m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03087
 [1]
Histone modification H3K18la p300 FTO Indirect Inhibition m6A modification CDK2 CDK2 YTHDF2 : m6A sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
m6A Target Cyclin-dependent kinase 2 (CDK2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone acetyltransferase p300 (P300) WRITER View Details
Regulated Target Histone H3 lysine 18 lactylation (H3K18la) View Details
Downstream Gene FTO View Details
Crosstalk Relationship Histone modification  →  m6A Inhibition
Crosstalk Mechanism histone modification indirectly regulates m6A modification through downstream signaling pathways
Crosstalk Summary FTO affected EC features via modulating Cyclin-dependent kinase 2 (CDK2) mRNA stability in an m6A-YTHDF2-dependent manner. FTO up-regulation under diabetic conditions was driven by p300-mediated Histone H3 lysine 18 lactylation (H3K18la). FB23-2, an inhibitor to FTO's m6A demethylase activity, suppressed angiogenic phenotypes in vitro.
Responsed Disease Diabetic retinopathy ICD-11: 9B71.0
 Disease Info 
Responsed Drug FB23-2
 Drug Info 
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Cyclin-dependent kinase 2 (CDK2) 138 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PHA848125 Phase 2 [2]
Synonyms
Milciclib; PHA-848125; 802539-81-7; PHA 848125; Milciclib (PHA-848125); UNII-688000M8S8; MMV676602; 4,5-dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide; 688000M8S8; N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide; Milciclib [INN]; N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-4,5-Dihydro-1h-Pyrazolo[4,3-H]quinazoline-3-Carboxamide
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MOA Inhibitor
Activity IC50 = 45 nM
External Link
CID: 16718576
TTD: D0Q9UX
 Compound Name Ro 31-7453 Phase 2 [3]
Synonyms
Bisindolylmaleimide deriv. 44; MKC-1; Ro-31-7453; 3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione
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MOA Inhibitor
External Link
CID: 5327686
TTD: D01UMT
DrugBank: DB05608
 Compound Name R-roscovitine Phase 2 [4]
Synonyms
Seliciclib; roscovitine; 186692-46-6; (R)-roscovitine; CYC202; CYC-202; CYC 202; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; UNII-0ES1C2KQ94; Roscovitine (Seliciclib,CYC202); NSC 701554; AL-39256; CHEMBL14762; 0ES1C2KQ94; CHEBI:45307; NSC701554; NSC-701554; (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol; (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; RRC; Rosco; M02443; BMK1-E12; CYC202, Seliciclib, R-roscovitine, Roscovitine; (2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol; 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-(R)-1-butanol; 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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MOA Inhibitor
Activity IC50 = 100 nM
External Link
CID: 160355
TTD: D05ADP
DrugBank: DB06195
 Compound Name TG02 Phase 1/2 [5]
Synonyms
SB1317; 937270-47-8; TG-02; TG02 (Double bond Z/E); UNII-40D08182TT; CHEMBL1944698; 40D08182TT; SB-1317; 1204918-72-8; C23H24N4O; Tube011; SB-1317 free base; TG02 (Double bond E); TG02 [WHO-DD]; SCHEMBL823947; SCHEMBL2298965; GTPL9095; SCHEMBL17595943; EX-A239; MolPort-039-139-793; AOB87361; BCP07033; ZINC68251500; BDBM50363196; 4029AH; AKOS030527020; AKOS032950000; SB1317(TG-02); SB14606; CS-0884; compound 26h [PMID: 22148278]; KB-80503; HY-15166; W-5884
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MOA Modulator
Activity IC50 = 3 nM
External Link
CID: 16739650
TTD: D0P0KN
 Compound Name NUV-422 Phase 1/2 [6]
MOA Inhibitor
External Link
TTD: D70HZT
 Compound Name AZD-5438 Phase 1 [7]
Synonyms
602306-29-6; AZD5438; AZD 5438; 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine; CHEMBL488436; UNII-276Z913G29; MMV676604; 4-[2-METHYL-1-ISOPROPYL-1H-IMIDAZOL-5-YL]-N-[4-(METHYLSULFONYL)PHENYL]-2-PYRIMIDINAMINE; 2-Pyrimidinamine,4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-; 276Z913G29; 4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine
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MOA Modulator
Activity IC50 < 6 nM
External Link
CID: 16747683
TTD: D06WHY
 Compound Name AT7519 Phase 1 [8]
Synonyms
LZE; AT 7519, AT7519; AT-7519; 4-[(2,6-dichlorobenzoyl)amino]-N-(4-piperidyl)-2H-pyrazole-3-carboxamide
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MOA Inhibitor
Activity IC50 = 47 nM
External Link
CID: 11338033
TTD: D07DTV
DrugBank: DB08142
 Compound Name PF-07104091 Phase 1 [9]
MOA Inhibitor
External Link
TTD: D5TH2B
 Compound Name CYC065 Phase 1 [10]
Synonyms
DLPIYBKBHMZCJI-WBVHZDCISA-N; 1070790-89-4; CYC-065; UNII-YET2XNU791; YET2XNU791; SCHEMBL13300946; CHEMBL3655762; BDBM106950; CS-7615; HY-101212; US8592581, 1; 2-Pentanol, 3-((6-(((4,6-dimethyl-3-pyridinyl)methyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-, (2R,3S)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24983461
TTD: D0PL7P
DrugBank: DB15425
 Compound Name AG-024322 Phase 1 [4]
Synonyms
AG-24322; N-[[5-[(3E)-3-(4,6-difluorobenzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 135413565
TTD: D0IX4B
DrugBank: DB13035
 Compound Name PHA-793887 Phase 1 [11]
Synonyms
Cyclin-dependent kinase inhibitor (cancer), Nerviano
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MOA Inhibitor
External Link
CID: 46191454
TTD: D0P1CV
DrugBank: DB12686
 Compound Name SNS-032 Phase 1 [12]
Synonyms
BMS-387032; BMS-387072; BMS-387032, SNS-032; N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide L-tartaric acid salt (2:1); N-(5-(((5-(1,1-Dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide; N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
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MOA Inhibitor
Activity Ki = 38 nM
External Link
CID: 3025986
TTD: D0S5RC
DrugBank: DB05969
 Compound Name RGT-419B Phase 1 [13]
MOA Inhibitor
External Link
TTD: DYH94Z
 Compound Name FN-1501 Phase 1 [14]
Synonyms
1429515-59-2; CHEMBL4077071; UNII-6MC966B505; TQR1001; BDBM50270304; NSC781143; 6MC966B505; NSC-781143; HY-111361; CS-0039834; 4((7HPyrrolo[2,3d]pyrimidin-4-yl)amino)N(4-((4-methylpiperazin-1-yl)methyl)phenyl)1Hpyrazole-3-carboxamide; 4-((7H-Pyrrolo (2,3-d)pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide; 4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-5-carboxamide; 4a?(7Ha'Pyrrolo[2,3a'd]pyrimidin-4-yl)amino)a'Na?4-((4-methylpiperazin-1-yl)methyl)phenyl)a?Ha'pyrazole-3-carboxamide; N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide
