m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03066
 [1]
m6A modification SNHG15 SNHG15 ALKBH5 Demethylation : m6A sites Direct Enhancement Histone modification H3K36me3 SETD2 CDH4
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target small nucleolar RNA host gene 15 (SNHG15)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone-lysine N-methyltransferase SETD2 (SETD2) WRITER View Details
Regulated Target Histone H3 lysine 36 trimethylation (H3K36me3) View Details
Downstream Gene CDH4 View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification directly impacts histone modification through recruiting histone-associated enzymes
Crosstalk Summary ALKBH5-demethylated lncRNA small nucleolar RNA host gene 15 (SNHG15) promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting Histone H3 lysine 36 trimethylation (H3K36me3) modifier SETD2 to activate H3K36me3-associated downstream transcription such as CDH4.
Responsed Disease Multiple myeloma ICD-11: 2A83
 Disease Info 
In-vivo Model A total of 1 × 107 cotransfected RPMI8226 MM cells, control RPMI8226 MM cells (shNC + LV-NC), ALKBH5-depleted RPMI8226 MM cells (shALKBH5 + LV-NC), or ALKBH5-depleted-SNHG15-overexpressed RPMI8226 MM cells (shALKBH5 + LV-SNHG15), were subcutaneously injected into the right flanks of the 4-wk-old male NOD/SCID mice (n = 6 for each group) to establish a human MM-xenografted model.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
2A83: Multiple myeloma 259 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Talquetamab Approved [2]
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TTD: DXR1A6
 Compound Name Dostarlimab Approved [3]
External Link
TTD: DGQU43
 Compound Name Belantamab mafodotin Approved [4]
External Link
TTD: D52NZX
 Compound Name Elranatamab Approved [5]
Synonyms
PF-06863135
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TTD: D3KO5Y
 Compound Name Atezolizumab Approved [6]
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TTD: D0YM2K
 Compound Name Metadoxine Approved [7]
Synonyms
MG01CI; Metadoxine (oral sustained release, ADHD); Metadoxine (oral extended release, ADHD), Alcobra; Metadoxine (oral sustained release, ADHD), Alcobra
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CID: 115198
TTD: D0YH0N
 Compound Name Ixazomib Approved [8]
External Link
CID: 25183872
TTD: D0Y2SW
DrugBank: DB09570
 Compound Name Thalidomide Approved [9]
Synonyms
Algosediv; Asmadion; Asmaval; Bonbrain; Bonbrrin; Calmore; Calmorex; Contergan; Corronarobetin; Distaval; Distaxal; Distoval; Ectiluran; Enterosediv; Gastrinide; Glupan; Glutanon; Grippex; Hippuzon; Imidene; Isomin; Kedavon; Kevadon; Neaufatin; Neosedyn; Neosydyn; Nerosedyn; Neufatin; Neurodyn; Neurosedin; Neurosedym; Neurosedyn; Nevrodyn; Nibrol; Noctosediv; Noxodyn; Pangul; Pantosediv; Polygripan; Profarmil; Psycholiquid; Psychotablets; Quetimid; Quietoplex; Sandormin; Sedalis; Sedimide; Sedin; Sedisperil; Sedoval; Shinnibrol; Sleepan; Slipro; Softenil; Softenon; Synovir; Talargan; Talidomida; Talidomide; Talimol; Talismol; Talizer; Telagan; Telargan; Telargean; Tensival; Thaled; Thalidomidum; Thalin; Thalinette; Thalomid; Thalomide; Theophilcholine; Valgis; Valgraine; Yodomin; Celgene Brand of Thalidomide; Talidomide [DCIT]; Thalidomide Celgene; Thalidomide Pharmion; Asidon 3; ENMD 0995; IN1061; Thalidomine USP26; Alpha-Phthalimidoglutarimide; E-217; Imida-lab; Imidan (peyta); N-Phthalimidoglutamic acid imide; N-Phthaloylglutamimide; N-Phthalylglutamic acid imide; Poly-Giron; Predni-Sediv; Pro-Bam M; Pro-ban M; Sedalis sedi-lab; Shin-naito S; THALIDOMIDE (AIDS INITIATIVE); Talidomida [INN-Spanish]; Thaled (TN); Thalidomide (soluble form); Thalidomidum [INN-Latin]; Thalomid (TM); Thalomid (TN); Thalomid, Thalidomide; Alpha-N-Phthalylglutaramide; Thalidomide [USAN:INN:BAN]; Alpha-(N-Phthalimido)glutarimide; N-Phthalyl-glutaminsaeure-imid; N-Phthalyl-glutaminsaeure-imid [German]; Thalidomide (+ and-); Thalidomide (JAN/USP/INN); N-(2,6-Dioxo-3-piperidyl)phthalimide; (+)-Thalidomide; (+-)-Thalidomide; (+/-)-THALIDOMIDE; (inverted question mark)-Thalidomide; 2,6-Dioxo-3-phthalimidopiperidine; 3-Phthalimidoglutarimide
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CID: 5426
TTD: D0U7GK
DrugBank: DB01041
