m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03167
|
[1] | |||
Histone modification
H3K27ac
Epigenetic Regulator
Downstream Gene
Direct
Enhancement
m6A modification
m6A Target
m6A Target
METTL3
Methylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | View Details | |||
| Crosstalk Relationship | Histone modification → m6A | Enhancement | |||
| Crosstalk Mechanism | Histone modification directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | METTL3 interacts with RNA polymerase II and active histone modifications such as H3K9ac, Histone H3 lysine 27 acetylation (H3K27ac), and H3K36me3 to maintain the expression of proteasome-related genes. | ||||
| Responsed Disease | Liver injury | ICD-11: NB91.1 | |||
| Responsed Drug | Acetaminophen (APAP) | ||||
| Cell Process | mRNA stability | ||||
In-vitro Model |
Hepa 1-6 | Hepatocellular carcinoma of the mouse | Mus musculus | CVCL_0327 | |