m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03148
 [1]
m6A modification HDAC6 HDAC6 METTL3 Methylation : m6A sites Direct Enhancement Histone modification HisMod sites HDAC6 Downstream Gene
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Protein deacetylase HDAC6 (HDAC6)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Protein deacetylase HDAC6 (HDAC6) ERASER View Details
Regulated Target Histone acetylation View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes
Crosstalk Summary Depletion of METTL3-mediated m6A modification leads to abnormally elongated cilia via suppressing Protein deacetylase HDAC6 (HDAC6)-dependent deacetylation of axonemal alpha-tubulin, ultimately attenuating cell growth and cervical cancer development.
In-vitro Model
 HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
In-vivo Model To construct the subcutaneous xenograft model, ~1 × 106 HeLa cells suspended in 50% Matrigel in DMEM were subcutaneously injected into the right flanks of the mice.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Protein deacetylase HDAC6 (HDAC6) 171 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Citarinostat Phase 1 [2]
Synonyms
ACY-241; 1316215-12-9; HDAC-IN-2; 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-441P620G3P; 441P620G3P; Citarinostat [USAN]; Citarinostat (USAN); 2-(N-(2-chlorophenyl)anilino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide; 2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide; 2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; Citarinostat (ACY-241); SCHEMBL2225863; GTPL942
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MOA Inhibitor
Activity IC50 = 2.6 nM
External Link
CID: 53340426
TTD: D01WKZ
DrugBank: DB15449
 Compound Name KA2507 Phase 1 [2]
MOA Inhibitor
External Link
TTD: D0O6SA
 Compound Name Sulfonamide derivative 16 Patented [3]
Synonyms
PMID29886770-Compound-Figure6
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D05OKZ
 Compound Name PMID29671355-Compound-15 Patented [4]
MOA Inhibitor
Activity IC50 < 100 nM
External Link
CID: 122439227
TTD: D0H5GP
 Compound Name PMID29671355-Compound-14 Patented [4]
MOA Inhibitor
Activity IC50 <= 100 nM
External Link
TTD: D0N6WW
 Compound Name PMID29671355-Compound-16 Patented [4]
MOA Inhibitor
Activity IC50 < 100 nM
External Link
CID: 122616384
TTD: D0TO3O
 Compound Name PMID28092474-Compound-33d Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 117703486
TTD: D00ACL
 Compound Name PMID28092474-Compound-32u Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D00GLJ
 Compound Name PMID28092474-Compound-33a Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D00LLN
 Compound Name PMID28092474-Compound-32a Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D00XWZ
 Compound Name PMID28092474-Compound-32j Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D01LCZ
 Compound Name PMID28092474-Compound-32z Patented [5]
MOA Inhibitor
Activity IC50 >= 500 nM; IC50 <= 1000 nM
External Link
TTD: D02YDG
 Compound Name PMID28092474-Compound-32g Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D03EUD
 Compound Name PMID28092474-Compound-34c Patented [5]
MOA Inhibitor
Activity IC50 >= 1000 nM; IC50 <= 10000 nM
External Link
TTD: D04AMI
 Compound Name PMID28092474-Compound-32x Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 117703583
TTD: D04KQU
 Compound Name PMID28092474-Compound-33b Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D04MVN
 Compound Name PMID28092474-Compound-32b Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282589
TTD: D04VQE
 Compound Name PMID28092474-Compound-32o Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282321
TTD: D06IIL
 Compound Name PMID28092474-Compound-33g Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 117703541
TTD: D08GBR
 Compound Name PMID28092474-Compound-33j Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 117703439
TTD: D08GQL
 Compound Name PMID28092474-Compound-33p Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D08SNJ
 Compound Name PMID28092474-Compound-33m Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D08XLK
 Compound Name PMID28092474-Compound-32v Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D08ZJZ
 Compound Name PMID29671355-Compound-24 Patented [4]
MOA Inhibitor
Activity IC50 = 0.26 nM
External Link
TTD: D09PVH
 Compound Name PMID28092474-Compound-34b Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0BY1R
 Compound Name PMID28092474-Compound-33e Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0CH4M
