: D03YVR
Compound Name	6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide		Investigative	[17]
Synonyms	UNII-2OJV8MB11B; EX-2; 2OJV8MB11B; CHEMBL1083439; 851365-34-9; Benzamide, N-(((6-(hydroxyamino)-6-oxohexyl)amino)carbonyl)-; Benzamide, N-[[[6-(hydroxyamino)-6-oxohexyl]amino]carbonyl]-; SCHEMBL4258321; CTK2I4390; DTXSID80234280; VQLQZMGNGMOMPU-UHFFFAOYSA-N; BDBM50319235 Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 16 nM
External Link	CID: 11449246 TTD: D00GBB
Compound Name	N,8-dihydroxy-8-(naphthalen-2-yl)octanamide		Investigative	[18]
Synonyms	CHEMBL319738; SCHEMBL3382032; JWCSCYWHCCHTEF-UHFFFAOYSA-N; BDBM50114820; N-Hydroxy-8-hydroxy-8-(2-naphthyl)octanamide; 8-Hydroxy-8-naphthalen-2-yl-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 35 nM
External Link	CID: 11044829 TTD: D00LSZ
Compound Name	N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide		Investigative	[19]
Synonyms	CHEMBL216292; SCHEMBL5903988 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1130 nM
External Link	CID: 44418106 TTD: D00PLM
Compound Name	N-hydroxy-8-oxo-8-(pyridin-3-yl)octanamide		Investigative	[18]
Synonyms	CHEMBL98911; SCHEMBL3378753; BDBM50114831; 8-Oxo-8-pyridin-3-yl-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 153 nM
External Link	CID: 11128726 TTD: D00RGD
Compound Name	NSC-746457		Investigative	[20]
MOA	Inhibitor
Activity	IC50 = 104 nM
External Link	CID: 135903324 TTD: D01EDB
Compound Name	4-Benzenesulfonylamino-N-hydroxy-benzamide		Investigative	[21]
Synonyms	CHEMBL98345; SCHEMBL15480538; BDBM50105682; N-hydroxy-4-(phenylsulfonamido)benzamide; 4-(Phenylsulfonylamino)benzohydroximic acid Click to Show/Hide
MOA	Inhibitor
Activity	EC50 = 5000 nM
External Link	CID: 44328873 TTD: D02VVU
Compound Name	N-hydroxy-7-(naphthalen-2-yl)-7-oxoheptanamide		Investigative	[18]
Synonyms	CHEMBL320909; SCHEMBL1520961; AQLMJRZLPWGPGD-UHFFFAOYSA-N; BDBM50114827; N-Hydroxy-6-(2-naphthoyl)hexanamide; 7-Naphthalen-2-yl-7-oxo-heptanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 35 nM
External Link	CID: 11129854 TTD: D03FFI
Compound Name	4-tert-butyl-N-hydroxybenzamide		Investigative	[22]
Synonyms	62034-73-5; CHEMBL249284; Benzamide, 4-(1,1-dimethylethyl)-N-hydroxy-; p-tert-butyl benzohydroxamic acid; Oprea1_740446; SCHEMBL5696343; 4-tert-Butylbenzhydroxamic Acid; 4-tert-Butylbenzohydroxamic acid; CTK2C8432; DTXSID80613051; BDBM50215019; 4-(tert-butyl )-benzhydroxamic acid; ZINC19478595; AKOS000181279 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 715 nM
External Link	CID: 21397854 TTD: D03FOD
Compound Name	N-hydroxy-7-(naphthalen-2-yloxy)heptanamide		Investigative	[23]
Synonyms	CHEMBL217083 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.9 nM
External Link	CID: 16655084 TTD: D03OYL
Compound Name	8-(3-Benzoyl-ureido)-octanoic acid hydroxyamide		Investigative	[17]
Synonyms	CHEMBL1083441; SCHEMBL4928514; WUKFQTZVXXYEAB-UHFFFAOYSA-N Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 8280 nM
External Link	CID: 11381650 TTD: D03ZUZ
Compound Name	N-hydroxy-8-(naphthalen-2-yl)non-8-enamide		Investigative	[18]
Synonyms	CHEMBL95535; SCHEMBL3382075; BDBM50114823; 8-Naphthalen-2-yl-non-8-enoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 8 nM
External Link	CID: 11822609 TTD: D04XPZ
Compound Name	N-hydroxy-5-(pyridin-2-yl)thiophene-2-carboxamide		Investigative	[19]
Synonyms	CHEMBL216509; SCHEMBL5903774; BDBM50198477 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 243 nM
External Link	CID: 10242569 TTD: D05PYF
Compound Name	N-hydroxy-5-phenylthiophene-2-carboxamide		Investigative	[19]
Synonyms	CHEMBL217573; SCHEMBL5903684 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 900 nM
External Link	CID: 25002768 TTD: D06NVX
Compound Name	Azithromycin-N-benzyltriazolyldecahydroxamic Acid		Investigative	[24]
Synonyms	CHEMBL496761; SCHEMBL14328159; BDBM27184; triazole-linked azithromycin-based compound, 16h Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25190759 TTD: D06ONC
Compound Name	7-(4-(dimethylamino)phenoxy)-N-hydroxyheptanamide		Investigative	[23]
Synonyms	CHEMBL265479 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 18.8 nM
External Link	CID: 44418155 TTD: D07HUH
Compound Name	8-(biphenyl-4-yl)-N-hydroxy-8-oxooctanamide		Investigative	[18]
Synonyms	CHEMBL95313; SCHEMBL1520838; BDBM50114816; 8-Biphenyl-4-yl-8-oxo-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 5 nM
External Link	CID: 10314237 TTD: D0A6CB
Compound Name	N-hydroxy-5-(pyridin-4-yl)thiophene-2-carboxamide		Investigative	[19]
Synonyms	CHEMBL217816; SCHEMBL5903934 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1260 nM
External Link	CID: 44418125 TTD: D0A7IF
Compound Name	Gymnochrome E		Investigative	[25]
MOA	Inhibitor
Activity	IC50 = 10900 nM
External Link	CID: 135894458 TTD: D0B1YM
Compound Name	N-hydroxy-8-(naphthalen-2-yl)oct-7-enamide		Investigative	[18]
Synonyms	CHEMBL451182; SCHEMBL3382916; SCHEMBL3382922; PGGPUSMJSOKMEA-XBXARRHUSA-N; ZINC13474418; BDBM50114829; (E)-N-Hydroxy-8-(2-naphthyl)-7-octenamide; 8-Naphthalen-2-yl-oct-7-enoic acid hydroxyamide; (E)-8-Naphthalen-2-yl-oct-7-enoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 6 nM
External Link	CID: 10891349 TTD: D0CJ7L
Compound Name	N-hydroxybenzo[b]thiophene-2-carboxamide		Investigative	[26]
Synonyms	CHEMBL245946; 211172-97-3; Benzo[b]thiophene-2-carboxamide, N-hydroxy-; SCHEMBL999904; CTK0J7987; DTXSID40470925; BDBM50216024; benzothiophene-2-carbohydroxamic acid Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 670 nM
External Link	CID: 11708207 TTD: D0D3XC
Compound Name	7-(1H-indol-5-yloxy)-N-hydroxyheptanamide		Investigative	[23]
Synonyms	CHEMBL426516 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3.6 nM
External Link	CID: 44418145 TTD: D0G0OF
