m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03083
 [1]
m6A modification HDAC4 HDAC4 YTHDF2 : m6A sites Direct Enhancement Histone modification HIF1A HDAC4 Downstream Gene
m6A Modification:
m6A Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
m6A Target Histone deacetylase 4 (HDAC4)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone deacetylase 4 (HDAC4) ERASER View Details
Regulated Target Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes
Crosstalk Summary m6A methylation recognized by m6A reader-YTHDF2 enhanced the stability of Histone deacetylase 4 (HDAC4), and then promoted glycolytic metabolism and migration of PC cells. m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) positive feedback loop
Responsed Disease Pancreatic cancer ICD-11: 2C10
 Disease Info 
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Histone deacetylase 4 (HDAC4) 104 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PMID29671355-Compound-52 Patented [2]
MOA Inhibitor
Activity IC50 = 55 nM
External Link
CID: 117603070
TTD: D02YLT
 Compound Name PMID29671355-Compound-72a Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
TTD: D03KOH
 Compound Name PMID29671355-Compound-47c Patented [2]
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 72948227
TTD: D07KQB
 Compound Name PMID29671355-Compound-70 Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 122669618
TTD: D08CYC
 Compound Name PMID29671355-Compound-71b Patented [2]
MOA Inhibitor
Activity IC50 = 8 nM
External Link
TTD: D0BV4M
 Compound Name PMID29671355-Compound-72b Patented [2]
MOA Inhibitor
Activity IC50 = 21 nM
External Link
TTD: D0E7TU
 Compound Name PMID29671355-Compound-47a Patented [2]
MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 72722126
TTD: D0L1NO
 Compound Name PMID29671355-Compound-50 Patented [2]
MOA Inhibitor
Activity IC50 = 12 nM
External Link
TTD: D0M7GG
 Compound Name PMID29671355-Compound-47b Patented [2]
MOA Inhibitor
Activity IC50 = 20 nM
External Link
CID: 72950863
TTD: D0NG9V
 Compound Name PMID29671355-Compound-71a Patented [2]
MOA Inhibitor
Activity IC50 = 3 nM
External Link
TTD: D0O1LX
 Compound Name PMID29671355-Compound-47d Patented [2]
MOA Inhibitor
Activity IC50 = 40 nM
External Link
CID: 72948224
TTD: D0SP7T
 Compound Name PMID29671355-Compound-12 Patented [2]
MOA Inhibitor
Activity IC50 = 120 nM
External Link
CID: 78425879
TTD: D0UE9B
 Compound Name PMID29671355-Compound-68b Patented [2]
MOA Inhibitor
Activity IC50 = 2.74 nM
External Link
TTD: D0GD6R
 Compound Name PMID29671355-Compound-45a Patented [2]
MOA Inhibitor
Activity IC50 = 49 nM
External Link
CID: 86302836
TTD: D0YN2T
 Compound Name PMID29671355-Compound-61 Patented [2]
MOA Inhibitor
Activity IC50 > 1000000 nM
External Link
TTD: D0JB4S
 Compound Name PMID29671355-Compound-23 Patented [2]
MOA Inhibitor
Activity IC50 = 3820 nM
External Link
CID: 118884610
TTD: D00HXJ
 Compound Name PMID29671355-Compound-56 Patented [2]
MOA Inhibitor
Activity IC50 = 9220 nM
External Link
CID: 56965342
TTD: D0CH8Q
 Compound Name PMID29671355-Compound-67 Patented [2]
MOA Inhibitor
Activity IC50 = 2840 nM
External Link
CID: 60201048
TTD: D0M0RE
 Compound Name PMID29671355-Compound-31 Patented [2]
MOA Inhibitor
Activity IC50 = 1970 nM
External Link
CID: 90479372
TTD: D0DI9S
DrugBank: DB14979
 Compound Name PMID29671355-Compound-21 Patented [2]
MOA Inhibitor
Activity IC50 = 16400 nM
External Link
CID: 86295624
TTD: D0LP1K
 Compound Name PMID29671355-Compound-62 Patented [2]
MOA Inhibitor
Activity IC50 = 100 to 500 nM
External Link
TTD: D07WAT
 Compound Name PMID29671355-Compound-43 Patented [2]
MOA Inhibitor
Activity IC50 > 100000 nM
External Link
CID: 118515590
TTD: D0BP8I
 Compound Name PMID29671355-Compound-25 Patented [2]
MOA Inhibitor
Activity IC50 = 3310 nM
External Link
CID: 126569528
TTD: D0RA0D
 Compound Name N-hydroxy-9,10-dihydroanthracene-9-carboxamide Investigative [3]
Synonyms
CHEMBL575482; SCHEMBL4541357
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2320 nM
External Link
CID: 45482666
TTD: D03BQS
 Compound Name N-hydroxy-2,2-diphenylacetamide Investigative [3]
Synonyms
Diphenylacetohydroxamic acid; 4099-51-8; N-Hydroxy diphenylacetamide; CHEMBL396097; NSC44620; benzeneacetamide, n-hydroxy-; A-phenyl-; N-Hydroxydiphenylacetamide; BENZENEACETAMIDE,N-HYDROXY-A-PHENYL-; AC1Q5QC3; SCHEMBL2839032; CTK8I6435; DTXSID10286297; AC1L6390; ZINC4522248; NSC-44620; BDBM50207561; MFCD16314231; AKOS022308585; Diphenylacetohydroxamic acid, &gt
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 239512
TTD: D03QOD
 Compound Name N-hydroxy-9H-xanthene-9-carboxamide Investigative [3]
Synonyms
CHEMBL583490; 9H-Xanthene-9-carboxamide,N-hydroxy-; SCHEMBL2843958; BDBM50300446
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 44626296
TTD: D06IMY
 Compound Name 2,2-bis(3-fluorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL574594; SCHEMBL4536216
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 700 nM
External Link
CID: 45482630
TTD: D0A4HF
 Compound Name AZUMAMIDE E Investigative [4]
Synonyms
CHEMBL402363
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2280 nM
External Link
CID: 16095101
TTD: D0E9DD
 Compound Name 2,2-bis(4-fluorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL573190; SCHEMBL2841871
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1100 nM
External Link
CID: 45482672
TTD: D0FN5D
 Compound Name N-hydroxy-2,2-diphenylpropanamide Investigative [3]
Synonyms
CHEMBL585365; SCHEMBL2844474
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4500 nM
External Link
CID: 45482660
TTD: D0I4RK
 Compound Name AZUMAMIDE B Investigative [4]
Synonyms
CHEMBL402727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3660 nM
External Link
CID: 16095112
TTD: D0M1ZI
 Compound Name 2,2-bis(4-chlorophenyl)-N-hydroxyacetamide Investigative [3]
Synonyms
CHEMBL572805; SCHEMBL2848402
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 960 nM
External Link
CID: 45482643
TTD: D0PK9V
 Compound Name AZUMAMIDE C Investigative [4]
Synonyms
CHEMBL257972
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3160 nM
External Link
CID: 16095114
TTD: D0Q9PO
 Compound Name LARGAZOLE Investigative [5]
Synonyms
CHEMBL1173445; (+)-Largazole; SCHEMBL71330; ZINC56861395
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3000 nM
External Link
CID: 24757913
TTD: D0Z8PX
 Compound Name Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393260
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 25 nM
External Link
CID: 44437872
TTD: D00XTC
 Compound Name 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide Investigative [7]
Synonyms
CHEMBL419758; NCH-31; JMC505425 Compound 7; BDBM19131; 7-mercapto-N-(4-phenyl-2-thiazolyl)heptanamide; N-(4-phenyl-1,3-thiazol-2-yl)-7-sulfanylheptanamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 32 nM
External Link
CID: 11427204
TTD: D02HVH
 Compound Name Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL390991
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.4 nM
External Link
CID: 44437870
TTD: D02NAF
 Compound Name Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL394261
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 44437869
TTD: D02NVY
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) Investigative [6]