 Compound Name PMID28092474-Compound-32t Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282179
TTD: D0CX1Y
 Compound Name PMID28092474-Compound-32c Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0DH7R
 Compound Name PMID28092474-Compound-33i Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0E5CO
 Compound Name PMID28092474-Compound-32r Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282178
TTD: D0ET4U
 Compound Name PMID28092474-Compound-32h Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0EU5A
 Compound Name PMID29671355-Compound-65a Patented [4]
MOA Inhibitor
Activity IC50 = 7.9 nM
External Link
CID: 126720707
TTD: D0F3TB
 Compound Name PMID28092474-Compound-32y Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0HM6Y
 Compound Name PMID28092474-Compound-33h Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0JN0A
 Compound Name PMID29671355-Compound-38a Patented [4]
MOA Inhibitor
Activity IC50 <= 100 nM
External Link
CID: 121304883
TTD: D0JR9L
 Compound Name PMID28092474-Compound-33f Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0K2UF
 Compound Name Diaryl amine derivative 3 Patented [5]
Synonyms
PMID28092474-Compound-11
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 9 nM
External Link
TTD: D0KA3X
 Compound Name PMID28092474-Compound-33c Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0L3CU
 Compound Name PMID29671355-Compound-39 Patented [4]
MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 124093354
TTD: D0L7HG
 Compound Name PMID29671355-Compound-19 Patented [4]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0LV6K
 Compound Name PMID28092474-Compound-32e Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0M7XL
 Compound Name PMID28092474-Compound-32m Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 117703481
TTD: D0MQ2D
 Compound Name PMID28092474-Compound-32p Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282322
TTD: D0MR7U
 Compound Name PMID28092474-Compound-32d Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282452
TTD: D0N1RX
 Compound Name PMID29671355-Compound-74 Patented [4]
MOA Inhibitor
Activity IC50 = 433500 nM
External Link
CID: 72946782
TTD: D0N2FN
 Compound Name PMID28092474-Compound-32n Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86282455
TTD: D0O6SJ
 Compound Name PMID28092474-Compound-33k Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0Q9XK
 Compound Name PMID28092474-Compound-32k Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0QF0Y
 Compound Name PMID28092474-Compound-34a Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0QN8W
 Compound Name PMID29671355-Compound-22 Patented [4]
MOA Inhibitor
Activity IC50 = 56 nM
External Link
CID: 71532921
TTD: D0QX3G
 Compound Name PMID29671355-Compound-26 Patented [4]
MOA Inhibitor
Activity IC50 = 2.9 nM
External Link
CID: 130361892
TTD: D0R3RJ
 Compound Name PMID28092474-Compound-33o Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0RD7T
 Compound Name PMID28092474-Compound-32f Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0S3ZB
 Compound Name Diaryl amine derivative 2 Patented [5]
Synonyms
PMID28092474-Compound-10
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 45 nM
External Link
TTD: D0S7NE
 Compound Name PMID28092474-Compound-33l Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0SF8N
 Compound Name PMID28092474-Compound-32i Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0SK9K
 Compound Name PMID28092474-Compound-32q Patented [5]
MOA Inhibitor
Activity IC50 >= 1000 nM; IC50 <= 10000 nM
External Link
CID: 86282451
TTD: D0TH3L
 Compound Name PMID29671355-Compound-18 Patented [4]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 86302675
TTD: D0TN6E
 Compound Name PMID29671355-Compound-27 Patented [4]
MOA Inhibitor
Activity IC50 = 66 nM
External Link
CID: 130227480
TTD: D0V5IQ
 Compound Name PMID28092474-Compound-32l Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
TTD: D0W1AX
 Compound Name Diaryl amine derivative 4 Patented [5]
Synonyms
PMID28092474-Compound-9
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4 nM
External Link
TTD: D0XN2W
 Compound Name PMID28092474-Compound-32s Patented [5]
MOA Inhibitor
Activity IC50 <= 500 nM
External Link
CID: 117703493
TTD: D0YC2M
 Compound Name PMID29671355-Compound-38b Patented [4]
MOA Inhibitor
Activity IC50 = 1.76 nM
External Link
CID: 73774655
TTD: D0YD7B
 Compound Name PMID29671355-Compound-28 Patented [4]
MOA Inhibitor
Activity IC50 = 107 nM
External Link
TTD: D0Z7QI
