m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03141
|
[1] | |||
m6A modification
NEAT1
NEAT1
METTL3
Methylation
 : m6A sites
Indirect
Enhancement
Histone modification
H3K27ac
CHD4
Downstream Gene
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Nuclear paraspeckle assembly transcript 1 (NEAT1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Chromodomain-helicase-DNA-binding protein 4 (CHD4) | READER | View Details | ||
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | View Details | |||
| Crosstalk Relationship | m6A → Histone modification | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly regulates histone modification through downstream signaling pathways | ||||
| Crosstalk Summary | The genome-protective role of Nuclear paraspeckle assembly transcript 1 (NEAT1) is mediated by the RNA methyltransferase 3 (METTL3) and involves the release of the chromodomain helicase DNA binding protein 4 (CHD4) from NEAT1 to fine-tune Histone H3 lysine 27 acetylation (H3K27ac) at DSBs. Our data suggest a direct role for NEAT1 in DDR. | ||||