Synonyms
CHEMBL391384
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.7 nM
External Link
CID: 44437878
TTD: D03PRG
 Compound Name Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393261
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
CID: 44437873
TTD: D04CDZ
 Compound Name santacruzamate A Investigative [8]
Synonyms
CAY10683
    Click to Show/Hide
MOA Inhibitor
Activity IC50 > 1000 nM
External Link
CID: 72946782
TTD: D09RKA
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) Investigative [6]
Synonyms
CHEMBL241555
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 44437879
TTD: D0E8UH
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) Investigative [6]
Synonyms
CHEMBL428737
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 56 nM
External Link
CID: 44437876
TTD: D0G1EX
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) Investigative [6]
Synonyms
CHEMBL238587
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4.2 nM
External Link
CID: 44437875
TTD: D0N5RV
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL238596; BDBM50222727
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5.2 nM
External Link
CID: 44437883
TTD: D0R3XO
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) Investigative [6]
Synonyms
CHEMBL393961
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 44437880
TTD: D0U0EZ
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) Investigative [6]
Synonyms
CHEMBL391383
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3.2 nM
External Link
CID: 44437877
TTD: D0X4QC
 Compound Name Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) Investigative [6]
Synonyms
CHEMBL393464
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2.2 nM
External Link
CID: 44437874
TTD: D0Z6HR
 Compound Name Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) Investigative [6]
Synonyms
CHEMBL238829; BDBM50222732
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.8 nM
External Link
CID: 44437868
TTD: D0Z6MI
 Compound Name TMP269 Investigative [9]
Synonyms
TMFO1; compound 1 [PMID: 23524983]; TMP-269; TMP 269
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 90.5 nM
External Link
CID: 53344908
TTD: D0R7JA
 Compound Name 8-Oxo-8-phenyl-octanoic acid hydroxyamide Investigative [10]
Synonyms
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11075845
TTD: D0S0WK
 Compound Name ST-3050 Investigative [11]
Synonyms
CHEMBL472631; SCHEMBL3445133; SCHEMBL3445139; BDBM50278222
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 16100 nM
External Link
CID: 44591988
TTD: D01YBR
 Compound Name Octanedioic acid bis-hydroxyamide Investigative [12]
Synonyms
Suberohydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5173
TTD: D07YZZ
 Compound Name 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Investigative [10]
Synonyms
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 5.1 nM
External Link
CID: 9882812
TTD: D00KFF
DrugBank: DB07553
 Compound Name 7-Mercapto-heptanoic acid phenylamide Investigative [13]
Synonyms
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11379392
TTD: D00SEE
 Compound Name 6-benzenesulfinylhexanoic acid hydroxamide Investigative [14]
Synonyms
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11694528
TTD: D00ZSD
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Investigative [15]
Synonyms
CHEMBL193959
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44401339
TTD: D01MFV
 Compound Name 7-Mercapto-heptanoic acid biphenyl-4-ylamide Investigative [13]
Synonyms
CHEMBL112311
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11220728
TTD: D01XWZ
 Compound Name N-Hydroxy-4-phenylacetylamino-benzamide Investigative [16]
Synonyms
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11196500
TTD: D01XXN
 Compound Name 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Investigative [13]
Synonyms
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9927379
TTD: D02MQM
 Compound Name N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Investigative [17]
Synonyms
CHEMBL143674; SCHEMBL673760
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MOA Inhibitor
External Link
CID: 11323577
TTD: D02UTC
 Compound Name 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL126355; BDBM50222394
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350626
TTD: D02WZK
 Compound Name Octanedioic acid hydroxyamide pyridin-4-ylamide Investigative [19]
Synonyms
SCHEMBL8082656; CHEMBL165162; ZINC13472304
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MOA Inhibitor
External Link
CID: 10967421
TTD: D04GGW
 Compound Name N-(6-Mercapto-hexyl)-benzamide Investigative [13]
Synonyms
CHEMBL112364; BDBM50223650
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MOA Inhibitor
External Link
CID: 11447748
TTD: D04HSS
 Compound Name 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [19]
Synonyms
CHEMBL167455
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MOA Inhibitor
External Link
CID: 11086699
TTD: D04NSP
 Compound Name N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL675474
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MOA Inhibitor
External Link
CID: 11231829
TTD: D04ZDI
 Compound Name 6-benzenesulfonylhexanoic acid hydroxamide Investigative [14]
Synonyms
CHEMBL203207
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MOA Inhibitor
External Link
CID: 11572583
TTD: D05AHZ
 Compound Name 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Investigative [10]
Synonyms
SCHEMBL7373122; CHEMBL116578
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MOA Inhibitor
External Link
CID: 44342872
TTD: D05FEJ
 Compound Name Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Investigative [13]
Synonyms
CHEMBL111806; SCHEMBL14812153
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MOA Inhibitor
External Link
CID: 11254470
TTD: D05GVY
 Compound Name 4-Butyrylamino-N-hydroxy-benzamide Investigative [17]
Synonyms
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11287488
TTD: D05LLX
 Compound Name 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL127328
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MOA Inhibitor
External Link
CID: 44350703
TTD: D05VFP
 Compound Name 7-Mercapto-heptanoic acid biphenyl-3-ylamide Investigative [13]
Synonyms
CHEMBL320323
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11449823
TTD: D05XAN
 Compound Name 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Investigative [20]
MOA Inhibitor
External Link
CID: 3082127
TTD: D06IQB
 Compound Name N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL676079
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MOA Inhibitor
External Link
CID: 11347053
TTD: D06VBN
 Compound Name 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Investigative [13]
Synonyms
CHEMBL324126
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MOA Inhibitor
External Link
CID: 11277483
TTD: D06XNP
 Compound Name 7-Mercapto-heptanoic acid pyridin-3-ylamide Investigative [13]
Synonyms
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11345433
TTD: D07FJU
 Compound Name 6-Phenoxy-hexane-1-thiol Investigative [13]
Synonyms
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11298778
TTD: D09YBN
 Compound Name 4-Benzoylamino-N-hydroxy-benzamide Investigative [16]
Synonyms