 Compound Name PMID29671355-Compound-73 Patented [4]
MOA Inhibitor
Activity IC50 = 1000 nM
External Link
CID: 124194015
TTD: D0T7OQ
 Compound Name PMID29671355-Compound-13 Patented [4]
MOA Inhibitor
Activity IC50 <= 100 nM
External Link
CID: 71811260
TTD: D0ZG5X
 Compound Name PMID29671355-Compound-11 Patented [4]
MOA Inhibitor
Activity IC50 = 1.5 nM
External Link
CID: 118005782
TTD: D0EH2K
 Compound Name PMID29671355-Compound-9 Patented [4]
MOA Inhibitor
Activity IC50 = 1.7 nM
External Link
CID: 57381425
TTD: D0Q1QY
 Compound Name PMID29671355-Compound-8 Patented [4]
MOA Inhibitor
Activity IC50 = 6 nM
External Link
TTD: D0LN1T
 Compound Name PMID29671355-Compound-61 Patented [4]
MOA Inhibitor
Activity IC50 > 1000000 nM
External Link
TTD: D0JB4S
 Compound Name PMID29671355-Compound-23 Patented [4]
MOA Inhibitor
Activity IC50 = 3.57 nM
External Link
CID: 118884610
TTD: D00HXJ
 Compound Name PMID29671355-Compound-44 Patented [4]
MOA Inhibitor
Activity IC50 < 150 nM
External Link
CID: 72710871
TTD: D0N2DK
 Compound Name PMID29671355-Compound-56 Patented [4]
MOA Inhibitor
Activity IC50 > 30000 nM
External Link
CID: 56965342
TTD: D0CH8Q
 Compound Name PMID29671355-Compound-67 Patented [4]
MOA Inhibitor
Activity IC50 = 9000 nM
External Link
CID: 60201048
TTD: D0M0RE
 Compound Name PMID29671355-Compound-31 Patented [4]
MOA Inhibitor
Activity IC50 = 4.1 nM
External Link
CID: 90479372
TTD: D0DI9S
DrugBank: DB14979
 Compound Name PMID29671355-Compound-21 Patented [4]
MOA Inhibitor
Activity IC50 = 5 nM
External Link
CID: 86295624
TTD: D0LP1K
 Compound Name PMID29671355-Compound-62 Patented [4]
MOA Inhibitor
Activity IC50 > 1000000 nM
External Link
TTD: D07WAT
 Compound Name PMID29671355-Compound-43 Patented [4]
MOA Inhibitor
Activity IC50 = 6.8 nM
External Link
CID: 118515590
TTD: D0BP8I
 Compound Name PMID29671355-Compound-25 Patented [4]
MOA Inhibitor
Activity IC50 = 0.958 nM
External Link
CID: 126569528
TTD: D0RA0D
 Compound Name IKH-25 Investigative [6]
Synonyms
HDAC-6 inhibitors (cancer), Ikerchem
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MOA Inhibitor
External Link
TTD: D00JIX
 Compound Name (S)-2-Amino-N-cyclopentyl-7-mercaptoheptanamide Investigative [7]
Synonyms
thiolate analogue, 26a; CHEMBL235911; SCHEMBL16338810; BDBM19139
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23634888
TTD: D01DOV
 Compound Name Tubacin Investigative [8]
Synonyms
537049-40-4; AC1O7Y2P; CHEMBL356769; 1350555-93-9; N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide; Tubacin (BML-GR362); Octanediamide, N1-(4-((2R,4R,6S)-4-(((4,5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy-, rel-; N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide; SCHEMBL4741166
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.9 nM
External Link
CID: 6675804
TTD: D04KQF
 Compound Name ST-2741 Investigative [9]
Synonyms
CHEMBL564876; SCHEMBL1306499; BDBM50297444
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 6 nM
External Link
CID: 11993691
TTD: D05OVV
 Compound Name N-(quinolin-8-yl)-6-(sulfamoylamino)hexanamide Investigative [10]
Synonyms
CHEMBL507114; SCHEMBL5330834
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 390 nM
External Link
CID: 25216936
TTD: D0G3ZH
 Compound Name PMID19111466C7d Investigative [11]
Synonyms
GTPL7056; BDBM50255914
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 16661454
TTD: D0G6DH
 Compound Name UCL-67022 Investigative [6]
Synonyms
HDAC inhibitor (multiple myeloma), ST Barts/UCL
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0L0LR
 Compound Name PMID20947351C16 Investigative [12]
Synonyms
GTPL7057; BDBM50331106
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 26 nM
External Link
CID: 50908800
TTD: D0MC9C
 Compound Name N-(quinolin-6-yl)-6-(sulfamoylamino)hexanamide Investigative [10]
Synonyms
CHEMBL454438; SCHEMBL5359458; CGIYOYXFUHZSMD-UHFFFAOYSA-N
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 490 nM
External Link
CID: 25216938
TTD: D0Q4AV
 Compound Name NQN-1 Investigative [13]
Synonyms
PPM-18; NSC 73233
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5540 nM
External Link
CID: 4882
TTD: D0Q4EG
 Compound Name N-phenyl-6-(sulfamoylamino)hexanamide Investigative [10]
Synonyms
CHEMBL474097; SCHEMBL5326902
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1500 nM
External Link
CID: 25216937
TTD: D0R8JK
 Compound Name N-(biphenyl-3-yl)-6-(sulfamoylamino)hexanamide Investigative [10]
Synonyms
CHEMBL475301; SCHEMBL5327672
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1100 nM