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MOA Inhibitor
External Link
CID: 72195175
TTD: DKCU40
 Compound Name RGB-286638 Phase 1 [15]
Synonyms
GPC-286199; RGB-286199; RGB-344064; Non-selective CDK inhibitors, Agennix; Non-selective CDK inhibitors, GPC Biotech; Non-selective cyclin dependent kinase inhibitors, Agennix; Non-selective cyclin dependent kinase inhibitors, GPC Biotech
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MOA Inhibitor
External Link
CID: 11285001
TTD: D03DKV
 Compound Name Fluorinated compound 1 Patented [16]
Synonyms
PMID26161698-Compound-15
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MOA Inhibitor
Activity IC50 = 1.7 nM
External Link
TTD: D09ISI
 Compound Name 4-amino-3,5-di-substituted-thiazole derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-54
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MOA Inhibitor
External Link
TTD: D0JU4Z
 Compound Name Indole-based analog 11 Patented [16]
Synonyms
PMID26161698-Compound-16
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MOA Inhibitor
Activity IC50 = 10 nM
External Link
TTD: D02KWX
 Compound Name N-(pyridin-2-yl)pyridine methylsulfone derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-27
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MOA Inhibitor
Activity IC50 = 170 nM
External Link
CID: 73508010
TTD: D03EYT
 Compound Name Palbociclib/ribociclib analog 1 Patented [16]
Synonyms
PMID26161698-Compound-4
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MOA Inhibitor
External Link
CID: 89798202
TTD: D03HED
 Compound Name Alkyl sulfone derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-29
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MOA Inhibitor
External Link
CID: 73672849
TTD: D05UJQ
 Compound Name Aniline derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-33
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MOA Inhibitor
Activity IC50 = 39 nM
External Link
CID: 59176838
TTD: D06QPW
 Compound Name 4-(thiazol-5-yl)-pyrimidine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-35
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MOA Inhibitor
Activity IC50 = 45 nM
External Link
CID: 44253187
TTD: D07QIP
 Compound Name N-phenyl-pyrimidin-4-amine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-30
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MOA Inhibitor
Activity IC50 = 1300 nM
External Link
CID: 74763288
TTD: D0AY5G
 Compound Name PMID26161698-Compound-25 Patented [16]
MOA Inhibitor
Activity IC50 = 260 nM
External Link
CID: 71618654
TTD: D0GQ7L
 Compound Name Diaryl amine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-23
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MOA Inhibitor
Activity IC50 = 2 to 6 nM
External Link
CID: 71515733
TTD: D0P4NP
 Compound Name Flavopiridol analog 1 Patented [16]
Synonyms
PMID26161698-Compound-5
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MOA Inhibitor
Activity IC50 = nM range
External Link
CID: 86272549
TTD: D0P9WR
 Compound Name Isosteric imidazolyl pyrimidine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-37
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MOA Inhibitor
Activity IC50 = 2 nM
External Link
CID: 44555024
TTD: D0QR1Z
 Compound Name N-(pyridin-2-yl)pyrimidin-4-amine derivative 2 Patented [16]
Synonyms
PMID26161698-Compound-31
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MOA Inhibitor
Activity IC50 = 63 nM
External Link
CID: 73891126
TTD: D0QS2B
 Compound Name Pyrazolo-triazine derivative 2 Patented [16]
Synonyms
PMID26161698-Compound-14
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MOA Inhibitor
External Link
CID: 71731909
TTD: D0T6CM
 Compound Name 1,5-di-substituted pyridine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-26
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MOA Inhibitor
Activity Kd < 100 nM
External Link
CID: 60197050
TTD: D0UU0V
 Compound Name 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-28
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MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 74767011
TTD: D0V7RP
 Compound Name Pyrrolo[2,3-d]pyrimidine derivative 9 Patented [16]
Synonyms
PMID26161698-Compound-1
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MOA Inhibitor
Activity IC50 < 1 nM
External Link
CID: 44818950
TTD: D08KKC
 Compound Name Naphthyridine and isoquinoline derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-51
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MOA Inhibitor
Activity IC50 = 40 nM
External Link
TTD: D08WJG
 Compound Name Nitrogen mustard derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-55
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MOA Inhibitor
Activity IC50 = 2.7 nM
External Link
CID: 71515463
TTD: D0LK4L
 Compound Name 4-(thiazol-5-yl)-pyrimidine derivative 2 Patented [16]
Synonyms
PMID26161698-Compound-36
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MOA Inhibitor
Activity Ki = single digit nM
External Link
CID: 71561915
TTD: D01CJE
 Compound Name Diamidothiazole derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-53
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MOA Inhibitor
External Link
CID: 25256147
TTD: D0LR2Y
 Compound Name Indole-based analog 13 Patented [16]
Synonyms
PMID26161698-Compound-20
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MOA Inhibitor
External Link
CID: 73293
TTD: D0LX6X
 Compound Name Pyrazolo[1,5-a]-1,3,5-triazine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-12
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MOA Inhibitor
Activity IC50 = 12 nM
External Link
TTD: D0NB7Y
 Compound Name Isoquinoline 1,3-dione derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-49
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MOA Inhibitor
Activity IC50 = 3100 nM
External Link
TTD: D0W4MN
 Compound Name Roscovitine derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-8
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MOA Inhibitor
Activity IC50 = nM range
External Link
CID: 73353575
TTD: D07DUX
 Compound Name PMID25991433-Compound-A1 Patented [17]
MOA Inhibitor
Activity IC50 = 300 nM
External Link
TTD: D0H4HD
 Compound Name Oxazolyl methylthiothiazole derivative 1 Patented [16]
Synonyms
PMID26161698-Compound-52
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MOA Inhibitor