SCHEMBL673678; CHEMBL191227
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MOA Inhibitor
External Link
CID: 11817702
TTD: D09ZNU
 Compound Name 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [10]
Synonyms
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 403373
TTD: D0A5LS
 Compound Name 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [18]
Synonyms
CHEMBL112148; SCHEMBL7364383; BDBM50218532
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MOA Inhibitor
External Link
CID: 44341053
TTD: D0AX7B
 Compound Name 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [18]
Synonyms
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350718
TTD: D0B2ZJ
 Compound Name 6-Mercapto-hexanoic acid phenylamide Investigative [13]
Synonyms
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
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MOA Inhibitor
External Link
CID: 11436024
TTD: D0B3ZM
 Compound Name Cyclostellettamine derivative Investigative [21]
Synonyms
CHEMBL88332
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MOA Inhibitor
External Link
CID: 23327627
TTD: D0C0VP
 Compound Name N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Investigative [10]
Synonyms
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
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MOA Inhibitor
External Link
CID: 9943996
TTD: D0C2KD
 Compound Name 5-Mercapto-pentanoic acid phenylamide Investigative [13]
Synonyms
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11608171
TTD: D0D2KE
 Compound Name Octanedioic acid hydroxyamide pyridin-2-ylamide Investigative [19]
Synonyms
SCHEMBL8090513; CHEMBL164872; ZINC13472303
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MOA Inhibitor
External Link
CID: 11747496
TTD: D0E8KR
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Investigative [15]
Synonyms
CHEMBL193979
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MOA Inhibitor
External Link
CID: 44401305
TTD: D0F0KS
 Compound Name 2-(methylsulfonylthio)ethyl 2-propylpentanoate Investigative [20]
Synonyms
CHEMBL271677; SCHEMBL4156413
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MOA Inhibitor
External Link
CID: 24759251
TTD: D0H1FZ
 Compound Name (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Investigative [18]
Synonyms
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44350655
TTD: D0KE3I
 Compound Name N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL676080
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11312563
TTD: D0QO0L
 Compound Name N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Investigative [16]
Synonyms
N-hydroxy-4-(3-phenylpropanamido)benzamide
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0R4BS
 Compound Name N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Investigative [16]
Synonyms
SCHEMBL7311087
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11472431
TTD: D0R5VG
 Compound Name 8-Oxo-8-phenyl-octanoic acid Investigative [19]
Synonyms
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 298878
TTD: D0RU1X
 Compound Name N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Investigative [16]
Synonyms
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9994848
TTD: D0S7WQ
 Compound Name 6-phenylsulfanylhexanoic acid hydroxamide Investigative [14]
Synonyms
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11637291
TTD: D0S9JF
 Compound Name ST-2987 Investigative [11]
Synonyms
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2040 nM
External Link
CID: 44138032
TTD: D0T0SK
 Compound Name 7-Mercapto-heptanoic acid quinolin-3-ylamide Investigative [13]
Synonyms
CHEMBL112234
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10379373
TTD: D0T4IY
 Compound Name 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Investigative [22]
Synonyms
CHEMBL84288
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11528707
TTD: D0V2ZO
 Compound Name 8-Mercapto-octanoic acid phenylamide Investigative [13]
Synonyms
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11149404
TTD: D0XZ9Q
 Compound Name N-(6-Hydroxycarbamoyl-hexyl)-benzamide Investigative [19]
Synonyms
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9965141
TTD: D0YY9M
 Compound Name 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Investigative [10]
Synonyms
CHEMBL326529; SCHEMBL7365237; BDBM50217957
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44342825
TTD: D0Z3BM
 Compound Name 7-Mercapto-heptanoic acid benzothiazol-2-ylamide Investigative [13]
Synonyms
CHEMBL178779
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11346934
TTD: D0Z5KX
 Compound Name N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Investigative [17]
Synonyms
CHEMBL143102
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MOA Inhibitor
External Link
CID: 44361923
TTD: D0Z7YS
 Compound Name PSAMMAPLIN A Investigative [10]
Synonyms
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 6400741
TTD: D0N0TS
Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) 21 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PT2385 Phase 2 [23]
Synonyms
ONBSHRSJOPSEGS-INIZCTEOSA-N; PT-2385; UNII-6O16716DXP; 1672665-49-4; 6O16716DXP; SCHEMBL16555810; ZINC230453533; AKOS030526641; HY-12867; PT2385,1672665-49-4, PT 2385,PT-2385; Benzonitrile, 3-(((1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl)oxy)-5-fluoro-; 3-{[(1s)-2,2-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile; 3-(((1S)-2,2-Difluoro-1-hydroxy-7-methanesulfonyl-2,3-dihydro-1hinden-4-yl)oxy)-5-fluorobenzonitrile; 79A
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 91754484
TTD: D0C9PZ
 Compound Name ISIS 298697 Investigative [24]
External Link
TTD: D00JHE
 Compound Name ISIS 298744 Investigative [24]
External Link
TTD: D01DDQ
 Compound Name ISIS 298746 Investigative [24]
External Link
TTD: D01ZCK
 Compound Name ISIS 298745 Investigative [24]
External Link
TTD: D07GVC
 Compound Name ISIS 298743 Investigative [24]
External Link
TTD: D09DCJ
 Compound Name ISIS 298702 Investigative [24]
External Link
TTD: D0B5LQ
 Compound Name ISIS 298700 Investigative [24]
External Link
TTD: D0C2IG
 Compound Name ISIS 175510 Investigative [24]
External Link
TTD: D0G9BP
 Compound Name ISIS 298699 Investigative [24]
External Link
TTD: D0L5ME
 Compound Name ISIS 298712 Investigative [24]
External Link
TTD: D0L9KW
 Compound Name ISIS 298711 Investigative [24]
External Link
TTD: D0SN5O
 Compound Name ISIS 298701 Investigative [24]
External Link
TTD: D0X8GB
 Compound Name (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol Investigative [25]
Synonyms
Lificiguat; yc-1; 170632-47-0; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; YC 1; UNII-515CC1WPTE; Lificiguat(YC-1); 154453-18-6; [5-(1-benzyl-1h-indazol-3-yl)-2-furyl]methanol; 515CC1WPTE; CHEMBL333985; OQQVFCKUDYMWGV-UHFFFAOYSA-N; C19H16N2O2; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole; 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole; [5-(1-benzyl-1H-indazol-3-yl)furan-2-yl]methanol; 5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5712
TTD: D00REK
 Compound Name HIF-1alpha Phase 4 [26]
Synonyms