External Link
CID: 23634372
TTD: D0T8AJ
 Compound Name N-[5-(Formyl-hydroxy-amino)-pentyl]-benzamide Investigative [14]
Synonyms
CHEMBL337584; TWZ-109
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4300 nM
External Link
CID: 44359538
TTD: D0X4VO
 Compound Name N-(quinolin-3-yl)-6-(sulfamoylamino)hexanamide Investigative [10]
Synonyms
CHEMBL475714; SCHEMBL5458681
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 710 nM
External Link
CID: 44591342
TTD: D0XU0G
 Compound Name 6-(9H-carbazol-9-yl)-N-hydroxyhexanamide Investigative [12]
Synonyms
CHEMBL1290142; A1-02262; SCHEMBL1004139; SOMDVJCUFVPZKM-UHFFFAOYSA-N; BDBM50331109; 9H-Carbazole-9-hexanamide, N-hydroxy-; 6-Carbazol-9-ylhexanoic acid hydroxyamide; US8748451, 1
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 41 nM
External Link
CID: 46918725
TTD: D06FAK
 Compound Name N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide Investigative [10]
Synonyms
CHEMBL473270
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 9 nM
External Link
CID: 44591267
TTD: D08XMS
 Compound Name NILTUBACIN Investigative [15]
Synonyms
Probes1_000174; Probes2_000141; AC1O7Y2N; CHEMBL1213539; SCHEMBL14476139; DIOX-H_003550; 8-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]anilino]-8-oxooctanoic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2200 nM
External Link
CID: 6675803
TTD: D0L7HP
 Compound Name nexturastat A Investigative [16]
Synonyms
S7473
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3.8 nM
External Link
CID: 71462653
TTD: D0Q5DI
 Compound Name N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide Investigative [17]
Synonyms
CHEMBL511212; BDBM50258645
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 10383069
TTD: D0YP4F
 Compound Name droxinostat Investigative [18]
Synonyms
NS-41080; NS41080
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 568416
TTD: D00VXM
 Compound Name Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) Investigative [19]
Synonyms
CHEMBL393260
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437872
TTD: D00XTC
 Compound Name 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide Investigative [7]
Synonyms
CHEMBL419758; NCH-31; JMC505425 Compound 7; BDBM19131; 7-mercapto-N-(4-phenyl-2-thiazolyl)heptanamide; N-(4-phenyl-1,3-thiazol-2-yl)-7-sulfanylheptanamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 230 nM
External Link
CID: 11427204
TTD: D02HVH
 Compound Name Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) Investigative [19]
Synonyms
CHEMBL390991
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437870
TTD: D02NAF
 Compound Name Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) Investigative [19]
Synonyms
CHEMBL394261
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437869
TTD: D02NVY
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) Investigative [19]
Synonyms
CHEMBL391384
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437878
TTD: D03PRG
 Compound Name Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) Investigative [19]
Synonyms
CHEMBL393261
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437873
TTD: D04CDZ
 Compound Name N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide Investigative [17]
Synonyms
CHEMBL512644; SCHEMBL8226957
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5 nM
External Link
CID: 25032059
TTD: D04DOL
 Compound Name santacruzamate A Investigative [20]
Synonyms
CAY10683
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 433 nM
External Link
CID: 72946782
TTD: D09RKA
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) Investigative [19]
Synonyms
CHEMBL241555
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437879
TTD: D0E8UH
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) Investigative [19]
Synonyms
CHEMBL428737
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437876
TTD: D0G1EX
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) Investigative [19]
Synonyms
CHEMBL238587
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437875
TTD: D0N5RV
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) Investigative [19]
Synonyms
CHEMBL238596; BDBM50222727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 430 nM
External Link
CID: 44437883
TTD: D0R3XO
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) Investigative [19]
Synonyms
CHEMBL393961
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437880
TTD: D0U0EZ
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) Investigative [19]
Synonyms