Compound Name	8-(4-bromophenyl)-N-hydroxy-8-oxooctanamide		Investigative	[18]
Synonyms	CHEMBL319070; SCHEMBL3382402; RFYYZRFJBNAHCG-UHFFFAOYSA-N; BDBM50114817; n-hydroxy-7-(4-bromobenzoyl)heptanamide; 8-(4-Bromo-phenyl)-8-oxo-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 45 nM
External Link	CID: 11120992 TTD: D0GJ1E
Compound Name	N-hydroxy-7-(4-methoxyphenyl)-7-oxoheptanamide		Investigative	[18]
Synonyms	CHEMBL95990; SCHEMBL1521117; NIGGAQZXTHMKPL-UHFFFAOYSA-N; BDBM50114822; N-Hydroxy-6-(4-methoxybenzoyl)hexanamide; 7-(4-Methoxy-phenyl)-7-oxo-heptanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 450 nM
External Link	CID: 10858374 TTD: D0K8MF
Compound Name	N-hydroxy-8-(2-methoxyphenyl)-8-oxooctanamide		Investigative	[18]
Synonyms	CHEMBL95885; SCHEMBL3382183; BDBM50114815; 8-(2-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 95 nM
External Link	CID: 11821974 TTD: D0KM7H
Compound Name	N-hydroxy-6-oxo-6-phenylhexanamide		Investigative	[18]
Synonyms	CHEMBL95152; SCHEMBL1521154; BDBM50114819; 6-Oxo-6-phenyl-hexanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1500 nM
External Link	CID: 11031415 TTD: D0L4ML
Compound Name	N-hydroxy-8-(naphthalen-2-yl)octanamide		Investigative	[18]
Synonyms	CHEMBL95747; SCHEMBL3378763; KWFDCRKEDDNSLQ-UHFFFAOYSA-N; N-Hydroxy-8-(2-naphthyl)octanamide; BDBM50114833; ZINC13474419; 8-Naphthalen-2-yl-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 25 nM
External Link	CID: 11833001 TTD: D0L5WI
Compound Name	ADS-102550		Investigative	[19]
Synonyms	CHEMBL217716; SCHEMBL5903759; BDBM50198218 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 29 nM
External Link	CID: 10452725 TTD: D0M0QJ
Compound Name	N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide		Investigative	[18]
Synonyms	CHEMBL95835; SCHEMBL3383312; LIOTZVIDBXLBAC-UHFFFAOYSA-N; n-hydroxy-7-(p-anisoyl)heptanamide; BDBM50114826; 8-(4-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 15 nM
External Link	CID: 10923922 TTD: D0O7UF
Compound Name	N-(2-aminophenyl)-4-(chroman-3-ylmethyl)benzamide		Investigative	[27]
Synonyms	CHEMBL238569; SCHEMBL1064835 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1000 nM
External Link	CID: 9924962 TTD: D0P1RQ
Compound Name	N-hydroxy-2,2'-bithiophene-5-carboxamide		Investigative	[19]
Synonyms	CHEMBL217750; SCHEMBL5903723; BDBM50198479 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2500 nM
External Link	CID: 44418185 TTD: D0PP3Q
Compound Name	ADS-100380		Investigative	[19]
Synonyms	CHEMBL216885; SCHEMBL5904027; BDBM50198221 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 750 nM
External Link	CID: 44418141 TTD: D0Q8QA
Compound Name	N-hydroxy-7-oxo-7-phenylheptanamide		Investigative	[18]
Synonyms	CHEMBL95916; SCHEMBL1521257; BDBM50114832; 7-Oxo-7-phenyl-heptanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 500 nM
External Link	CID: 10998964 TTD: D0QX6R
Compound Name	7-(3-Benzoyl-ureido)-heptanoic acid hydroxyamide		Investigative	[17]
Synonyms	CHEMBL1083440; SCHEMBL4922807 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 145 nM
External Link	CID: 11426781 TTD: D0T0BE
Compound Name	SK-683		Investigative	[28]
Synonyms	CHEMBL116620; SCHEMBL8089576; BDBM50148757 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1 nM
External Link	CID: 9888071 TTD: D0U3MB
Compound Name	N-hydroxy-9-oxo-9-phenylnonanamide		Investigative	[18]
Synonyms	CHEMBL99810; SCHEMBL1521077; BDBM50114824; 9-Oxo-9-phenyl-nonanoic acid hydroxyamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 135 nM
External Link	CID: 11139963 TTD: D0Z2VP
Compound Name	N-Hydroxy-N'-(4-methylphenyl)octanediamide		Investigative	[29]
Synonyms	CHEMBL1092762; BDBM50314138 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 76 nM
External Link	CID: 46884057 TTD: D00HFS
Compound Name	N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093043; BDBM50314143 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141955 TTD: D01AMS
Compound Name	N-(2-aminophenyl)quinoxaline-6-carboxamide		Investigative	[30]
Synonyms	benzamide-type inhibitor, 20; CHEMBL236060; BDBM19424 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2000 nM
External Link	CID: 23648267 TTD: D01FYB
Compound Name	7-Biphenyl-4-yl-heptanoic acid hydroxyamide		Investigative	[31]
Synonyms	CHEMBL125098; BDBM50222335; 7-(4-Biphenylyl)heptanehydroximic acid Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44349481 TTD: D01RJY
Compound Name	N-(2-Ethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093040; BDBM50314142 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141752 TTD: D01ZMJ
Compound Name	8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid		Investigative	[32]
Synonyms	CHEMBL115049; 436150-72-0; SCHEMBL7368556; CTK1D2674; DTXSID40658342; BDBM50221807; 8-[([1,1'-Biphenyl]-4-yl)oxy]-2-oxooctanoic acid; Octanoic acid, 8-([1,1'-biphenyl]-4-yloxy)-2-oxo- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44341224 TTD: D03XXI
Compound Name	1,1,1-Trifluoro-8-phenoxy-octan-2-one		Investigative	[33]
Synonyms	CHEMBL114796; BDBM50217940 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44342886 TTD: D04ETX
Compound Name	7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide		Investigative	[32]
Synonyms	CHEMBL114184; SCHEMBL3383144 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 22915465 TTD: D04LLD
Compound Name	N-(2,4-Dimethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1092032; BDBM50314141 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141956 TTD: D05GRZ
Compound Name	7-Phenoxy-heptanoic acid hydroxyamide		Investigative	[31]
Synonyms	CHEMBL124322; N-hydroxy-7-phenoxyheptanamide; 7-Phenoxyheptanehydroximic acid Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25798548 TTD: D05ZGM
Compound Name	1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one		Investigative	[33]