Unii-NA856793UT; 192705-79-6; PD-166866; PD166866; PD 166866; CHEMBL299763; NA856793UT; 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea; 1-(2-Amino-6-(3,5-dimethoxyphenyl)-pyrido(2,3-d)pyrimidin-7-yl)-3-tert-butyl urea; Urea,N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-; 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea; 6-arylpyrido[2,3-d]pyrimidine deriv 25; AC1NS3U5; SCHEMBL1248489; BDBM3443; CTK4E1060
    Click to Show/Hide
External Link
CID: 5328127
TTD: D0B0AX
 Compound Name IT-101 Phase 3 [26]
External Link
TTD: D06PEW
 Compound Name 2-Methoxyestradiol Phase 2 [26]
Synonyms
ESM; Panzem; PulmoLAR; Panzem NCD; M 6383; (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol; (17beta)-2-methoxyestra-1(10),2,4-triene-3,17-diol; (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol; 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER; 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether; 2,3,17beta-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether; 2-Hydroxyestradiol 2-methyl ether; 2-Hydroxyestradol 2-methyl ether; 2-ME2, 2-Methoxyestradiol; 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol; 2-Methoxyestradiol-17beta; 3,17beta-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
    Click to Show/Hide
External Link
CID: 66414
TTD: D06NYA
DrugBank: DB02342
 Compound Name PX-478 Phase 1 [26]
Synonyms
685898-44-6; PX-478 2HCl; UNII-T23U22X160; PX478; PX 478; Melphalan N-Oxide Impurity HCl; T23U22X160; 4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine; PX-478 dihydrochloride; SCHEMBL18548830; C13H18Cl2N2O3.2ClH; DTXSID00218688; MolPort-035-789-733; 2675AH; s7612; 2-Amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide; AKOS030231369; CS-5164; HY-10231; KB-80169; Z-3209; L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride; (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide di
    Click to Show/Hide
External Link
CID: 11234794
TTD: D06ZVO
DrugBank: DB06082
 Compound Name EZN-2968 Phase 1 [26]
External Link
TTD: D0NF5J
 Compound Name ENMD-1198 Phase 1 [26]
Synonyms
EM-5171; EM-883; EM-900; Hypoxia inducible factor 1 inhibitors, EntreMed; HIF-1 inhibitors, EntreMed; HIF-1 inhibitors (cancer), EntreMed; 2-ME2 analogs (oral, cancer), EntreMed; 2-methoxyestradiol analogs (oral, cancer), EntreMed
    Click to Show/Hide
External Link
CID: 11483754
TTD: D0Y5QD
DrugBank: DB05959
 Compound Name Pyrrolidine carboxamide derivative 1 Patented [26]
Synonyms
PMID26882240-Compound-22
    Click to Show/Hide
External Link
CID: 56684144
TTD: D0Q2SE
2C10: Pancreatic cancer 182 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Atezolizumab Approved [23]
External Link
TTD: D0YM2K
 Compound Name Trimethadione Approved [27]
Synonyms
Absentol; Absetil; Convenixa; Convexina; Edion; Epidione; Epidone; Epixal; Etydion; Minoaleuiatin; Minoaleviatin; Petidion; Petidon; Petilep; Petimalin; Pitmal; Ptimal; Tioxanona; Tredione; Tricione; Tridilona; Tridion; Tridione; Tridone; Trilidona; Trimedal; Trimedone; Trimetadiona; Trimetadione; Trimethadion; Trimethadionum; Trimethdione; Trimethin; Trimethinum; Trimetin; Trioksal; Trioxanona; Triozanona; Tromedone; Troxidone; Abbott Brand of Trimethadione; Trimetadione [DCIT]; A 2297; Mino-Aleviatin; Neo-Absentol; Tridione (TN); Trimetadiona [INN-Spanish]; Trimethadione [INN:JAN]; Trimethadionum [INN-Latin]; Trimethadione (JP15/INN); 3,3,5-Trimethyl-2,4-diketooxazolidine; 3,5,5,-Trimethyloxazolidine-2,4-dione; 3,5,5-TRIMETHYL-OXAZOLIDINE-2,4-DIONE; 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione; 3,5,5-Trimethyl-2,4-oxazolidinedione; 3,5,5-Trojmetylooksazolidyno-2,4-dion; 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish]
    Click to Show/Hide
External Link
CID: 5576
TTD: D0U4VT
DrugBank: DB00347
 Compound Name Motixafortide Approved [23]
External Link
CID: 91865076
TTD: D0T6CN
DrugBank: DB14939
 Compound Name Uridine triacetate Approved [28]
Synonyms
PN401
    Click to Show/Hide
External Link
CID: 20058
TTD: D0OL7F
DrugBank: DB09144
 Compound Name Bentiromide Approved [29]
Synonyms
Bentiromide sodium; 41748-47-4; N-Benzoyl-L-tyrosyl-4-aminobenzoic acid sodium salt; NCGC00164607-01; EINECS 255-530-7; DSSTox_CID_26476; DSSTox_RID_81647; DSSTox_GSID_46476; DTXSID6046476; CHEMBL3188891; Tox21_112229; AKOS024373587; ACM41748474; Sodium (S)-4-((2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)benzoate; CAS-41748-47-4; FT-0771579; ST51012404; N-Benzoyl-L-tyrosine p-amidobenzoic acid sodium salt; sodium (S)-4-(2-benzamido-3-(4-hydroxyphenyl)propanamido)benzoate; N-Benzoyl-L-tyrosine p-amidobenzoic acid so
    Click to Show/Hide
External Link
CID: 6957673
TTD: D0L0SW
DrugBank: DB00522
 Compound Name Olaparib Approved [23]
Synonyms
AZD 2281; AZD2281; AZD-2281; Acylpiperazine analogue, 47; KU-0059436; KU-59436; Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281; 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
    Click to Show/Hide
External Link
CID: 23725625
TTD: D0J9HW
DrugBank: DB09074
 Compound Name Streptozocin Approved [30]
Synonyms
Estreptozocina; STREPTOZOTOCIN; STRZ; Streptozocine; Streptozocinium; Streptozocinum; Streptozosin; Zanosar; Alkylating agent; Binds to DNA; Streptozocinium [Latin]; Streptozocine [INN-French]; Streptozocinum [INN-Latin]; Zanosar (TN); Streptozocin (USAN/INN); Streptozocin, Zanosar, STZ,Streptozotocin;N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff; N-D-Glucosyl-(2)-N'-nitrosomethylurea; D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-(9CI); 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose; 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
    Click to Show/Hide
External Link
CID: 29327
TTD: D0I8RR
DrugBank: DB00428
 Compound Name Plazomicin Phase 3 [31]
Synonyms
ACHN-490; UNII-LYO9XZ250J; 1154757-24-0; LYO9XZ250J; Plazomicin [USAN:INN]; Plazomicin (USAN); ZINC68150640; DB12615; D10151; D-Streptamine,
    Click to Show/Hide
External Link
CID: 42613186
TTD: D0E6BB
DrugBank: DB12615
 Compound Name Taxol Approved [23]
Synonyms
C47H51NO14; weekly paclitaxel; Micellar Paclitaxel; Paclitaxel [USAN:INN:BAN]; SCHEMBL15000506; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
    Click to Show/Hide
External Link
CID: 36314
TTD: D0C4RB
DrugBank: DB01229
 Compound Name Ibrutinib Phase 3 [23]
Synonyms
PCI-32765; Ibrutinib (BTK inhibitor)
    Click to Show/Hide
External Link
CID: 24821094
TTD: D09KTS
DrugBank: DB09053
 Compound Name Erlotinib Approved [32]
Synonyms
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
    Click to Show/Hide
External Link
CID: 176870
TTD: D07POC
DrugBank: DB00530
 Compound Name Ruxolitinib Approved [33]
Synonyms
Ruxolitinib (JAK inhibitor)
    Click to Show/Hide
External Link
CID: 25126798
TTD: D04LKS
DrugBank: DB08877
 Compound Name Nivolumab Approved [23]
External Link
TTD: D00GOV
 Compound Name Coenzyme Q10 Phase 2 [23]
Synonyms
CoQ10; Coenzyme Q10 (oral formulation); CoQ10 platform technology, Ryan (Receptagen); Coenzyme Q10 (oral formulation), Receptagen
    Click to Show/Hide
External Link
CID: 5281915
TTD: D01ZUA
DrugBank: DB09270
 Compound Name Aglatimagene besadenovec Phase 1/2 [23]
External Link
TTD: DE8H1W
 Compound Name Zolbetuximab Phase 3 [34]
Synonyms
IMAB362
    Click to Show/Hide
External Link
TTD: D4HQ1F
 Compound Name AC-1204 Phase 3 [35]
Synonyms