Activity IC50 < 100 nM
External Link
CID: 25195503
TTD: D0M5DX
 Compound Name SCH 727965 Discontinued in Phase 3 [4]
Synonyms
Dinaciclib; SCH-727965
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MOA Inhibitor
Activity IC50 = 1 nM
External Link
CID: 46926350
TTD: D0D3PX
DrugBank: DB12021
 Compound Name BAY 10-00394 Discontinued in Phase 2 [18]
Synonyms
roniciclib; BAY 1000394; KB-145902; 1223498-69-8; Tube010; SCHEMBL875845; GTPL7874
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MOA Inhibitor
External Link
CID: 45380979
TTD: D0NV9O
 Compound Name R547 Discontinued in Phase 1 [4]
Synonyms
LIA; R-547; [4-amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone
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MOA Inhibitor
Activity Ki = 3 nM
External Link
CID: 6918852
TTD: D04FHB
DrugBank: DB08094
 Compound Name ZK 304709 Discontinued in Phase 1 [4]
Synonyms
1010440-84-2; ZK CDK; UNII-87GI98VT0I; SCHEMBL955299; 87GI98VT0I; DTXSID20143701
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MOA Inhibitor
External Link
CID: 59733314
TTD: D00VBT
 Compound Name INOC-005 Preclinical [19]
Synonyms
Capridine beta (prostate cancer), Prostagenics
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MOA Inhibitor
External Link
TTD: D07ZJC
 Compound Name L-751250 Preclinical [20]
Synonyms
Purvalanol B; 212844-54-7; PURVALANOL; Purvalanol B(NG-95); (R)-2-chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzoic acid; (2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL; CHEMBL23254; CHEBI:49840; NG 95; NG-95; C20H25ClN6O3; 2-chloro-4-[[2-[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]-9-propan-2-ylpurin-6-yl]amino]benzoic acid; J-502183; PVB
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MOA Inhibitor
Activity IC50 = 9 nM
External Link
CID: 448991
TTD: D0WS1V
DrugBank: DB02733
 Compound Name Olomoucine Terminated [20]
Synonyms
101622-51-9; 4erk; UNII-6A839B2HYS; 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6A839B2HYS; CHEMBL280074; 2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol; 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine; 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine; Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-; OLO; 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine
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MOA Inhibitor
Activity IC50 = 1200 nM
External Link
CID: 4592
TTD: D00BPA
DrugBank: DB02116
 Compound Name PD-0183812 Terminated [21]
Synonyms
PETCVZZPKYJZAU-UHFFFAOYSA-N; PD183812; AC1NS8PJ; CHEMBL139653; SCHEMBL5268115; BDBM6280; PD 0183812; N8 Pyrido[2,3-d]pyrimidin-7-one deriv 72; 8-{bicyclo[221]heptan-2-yl}-2-({4-[4-(3-hydroxypropyl)piperidin-1-yl]phenyl}amino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one; 8-(3-bicyclo[221]heptanyl)-2-[4-[4-(3-hydroxypropyl)piperidin-1-yl]anilino]pyrido[2,3-d]pyrimidin-7-one; PD0183813
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MOA Inhibitor
External Link
CID: 5330258
TTD: D0Z0KD
 Compound Name 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide Investigative [22]
Synonyms
CHEMBL487738; 4-(6-chloropyrazin-2-ylamino)benzenesulfonamide; 642459-21-0; 2vtj; SCHEMBL6659290; BDBM24631; ZINC16052861; DB08134; FT-0723597; 4-[(6-chloropyrazin-2-yl)amino]benzene-1-sulfonamide; 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide, 10
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MOA Inhibitor
Activity IC50 = 1900 nM
External Link
CID: 9994066
TTD: D01LPG
DrugBank: DB08134
 Compound Name PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE Investigative [22]
Synonyms
4-{[6-(2,6-Dichlorobenzoyl)imidazo[1,2-A]pyridin-2-Yl]amino}benzenesulfonamide; 1ykr; 4-[[6-(2,6-dichlorobenzoyl)imidazo[1,2-a]pyridin-2-yl]amino]benzenesulfonamide; aminoimidazo[1,2-a]pyridine deriv. 2i; AC1NS9IQ; CHEMBL182260; BDBM6670; DB04607; 4-({6-[(2,6-dichlorophenyl)carbonyl]imidazo[1,2-a]pyridin-2-yl}amino)benzenesulfonamide
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MOA Inhibitor
External Link
CID: 5330608
TTD: D03BZV
DrugBank: DB04607
 Compound Name 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE Investigative [22]
Synonyms
N-(3-chlorophenyl)-6-(cyclohexylmethoxy)-7H-purin-2-amine; 444722-81-0; 1h1r; AC1L1IG7; CHEMBL341273; SCHEMBL6790651; BDBM5531; CTK1D2420; DTXSID10274437; O6-Cyclohexylmethylguanine deriv. 15; DB07203; 2-(3 -Chloroanilino)-6-cyclohexylmethoxypurine; N-(3-chlorophenyl)-6-(cyclohexylmethoxy)-9H-purin-2-amine; N-(3-Chlorophenyl)-6-(cyclohexylmethoxy)-9H-purine-2-amine; 1H-Purin-2-amine, N-(3-chlorophenyl)-6-(cyclohexylmethoxy)-
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MOA Inhibitor
External Link
CID: 4565
TTD: D06FIQ
DrugBank: DB07203
 Compound Name BOHEMINE Investigative [23]
Synonyms
189232-42-6; 3-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)propan-1-ol; 3-{[6-(benzylamino)-9-(propan-2-yl)-9h-purin-2-yl]amino}propan-1-ol; CHEMBL83980; CHEBI:86007; 2-(3-Hydroxypropylamino)-6-benzylamino-9-isopropylpurine; [6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine; 2-[(3-hydroxypropyl)amino]-6-benzylamino-9-isopropylpurine; 3-{[6-(benzylamino)-9-isopropyl-9H-purin-2-yl]amino}propan-1-ol; purine deriv. 1; AC1L1DN2; SCHEMBL1443403; GTPL5938; BDBM10633; CTK8A4395; DTXSID00274365; EX-A931
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MOA Inhibitor
Activity IC50 = 800 nM
External Link
CID: 2422
TTD: D07ADR
 Compound Name N-phenyl-1H-pyrazole-3-carboxamide Investigative [22]
Synonyms
124828-46-2; CHEMBL445420; N-phenyl-1H-pyrazole-5-carboxamide; 1H-Pyrazole-3-carboxylic Acid Phenylamide; MLS000519301; 2vtl; pyrazole amide, 15; pyrazole-5-carboxanilide; ChemDiv2_004267; AC1LE63W; SCHEMBL19748; N-phenylpyrazol-3-ylcarboxamide; SCHEMBL13373589; BDBM24636; MolPort-001-664-649; HMS2155C18; HMS3604B14; HMS1381B21; HMS3323C02; ALBB-018739; ZINC5286379; STK926745; BDBM50109707; AKOS000321787; DB08135; 1H-pyrazole-3-carboxamide, N-phenyl-; MCULE-7079696193; IDI1_002982; ST034406
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MOA Inhibitor
Activity IC50 = 97000 nM
External Link
CID: 680935
TTD: D07ODE
DrugBank: DB08135
 Compound Name 5-hydroxynaphthalene-1-sulfonamide Investigative [22]
Synonyms