CHEMBL391383
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437877
TTD: D0X4QC
 Compound Name Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) Investigative [19]
Synonyms
CHEMBL393464
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44437874
TTD: D0Z6HR
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) Investigative [19]
Synonyms
CHEMBL238829; BDBM50222732
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 404 nM
External Link
CID: 44437868
TTD: D0Z6MI
 Compound Name 4-Phenylbutyrohydroxamic acid Investigative [15]
Synonyms
N-Hydroxy-4-phenylbutanamide; 32153-46-1; NSC131300; UNII-QX182FOM5S; QX182FOM5S; 4-phenylbutanehydroxamic acid; CHEMBL55895; Benzenebutanamide, N-hydroxy-; NSC 131300; AC1Q7DIW; AC1L5RDX; Phenylbutyrylhydroxamic Acid; AC1Q5QD1; N-Hydroxy-4-phenyl-butyramide; 4-Phenylbutyryl hydroxamic acid; SCHEMBL1350853; CTK4G8310; DTXSID60185943; MolPort-011-492-164; UPHXPXYRKPCXHK-UHFFFAOYSA-N; ZINC4962622; STL301752; BDBM50015142; AKOS009266186; MCULE-9765156954; NSC-131300; NE28489; BCB03_000829; EN300-68596
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 150 nM
External Link
CID: 279980
TTD: D02NWS
 Compound Name 8-Oxo-8-phenyl-octanoic acid hydroxyamide Investigative [21]
Synonyms
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11075845
TTD: D0S0WK
 Compound Name ST-3050 Investigative [22]
Synonyms
CHEMBL472631; SCHEMBL3445133; SCHEMBL3445139; BDBM50278222
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 303 nM
External Link
CID: 44591988
TTD: D01YBR
 Compound Name Octanedioic acid bis-hydroxyamide Investigative [23]
Synonyms
Suberohydroxamic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 14.5 nM
External Link
CID: 5173
TTD: D07YZZ
 Compound Name ST-2986 Investigative [22]
Synonyms
CHEMBL471041; SCHEMBL3444455; BDBM50278219
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 661 nM
External Link
CID: 44138031
TTD: D0N9AK
 Compound Name 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Investigative [21]
Synonyms
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 4500 nM
External Link
CID: 9882812
TTD: D00KFF
DrugBank: DB07553
 Compound Name 7-Mercapto-heptanoic acid phenylamide Investigative [24]
Synonyms
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 19 nM
External Link
CID: 11379392
TTD: D00SEE
 Compound Name 6-benzenesulfinylhexanoic acid hydroxamide Investigative [25]
Synonyms
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11694528
TTD: D00ZSD
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Investigative [26]
Synonyms
CHEMBL193959
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401339
TTD: D01MFV
 Compound Name 7-Mercapto-heptanoic acid biphenyl-4-ylamide Investigative [24]
Synonyms
CHEMBL112311
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11220728
TTD: D01XWZ
 Compound Name N-Hydroxy-4-phenylacetylamino-benzamide Investigative [27]
Synonyms
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11196500
TTD: D01XXN
 Compound Name 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Investigative [24]
Synonyms
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9927379
TTD: D02MQM
 Compound Name N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Investigative [28]
Synonyms
CHEMBL143674; SCHEMBL673760
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11323577
TTD: D02UTC
 Compound Name 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [29]
Synonyms
CHEMBL126355; BDBM50222394
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350626
TTD: D02WZK
 Compound Name Octanedioic acid hydroxyamide pyridin-4-ylamide Investigative [30]
Synonyms
SCHEMBL8082656; CHEMBL165162; ZINC13472304
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10967421
TTD: D04GGW
 Compound Name N-(6-Mercapto-hexyl)-benzamide Investigative [24]
Synonyms
CHEMBL112364; BDBM50223650
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11447748
TTD: D04HSS
 Compound Name 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [30]
Synonyms
CHEMBL167455
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11086699
TTD: D04NSP
 Compound Name N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Investigative [27]
Synonyms
SCHEMBL675474
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11231829
TTD: D04ZDI
 Compound Name 6-benzenesulfonylhexanoic acid hydroxamide Investigative [25]
Synonyms
CHEMBL203207
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11572583
TTD: D05AHZ
 Compound Name 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Investigative [21]