isoindoline hydrochloride; 32372-82-0; 2,3-Dihydroisoindole hydrochloride; 2,3-dihydro-1H-isoindole hydrochloride; 2,3-Dihydro-1H-isoindole HCl; Isoindoline HCl salt; 1H-Isoindole, 2,3-dihydro-, hydrochloride; Isoindoline hydrochloride, 97%; Isoindolinehydrochloride; Isoindoline, HCl; ISOINDOLINE HCL; AC1Q38WR; dihydroisoindole hydrochloride; KSC491I3F; AMBZ0192; SCHEMBL4702076; CTK3J1432; DTXSID50487241; MolPort-003-986-749; NOVIRODZMIZUPA-UHFFFAOYSA-N; BH168; CS-D1516; ACT08858; ACN-S003258; KS-000001RA
    Click to Show/Hide
External Link
CID: 12311031
TTD: D0Y1RN
 Compound Name Radiosensitizer gene therapy Phase 3 [36]
Synonyms
Radiosensitizer gene therapy (prostate cancer)
    Click to Show/Hide
External Link
TTD: D0X4NF
 Compound Name Glufosfomide Phase 3 [37]
External Link
TTD: D0W7PQ
 Compound Name Yttrium (90Y) clivatuzumab tetraxetan Phase 3 [38]
Synonyms
PAM4 mAb; Yttrium Y 90 clivatuzumab tetraxetan; Anti-MUC1 PAM4 monoclonal antibody; Clivatuzumab tetraxetan-[90Y]; HPAM4-Cide; IMMU-107; PAM-4; PAM4-Y-90; Yttrium-90-hPAM4; 90Y-clivatuzumab tetraxetan; 90Y-hPAM4
    Click to Show/Hide
External Link
TTD: D0V2KR
 Compound Name Y-90 Clivatuzumab Phase 3 [39]
External Link
TTD: D0T8AI
 Compound Name Civacir Phase 3 [40]
External Link
TTD: D0P9UP
 Compound Name GV1001 Phase 3 [41]
External Link
TTD: D0N0QC
 Compound Name Masitinib Phase 3 [23]
Synonyms
790299-79-5; AB1010; Masatinib; Masitinib (AB1010); Masivet; AB-1010; AB 1010; UNII-M59NC4E26P; Masitinib [INN]; M59NC4E26P; 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide; CHEMBL1908391; CHEBI:63450; Masitinib (INN); N-(4-Methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide; Q-201339; C28H30N6OS; N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
    Click to Show/Hide
External Link
CID: 10074640
TTD: D0MW0N
DrugBank: DB11526
 Compound Name Glufosfamide Phase 3 [23]
Synonyms
Glucosylifostamide mustard; D 19575; D-19575; Glc-IPM; Glucosyl-ifosfamide mustard; Beta-D-Glucopyranose 1-(N,N'-bis(2-chloroethyl)phosphorodiamidate; Beta-D-Glucopyranose, 1-(N,N'-bis(2-chloroethyl)phosphorodiamidate); (2S,3R,4S,5S,6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,5-triol
    Click to Show/Hide
External Link
CID: 123628
TTD: D0L9IA
DrugBank: DB06177
 Compound Name Sapacitabine Phase 3 [23]
Synonyms
CYC682
    Click to Show/Hide
External Link
CID: 153970
TTD: D0D4RF
DrugBank: DB06365
 Compound Name Pelareorep Phase 2 [42]
External Link
TTD: D0BF8Y
 Compound Name Pamrevlumab Phase 3 [43]
External Link
TTD: D09TJJ
 Compound Name GRASPA Phase 1 [44]
Synonyms
L-asparaginase (erythrocyte-encapsulated, acute lymphoblastic leukemia/solid tumor), ERYtech
    Click to Show/Hide
External Link
TTD: D09JKS
 Compound Name Pancreas algenpantucel-L Phase 3 [45]
Synonyms
HyperAcute (TN)
    Click to Show/Hide
External Link
TTD: D08PBQ
 Compound Name CPI-613 Phase 3 [46]
Synonyms
95809-78-2; 6,8-bis(benzylthio)octanoic acid; CPI 613; MLS006010202; SCHEMBL1062218; 6,8-Bis(benzylsulfanyl)octanoic acid; Octanoic acid, 6,8-bis((phenylmethyl)thio)-; Octanoic acid, 6,8-bis[(phenylMethyl)thio]-; 6,8-Bis[(phenylmethyl)thio]octanoic acid; CPI613; CHEMBL3186849; QCR-193; AOB1058; MolPort-023-219-128; HMS3656L06; C22H28O2S2; BCP04663; EX-A2043; s2776; AKOS025142095; BCP9000552; DB12109; RL06062; CS-0961; NCGC00344764-01; SMR004701300; AS-16613; BC261916; AK174899; HY-15453; BCP0726000030; KB-293127; AB0035874
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External Link
CID: 24770514
TTD: D07NVI
DrugBank: DB12109
 Compound Name Zarnestra Phase 3 [47]
Synonyms
JAN; Tipifarnib; Tipifarnib [USAN]; R 115777; R115777; R-11577; R-115777; Tipifarnib (USAN/INN); Zarnestra, IND 58359, R115777, Tipifarnib; (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-R115777; 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone; 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one; 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE
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External Link
CID: 159324
TTD: D07NPS
DrugBank: DB04960
 Compound Name MM-398 Phase 3 [48]
External Link
CID: 91809656
TTD: D07HOH
 Compound Name Marimastat Phase 3 [49]
Synonyms
Marimastat [USAN]; BB 2516; BB-2516; Marimastat (USAN/INN); (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide; (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic acid; (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl)carbamoyl)-2-hydroxy-5-methylhexanohydroxamic acid; (2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide
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External Link
CID: 119031
TTD: D05VZE
DrugBank: DB00786
 Compound Name AM0010 Phase 3 [50]
External Link
TTD: D03MYX
 Compound Name ANX-510 Phase 3 [51]
External Link
CID: 135400185
TTD: D01YKI
 Compound Name Napabucasin Phase 3 [23]
Synonyms
83280-65-3; UNII-Z1HHM49K7O; 2-acetylnaphtho[2,3-b]furan-4,9-dione; Z1HHM49K7O; 2-Acetylnaphtho(2,3-b)furan-4,9-dione; 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione; Napabucasin [USAN:INN]; Napabucasin (BBI608); 2-Acetylfuranonaphthoquinone; CHEMBL64130; Napabucasin (JAN/USAN/INN); SCHEMBL1883845; Napabucasin - BBI 608/ FNQ; 2-Acetylfuro-1,4-naphthoquinone; DPHUWDIXHNQOSY-UHFFFAOYSA-N; MolPort-039-101-321; EX-A1314; ZINC13306865; s7977; AKOS027470201; DB12155; CS-1747; ACN-053294; HY-13919
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External Link
CID: 10331844
TTD: D01IGZ
DrugBank: DB12155
 Compound Name Algenpantucel-L Phase 3 [52]
Synonyms
HyperAcute pancreas (TN)
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External Link
TTD: D00HSK
 Compound Name OT-101 Phase 2/3 [23]
External Link
TTD: DO5H6K
 Compound Name RP101 Phase 2/3 [53]
Synonyms
SCHEMBL15589316; CHEMBL3703295; BDBM149820; US8975415,
    Click to Show/Hide
External Link
CID: 446727
TTD: D0Z9LP
DrugBank: DB03312
 Compound Name NLG8189 Phase 2/3 [23]
Synonyms
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
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External Link
CID: 405012
TTD: D0B5HS
DrugBank: DB12827
 Compound Name LY2157299 Phase 2/3 [23]
Synonyms
Galunisertib; 700874-72-2; LY 2157299; LY-2157299; UNII-3OKH1W5LZE; 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; 3OKH1W5LZE; Galunisertib (LY2157299); AK-79916; 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide; 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo-[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; 4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
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External Link
CID: 10090485
TTD: D06TFI
DrugBank: DB11911
 Compound Name SM-88 Phase 2/3 [54]
External Link
CID: 3125
TTD: D03ZDX
 Compound Name SiG12D-LODER Phase 2 [23]
External Link
TTD: DNH67V
 Compound Name BNT141 Phase 2 [55]
External Link
TTD: DFZ19J
 Compound Name BNT321 Phase 2 [56]
Synonyms
MVT-5873
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External Link
TTD: D7AOL8
 Compound Name BPM 31510 Phase 2 [57]
External Link
TTD: D4MZR2
 Compound Name GC4711 Phase 2 [58]
Synonyms
UNII-FW5T90VM32; FW5T90VM32; GC-4419 dipropionate; Bis-propionato(gc4419); Avasopasem manganese dipropionate; GC-4711; 2248030-85-3; Manganese(II), bis-propionato((4aS,13aS,17aS,21aS)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7H-dibenzo(b,H)(1,4,7,10)tetraaza-cycloheptadecine-kn5,kn13,kn18,kn21,kn22)-,