17286-26-9; 5-Hydroxynaphthalene-1-sulphonamide; NFVBVKHGDDDCEA-UHFFFAOYSA-N; 5-Hydroxy-1-naphthalenesulfonamide; 5-hydroxy-naphthalene-1-sulfonic acid amide; 2vth; EINECS 241-319-7; AC1L3CSX; AC1Q6ULI; SCHEMBL588923; CHEMBL457047; CTK4D4388; NFVBVKHGDDDCEA-UHFFFAOYSA-; BDBM24628; DTXSID50169414; ZINC2242749; 5-hydroxy-1-naphthalenesulphonamide; 1-Naphthalenesulfonamide,5-hydroxy-; 1-Naphthalenesulfonamide, 5-hydroxy-; 5-hydroxynaphthalene-1-sulfonamide, 7; AKOS030618521; DB08132; TX-017211
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 120000 nM
External Link
CID: 87031
TTD: D07SGT
DrugBank: DB08132
 Compound Name N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide Investigative [22]
Synonyms
N-(4-Sulphamoylphenyl)-1H-indazole-3-carboxamide; 660822-60-6; 2vti; indazole amide, 14; CHEMBL455946; SCHEMBL4524087; BDBM24635; MNHPHKFLWAPNOV-UHFFFAOYSA-N; ZINC15270554; DB08133; DA-41761; FT-0707176; 1H-Indazole-3-carboxylic acid (4-sulphamoyl-phenyl)-amide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 660 nM
External Link
CID: 9926933
TTD: D0D3HB
DrugBank: DB08133
 Compound Name N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE Investigative [22]
Synonyms
2365-40-4; Isopentenyladenine; N6-Isopentenyladenine; N6-(2-Isopentenyl)adenine; Isopentenyl adenine; 6-(gamma,gamma-Dimethylallylamino)purine; IPADE; Dimethylallyladenine; N6-(2-Isopentenyl)-adenine; N6-Dimethylallyladenine; N6-(delta2-Isopentenyl)adenine; N-(3-Methyl-2-butenyl)adenine; N6-(3-Methyl-2-butenyl)adenine; N6-(delta 2-Isopentenyl)-adenine; N(6)-(delta(2)-Isopentenyl)adenine; 1H-Purin-6-amine, N-(3-methyl-2-butenyl)-; N-(3-methylbut-2-enyl)-7H-purin-6-amine; Adenine, N-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 92180
TTD: D0I1SZ
DrugBank: DB08768
 Compound Name 1-Amino-6-Cyclohex-3-Enylmethyloxypurine Investigative [24]
Synonyms
872556-74-6; 4-(cyclohexylmethoxy)-1H-imidazo[4,5-c]pyridin-6-amine; AC1L9IVC; CTK2I2667; DTXSID90332206; 3h-imidazo[4,5-c]pyridin-6-amine,4-(cyclohexylmethoxy)-; ZINC20149007; AKOS030619175; DB02603; KB-268453; 1H-Imidazo[4,5-c]pyridin-6-amine, 4-(cyclohexylmethoxy)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 445967
TTD: D0I9VN
DrugBank: DB02603
 Compound Name Benzyl-(9-isopropyl-9H-purin-6-yl)-amine Investigative [23]
Synonyms
CHEMBL85015; 111853-20-4; 9H-Purin-6-amine, 9-(1-methylethyl)-N-(phenylmethyl)-; purine deriv. 9; ACMC-20mewm; SCHEMBL754120; BDBM10641; CTK0D3360; DTXSID10444118; 6-(benzylamino)-9-isopropylpurine; ZINC13538226; AKOS030562149; 6-(Benzylamino)-9-isopropyl-9H-purine; N-benzyl-9-isopropyl-9H-purin-6-amine
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4500 nM
External Link
CID: 10730551
TTD: D0M5PI
 Compound Name N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide Investigative [24]
Synonyms
CHEMBL324942; N-(3-cyclopropyl-1H-pyrazol-5-yl)benzamide; N5B; 1vyz; AC1L9MPJ; SCHEMBL4314346; BDBM7127; LUCORKWTQSQFFU-UHFFFAOYSA-N; 3-Benzamidoaminopyrazole deriv. 4; DB02647
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MOA Inhibitor
Activity IC50 = 289.73 nM
External Link
CID: 449088
TTD: D0MK6D
DrugBank: DB02647
 Compound Name TRIAZOLOPYRIMIDINE Investigative [22]
Synonyms
8-Azapurine; 273-40-5; 2H-triazolo[4,5-d]pyrimidine; 179268-22-5; 6H-1,2,3-Triazolo[4,5-d]pyrimidine; 2H-1,2,3-Triazolo[4,5-d]pyrimidine; 3H-1,2,3-Triazolo[4,5-d]pyrimidine; 3H-[1,2,3]triazolo[4,5-d]pyrimidine; triazolo[4,5-d]pyrimidine; triazolo(4,5-d)pyrimidine; 273-39-2; 99331-25-6; 3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDINE; ACMC-1CNOM; AC1L22AZ; SCHEMBL26606; 179268-21-4; SCHEMBL11026556; CTK1A0899; CTK0H1173; CTK0H1170; CTK3G7531; CTK0H1174; DTXSID80181745; GIIGHSIIKVOWKZ-UHFFFAOYSA-N; ZINC2020258; ACM273405; FCH907879; AKOS006372727
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 64962
TTD: D0P7RO
 Compound Name 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE Investigative [22]
Synonyms
6-(cyclohexylmethoxy)-N-phenyl-7H-purin-2-amine; CHEMBL122264; 444722-80-9; 2A6; NU-6094; 1h1q; AC1L1BOU; SCHEMBL6791643; BDBM5530; CTK1D2421; DTXSID30274313; XWWRLKIBRPJQJX-UHFFFAOYSA-N; O6-Cyclohexylmethylguanine deriv 2; AKOS030619892; DB06948; N-Phenyl-6-(cyclohexylmethoxy)-9H-purine-2-amine; 6-(cyclohexylmethoxy)-N-phenyl-9H-purin-2-amine; 1H-Purin-2-amine,
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MOA Inhibitor
Activity IC50 = 2300 nM
External Link
CID: 1540
TTD: D0QI7H
DrugBank: DB06948
 Compound Name SCH-546909 Investigative [25]
Synonyms
CDK2 inhibitors (cancer), Merck & Co; CDK2 inhibitors (cancer), Schering-Plough; Cyclindependent kinase 2 inhibitors (cancer), Schering-Plough
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MOA Inhibitor
Activity IC50 = 140 nM
External Link
CID: 10356352
TTD: D0T4SJ
 Compound Name PHA-690509 Investigative [26]
Synonyms
PHA-404611; PHA-533533; PNU-252808; PNU-292137; CDK inhibitors (cancer), Nerviano; Cyclin dependent kinase inhibitors (cancer), Nerviano; CDK-2 inhibitors (anticancer), Pfizer; CDK-2 inhibitors (anticancer), Pharmacia
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9902100
TTD: D0T5AH
 Compound Name 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine Investigative [24]
Synonyms
364334-94-1; 4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-amine; 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE; CTFDMGIBHFQWKB-UHFFFAOYSA-N; 4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-ylamine; CK2; 4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine; 1pxj; 2c5o; AC1L9LFI; Maybridge3_001247; CHEMBL47302; CS12; SCHEMBL4314069; BDBM8037; CTK4H6460; DTXSID70332264; MolPort-002-896-655; HMS1434I15; ZINC141286; HMS3604E21; ANW-58550; 4623AB; AKOS013063215; MCULE-3137548628; DB02091; CCG-243780
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MOA Inhibitor
Activity Ki = 396 nM
External Link
CID: 447956
TTD: D0U0GE
DrugBank: DB02091
 Compound Name VER-54505 Investigative [25]
Synonyms
Cdk2 inhibitors, Vernalis; RBT-0049985
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MOA Inhibitor
External Link
TTD: D0V1NK
 Compound Name 2-Amino-6-Chloropyrazine Investigative [24]
Synonyms
33332-28-4; 6-chloropyrazin-2-amine; 2-chloro-6-aminopyrazine; Pyrazinamine, 6-chloro-; 2-Pyrazinamine, 6-chloro-; 6-Chloro-pyrazin-2-ylamine; 6-chloropyrazin-2-ylamine; 2-amino-6-chloro-pyrazine; CHEMBL191632; 6-CHLORO-2-PYRAZINAMINE; CIG; 6-chlorpyrazin-2-amin; 1wcc; PubChem8543; zlchem 1337; AI3-61778; AC1Q3PRB; AC1L3MZH; ACMC-209i0e; 6-chloropyrazine-2-ylamine; SCHEMBL67803; 6-chloro-pyrazin-2-yl-amine; 6-chloropyrazin-2-amine, 5; KSC222G6J; AC1Q52Q1; Jsp006119; DTXSID0067761; CTK1C2364; BDBM24626; ZLE0115