Synonyms	CHEMBL117916; SCHEMBL7366611; BDBM50217945 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44342905 TTD: D06BKA
Compound Name	6-(9H-carbazol-9-yl)-N-hydroxyhexanamide		Investigative	[34]
Synonyms	CHEMBL1290142; A1-02262; SCHEMBL1004139; SOMDVJCUFVPZKM-UHFFFAOYSA-N; BDBM50331109; 9H-Carbazole-9-hexanamide, N-hydroxy-; 6-Carbazol-9-ylhexanoic acid hydroxyamide; US8748451, 1 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3074 nM
External Link	CID: 46918725 TTD: D06FAK
Compound Name	Desclasinose Azithromycinarylalkyl Hydroxamate		Investigative	[24]
Synonyms	CHEMBL454025; SCHEMBL14329692; BDBM27176; Desclasinose Azithromycinarylalkyl Hydroxamate, 10 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25151110 TTD: D06THS
Compound Name	N-(4-Ethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093042; BDBM50314139 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141954 TTD: D08ICY
Compound Name	N-(3,5-Dimethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093713; BDBM50314133 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141960 TTD: D08TIJ
Compound Name	N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide		Investigative	[35]
Synonyms	CHEMBL473270 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 9 nM
External Link	CID: 44591267 TTD: D08XMS
Compound Name	N-(2,5-Dimethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093357; BDBM50314144 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141957 TTD: D0B8RC
Compound Name	Azithromycin-N-benzyltriazolyloctahydroxamic Acid		Investigative	[24]
Synonyms	SCHEMBL8976909; CHEMBL455342; BDBM27181; triazole-linked azithromycin-based compound, 16e Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25151675 TTD: D0D7KH
Compound Name	N-(4-hydroxybiphenyl-3-yl)benzamide		Investigative	[36]
Synonyms	CHEMBL269935; SCHEMBL5724398; BDBM50232005 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 58 nM
External Link	CID: 44454650 TTD: D0E0TA
Compound Name	AZUMAMIDE E		Investigative	[37]
Synonyms	CHEMBL402363 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 50 nM
External Link	CID: 16095101 TTD: D0E9DD
Compound Name	Azithromycin-N-benzyltriazolylnonahydroxamic Acid		Investigative	[24]
Synonyms	CHEMBL509089; SCHEMBL14329756; BDBM27183; triazole-linked azithromycin-based compound, 16g Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25190758 TTD: D0H3RO
Compound Name	N-Hydroxy-N'-(3-methylphenyl)octanediamide		Investigative	[29]
Synonyms	CHEMBL1089339; BDBM50314136 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 57 nM
External Link	CID: 46884056 TTD: D0H7QA
Compound Name	8-Phenyl-octanoic acid hydroxyamide		Investigative	[31]
Synonyms	CHEMBL123624; N-Hydroxy-8-phenyloctanamide; SCHEMBL5807174 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 14098189 TTD: D0H9DS
Compound Name	Azithromycin-N-benzyltriazolylhexahydroxamic Acid		Investigative	[24]
Synonyms	CHEMBL446811; SCHEMBL14328156; CHEMBL3735805; BDBM27177; triazole-linked azithromycin-based compound, 16a Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25152062 TTD: D0I5XM
Compound Name	N-(3-Ethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093041; BDBM50314134 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141753 TTD: D0J3CY
Compound Name	N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093359; BDBM50314135 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141959 TTD: D0L5KP
Compound Name	N-Hydroxy-N'-(4-methoxyphenyl)octanediamide		Investigative	[29]
Synonyms	CHEMBL1091487; BDBM50314137 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 71 nM
External Link	CID: 46884016 TTD: D0L6YF
Compound Name	AZUMAMIDE B		Investigative	[37]
Synonyms	CHEMBL402727 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1830 nM
External Link	CID: 16095112 TTD: D0M1ZI
Compound Name	8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one		Investigative	[33]
Synonyms	CHEMBL116023; SCHEMBL7368359; BDBM50218558 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44343094 TTD: D0NL6C
Compound Name	Azithromycinarylalkylhydroxamic Acid		Investigative	[24]
Synonyms	CHEMBL510806; SCHEMBL14329660; BDBM27175; Azithromycinarylalkylhydroxamic Acid, 8 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 25151109 TTD: D0P9CQ
Compound Name	N-Hydroxy-N'-(2-methylphenyl)octanediamide		Investigative	[29]
Synonyms	CHEMBL1076794; BDBM50314140 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 576 nM
External Link	CID: 46884055 TTD: D0Q2CC
Compound Name	nexturastat A		Investigative	[38]
Synonyms	S7473 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 360 nM
External Link	CID: 71462653 TTD: D0Q5DI
Compound Name	AZUMAMIDE C		Investigative	[37]
Synonyms	CHEMBL257972 Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 20 nM
External Link	CID: 16095114 TTD: D0Q9PO
Compound Name	N-(2,6-Dimethylphenyl)-N'-hydroxyoctanediamide		Investigative	[29]
Synonyms	CHEMBL1093358; BDBM50314145 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 45141958 TTD: D0SQ1F
Compound Name	N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide		Investigative	[39]
Synonyms	CHEMBL511212; BDBM50258645 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3 nM
External Link	CID: 10383069 TTD: D0YP4F
Compound Name	LARGAZOLE		Investigative	[40]
Synonyms	CHEMBL1173445; (+)-Largazole; SCHEMBL71330; ZINC56861395 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 10.09 nM
External Link	CID: 24757913 TTD: D0Z8PX
Compound Name	Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL393260 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 36 nM
External Link	CID: 44437872 TTD: D00XTC
Compound Name	7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide		Investigative	[42]