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External Link
CID: 131634674
TTD: D3P8JK
 Compound Name CYTO-401 Phase 2 [59]
External Link
TTD: D2Q5XO
 Compound Name Zenocutuzumab Phase 2 [60]
External Link
TTD: D1J4CI
 Compound Name Cabiralizumab Phase 2 [23]
External Link
TTD: D0YO4B
 Compound Name VS-6063 Phase 2 [23]
Synonyms
Defactinib hydrochloride; 1073160-26-5; Defactinib (hydrochloride); UNII-L2S469LM49; Defactinib hydrochloride [USAN]; L2S469LM49; Defactinib hydrochloride (USAN); Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-, hydrochloride; Defactinib HCl; Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl)amino)-5-(trifluoromethyl)-2-pyrimidinyl)amino)-, hydrochloride (1:1); Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsu
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External Link
CID: 25117126
TTD: D0Y1UO
DrugBank: DB12282
 Compound Name MENK Phase 2 [37]
External Link
TTD: D0VG7I
 Compound Name CO-101 Phase 2 [61]
Synonyms
methyl 2-(dimethylcarbamoyl)benzoate; 26593-43-1; Phthalamic acid, N,N-dimethyl-, methyl ester; CO 101; BRN 2504723; N,N-Dimethylphthalamic acid methyl ester; N,N-Dimethylphthalamic acid, methyl ester; AC1Q5ZAU; 2-09-00-00601 (Beilstein Handbook Reference); AC1L4V19; CTK4F8203; DTXSID50181156; 2-methoxycarbonyl-N,N-dimethylbenzamide; LS-109082; Benzoic acid,2-[(dimethylamino)carbonyl]-, methyl ester
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External Link
CID: 9828310
TTD: D0V0CJ
DrugBank: DB12564
 Compound Name MENK Phase 2 [23]
Synonyms
IRT-101
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External Link
TTD: D0TN1J
 Compound Name TL-118 Phase 2 [62]
Synonyms
Hamsa 1; TL-111; TL-112; Combination anti-angiogenic therapy (oral suspension, solid tumors), Tiltan Pharma
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External Link
TTD: D0T9OC
 Compound Name Antroquinonol Phase 2 [23]
Synonyms
Hocena; Fungal extract (cancer), Golden Biotechnology
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External Link
CID: 24875259
TTD: D0T3AW
DrugBank: DB12326
 Compound Name NPC-1C Phase 2 [23]
Synonyms
Ensituximab
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External Link
TTD: D0T2FC
 Compound Name Necuparanib Phase 2 [63]
External Link
TTD: D0S3CX
 Compound Name CCX872 Phase 2 [23]
External Link
TTD: D0Q3PB
 Compound Name GC4419 Phase 1/2 [23]
Synonyms
Avasopasem manganese; UNII-EY1WA413UL; EY1WA413UL; Avasopasem manganese [USAN]; SC-72325A; M-40419; 435327-40-5; Manganese, dichloro((4aS,13aS,17aS,21aS)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-7,11-nitrilo-7H-dibenzo(b,H)-5,13,18,21-tetraazacycloheptadecine-kappaN5,kappaN13,kappaN18,kappaN21,kappaN22)-, (pb-7-11-2344'3')-
    Click to Show/Hide
External Link
CID: 71587734
TTD: D0PV9N
 Compound Name Istiratumab Phase 2 [42]
External Link
TTD: D0P4ZR
 Compound Name GI-4000 Phase 2 [64]
External Link
TTD: D0N4SF
 Compound Name OCV-101 Phase 2 [65]
Synonyms
OTS-11101
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External Link
TTD: D0LX8Z
 Compound Name RX-3117 Phase 2 [23]
Synonyms
Antimetabolite (cancer), Rexahn; Antimetabolite (cancer), Rexahn/ Teva
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External Link
CID: 11242315
TTD: D0L7WS
 Compound Name Ensitiximab Phase 2 [37]
External Link
TTD: D0KL4T
 Compound Name GI-4000 + gemcitabine Phase 2 [66]
External Link
TTD: D0KK9V
 Compound Name BC-819 Phase 2 [67]
External Link
TTD: D0K0KQ
 Compound Name IRT-102 Phase 2 [68]
External Link
CID: 42785
TTD: D0J5UK
 Compound Name LE-DT Phase 2 [69]
Synonyms
Liposomal docetaxel
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External Link
TTD: D0J2NX
 Compound Name TH-302 Phase 2 [23]
Synonyms
evofosfamide; 918633-87-1; TH 302; TH302; UNII-8A9RZ3HN8W; Evofosfamide(TH 302); n,n'-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl ester; 8A9RZ3HN8W; compound 3b; Evofosfamide;HAP-302; Phosphorodiamidic acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester; 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine; Evofosfamide [USAN:INN]; Evofosfamide(TH-302); C9H16Br2N5O4P; CHEMBL260046; SCHEMBL2357174
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External Link
CID: 11984561
TTD: D0H1EA
DrugBank: DB06091
 Compound Name Demcizumab Phase 2 [37]
External Link
TTD: D0GJ7N
 Compound Name Anti-PSCA mab Phase 2 [70]
External Link
TTD: D0G7ZT
 Compound Name ALT-803 Phase 2 [42]
Synonyms
IL-15 agonist/ IL-15R alpha-Fc fusion complex (cancer), Altor BioScience
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External Link
TTD: D0FD7H
 Compound Name ARQ 761 Phase 2 [23]
External Link
TTD: D0DR0P
 Compound Name Reolysinpelareorep Phase 2 [23]
External Link
TTD: D0CW2N
 Compound Name PBI-05204 Phase 2 [23]
External Link
CID: 11541511
TTD: D0A4YK
DrugBank: DB12843
 Compound Name PCI-27483 Phase 2 [71]
External Link
CID: 135425273
TTD: D09TFL
DrugBank: DB13000
 Compound Name RX-0201 Phase 2 [37]
External Link
TTD: D07SYZ
 Compound Name CP-613 Phase 2 [72]
External Link
TTD: D07FXF
 Compound Name CART 19 Preclinical [73]
External Link
TTD: D06TKR
 Compound Name VT-122 Phase 1 [37]
External Link
TTD: D05VKS
 Compound Name PEGPH20 Phase 2 [74]
External Link
TTD: D05INV
 Compound Name Ficlatuzumab Phase 2 [23]
Synonyms
AV-299
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External Link
TTD: D03UBW
 Compound Name Tigatuzumab Phase 2 [75]
External Link
TTD: D03LTO
 Compound Name CRS-207 Phase 2 [76]
External Link
TTD: D02WSB
 Compound Name CAP1-6D Phase 2 [77]
Synonyms
Modified CEA peptide (pancreatic cancer), University of Chicago
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External Link
CID: 396060
TTD: D02UKX
 Compound Name SGT-53 Phase 2 [23]
Synonyms
P53 gene stimulator (solid tumor), Synergene Therapeutics
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External Link
TTD: D02EOH
 Compound Name Tarextumab Phase 2 [78]
External Link
TTD: D01QLP
 Compound Name BVD-523 Phase 2 [23]
External Link
CID: 11719003
TTD: D01IED
DrugBank: DB13930
 Compound Name Ocaperidone Phase 2 [42]
Synonyms
Ocaperidona; 129029-23-8; UNII-26HUS7139V; 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-2,9-dimethyl-4H-pyrido(1,2-a)pyrimidin-4-one; 26HUS7139V; Ocaperidonum; Ocaperidonum [INN-Latin]; Ocaperidona [INN-Spanish]; 4H-Pyrido[1,2-a]pyrimidin-4-one,3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2,9-dimethyl-; Ocaperidone (USAN); Ocaperidone [USAN:INN:BAN]; 3-[2-[4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]ethyl]-2,9-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2,9-dimethylpyrido[1,2-a]pyrimidin-4-one; 8-[2-[4-(6-fluorobenzo[d]isoxazol-3-yl)-1-piperidyl]ethyl]-2,9-dimethyl-6,10-diazabicyclo[440]deca-2,4,8,10-tetraen-7-one; FG-3019
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External Link
CID: 71351
TTD: D01FQR
DrugBank: DB06229
 Compound Name Encapsulated live cells converting ifosfamide Phase 2 [23]
External Link
TTD: D01DLT
 Compound Name LY2603618 Phase 2 [79]
Synonyms
Rabusertib; 911222-45-2; LY 2603618; LY-2603618; UNII-3S9L1NU6U7; 3S9L1NU6U7; IC-83; ly2603618 IC-83; (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea; n-(5-bromo-4-methyl-2-((2s)-2-morpholinylmethoxy)phenyl)-n'-(5-methyl-2-pyrazinyl)urea; LY2603618 (IC-83); Rabusertib [USAN:INN]; 3-(5-Bromo-4-methyl-2-[(2s)-morpholin-2-ylmethoxy]phenyl)-1-(5-methylpyrazin-2-yl)urea; N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