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 350000 nM
External Link
CID: 118458
TTD: D0W0PF
DrugBank: DB02297
 Compound Name 6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine Investigative [22]
Synonyms
CHEMBL340813; 4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}phenol; N20; NU-6086; 1oi9; AC1L9L2Q; BDBM5541; SCHEMBL6792176; O6-Cyclohexylmethylguanine deriv 25; DB08233; 6-Cyclohexylmethoxy-2-(4 -hydroxyanilino)purine
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1000 nM
External Link
CID: 447649
TTD: D0Y6DX
DrugBank: DB08233
 Compound Name 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine Investigative [27]
Synonyms
CHEMBL115498; O6-Substituted Guanine Deriv. 27; AC1NS6ZQ; 9H-Purin-2-amine, 6-(3-cyclohexen-1-ylmethoxy)-; SCHEMBL6267556; BDBM5487; 220035-95-0; 6-(cyclohex-3-en-1-ylmethoxy)-9H-purin-2-amine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5329512
TTD: D01FJB
 Compound Name (2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222473
TTD: D01PSU
 Compound Name 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine Investigative [29]
Synonyms
6-(cyclohexylmethoxy)pyrimidine-2,4,5-triamine; pyrimidine deriv. 16; AC1NS76Q; CHEMBL71036; BDBM5588; SCHEMBL6263731; IMNSQZHRHASLAR-UHFFFAOYSA-N
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5329597
TTD: D02ZYA
 Compound Name (2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222697
TTD: D03KLM
 Compound Name 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine Investigative [27]
Synonyms
O6-Substituted Guanine Deriv. 32; CHEMBL405773; BDBM5492; AC1NS702; SCHEMBL12227591; O6-[3-(Methyl)Benzyl]Guanine; ZINC13475147; 2-Amino-6-(3 -methylbenzyl)oxypurine; 6-[(3-methylphenyl)methoxy]-9H-purin-2-amine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5329516
TTD: D03XKK
 Compound Name (2'Z,3'E)-5-Fluoro-5'-methoxy-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46223585
TTD: D04AGE
 Compound Name JNJ-7706621 Investigative [30]
Synonyms
443797-96-4; JNJ7706621; 4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide; UNII-74GK72DON8; RWJ-387252; 4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide; CHEMBL191003; 74GK72DON8; 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide; JNJ 7706621; 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzenesulfonamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2 nM
External Link
CID: 5330790
TTD: D04NGS
 Compound Name GW-8510 Investigative [31]
MOA Inhibitor
Activity IC50 = 9.7 nM
External Link
CID: 3536
TTD: D04RBG
 Compound Name BMS-265246 Investigative [32]
Synonyms
BMS 265246; BMS265246
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 135402864
TTD: D05SZH
 Compound Name (2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222694
TTD: D06GLV
 Compound Name (2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222474
TTD: D06XIW
 Compound Name RESCOVITINE Investigative [33]
Synonyms
CHEMBL1087791
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 46881287
TTD: D07AEC
 Compound Name Cdk4 inhibitor III Investigative [34]
Synonyms
Ryuvidine; 265312-55-8; CHEMBL290904; 2-Methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione; 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole; 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione; AC1Q6BBC; AC1LA59T; 2-Methyl-5-p-tolylamino-benzothiazole-4,7-dione; SCHEMBL2169284; GTPL5952; CTK4F8075; CHEBI:92119; AOB6479; MolPort-023-276-509; HMS3269F11; HMS3229E08; ZINC5930916; BDBM50086655; 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE; AKOS024457195; CCG-206830
    Click to Show/Hide
MOA Inhibitor
Activity IC50 > 200000 nM
External Link
CID: 481747
TTD: D07HPE
 Compound Name 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine Investigative [27]
Synonyms
O6-Substituted Guanine Deriv. 33; BDBM5493; CHEMBL270977; AC1NS705; 2-Amino-6-(3 -aminobenzyl)oxypurine; 6-[(3-aminophenyl)methoxy]-9H-purin-2-amine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5329517
TTD: D07JHG
 Compound Name (2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222693
TTD: D0B1LM
 Compound Name 2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol Investigative [35]
MOA Inhibitor
External Link
CID: 44417638
TTD: D0F3OM
 Compound Name 5-nitroindirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 11450099
TTD: D0GP3R
 Compound Name (2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222696
TTD: D0H0EN
 Compound Name (2'Z,3'E)-5-Nitro-5'-chloro-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222472
TTD: D0I6AE
 Compound Name (2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222470
TTD: D0J3RS
 Compound Name (2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222245
TTD: D0JR0G
 Compound Name 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline Investigative [36]
Synonyms
whi-p180; 211555-08-7; 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol; WHI-P180, Hydrochloride; JANEX 3; CHEMBL127907; 3-((6,7-Dimethoxyquinazolin-4-yl)amino)phenol; AK341047; DTQ; 4-(3&amp; -Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, HCl; JANEX-3; 4btk; 1di8; AC1L1KWT; AC1Q4XVE; 3-(6,7-dimethoxyquinazolin-4-ylamino)phenol; Anilinoquinazoline deriv 5; WHI-P180(Janex 3); BDBM4622; SCHEMBL1180103; CTK4E5981; AOB5495; MolPort-000-672-017; BNDYIYYKEIXHNK-UHFFFAOYSA-N; HMS3229P15
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1000 nM
External Link
CID: 5687
TTD: D0KH5T
DrugBank: DB03365
 Compound Name (2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222476
TTD: D0L5PI
 Compound Name (2'Z,3'E)-5-Nitro-5'-methoxy-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46223584
TTD: D0M4XD
 Compound Name Oxindole 95 Investigative [20]
MOA Inhibitor
External Link
TTD: D0MS4R
 Compound Name CVT-313 Investigative [25]
Synonyms
AC1OCFD4; NG 26
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 6918386
TTD: D0P2WA
 Compound Name 6-O-Cyclohexylmethyl Guanine Investigative [24]
Synonyms
6-(Cyclohexylmethoxy)-9H-purin-2-amine; nu2058; 161058-83-9; 2-amino-6-[(cyclohexylmethyl)oxy]purine; NU 2058; 2-amino-6-cyclohexylmethoxypurine; NU-2058; O6-Cyclohexylmethylguanine; CHEMBL269881; 1e1v; 1h1p; O-Cyclohexylmethylguanine; AC1Q4XUD; 9H-Purin-2-amine, 6-(cyclohexylmethoxy)-; O6-Cyclohexylmethyl guanine; AC1L1IG4; MLS001074898; SCHEMBL3462331; BDBM5485; CTK8D6642; CTK0E6580; EX-A790; AOB6207; MolPort-033-437-778; MolPort-003-958-993; MolPort-044-561-861; HMS3372K06; HMS3262L18; HMS2233F06