Synonyms	CHEMBL419758; NCH-31; JMC505425 Compound 7; BDBM19131; 7-mercapto-N-(4-phenyl-2-thiazolyl)heptanamide; N-(4-phenyl-1,3-thiazol-2-yl)-7-sulfanylheptanamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 48 nM
External Link	CID: 11427204 TTD: D02HVH
Compound Name	Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL390991 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2.7 nM
External Link	CID: 44437870 TTD: D02NAF
Compound Name	Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL394261 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2 nM
External Link	CID: 44437869 TTD: D02NVY
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL391384 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 5.3 nM
External Link	CID: 44437878 TTD: D03PRG
Compound Name	Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL393261 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 170 nM
External Link	CID: 44437873 TTD: D04CDZ
Compound Name	N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide		Investigative	[39]
Synonyms	CHEMBL512644; SCHEMBL8226957 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 33 nM
External Link	CID: 25032059 TTD: D04DOL
Compound Name	N-(2-aminophenyl)nicotinamide		Investigative	[36]
Synonyms	N-(2-Amino-phenyl)-nicotinamide; 436089-31-5; N-(2-aminophenyl)pyridine-3-carboxamide; CHEMBL236678; AC1LMN6K; SCHEMBL18086514; CTK4I7538; DTXSID50360661; CHEBI:125506; ZINC873967; BDBM50220259; 3463AE; AKOS000129725; RTR-042156; MCULE-7933541910; N-(2-aminophenyl)-3-pyridylcarboxamide; ZB014940; ACM436089315; ST086607; ASN 01337807; KB-298440; TR-042156; BC4148434; SR-01000329900; SR-01000329900-1; BRD-K20880473-001-04-6 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2600 nM
External Link	CID: 1133083 TTD: D04UVL
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL241555 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3.2 nM
External Link	CID: 44437879 TTD: D0E8UH
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL428737 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 88 nM
External Link	CID: 44437876 TTD: D0G1EX
Compound Name	N-(4-aminobiphenyl-3-yl)nicotinamide		Investigative	[36]
Synonyms	CHEMBL255805; BDBM50232035 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 48 nM
External Link	CID: 44454415 TTD: D0M9LJ
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-)		Investigative	[41]
Synonyms	CHEMBL238587 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 4.7 nM
External Link	CID: 44437875 TTD: D0N5RV
Compound Name	N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide		Investigative	[36]
Synonyms	CHEMBL256440; SCHEMBL1066609 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 65 nM
External Link	CID: 44454416 TTD: D0Q2GM
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL238596; BDBM50222727 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 94 nM
External Link	CID: 44437883 TTD: D0R3XO
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL393961 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 6.4 nM
External Link	CID: 44437880 TTD: D0U0EZ
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL391383 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 6.2 nM
External Link	CID: 44437877 TTD: D0X4QC
Compound Name	N-(2-aminophenyl)-4-methoxybenzamide		Investigative	[30]
Synonyms	AC1LFX2W; Cambridge id 5129152; Oprea1_722128; benzamide-type inhibitor, 22; CHEMBL236061; SCHEMBL5226034; BDBM19426; CTK7A1998; MolPort-001-019-504; BDYVCYUXCNZYRW-UHFFFAOYSA-N; ZINC281656; STK156256; AKOS000130378; MCULE-9183453747; N-(2-Amino-phenyl)4-methoxy-benzamide; N-(2-amino-phenyl)-4-methoxy-benzamide; NCGC00240897-01; N1-(4-methoxybenzoyl)-1,2-benzenediamine; N1-(4-methoxy-benzoyl)-1,2-benzenediamine; ST50908739; N-(2-aminophenyl)(4-methoxyphenyl)carboxamide; SR-01000196394 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2000 nM
External Link	CID: 785232 TTD: D0YO6M
Compound Name	Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL393464 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3.7 nM
External Link	CID: 44437874 TTD: D0Z6HR
Compound Name	Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-)		Investigative	[41]
Synonyms	CHEMBL238829; BDBM50222732 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3.9 nM
External Link	CID: 44437868 TTD: D0Z6MI
Compound Name	4-Phenylbutyrohydroxamic acid		Investigative	[43]
Synonyms	N-Hydroxy-4-phenylbutanamide; 32153-46-1; NSC131300; UNII-QX182FOM5S; QX182FOM5S; 4-phenylbutanehydroxamic acid; CHEMBL55895; Benzenebutanamide, N-hydroxy-; NSC 131300; AC1Q7DIW; AC1L5RDX; Phenylbutyrylhydroxamic Acid; AC1Q5QD1; N-Hydroxy-4-phenyl-butyramide; 4-Phenylbutyryl hydroxamic acid; SCHEMBL1350853; CTK4G8310; DTXSID60185943; MolPort-011-492-164; UPHXPXYRKPCXHK-UHFFFAOYSA-N; ZINC4962622; STL301752; BDBM50015142; AKOS009266186; MCULE-9765156954; NSC-131300; NE28489; BCB03_000829; EN300-68596 Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 295 nM
External Link	CID: 279980 TTD: D02NWS
Compound Name	8-Oxo-8-phenyl-octanoic acid hydroxyamide		Investigative	[44]
Synonyms	CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 65 nM
External Link	CID: 11075845 TTD: D0S0WK
Compound Name	ST-3050		Investigative	[45]
Synonyms	CHEMBL472631; SCHEMBL3445133; SCHEMBL3445139; BDBM50278222 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3060 nM
External Link	CID: 44591988 TTD: D01YBR
Compound Name	Octanedioic acid bis-hydroxyamide		Investigative	[46]
Synonyms	Suberohydroxamic acid Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 19 nM
External Link	CID: 5173 TTD: D07YZZ
Compound Name	ST-2986		Investigative	[45]
Synonyms	CHEMBL471041; SCHEMBL3444455; BDBM50278219 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 5480 nM
External Link	CID: 44138031 TTD: D0N9AK