Synonyms
SCHEMBL7373122; CHEMBL116578
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342872
TTD: D05FEJ
 Compound Name Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Investigative [24]
Synonyms
CHEMBL111806; SCHEMBL14812153
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11254470
TTD: D05GVY
 Compound Name 4-Butyrylamino-N-hydroxy-benzamide Investigative [28]
Synonyms
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11287488
TTD: D05LLX
 Compound Name 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [29]
Synonyms
CHEMBL127328
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350703
TTD: D05VFP
 Compound Name 7-Mercapto-heptanoic acid biphenyl-3-ylamide Investigative [24]
Synonyms
CHEMBL320323
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11449823
TTD: D05XAN
 Compound Name 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Investigative [31]
MOA Inhibitor
External Link
CID: 3082127
TTD: D06IQB
 Compound Name N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Investigative [27]
Synonyms
SCHEMBL676079
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11347053
TTD: D06VBN
 Compound Name 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Investigative [24]
Synonyms
CHEMBL324126
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11277483
TTD: D06XNP
 Compound Name 7-Mercapto-heptanoic acid pyridin-3-ylamide Investigative [24]
Synonyms
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11345433
TTD: D07FJU
 Compound Name 6-Phenoxy-hexane-1-thiol Investigative [24]
Synonyms
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11298778
TTD: D09YBN
 Compound Name 4-Benzoylamino-N-hydroxy-benzamide Investigative [27]
Synonyms
SCHEMBL673678; CHEMBL191227
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11817702
TTD: D09ZNU
 Compound Name 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [21]
Synonyms
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 403373
TTD: D0A5LS
 Compound Name 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [29]
Synonyms
CHEMBL112148; SCHEMBL7364383; BDBM50218532
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44341053
TTD: D0AX7B
 Compound Name 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [29]
Synonyms
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350718
TTD: D0B2ZJ
 Compound Name 6-Mercapto-hexanoic acid phenylamide Investigative [24]
Synonyms
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 67 nM
External Link
CID: 11436024
TTD: D0B3ZM
 Compound Name Cyclostellettamine derivative Investigative [32]
Synonyms
CHEMBL88332
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23327627
TTD: D0C0VP
 Compound Name N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Investigative [21]
Synonyms
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9943996
TTD: D0C2KD
 Compound Name 5-Mercapto-pentanoic acid phenylamide Investigative [24]
Synonyms
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11608171
TTD: D0D2KE
 Compound Name Octanedioic acid hydroxyamide pyridin-2-ylamide Investigative [30]
Synonyms
SCHEMBL8090513; CHEMBL164872; ZINC13472303
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11747496
TTD: D0E8KR
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Investigative [26]
Synonyms
CHEMBL193979
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401305
TTD: D0F0KS
 Compound Name 2-(methylsulfonylthio)ethyl 2-propylpentanoate Investigative [31]
Synonyms
CHEMBL271677; SCHEMBL4156413
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24759251
TTD: D0H1FZ
 Compound Name (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Investigative [29]
Synonyms
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350655
TTD: D0KE3I
 Compound Name N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Investigative [27]
Synonyms
SCHEMBL676080
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11312563
TTD: D0QO0L
 Compound Name N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Investigative [27]
Synonyms
N-hydroxy-4-(3-phenylpropanamido)benzamide
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0R4BS
 Compound Name N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Investigative [27]
Synonyms
SCHEMBL7311087
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11472431
TTD: D0R5VG
 Compound Name 8-Oxo-8-phenyl-octanoic acid Investigative [30]
Synonyms
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 298878
TTD: D0RU1X
 Compound Name N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Investigative [27]