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External Link
CID: 11955855
TTD: D00NZL
DrugBank: DB11662
 Compound Name Salirasib Discontinued in Phase 1/2 [80]
Synonyms
162520-00-5; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; UNII-MZH0OM550M; MZH0OM550M; CHEMBL23293; AK186909; Farnesyl Thiosalicylic Acid; 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid; 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzoic acid; 2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid; 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic acid; Benzoic acid, 2-(((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl)thio)-; FTS; Farnesylthiosalicyclic acid; FTS, Thyreos; Ras antagonists, Thyreos; S-trans; Th-101; Trans-farnesylthiosalicylicacid; FTS (oral, cancer), Concordia; Farnesylthiosalicyclic acid (oral, cancer), Concordia; Ras-inhibitors (cancer), Concordia; FTS (oral, cancer), Concordia/Ono; KD032
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External Link
CID: 5469318
TTD: D00KTV
DrugBank: DB12681
 Compound Name MM-141 Phase 2 [23]
External Link
TTD: D00BUO
 Compound Name GB1275 Phase 1/2 [81]
External Link
TTD: DZ5K6F
 Compound Name ABTL0812 Phase 1/2 [82]
Synonyms
(9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoic acid; (9Z,12Z)-2-hydroxyoctadecadienoic acid; (alpha)-Hydroxylinoleic acid; .ALPHA.-HYDROXYLINOLEIC ACID; 0DE74TJ7EZ; 2-hydroxy-9Z,12Z-Octadecadienoic acid; 2-hydroxylinoleic acid; 57818-44-7; 9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-; 9,12-Octadecadienoic acid, 2-hydroxy-, (Z,Z)-; ABTL0812; ABTL-0812; a-Hydroxylinoleic acid; AKOS040740632; alpha-Hydroxylinoleic acid; CHEBI:136927; CS-7178; DTXSID301258077; hydroxylinoleic acid; HY-U00141; LMFA02000290; MS-24253; s9611; SCHEMBL320069; UNII-0DE74TJ7EZ
    Click to Show/Hide
External Link
CID: 21158511
TTD: DMBQ10
 Compound Name GP-2250 Phase 1/2 [83]
External Link
TTD: DARV32
 Compound Name Delolimogene mupadenorepvec Phase 1/2 [84]
Synonyms
LOAd703
    Click to Show/Hide
External Link
TTD: D5V7XP
 Compound Name GSK3145095 Phase 1/2 [85]
Synonyms
1622849-43-7; CHEMBL4452233; (S)-5-benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-4H-1,2,4-triazole-3-carboxamide; UNII-B4D3WPS7JY; B4D3WPS7JY; SCHEMBL17312826; BCP31015; EX-A3069; BDBM50502339; s8845; GSK-3145095; HY-111946; CS-0094287; GSK 3145095; FC1=CC2=C(NC(=O)[C@H](CC2)NC(=O)C2=NN=C(CC3=CC=CC=C3)N2)C(F)=C1; (S)-5-Benzyl-N-(7,9-difluoro-2-oxo-2,3,4,5-tetrahydro-1hbenzo(b)azepin-3-yl)-1H-1,2,4-triazole-3-carboxamide (7,7-dimethyl-2- oxobicyclo(2.2.1)heptan-1-yl)
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External Link
CID: 118557502
TTD: D0Z7BX
 Compound Name Encapsulated cell therapy Phase 1/2 [86]
External Link
TTD: D0XY8C
 Compound Name ETBX-011 cancer vaccine Phase 1/2 [64]
External Link
TTD: D0U1WU
 Compound Name BPX-601 Phase 1/2 [87]
External Link
TTD: D0TY6U
 Compound Name NANT Phase 1/2 [23]
External Link
TTD: D0T4GG
 Compound Name BrevaRex Phase 1/2 [88]
Synonyms
BrevaRex MAb; monoclonal antibody
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External Link
TTD: D0M5JC
 Compound Name DCVax-Pancreas Phase 1/2 [89]
Synonyms
Dendritic cell-based immunotherapy (pancreatic cancer), Northwest Biotherapeutics
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External Link
TTD: D0L7LT
 Compound Name PEGylated hyaluronidase (human recombinant) Phase 1/2 [90]
Synonyms
PEGylated hyaluronidase; PEGylated hyaluronidase (human recombinant) (intravenous, stroke/cancer), Halozyme
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External Link
TTD: D0L5IA
 Compound Name CAR-T cells targeting mesothelin Phase 1/2 [91]
External Link
TTD: D0KC2S
 Compound Name MALP-2S Phase 1/2 [92]
External Link
TTD: D0K3SM
 Compound Name Anti-Mesothelin CAR-T cells Phase 1/2 [93]
External Link
TTD: D0BE6M
 Compound Name Anti-MUC1 CAR T Cells Phase 1/2 [94]
External Link
TTD: D08WII
 Compound Name Anti-HER2 CAR-T Phase 1/2 [95]
External Link
TTD: D08QZH
 Compound Name CAR-T Cells targeting EpCAM Phase 1/2 [96]
External Link
TTD: D08QYW
 Compound Name Anti-MUC1 AR20.5 Phase 1/2 [42]
External Link
TTD: D07YGQ
 Compound Name AR20.5 Phase 1/2 [23]
External Link
TTD: D07PCZ
 Compound Name G0-203-2c Phase 1/2 [97]
External Link
TTD: D04WHM
 Compound Name LOAd703 Phase 1/2 [23]
External Link
TTD: D03ZIP
 Compound Name Anti-mesothelin CAR transduced PBL Phase 1/2 [98]
External Link
TTD: D00YXG
 Compound Name M9241 Phase 1 [99]
Synonyms
NHS-IL12
    Click to Show/Hide
External Link
TTD: DO8W9E
 Compound Name NBF-006 Phase 1 [100]
External Link
TTD: D8UZ5R
 Compound Name AB680 Phase 1 [101]
Synonyms
AB-680; UNII-J6K8WSV73A; J6K8WSV73A; CHEMBL4471306; 2105904-82-1; (((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid; [[(2~{R},3~{S},4~{R},5~{R})-5-[6-chloranyl-4-[[(1~{S})-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid; SCHEMBL19100484; GTPL10707; BDBM50527134; HY-125286; CS-0090231; [[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid; QDH
    Click to Show/Hide
External Link
CID: 130205852
TTD: D7CE6N
 Compound Name STAT400 Phase 1 [102]
External Link
TTD: D75WVO
 Compound Name CEND-1 Phase 1 [103]
Synonyms
iRGD; UNII-Z8MXU5GH4Q; Z8MXU5GH4Q; iRGD-peptide; 1392278-76-0; Internalized-arginylglycylaspartic acid cyclic peptide; Q48988348; L-Cysteine, L-cysteinyl-L-arginylglycyl-L-alpha-aspartyl-L-lysylglycyl-L-prolyl-L-alpha-aspartyl-, cyclic (1->9)-disulfide
    Click to Show/Hide
External Link
CID: 134611625
TTD: D5WU7B
 Compound Name CAR-T Cells targeting EGFRvIII Phase 1 [104]
External Link
TTD: D0ZQ6N
 Compound Name HuCART-meso cells Phase 1 [105]
External Link
TTD: D0ZF9J
 Compound Name OCV-105 Phase 1 [106]
Synonyms
Cancer vaccine (pancreas), Otsuka/OncoTherapy
    Click to Show/Hide
External Link
TTD: D0X9YB
 Compound Name SBP-101 Phase 1 [37]
Synonyms
diethyl dihydroxyhomospermine
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External Link
TTD: D0VE9F
 Compound Name RG7882 Phase 1 [42]
External Link
TTD: D0V7QW
 Compound Name CART-meso-19 T cells Phase 1 [107]
External Link
TTD: D0V5DD
 Compound Name MOv19-BBz CAR T cells Phase 1 [108]
External Link
TTD: D0T7CR
 Compound Name Anti-MUC1 AR20.5 mab Phase 1 [109]
External Link
TTD: D0S3AE
 Compound Name Anti-CEA-CAR T Phase 1 [110]
External Link
TTD: D0S1QN
 Compound Name MVT-5873 Phase 1 [42]
External Link
TTD: D0Q5QV
 Compound Name CART-meso cells Phase 1 [111]
External Link
TTD: D0P2GA
 Compound Name CAR-20/19-T Cells Phase 1 [112]
External Link
TTD: D0NU9L
 Compound Name CARTmeso/19 Phase 1 [113]
External Link
TTD: D0MD8S
 Compound Name CAR-T Cells targeting Mesothelin Phase 1 [104]
External Link
TTD: D0L7OJ
 Compound Name CAR-T Cells targeting CEA Phase 1 [104]
External Link
TTD: D0L6HU
 Compound Name HLA-A*2402-restricted KIF20A and VEGFR-1 epitope peptide vaccine Phase 1 [114]
Synonyms
HLA-A*2402-restricted KIF20A and VEGFR-1 epitope peptide vaccine (pancreatic cancer, subcutaneous)
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External Link
TTD: D0K6UQ