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1200 nM
External Link
CID: 4564
TTD: D0R1FT
DrugBank: DB02407
 Compound Name NU-6027 Investigative [29]
MOA Inhibitor
Activity Ki = 1300 nM
External Link
CID: 398148
TTD: D0U8YN
DrugBank: DB08312
 Compound Name NSC-625987 Investigative [37]
Synonyms
NSC 625987
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MOA Inhibitor
External Link
CID: 3004085
TTD: D0VD8B
 Compound Name (2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222698
TTD: D0W2FM
 Compound Name (2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime Investigative [28]
MOA Inhibitor
External Link
CID: 46222244
TTD: D0YZ9Y
 Compound Name aloisine Investigative [38]
Synonyms
IN1538; RP106
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MOA Inhibitor
External Link
CID: 3641059
TTD: D00SEC
 Compound Name MERIOLIN 8 Investigative [39]
Synonyms
SCHEMBL2991886; CHEMBL406102
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MOA Inhibitor
External Link
CID: 24801181
TTD: D01PEF
 Compound Name PYRAZOLOPYRIDAZINE 1 Investigative [40]
Synonyms
551920-54-8; GW810576X; n-(3-methoxyphenyl)-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine; pyrazolo[1,5-b]pyridazine deriv. 19; AC1O6ZIQ; CHEMBL187081; BDBM8128; SCHEMBL4489357; CTK1F7320; DTXSID60424889; HMS3305F24; HMS3303K24; ZINC13582569; NCGC00242229-01; DA-42106; FT-0707969; AB01092291-01; 2-Pyrimidinamine, N-(3-methoxyphenyl)-4-pyrazolo[1,5-b]pyridazin-3-yl-; N-(3-methoxyphenyl)-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.995 nM
External Link
CID: 6539361
TTD: D02DLC
 Compound Name Purvalanol A Investigative [41]
Synonyms
Purvalanola; AC1L1JD0; IN1131; 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine; SCHEMBL3311119; GTPL6030; CTK8F1120; CHEBI:93781; HMS3229M14; KS-00001DB0; HSCI1_000128; AKOS030238850; CCG-206875; RT-015158; K00014; 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
CID: 456214
TTD: D07OAT
DrugBank: DB04751
 Compound Name Cdk1/2 inhibitor III Investigative [42]
Synonyms
443798-55-8; CDK 1/2 INHIBITOR; UNII-LFR1253W75; LFR1253W75; 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE; 5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide; 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide; 2wu6; AC1NS9OB; CHEMBL261720; GTPL5946; BDBM6878; SCHEMBL1394721; CTK8E9250; DTXSID60416209; MolPort-044-561-528; HMS3229C16; ZINC12355112; DB07664
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5330812
TTD: D07OCA
DrugBank: DB07664
 Compound Name MERIOLIN 1 Investigative [39]
Synonyms
341998-55-8; 4-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIMIDIN-2-AMINE; 2-Pyrimidinamine, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-; SCHEMBL2241315; CHEMBL405665; HQHSJJZIICGOIX-UHFFFAOYSA-; CTK1B7876; DTXSID60469811; BDBM50371404; ZINC29135178; AKOS027252841; 4-(7-aza-indol-3-yl)-2-amino pyrimidine; 3-(2-Amino-4-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11637090
TTD: D08KSQ
 Compound Name MERIOLIN 4 Investigative [39]
Synonyms
SCHEMBL3001373; CHEMBL406464
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24801697
TTD: D0B9YR
 Compound Name Lysine Nz-Carboxylic Acid Investigative [24]
Synonyms
N(6)-carboxylysine; N(6)-carboxy-L-lysine; (2S)-2-amino-6-(carboxyamino)hexanoic acid; N~6~-carboxy-L-lysine; SCHEMBL357483; CHEBI:43575; ZINC6753301
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 17754054
TTD: D0CC0B
DrugBank: DB03801
 Compound Name MERIOLIN 6 Investigative [39]
Synonyms
CHEMBL406463; SCHEMBL2999009
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24801185
TTD: D0D0ZQ
 Compound Name K00024 Investigative [43]
Synonyms
indolocarbazole deriv. 4(d)
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5330797
TTD: D0D5HQ
 Compound Name 10Z-Hymenialdisine Investigative [20]
Synonyms
Hymenialdisine; (Z)-Hymenialdisine; CHEMBL361708; 95569-43-0; 82005-12-7; (4Z)-4-(2-amino-4-oxo-1H-imidazol-5-ylidene)-2-bromo-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one; Hymenialdisine, 1; 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one; AC1MHZEP; SCHEMBL155899; STO156; BDBM7491; SCHEMBL15426167; MolPort-006-394-608; 4-(2-Amino-5-oxo-3,5-dihydro-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one; NSC607173
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 135413546
TTD: D0F0AX
 Compound Name aminopurvalanol A Investigative [44]
Synonyms
NG-97
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 6604931
TTD: D0G2GA
 Compound Name 9-Nitropaullone Investigative [20]
Synonyms
Alsterpaullone; 237430-03-4; NSC 705701; NSC-705701; CHEMBL50894; MLS002702475; 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; 9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one; 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one; 9-NITRO-5,12-DIHYDRO-7H-BENZO[2,3]AZEPINO[4,5-B]INDOL-6-ONE; Paullone Analog 1; AC1NMCUD; Kinome_3754; 1q3w; Alsterpaullone derivative, 2; Lopac0_000057; CBiol_001723; GTPL5925; BDBM7262; SCHEMBL2170104; CTK8F0374; ZINC23894; BDBM84528; DTXSID50407444
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 15 nM
External Link
CID: 5005498
TTD: D0H3EV
DrugBank: DB04014
 Compound Name MERIOLIN 5 Investigative [39]
Synonyms
1011711-76-4; 4-(4-Propoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-Amine; 4-{4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrimidin-2-amine; SCHEMBL2997013; CHEMBL270687; ZINC16052674; BDBM50371400; DB08182
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23727982
TTD: D0H6CQ
DrugBank: DB08182
 Compound Name SU9516 Investigative [20]
Synonyms
377090-84-1; SU 9516; SU-9516; AC1NRD9P; 666837-93-0; (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE; (Z)-3-((1H-imidazol-5-yl)methylene)-5-methoxyindolin-2-one; (3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3-dihydro-1H-indol-2-one; 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one; SU9; (Z)-1,3-DIHYDRO-3-(1H-IMIDAZOL-4-YLMETHYLENE)-5-METHOXY-2H-INDOL-2-ONE; 3py1; 3py0; imidazole indolinone driv.; MLS001074893; SCHEMBL1170686; BDBM7238; SCHEMBL1170687; CHEMBL258805
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 22 nM
External Link
CID: 5289419
TTD: D0L3FK
DrugBank: DB03428
 Compound Name PYRAZOLOPYRIDAZINE 2 Investigative [40]
Synonyms