Synonyms
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9994848
TTD: D0S7WQ
 Compound Name 6-phenylsulfanylhexanoic acid hydroxamide Investigative [25]
Synonyms
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11637291
TTD: D0S9JF
 Compound Name ST-2987 Investigative [22]
Synonyms
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 124 nM
External Link
CID: 44138032
TTD: D0T0SK
 Compound Name 7-Mercapto-heptanoic acid quinolin-3-ylamide Investigative [24]
Synonyms
CHEMBL112234
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10379373
TTD: D0T4IY
 Compound Name 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Investigative [33]
Synonyms
CHEMBL84288
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11528707
TTD: D0V2ZO
 Compound Name 8-Mercapto-octanoic acid phenylamide Investigative [24]
Synonyms
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
CID: 11149404
TTD: D0XZ9Q
 Compound Name N-(6-Hydroxycarbamoyl-hexyl)-benzamide Investigative [30]
Synonyms
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9965141
TTD: D0YY9M
 Compound Name 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Investigative [21]
Synonyms
CHEMBL326529; SCHEMBL7365237; BDBM50217957
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342825
TTD: D0Z3BM
 Compound Name 7-Mercapto-heptanoic acid benzothiazol-2-ylamide Investigative [24]
Synonyms
CHEMBL178779
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11346934
TTD: D0Z5KX
 Compound Name N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Investigative [28]
Synonyms
CHEMBL143102
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44361923
TTD: D0Z7YS
 Compound Name PSAMMAPLIN A Investigative [21]
Synonyms
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 6400741
TTD: D0N0TS
References
Ref 1 N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression. Adv Sci (Weinh). 2025 Jan;12(2):e2408488. doi: 10.1002/advs.202408488. Epub 2024 Nov 13.
Ref 2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 3 Sulfonamide inhibitors: a patent review 2013-present.Expert Opin Ther Pat. 2018 Jul;28(7):541-549.
Ref 4 HDAC inhibitors: a 2013-2017 patent survey. Expert Opin Ther Pat. 2018 Apr 19:1-17. doi: 10.1080/13543776.2018.1459568. Online ahead of print.
Ref 5 Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236.
Ref 6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2618).
Ref 7 Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38.
Ref 8 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. doi: 10.1517/14728210802676278.
Ref 9 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3.
Ref 10 Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40.
Ref 11 Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):688-92.
Ref 12 Inhibitors selective for HDAC6 in enzymes and cells. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70.
Ref 13 A novel class of small molecule inhibitors of HDAC6. ACS Chem Biol. 2012 Feb 17;7(2):331-9.
Ref 14 Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. Bioorg Med Chem Lett. 2004 Jan 19;14(2):449-53.
Ref 15 Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. doi: 10.1038/nchembio.313. Epub 2010 Feb 7.
Ref 16 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.
Ref 17 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6.
Ref 18 Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.
Ref 19 Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9.
Ref 20 Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Epub 2013 Oct 28.
Ref 21 Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. doi: 10.1021/jm0303094.
Ref 22 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. doi: 10.1016/j.bmcl.2009.02.029. Epub 2009 Feb 12.
Ref 23 Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem. 2002 Jul 18;45(15):3296-309. doi: 10.1021/jm0208119.
Ref 24 Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-32. doi: 10.1021/jm049207j.
Ref 25 Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. doi: 10.1021/jm051010j.
Ref 26 Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. doi: 10.1016/j.bmcl.2005.02.075.
Ref 27 Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. doi: 10.1021/jm0503749.
Ref 28 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. doi: 10.1021/jm0303655.
Ref 29 Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. doi: 10.1016/j.bmcl.2003.09.007.
Ref 30 Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. doi: 10.1021/jm015568c.
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