 Compound Name Anti-hCD70 CAR transduced PBL Phase 1 [115]
External Link
TTD: D0JO9M
 Compound Name MORAb-066 Phase 1 [116]
Synonyms
Anti-tissue factor monoclonal antibody (pancreatic tumor), Morphotek
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External Link
TTD: D0H8PX
 Compound Name Anti-MUC1 mab Phase 1 [117]
External Link
TTD: D0H2CF
 Compound Name Anti-meso-CAR vector transduced T cells Phase 1 [118]
External Link
TTD: D0G4GY
 Compound Name CRS-207 + GVAX Phase 2 [37]
External Link
TTD: D0EY1Y
 Compound Name Autologous T cells transfected with chimeric anti-mesothelin immunoreceptor SS1 Phase 1 [119]
External Link
TTD: D0EB0Y
 Compound Name Meso-CART Phase 1 [120]
External Link
TTD: D0D2LE
 Compound Name ASG-5ME Phase 1 [121]
External Link
TTD: D0BC6M
 Compound Name Anti-CD133-CAR vector-transduced T cells Phase 1 [122]
External Link
TTD: D09HRH
 Compound Name IRX4204 Phase 1 [23]
Synonyms
220619-73-8; CHEMBL75133; UNII-877M97Z38Y; VTP-194204; 877M97Z38Y; KB-145960; SCHEMBL3437269; MolPort-042-665-869; ZINC1550770; IRX-4204; 3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid; BDBM50101445; DB11806; VTP 194204; (+)-VTP-194204; AGN 4204; (2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
    Click to Show/Hide
External Link
CID: 9863341
TTD: D09DJC
DrugBank: DB11806
 Compound Name AbGn-107 Phase 1 [23]
External Link
TTD: D08GZE
 Compound Name LMB-100 Phase 1/2 [23]
External Link
TTD: D07RDQ
 Compound Name PLX7486 Phase 1 [123]
External Link
TTD: D07PSL
 Compound Name CAR-T Cells targeting HER2 Phase 1 [104]
External Link
TTD: D06XWD
 Compound Name CAR-T Cells targeting MUCI Phase 1 [104]
External Link
TTD: D06URX
 Compound Name SEL-403 Phase 1 [23]
External Link
TTD: D03ZLN
 Compound Name CAR-T Cells targeting PSCA Phase 1 [104]
External Link
TTD: D02MYI
 Compound Name Anti-CEA CAR-T cells Phase 1 [124]
External Link
TTD: D00KDQ
 Compound Name MVT-1075 Phase 1 [23]
External Link
TTD: D00IFQ
 Compound Name CAR-CLD18 T cell Clinical trial [125]
External Link
TTD: D06CWZ
 Compound Name CART-meso cells Clinical trial [126]
External Link
TTD: D04WZL
 Compound Name PMID28460551-Compound-1 Patented [127]
External Link
CID: 25190990
TTD: D0IH3I
DrugBank: DB14866
 Compound Name Tanomastat Discontinued in Phase 3 [128]
Synonyms
Tanomastat (USAN/INN); (2S)-4-[4-(4-chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid
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External Link
CID: 6918336
TTD: D0Q1CD
DrugBank: DB06276
 Compound Name Larotaxel Discontinued in Phase 3 [129]
Synonyms
Benzenepropanoic acid; PNU 100940; XRP 9881; XRP9881
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External Link
CID: 6918260
TTD: D0J0RV
DrugBank: DB12984
 Compound Name Apricoxib Discontinued in Phase 2 [130]
Synonyms
TG01
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External Link
CID: 9820073
TTD: D0S7IZ
DrugBank: DB12378
 Compound Name Lintitript Discontinued in Phase 2 [131]
Synonyms
SR 27897; SR 27897B; SR27897; SR-27897; SR-27897B; 1-((2-(4-(2-Chlorophenyl)thiazol-2-yl)aminocarbonyl)indolyl)acetic acid; 2-((4-(o-Chlorophenyl)-2-thiazolyl)carbamoyl)indole-1-acetic acid; 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]acetic acid
    Click to Show/Hide
External Link
CID: 122077
TTD: D01ZXW
DrugBank: DB04867
 Compound Name Merbarone Discontinued in Phase 2 [132]
Synonyms
NSC-336628
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External Link
CID: 4990817
TTD: D00VZF
 Compound Name LY293111 Discontinued in Phase 2 [133]
Synonyms
Etalocib; 161172-51-6; UNII-THY6RIW44R; LY 293111; THY6RIW44R; CHEMBL329123; LY-193111; 2-[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenoxy]benzoic acid; VML295; Etalocib [USAN:INN]; Etalocib (USAN); GTPL2948; SCHEMBL1649516; CTK8E7596; C33H33FO6; VML 295; DTXSID70167073; YFIZRWPXUYFCSN-UHFFFAOYSA-N; MolPort-009-019-411; ZINC3930629; AC1L4328; PDSP2_001221; BDBM50029450; PDSP1_001237; 1758AH; DB12850; RT-013626; D04074; L001468; J-009797; Benzoic acid, 2-(3-(3-((5-ethyl-4'-fluoro-2-hydroxy(1,1'-bipheny
    Click to Show/Hide
External Link
CID: 177941
TTD: D00GNK
DrugBank: DB12850
 Compound Name HMN-214 Discontinued in Phase 1 [134]
Synonyms
N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl]acetamide; (E)-4-(2-(2-(N-Acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide
    Click to Show/Hide
External Link
CID: 9888590
TTD: D0R7ID
 Compound Name RG7600 Discontinued in Phase 1 [135]
External Link
TTD: D04TYP
 Compound Name IC261 Preclinical [136]
Synonyms
IC-261; IC 261
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External Link
CID: 5288600
TTD: D0UN8H
DrugBank: DB03083
 Compound Name ANAVEX 1007 Preclinical [137]
External Link
TTD: D0M6OW
 Compound Name IPH-4201 Terminated [138]
Synonyms
MAb-16D10; MAb-J28; FAPP-targeting mAb (pancreatic cancer), Innate Pharma; FAPP-targeting mAb (pancreatic cancer), Universite de la Mediterranee/ INSERM; Feto-acinar pancreatic protein-targeting monoclonal antibodies (pancreatic cancer), Innate Pharma; Feto-acinar pancreatic protein-targeting monoclonal antibodies (pancreatic cancer), Universite de la Mediterranee/ INSERM
    Click to Show/Hide
External Link
TTD: D0F6HW
 Compound Name MesoTarg Investigative [139]
External Link
TTD: D0W5KO
 Compound Name PAT-PM-1 Investigative [139]
Synonyms
PM-1; Human monoclonal antibody (pancreatic cancer), Patrys; Human MAb (pancreas cancer), OncoMab/ Acceptys; Human monoclonal antibody (pancreatic cancer), OncoMab/ Acceptys; PM-1 antibody, OncoMab/ Acceptys
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External Link
TTD: D0U9YV
 Compound Name OP-04 Investigative [139]
Synonyms
OP-04 program (prodrug, pancreatic cancer); OP-04 program (prodrug, pancreatic cancer), Onco-Pharmakon
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External Link
TTD: D0S0DY
 Compound Name VLI-27 Investigative [140]
Synonyms
AKT inhibitor (pancreatic cancer), NovaLead Pharma
    Click to Show/Hide
External Link
TTD: D0N7CY
 Compound Name GS-326 Investigative [139]
Synonyms
GS-326C
    Click to Show/Hide
External Link
CID: 3041004
TTD: D0LI3A
 Compound Name PX-12 Phase 2 [141]
External Link
CID: 219104
TTD: D0FT8G
DrugBank: DB05448
 Compound Name Prodigiosin Investigative [139]
External Link
CID: 135455579
TTD: D06YEE
 Compound Name Pbi-shPDX-1 LP Investigative [139]
External Link
TTD: D02FAI
 Compound Name Gastrin 17C diphtheria toxoid conjugate Investigative [139]
Synonyms
Gastrin 17C diphtheria toxoid conjugate (pancreatic cancer)
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External Link
TTD: D01PNR
 Compound Name HS-P1 Investigative [139]
Synonyms
HS-310; Endoplasmin modulator (pancreas tumor, HeatShock/fusion protein/antigen), Heat Biologics; Gp-96-Ig + unspecified tumor antigen secreting live cell vaccine (pancreas tumor, HeatShock), Heat Biologics
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External Link
CID: 71537
TTD: D00JKJ
References
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Ref 50 ClinicalTrials.gov (NCT02923921) Study of Pegilodecakin (LY3500518) With FOLFOX Compared to FOLFOX Alone Second-line Tx in Participants With Metastatic Pancreatic Cancer (Sequoia). U.S. National Institutes of Health.
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