Compound Name	9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide		Investigative	[33]
Synonyms	9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 7800 nM
External Link	CID: 9882812 TTD: D00KFF DrugBank: DB07553
Compound Name	7-Mercapto-heptanoic acid phenylamide		Investigative	[47]
Synonyms	Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 218 nM
External Link	CID: 11379392 TTD: D00SEE
Compound Name	6-benzenesulfinylhexanoic acid hydroxamide		Investigative	[48]
Synonyms	6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11694528 TTD: D00ZSD
Compound Name	N-(2-Mercapto-ethyl)-N'-phenyl-succinamide		Investigative	[49]
Synonyms	CHEMBL193959 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44401339 TTD: D01MFV
Compound Name	7-Mercapto-heptanoic acid biphenyl-4-ylamide		Investigative	[47]
Synonyms	CHEMBL112311 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11220728 TTD: D01XWZ
Compound Name	N-Hydroxy-4-phenylacetylamino-benzamide		Investigative	[50]
Synonyms	CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11196500 TTD: D01XXN
Compound Name	6-(2-Bromo-acetylamino)-hexanoic acid phenylamide		Investigative	[47]
Synonyms	CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9927379 TTD: D02MQM
Compound Name	N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide		Investigative	[51]
Synonyms	CHEMBL143674; SCHEMBL673760 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11323577 TTD: D02UTC
Compound Name	7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one		Investigative	[52]
Synonyms	CHEMBL126355; BDBM50222394 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44350626 TTD: D02WZK
Compound Name	Octanedioic acid hydroxyamide pyridin-4-ylamide		Investigative	[53]
Synonyms	SCHEMBL8082656; CHEMBL165162; ZINC13472304 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 10967421 TTD: D04GGW
Compound Name	N-(6-Mercapto-hexyl)-benzamide		Investigative	[47]
Synonyms	CHEMBL112364; BDBM50223650 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11447748 TTD: D04HSS
Compound Name	4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide		Investigative	[53]
Synonyms	CHEMBL167455 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11086699 TTD: D04NSP
Compound Name	N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide		Investigative	[50]
Synonyms	SCHEMBL675474 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11231829 TTD: D04ZDI
Compound Name	6-benzenesulfonylhexanoic acid hydroxamide		Investigative	[48]
Synonyms	CHEMBL203207 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11572583 TTD: D05AHZ
Compound Name	9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one		Investigative	[33]
Synonyms	SCHEMBL7373122; CHEMBL116578 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44342872 TTD: D05FEJ
Compound Name	Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester		Investigative	[47]
Synonyms	CHEMBL111806; SCHEMBL14812153 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11254470 TTD: D05GVY
Compound Name	4-Butyrylamino-N-hydroxy-benzamide		Investigative	[51]
Synonyms	CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11287488 TTD: D05LLX
Compound Name	7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one		Investigative	[52]
Synonyms	CHEMBL127328 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44350703 TTD: D05VFP
Compound Name	7-Mercapto-heptanoic acid biphenyl-3-ylamide		Investigative	[47]
Synonyms	CHEMBL320323 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11449823 TTD: D05XAN
Compound Name	5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione		Investigative	[54]
MOA	Inhibitor
External Link	CID: 3082127 TTD: D06IQB
Compound Name	N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide		Investigative	[50]
Synonyms	SCHEMBL676079 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11347053 TTD: D06VBN
Compound Name	4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide		Investigative	[47]
Synonyms	CHEMBL324126 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11277483 TTD: D06XNP
Compound Name	7-Mercapto-heptanoic acid pyridin-3-ylamide		Investigative	[47]
Synonyms	CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11345433 TTD: D07FJU
Compound Name	6-Phenoxy-hexane-1-thiol		Investigative	[47]
Synonyms	CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11298778 TTD: D09YBN
Compound Name	4-Benzoylamino-N-hydroxy-benzamide		Investigative	[50]
Synonyms	SCHEMBL673678; CHEMBL191227 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11817702 TTD: D09ZNU
Compound Name	4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide		Investigative	[44]
Synonyms	CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid Click to Show/Hide
MOA	Inhibitor
External Link	CID: 403373 TTD: D0A5LS
Compound Name	8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one		Investigative	[33]
Synonyms	CHEMBL112148; SCHEMBL7364383; BDBM50218532 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44341053 TTD: D0AX7B
Compound Name	7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one		Investigative	[52]
Synonyms	CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44350718 TTD: D0B2ZJ
Compound Name	6-Mercapto-hexanoic acid phenylamide		Investigative	[47]
Synonyms	CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 791 nM
External Link	CID: 11436024 TTD: D0B3ZM
Compound Name	Cyclostellettamine derivative		Investigative	[55]
Synonyms	CHEMBL88332 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 23327627 TTD: D0C0VP
Compound Name	N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide		Investigative	[44]
Synonyms	CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9943996 TTD: D0C2KD
Compound Name	5-Mercapto-pentanoic acid phenylamide		Investigative	[47]
Synonyms	N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11608171 TTD: D0D2KE
