m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03096
|
[1] | |||
m6A modification
pri-rRNA
pri-rRNA
METTL3
Methylation
 : m6A sites
Direct
Inhibition
Histone modification
H3K9me3
SUV39H1
Downstream Gene
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | pri-rRNA | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) | WRITER | View Details | ||
| Regulated Target | Histone H3 lysine 9 trimethylation (H3K9me3) | View Details | |||
| Crosstalk Relationship | m6A → Histone modification | Inhibition | |||
| Crosstalk Mechanism | m6A modification directly impacts histone modification through recruiting histone-associated enzymes | ||||
| Crosstalk Summary | SUV39H1/H2 protein, the methyltransferases catalyzing Histone H3 lysine 9 trimethylation (H3K9me3) were dramatically elevated in METTL3/METTL14 deficient cells, which causes an accumulation and infiltration of H3K9me3 across the whole nucleolus and impairs the LLPS. Mechanistically, METTL3/METTL14 complex serves as an essential adapter for CRL4 E3 ubiquitin ligase targeting SUV39H1/SUV39H2 for polyubiquitination and proteasomal degradation and therefore prevents H3K9me3 accumulation in nucleoli. | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) | 1 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
 Compound Name |
chaetocin | Investigative | [2] | |
|---|---|---|---|---|
| Synonyms |
Chetocin; 28097-03-2; Chaetocin from Chaetomium minutum; BRN 5722505; AC1L4PPK; GTPL8388; SCHEMBL13662584; CHEBI:94977; MolPort-003-983-881; NSC745363; NSC-745363; LS-52961; Chaetocin from Chaetomium minutum, > J-016970; BRD-A85860691-001-01-4; BRD-A85860691-001-03-0; hydroxymethyl-(hydroxymethyl-methyl-dioxo-[ ]yl)-methyl-[ ]dione; [10b,10'b(11H,11'H)-Bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone, 2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dime
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 800 nM | |||
| External Link | ||||