pyrazolo[1,5-b]pyridazine deriv. 25; AC1O6ZJ2; BDBM8134; CHEMBL186054; N-(3,4-dimethoxyphenyl)-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 50 nM
External Link
CID: 6539367
TTD: D0O0VP
 Compound Name MERIOLIN 3 Investigative [39]
Synonyms
954143-48-7; 4-(4-Methoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-Amine; 4-{4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrimidin-2-amine; SCHEMBL2996575; CHEMBL270686; BDBM50371402; ZINC16052675; DB08178; KB-274295
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23727981
TTD: D0S8VE
DrugBank: DB08178
 Compound Name MERIOLIN 2 Investigative [39]
Synonyms
SCHEMBL2999865; CHEMBL270897; 1H-Pyrrolo[2,3-b]pyridin-4-ol, 3-(2-amino-4-pyrimidinyl)-; BDBM50371403; 954143-47-6
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24801699
TTD: D0U1WL
 Compound Name PMID18986805C9b Investigative [45]
Synonyms
GTPL8160; BDBM50246396; ZINC38224644
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 1 nM
External Link
CID: 11675054
TTD: D0P6JS
 Compound Name 3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol Investigative [35]
MOA Inhibitor
External Link
CID: 9964499
TTD: D0W0BL
 Compound Name Indirubin-5-sulfonate Investigative [20]
Synonyms
indirubin-5-sulphonate; CHEMBL1207227; 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID; INR; AC1NRBUE; AC1NZHHM; 1v0o; AC1O8NUW; Indirubin derivative, 20; SCHEMBL490806; BDBM84534; A05-A11B1-I; NSC717821; BDBM50023871; NSC-717821; DB02519; NCI60_040625; 2-oxo-3-(3-oxo-1H-indol-2-ylidene)-1H-indole-5-sulfonic acid; (3Z)-2-oxo-3-(3-oxoindolin-2-ylidene)indoline-5-sulfonic acid; (3E)-2-oxo-3-(3-oxo-1H-indol-2-ylidene)-1H-indole-5-sulfonic acid; (2Z)-2',3-dioxo-1,1',2',3-tetrahydro-2,3'-biindole-5'-sulfonic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 22 nM
External Link
CID: 3708
TTD: D0G2CT
DrugBank: DB02519
 Compound Name N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide Investigative [46]
Synonyms
Kinome_3019; CHEMBL210032; SCHEMBL1145340; BDBM15968; Aminopyridine-Based Inhibitor 24
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1300 nM
External Link
CID: 11658882
TTD: D0S7IE
 Compound Name NU-6102 Investigative [47]
Synonyms
nu6102; 444722-95-6; NU 6102; O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE; Cdk1/2 Inhibitor II, NU6102; 6-Cyclohexylmethoxy-2-(4&amp; -sulfamoylanilino)purine; 4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benzenesulfonamide; 4SP; 1h1s; 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide; 4-{[6-(cyclohexylmethoxy)-7h-purin-2-yl]amino}benzenesulfonamide; 4-[[6-(cyclohexylmethoxy)-9h-purin-2-yl]amino]benzenesulfonamide; 4eor; 4eok; 2iw9; 2c6o; 2iw8; AC1L1IGA; SCHEMBL2170816; CHEMBL319467
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5 nM
External Link
CID: 4566
TTD: D0Y5RO
DrugBank: DB07126
 Compound Name PF-228 Investigative [48]
Synonyms
869288-64-2; PF-573228; PF 573228; PF573228; CHEMBL514554; 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone; 6-((4-((3-(Methylsulfonyl)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(1H)-one; 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one; 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11612883
TTD: D02QAZ
 Compound Name aloisine A Investigative [49]
Synonyms
4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; 496864-16-5; RP107; 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE; CHEMBL75680; 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine; RP-107; ALH; 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol; 1ung; SCHEMBL80147; BDBM7377; GTPL5924; AC1NS169; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol; CHEBI:93641; CTK8D4068; DTXSID30416115; HMS3229A14; RM-39; BCP26893; ZINC2540737; ACT06534; IN1539; HSCI1_000219; MFCD04973541; AKOS005145972; CCG-206814; DB07364; RTC-063070; AJ-39131
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 448912
TTD: D02XHC
DrugBank: DB07364
 Compound Name NU6140 Investigative [50]
Synonyms
Cdk2 Inhibitor IV, NU6140; 444723-13-1; NU 6140; CHEMBL1802728; 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide; 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide; Cdk2 inhibitor IV; SCHEMBL2169233; GTPL5949; CTK8E7940; DTXSID30436732; MolPort-023-276-742; MolPort-044-561-419; HMS3229E18; IN1369; ZINC22309248; BDBM50347924; AKOS024457537; CCG-206836; NCGC00370819-01; NU6140, &gt; RT-011957; 4-(6-cyclohexylmethoxy-9hpurin-2-ylamino)-N,N-diethyl-benzamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 400 nM
External Link
CID: 10202471
TTD: D04WFN
 Compound Name BX-912 Investigative [51]
Synonyms
BX 912; BX912
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11754511
TTD: D0IX7Y
 Compound Name BX-795 Investigative [51]
Synonyms
BX795; BX 795
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10077147
TTD: D0RG0Z
 Compound Name PMID19115845C89S Investigative [52]
Synonyms
3du8; GTPL8114; BDBM27380; DB07149
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 138 nM
External Link
CID: 16757525
TTD: D0T8NU
DrugBank: DB07149
 Compound Name Indirubin-3'-monoxime Investigative [20]
Synonyms
indirubin-3'-oxime; 160807-49-8; indirubin-3-oxime; Indirubin-3monoxime; Indirubin-3-monoxime; 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one; CHEBI:43645; Indirubin 3'-monoxime; indirubin-3'-monooxime; Indirubin-3&amp; CHEMBL216543; CHEMBL126077; (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME; UNM-0000305771; 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one; 667463-82-3; IXM; SR-01000075929; Indirubin-3; Indirubin 3-oxime; Tocris-1813; BiomolKI_000070
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 3707
TTD: D0Y0ES
DrugBank: DB02052
 Compound Name Double Oxidized Cysteine Investigative [24]
MOA Inhibitor
External Link
CID: 6398956
TTD: D0H1GU
 Compound Name 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione Investigative [53]
Synonyms
CHEMBL380598; SCHEMBL3148490; HVQJGNALTWNDMX-UHFFFAOYSA-N; BDBM50375058; 2-(1H-Indole-3-yl)-3-phenylmaleimide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 15422868
TTD: D06AOY
 Compound Name BMS-536924 Investigative [54]
MOA Inhibitor
External Link
CID: 135440466
TTD: D0M4SY
 Compound Name 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione Investigative [53]
Synonyms
1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-; 108774-82-9; ACMC-20mbs9; CHEMBL381099; CTK0G2626; DTXSID90449388