Compound Name	Octanedioic acid hydroxyamide pyridin-2-ylamide		Investigative	[53]
Synonyms	SCHEMBL8090513; CHEMBL164872; ZINC13472303 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11747496 TTD: D0E8KR
Compound Name	N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide		Investigative	[49]
Synonyms	CHEMBL193979 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44401305 TTD: D0F0KS
Compound Name	2-(methylsulfonylthio)ethyl 2-propylpentanoate		Investigative	[54]
Synonyms	CHEMBL271677; SCHEMBL4156413 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 24759251 TTD: D0H1FZ
Compound Name	(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one		Investigative	[52]
Synonyms	CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44350655 TTD: D0KE3I
Compound Name	N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide		Investigative	[50]
Synonyms	SCHEMBL676080 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11312563 TTD: D0QO0L
Compound Name	N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide		Investigative	[56]
Synonyms	N-hydroxy-4-(3-phenylpropanamido)benzamide Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D0R4BS
Compound Name	N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide		Investigative	[50]
Synonyms	SCHEMBL7311087 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11472431 TTD: D0R5VG
Compound Name	8-Oxo-8-phenyl-octanoic acid		Investigative	[53]
Synonyms	8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 298878 TTD: D0RU1X
Compound Name	N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide		Investigative	[50]
Synonyms	CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9994848 TTD: D0S7WQ
Compound Name	6-phenylsulfanylhexanoic acid hydroxamide		Investigative	[48]
Synonyms	Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11637291 TTD: D0S9JF
Compound Name	ST-2987		Investigative	[45]
Synonyms	CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 790 nM
External Link	CID: 44138032 TTD: D0T0SK
Compound Name	7-Mercapto-heptanoic acid quinolin-3-ylamide		Investigative	[47]
Synonyms	CHEMBL112234 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 10379373 TTD: D0T4IY
Compound Name	5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide		Investigative	[57]
Synonyms	CHEMBL84288 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11528707 TTD: D0V2ZO
Compound Name	8-Mercapto-octanoic acid phenylamide		Investigative	[47]
Synonyms	8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 294 nM
External Link	CID: 11149404 TTD: D0XZ9Q
Compound Name	N-(6-Hydroxycarbamoyl-hexyl)-benzamide		Investigative	[53]
Synonyms	CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9965141 TTD: D0YY9M
Compound Name	7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one		Investigative	[33]
Synonyms	CHEMBL326529; SCHEMBL7365237; BDBM50217957 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44342825 TTD: D0Z3BM
Compound Name	7-Mercapto-heptanoic acid benzothiazol-2-ylamide		Investigative	[47]
Synonyms	CHEMBL178779 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11346934 TTD: D0Z5KX
Compound Name	N-Hydroxy-4-(pentanoylamino-methyl)-benzamide		Investigative	[51]
Synonyms	CHEMBL143102 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44361923 TTD: D0Z7YS
Compound Name	PSAMMAPLIN A		Investigative	[44]
Synonyms	110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 6400741 TTD: D0N0TS
2C90: Renal cell carcinoma		76 Compound(s) Regulating the Disease	Click to Show/Hide the Full List
Compound Name	Atezolizumab		Approved	[58]
External Link	TTD: D0YM2K
Compound Name	Tivozanib		Approved	[59]
Synonyms	ASP4130/AV-951 Click to Show/Hide
External Link	CID: 9911830 TTD: D0W7JZ DrugBank: DB11800
Compound Name	Sorafenib		Approved	[60]
Synonyms	Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor) Click to Show/Hide
External Link	CID: 216239 TTD: D0W5HK DrugBank: DB00398
Compound Name	Lenvatinib		Approved	[58]
Synonyms	E 7080; E-7080, E7080; 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide Click to Show/Hide
External Link	CID: 9823820 TTD: D0R0FO DrugBank: DB09078
Compound Name	Belzutifan		Approved	[61]
Synonyms	MK-6482 Click to Show/Hide
External Link	CID: 117947097 TTD: D0NU8J
Compound Name	Reniale		Approved	[62]
Synonyms	Autologous renal tumor cell vaccine (renal cell carcinoma), LipoNova Click to Show/Hide
External Link	TTD: D0N7KV
Compound Name	Romidepsin		Approved	[63]
Synonyms	Chromadax; Istodax; Antibiotic FR 901228; FK 228; FK228; FR 901228; FR901228; HDInhib_000006; Chromadax (TN); FK-228; FK-901228; FR-901228; Istodax (TN); Romidepsin (USAN); Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (35)-disulfide; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide; (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone Click to Show/Hide
External Link	CID: 5352062 TTD: D0L7LC DrugBank: DB06176
Compound Name	Avelumab		Approved	[58]
External Link	TTD: D0K7SX
Compound Name	Everolimus		Approved	[64]
Synonyms	Afinitor; Afinitor (TN); CERTICAN(R); Certican; Certican (TN); Everolimus (JAN/USAN/INN); Everolimus [USAN]; MTOR kinase inhibitors; NVP-RAD-001; RAD 001; RAD-001; RAD-001C; RAD001; RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus; SDZ-RAD; Zortress Click to Show/Hide
External Link	CID: 6442177 TTD: D0K3QS DrugBank: DB01590
Compound Name	Pazopanib HCl		Approved	[3]
Synonyms	Votrient (TN) Click to Show/Hide
External Link	CID: 11525740 TTD: D0F0ZY
Compound Name	Temsirolimus		Approved	[65]
Synonyms	Torisel Click to Show/Hide
External Link	CID: 6918289 TTD: D0ES1Q
Compound Name	Pembrolizumab		Approved	[58]
External Link	TTD: D08ANZ
Compound Name	CreaVax-RCC		Approved	[66]
Synonyms	Autologous DC vaccines (renal cell carcinoma), CreaGene; Autologous dendritic cell vaccines (renal cell carcinoma), CreaGene Click to Show/Hide
External Link	TTD: D06KPV
Compound Name	Aldesleukin		Approved	[67]
Synonyms	Proleukin (TN) Click to Show/Hide
External Link	TTD: D05PUD
Compound Name	Sifalimumab		Approved	[68]
Synonyms	Cci 779; CHEBI:79699; Torisel (TN); 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin; Temsirolimus (JAN/USAN/INN); 162635-04-3; DB06287; C15182; D06068; J-524319; (1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,18R,19R,21R,23S,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0; {4,9}]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate Click to Show/Hide
External Link	TTD: D05NDR
Compound Name	BOL-303259-X		Phase 3	[69]
Synonyms	Latanoprostene bunod; Latanoprostene bunod); NCX-116; PF-03187207; PF-3187207; BOL-303259-X1; NO donors (glaucoma), NicOx/Pfizer; NO-donating prostaglandin F2-alpha analogs (glaucoma), Pfizer; NO-donating prostaglandin F2-alpha analogs (glaucoma), NicOx/Pfizer; Nitric oxide-donating prostaglandin F2-alpha analogs (eye disease), NicOx/Pfizer; NO-donating prostaglandin F2-alpha analogs (glaucoma), NicOx/ Bausch & Lomb Click to Show/Hide
External Link	CID: 11156438 TTD: D05LQX DrugBank: DB11660
Compound Name	Axitinib		Approved	[70]
Synonyms	AG 013736; AG013736; AG-013736; AG-13736; AG-013736, Axitinib; N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide; N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; Axitinib (VEGFR inhibitor) Click to Show/Hide
External Link	CID: 6450551 TTD: D01ZRI DrugBank: DB06626
Compound Name	Nivolumab		Approved	[58]
External Link	TTD: D00GOV
Compound Name	HBI-8000		Phase 1/2	[58]
Synonyms	CS055; SCHEMBL5500152; GTPL8305; AKOS026750315; N-(2-amino-5-fluorophenyl)-4-{[3-(pyridin-3-yl)prop-2-enamido]methyl}benzamide Click to Show/Hide
External Link	CID: 12136798 TTD: D00SQN DrugBank: DB06334
Compound Name	Human coagulation factor X		BLA submitted	[71]
External Link	TTD: D07JEW
Compound Name	Trebananib		Phase 3	[72]
External Link	TTD: D9NL3R
Compound Name	Abexinostat		Phase 3	[73]
Synonyms	PCI-24781; 783355-60-2; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide Click to Show/Hide
External Link	CID: 11749858 TTD: D0V0SL DrugBank: DB12565
Compound Name	Vitespen		Phase 3	[74]
Synonyms	Oncophage (TN) Click to Show/Hide
External Link	TTD: D0UK2Z
Compound Name	AMD-070		Phase 3	[58]
Synonyms	AMD 070; AMD070; AMD11070; S14-0353; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate Click to Show/Hide
External Link	CID: 11256587 TTD: D0O2XQ DrugBank: DB05501
Compound Name	Nivolumab + ipilimumab		Phase 3	[75]
External Link	TTD: D0N5GV
Compound Name	Savolitinib		Phase 3	[58]
Synonyms	1313725-88-0; AZD-6094; AZD6094; UNII-2A2DA6857R; CHEMBL3334567; 2A2DA6857R; Savolitinib [INN]; Volitinib(Savolitinib); Savolitinib [USAN:INN]; GTPL9918; SCHEMBL12489208; EX-A845; BDBM50023342; ZINC149738712; AKOS030526403; DB12048; compound 28 [PMID: 25148209]; HY-15959; AS-35250; 1H-1,2,3-Triazolo(4,5-b)pyrazine, 1-((1S)-1-imidazo(1,2-a)pyridin-6-ylethyl)-6-(1-methyl-1H-pyrazol-4-yl)-; KB-333895; FT-0700162; J-690125; 4-{1-[(1S)-1-{imidazo[1,2-a]pyri Click to Show/Hide
External Link	CID: 68289010 TTD: D0LW0T DrugBank: DB12048
Compound Name	Rocapuldencel-T		Phase 3	[76]
External Link	TTD: D0J0GR
Compound Name	Cotellic		Phase 3	[58]
Synonyms	Cobimetinib fumarate; Cobimetinib hemifumarate; Xl-518 hemifumarate; GDC-0973 hemifumarate; UNII-6EXI96H8SV; 6EXI96H8SV; Cobimetinib fumarate [USAN]; 1369665-02-0; Cobimetinib fumarate (USAN); Cotellic (TN); CHEMBL2364607; CHEBI:90853; Methanone, (3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl)-, (2E)-2-butenedioate (2:1); D10615; bis[(2S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoyl]-3-hydroxyazetidin-3-yl}piperidin-1-ium] (2E)-but-2-enedioate Click to Show/Hide
External Link	CID: 16222096 TTD: D0FJ9I DrugBank: DB05239
Compound Name	BMS-986205		Phase 3	[58]
Synonyms	KRTIYQIPSAGSBP-KLAILNCOSA-N; 1923833-60-6; BMS986205; UNII-0A7729F42K; 0A7729F42K; GTPL9707; SCHEMBL18826792; SCHEMBL17740982; SCHEMBL19105151; EX-A2606; AKOS032954040; HY-101560; CS-0021719; Q29213697; (R)-N-(4-chlorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide; (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide; (2R)-N-(4-Chlorophenyl)-2-(4-(6-fluoro-4-quinolyl)cyclohexyl)propanamide, cis; Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-alpha-methyl-, cis-(alphaR)- Click to Show/Hide
External Link	CID: 121328278 TTD: D0DP5I DrugBank: DB14986
Compound Name	TKI258		Phase 3	[77]
Synonyms	Dovitinib; 405169-16-6; CHIR-258; TKI-258; Chir 258; 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one; CHIR258; Dovitinib (TKI-258, CHIR-258); UNII-I35H55G906; CHEMBL522892; 804551-71-1; I35H55G906; TKI 258; 1027263-12-2; (3Z)-4-Amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]-2(3H)-quinolinone; C21H21FN6O; 4-Amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one Click to Show/Hide
External Link	CID: 135611162 TTD: D07OZR
Compound Name	AM0010		Phase 3	[75]
External Link	TTD: D03MYX
Compound Name	IMA-901		Phase 3	[78]
Synonyms	TUMAP vaccine (RCC), immatics; Tumor-associoated peptide vaccine (renal cell carcinoma), immatics Click to Show/Hide
External Link	TTD: D02UNP
Compound Name	NKTR 214		Phase 3	[75]
External Link	TTD: D02QQE
Compound Name	TRC105		Phase 2	[75]
External Link	TTD: D00YQI
Compound Name	CAP-232		Phase 2a	[79]
Synonyms	TT-232; UNII-49D4Q4254Z; TT 232; 49D4Q4254Z; 147159-51-1; Phe-cys-tyr-trp-lys-cys-thr-NH2 (2-6)-disulfide; TLN 232; CAP 232; Phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-cysteinyl-threoninamide (2-6)-disulfide; AC1OCF7X; CHEMBL539934; TLN-232; L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-, cyclic (2-6)-disulfide; TT2-32; ZINC169289417; AKOS024458270; DB12088; NCGC00249606-01 Click to Show/Hide