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10946795
TTD: D00NYT
 Compound Name 3,4-diphenyl-1H-pyrrole-2,5-dione Investigative [53]
Synonyms
2,3-diphenylmaleimide; 1H-Pyrrole-2,5-dione, 3,4-diphenyl-; 31295-36-0; AC1MBL6S; SCHEMBL114611; CHEMBL201949; CTK1B9880; 3,4-diphenylpyrrole-2,5-dione; DTXSID70372903; ZINC3847556
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 2752461
TTD: D0C3WY
 Compound Name 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione Investigative [53]
Synonyms
CHEMBL372076; SCHEMBL3822337
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11572699
TTD: D0EK0G
 Compound Name 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol Investigative [35]
MOA Inhibitor
External Link
CID: 9859248
TTD: D0A5RM
Histone acetyltransferase p300 (P300) 2 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name CCS1477 Phase 1/2 [55]
Synonyms
CCS-1477; CBP-IN-1; 2222941-37-7; (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; SCHEMBL20094038; SCHEMBL21515367; SCHEMBL22134021; EX-A3687; NSC818619; NSC-818619; HY-111784; CS-0091862; (S)-1-(3,4-Difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-(trans-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 134457551
TTD: DIY4C2
 Compound Name FT-7051 Phase 1 [56]
MOA Inhibitor
External Link
TTD: DT8IL6
9B71: Retinopathy 12 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name SHP607 Phase 2 [57]
External Link
TTD: D0R1JO
 Compound Name RST-001 Phase 1/2 [58]
Synonyms
ChR2 gene therapy (retinopathy), RetroSense; AAV-based ChR2 gene therapy (retinopathy), RetroSense; Channelrhodopsin-2 gene therapy (retinopathy), RetroSense
    Click to Show/Hide
External Link
TTD: D0RM6A
 Compound Name ReN-003 Phase 1/2 [59]
Synonyms
Stem cell therapy (retinal diseases), ReNeuron
    Click to Show/Hide
External Link
TTD: D03OVN
 Compound Name PMID28621580-Compound-WO2015089220C70 Patented [60]
External Link
TTD: D07AVU
 Compound Name SIR-1076 Preclinical [61]
Synonyms
Antioxidants (topical, retinal oxidative stress), Sirion Therapeutics
    Click to Show/Hide
External Link
TTD: D06RVY
 Compound Name CytoRet Investigative [59]
Synonyms
Retinal cell therapy (retinal disease), International Stem Cell; Retinal layers (parthenogenetic stem-cell derived), ISCO
    Click to Show/Hide
External Link
TTD: D0V4YT
 Compound Name LPO-1010CSR Investigative [59]
External Link
TTD: D0MH8K
 Compound Name INDUS-815C Investigative [62]
Synonyms
VEGF modulator (age related macular degeneration/retinopathy), Indus Biotech; INDUS-815C (Huntington's disease), Indus Biotech; INDUS-815C (age related macular degeneration/retinopathy), Indus Biotech; SIRT2 inhibtior (Parkinson's disease/dementia/Huntington's disease), Indus Biotech; NAD-dependent deacetylase sirtuin-2inhibitor (Parkinson's disease/dementia/Huntington's disease), Indus Biotech
    Click to Show/Hide
External Link
TTD: D0IR8J
 Compound Name SF-113 Investigative [59]
External Link
TTD: D0I2AD
 Compound Name SF-106 Investigative [59]
External Link
TTD: D07DRO
 Compound Name Gene therapy, retinopathy, Investigative [59]
Synonyms
Gene therapy (retinopathy)
    Click to Show/Hide
External Link
TTD: D04ENF
 Compound Name Superoxide dismutase mimetics Investigative [59]
Synonyms
INO-6001; INO-6002; Superoxide dismutase mimetics (retinal disease); Superoxide dismutase mimetics (retinal disease), Inotek; Superoxide dismutase mimetics (age-related macular degeneration/diabetic retinopathy/diabetic macular edema), Inotek
    Click to Show/Hide
External Link
TTD: D03KRF
References
Ref 1 Author Correction: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. EMBO Mol Med. 2025 Apr 25. doi: 10.1038/s44321-025-00238-y. Online ahead of print.
Ref 2 Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. J Med Chem. 2009 Aug 27;52(16):5152-63. doi: 10.1021/jm9006559.
Ref 3 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
Ref 4 Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. doi: 10.1038/nrd2907.
Ref 5 Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42. doi: 10.2174/187231212800229336.
Ref 6 ClinicalTrials.gov (NCT04541225) Phase 1/2 Dose Escalation, Safety, Pharmacokinetics, and Efficacy Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors. U.S.National Institutes of Health.
Ref 7 AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14. doi: 10.1016/j.ijrobp.2012.05.035. Epub 2012 Jul 12.
Ref 8 Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009 Feb;8(2):324-32. doi: 10.1158/1535-7163.MCT-08-0890. Epub 2009 Jan 27.
Ref 9 ClinicalTrials.gov (NCT04553133) PF-07104091 as a Single Agent and in Combination Therapy. U.S. National Institutes of Health.
Ref 10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 11 A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors. Cell Cycle. 2011 Mar 15;10(6):963-70. doi: 10.4161/cc.10.6.15075. Epub 2011 Mar 15.
Ref 12 Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45. doi: 10.1182/blood-2008-12-190256. Epub 2009 Feb 20.
Ref 13 Clinical pipeline report, company report or official report of Regor Therapeutics
Ref 14 Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. doi: 10.1021/acs.jmedchem.7b01261. Epub 2018 Feb 12.
Ref 15 Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75. doi: 10.1038/leu.2013.194. Epub 2013 Jun 28.
Ref 16 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014). Expert Opin Ther Pat. 2015;25(9):953-70. doi: 10.1517/13543776.2015.1045414. Epub 2015 Jul 13.
Ref 17 c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014). Expert Opin Ther Pat. 2015;25(8):849-72. doi: 10.1517/13543776.2015.1039984. Epub 2015 May 19.
Ref 18 National Cancer Institute Drug Dictionary (drug id 770319).
Ref 19 What are next generation innovative therapeutic targets? Clues from genetic, structural, physicochemical, and systems profiles of successful targets. J Pharmacol Exp Ther. 2009 Jul;330(1):304-15. doi: 10.1124/jpet.108.149955. Epub 2009 Apr 8.
Ref 20 Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. doi: 10.1016/s0165-6147(02)02071-0.
Ref 21 Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. doi: 10.1021/jm000271k.
Ref 22 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. doi: 10.1093/nar/28.1.235.
Ref 23 Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2. J Med Chem. 2000 Jun 29;43(13):2506-13. doi: 10.1021/jm990506w.
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