External Link	CID: 6918265 TTD: D09EFC DrugBank: DB12088
Compound Name	CMN-001		Phase 2	[80]
External Link	TTD: DVQ1F5
Compound Name	DS-3201b		Phase 2	[81]
Synonyms	Valemetostat; 1809336-39-7; UNII-60RD0234VE; 60RD0234VE; 1809336-39-7 (free base); DS-3201; (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide; Valemetostat 2HCl; Valemetostat [INN]; Valemetostat (DS-3201); CHEMBL4597193; EZH1/2 inhibitor DS-3201; SCHEMBL18393626; SCHEMBL18393627; SCHEMBL18639210; EX-A3423; DS3201; NSC813381; s8926; NSC-813381; HY-109108; CS-0039740; D11551 Click to Show/Hide
External Link	CID: 126481870 TTD: DNM79H
Compound Name	AGS-16C3F		Phase 2	[58]
External Link	TTD: D0XT5Q
Compound Name	TV-Kidney-1		Phase 2	[76]
External Link	TTD: D0WZ0E
Compound Name	IMO-2055		Phase 2	[82]
External Link	TTD: D0W6HO
Compound Name	Anti-LAG3		Phase 2	[75]
External Link	TTD: D0T7OI
Compound Name	AGS-003		Phase 2	[83]
External Link	TTD: D0Q5OC
Compound Name	Ispinesib		Phase 2	[84]
Synonyms	SB-715992; Ispinesib (SB-715992 /CK0238273); SB-715992, CK0238273,Ispinesib; N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide Click to Show/Hide
External Link	CID: 6851740 TTD: D0PW4N DrugBank: DB06188
Compound Name	Ilixadencel		Phase 2	[58]
External Link	TTD: D0PR4O
Compound Name	CRLX101		Phase 2	[58]
External Link	CID: 184196 TTD: D0ND9T
Compound Name	FolateImmune		Phase 2	[85]
Synonyms	Folate-FITC; EC-17; UNII-V7YQ6134AE; V7YQ6134AE; EC17 (Folate-FITC); Folate-fluorescein conjugate; DTXSID40207031; ZMTAPBHUSYTHBY-PMERELPUSA-N; EC 17; DB12559; 910661-23-3; 1159606-35-5 Click to Show/Hide
External Link	CID: 135564966 TTD: D0N8JG DrugBank: DB12559
Compound Name	Varlilumab		Phase 2	[58]
External Link	TTD: D0KV3M
Compound Name	TVI-Kidney-1		Phase 2	[86]
External Link	TTD: D0JH5K
Compound Name	OSI-027		Phase 2	[87]
External Link	CID: 135398516 TTD: D0H7XL DrugBank: DB12387
Compound Name	XL880		Phase 2	[88]
Synonyms	GSK 089; GSK 1363089; GSK1363089; XL 880; GSK1363089, GSK089, foretinib, EXEL-2880, XL880; 88Z; MET inhibitors Click to Show/Hide
External Link	CID: 42642645 TTD: D0D1GF DrugBank: DB12307
Compound Name	Girentuximab I-124		Phase 2	[89]
Synonyms	Redectane (TN) Click to Show/Hide
External Link	TTD: D0BH7Z
Compound Name	Autologous renal cell carcinoma vaccine		Phase 2	[90]
External Link	TTD: D08FKD
Compound Name	RX-0201		Phase 2	[58]
External Link	TTD: D07SYZ
Compound Name	Human interleukin-2		Phase 2	[91]
Synonyms	Pulmoleukin; Human interleukin-2 (inhaled, renal cell carcinoma); Human IL-2 (inhaled, renal cell carcinoma),Immunservice; Human interleukin-2 (inhaled, renal cell carcinoma), Immunservice Click to Show/Hide
External Link	TTD: D04OJM
Compound Name	CB-839		Phase 2	[58]
External Link	CID: 71577426 TTD: D01PBW DrugBank: DB15232
Compound Name	ATN-161		Phase 2	[92]
Synonyms	PHSCN; PHSCN, University of Michigan; Angiogenesis inhibitors (cancer), Attenuon; Integrin antagonists (cancer), Attenuon; Ac-PHSCN-NH2, University of Michigan Click to Show/Hide
External Link	CID: 9960285 TTD: D00QVT
Compound Name	TV1-Kidney-1		Phase 2	[93]
External Link	TTD: D00HMZ
Compound Name	CCT301-38 (targeting ROR2)		Phase 1/2	[94]
External Link	TTD: D0RA9C
Compound Name	LAG525		Phase 1/2	[58]
External Link	TTD: D0E4LS
Compound Name	CCT301-59 (targeting ROR2)		Phase 1/2	[94]
External Link	TTD: D0C2PH
Compound Name	Anti-C-met CAR-T cells		Phase 1/2	[95]
External Link	TTD: D0A3OE
Compound Name	CDX-014		Phase 1/2	[58]
External Link	TTD: D09WXY
Compound Name	IL-2 XL		Phase 1/2	[96]
Synonyms	IL-2 XL (controlled release, Medusa); IL-2 XL (controlled release, Medusa), Flamel; Interleukin-2 (long-acting, Medusa), Flamel Click to Show/Hide
External Link	TTD: D08XFA
Compound Name	ARO-HIF2		Phase 1	[97]
External Link	TTD: DE8V1R
Compound Name	AGS-16 mab		Phase 1	[98]
Synonyms	AGS-16M18 Click to Show/Hide
External Link	TTD: D0X7MY
Compound Name	Neovastat		Phase 1	[6]
External Link	TTD: D0T4BL
Compound Name	Biomed 101		Discontinued in Phase 1	[99]
Synonyms	SC-41930; SC 41930; 120072-59-5; CHEMBL14823; CGS 24115; 7-(3-(4-Acetyl-3-methoxy-2-propylphenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid; 2H-1-Benzopyran-2-carboxylic acid, 7-(3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy)-3,4-dihydro-8-propyl-; 2H-1-Benzopyran-2-carboxylicacid, 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-; 7-(3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy)-8-propylchroman-2-carboxylic acid; SC-41390 Click to Show/Hide
External Link	CID: 114999 TTD: D0S0WN
Compound Name	AMG 172		Phase 1	[100]
External Link	TTD: D0NC1Q
Compound Name	Anti-hCD70 CAR transduced PBL		Phase 1	[101]
External Link	TTD: D0JO9M
Compound Name	Veglin		Phase 1	[102]
External Link	TTD: D0G6GB
Compound Name	IL-7/CD80-expressing allogeneic RCC-26 tumor cell vaccine		Phase 1	[103]
Synonyms	RCC-26 tumor cell vaccine; IL-7/CD80-expressing allogeneic RCC-26 tumorcell vaccine (renal cell carcinoma) Click to Show/Hide
External Link	TTD: D04HWK
Compound Name	Vorsetuzumab mafodotin		Discontinued in Phase 1	[104]
External Link	TTD: D08WTE
Compound Name	BCL-004		Investigative	[105]
External Link	TTD: D09KTE
Compound Name	GM-CAIX		Investigative	[105]
Synonyms	GM-CSF/cancer antigen chimeric protein (renal cancer), Kite Click to Show/Hide
External Link	TTD: D07OQJ
Compound Name	GS-168		Investigative	[105]
Synonyms	GS-168A Click to Show/Hide
External Link	TTD: D05YWN
Compound Name	STF-62247		Investigative	[105]
Synonyms	Renal cell carcinoma therapy, Stanford University Click to Show/Hide
External Link	CID: 704473 TTD: D01CIN

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m6A-centered Crosstalk Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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