 Compound Name Motixafortide Approved [10]
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CID: 91865076
TTD: D0T6CN
DrugBank: DB14939
 Compound Name Bortezomib Approved [11]
Synonyms
179324-69-7; Velcade; Bortezomib (PS-341); UNII-69G8BD63PP; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; MLN-341; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid; CHEMBL325041; 69G8BD63PP; Boronic acid,; DPBA; PROSCRIPT BORONIC ACID; LPD 341; LPD-341; VELCADE (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor); Peptide boronate
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CID: 387447
TTD: D0SH3I
DrugBank: DB00188
 Compound Name Daratumumab Approved [12]
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TTD: D0RV4P
 Compound Name Lenalidomide Approved [13]
Synonyms
Revamid; Revimid; Revlimid; Celgene brand of lenalidomide; Lenalidomide [USAN]; CC 5013; CC5013; CDC 501; IMiD3; IMiD3cpd; ALBB-015321; CC-5013; CDC-501; CDC-5013; ENMD-0997; IMID-5013; Revlimid (Celgene); Revlimid (TN); Thalidomide analog CC-5013; Lenalidomide (USAN/INN); CC-5013, Revlimid, Lenalidomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione; 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; Lenalidomide (Immunomodulator)
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CID: 216326
TTD: D0Q5NX
DrugBank: DB00480
 Compound Name Isatuximab Approved [14]
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TTD: D0JB2J
 Compound Name Dasatinib Approved [15]
Synonyms
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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CID: 3062316
TTD: D0E6XR
DrugBank: DB01254
 Compound Name Panobinostat Approved [16]
Synonyms
Faridak; LBH 589; LBH589; LBH-589; LBH-589B; NVP-LBH589; NVP-LBH-589; Panobinostat, NVP-LBH589, LBH589; (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE; (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
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CID: 6918837
TTD: D0E3SH
DrugBank: DB06603
 Compound Name Siltuximab Approved [6]
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TTD: D07NJN
 Compound Name Elotuzumab Approved [17]
Synonyms
BMS-901608
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TTD: D05DZR
 Compound Name Idecabtagene vicleucel Approved [18]
Synonyms
Bb2121
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TTD: D03NPI
 Compound Name Sirolimus Approved [19]
Synonyms
53123-88-9; Rapamune; Rapamycin (Sirolimus); AY-22989; Rapammune; sirolimusum; WY-090217; RAPA; Antibiotic AY 22989; AY 22989; UNII-W36ZG6FT64; CCRIS 9024; CHEBI:9168; SILA 9268A; W36ZG6FT64; HSDB 7284; C51H79NO13; NSC 226080; DE-109; NCGC00021305-05; DSSTox_CID_3582; DSSTox_RID_77091; DSSTox_GSID_23582; Cypher; Supralimus; Wy 090217; Perceiva; RAP; RPM; Rapamycin from Streptomyces hygroscopicus; SIIA 9268A; LCP-Siro; MS-R001; Rapamune (TN); Rapamycin (TN); Sirolimus (RAPAMUNE); Rapamycin C-7, analog 4; Sirolimus (USAN/INN); Sirolimus [USAN:BAN:INN]; Sirolimus, Rapamune,Rapamycin; Heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy; 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; 23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29; 3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; Sirolimus (MTOR inhibitor)
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CID: 5284616
TTD: D03LJR
DrugBank: DB00877
 Compound Name Cerivastatin Approved [20]
Synonyms
Baycol; cerivastatin acid; Lipobay; 145599-86-6; Cerivastatin [INN:BAN]; UNII-AM91H2KS67; CHEBI:3558; AM91H2KS67; HSDB 7357; (3R,5S,6E)-7-(4-(p-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid; (3R,5S,6E)-7-(4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic acid; 143201-11-0; 6-Heptenoic acid, 7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-, (3R,5S,6E)-; Statins
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CID: 446156
TTD: D03KIA
DrugBank: DB00439
 Compound Name Teclistamab Approved [21]
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TTD: D03AFF
 Compound Name Futibatinib Phase 1/2 [22]
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CID: 71621331
TTD: D01ZLU
DrugBank: DB15149
 Compound Name Romiplostim Approved [23]
External Link
CID: 5329098
TTD: D01PZD
DrugBank: DB06436
 Compound Name MLN9708 Approved [24]
External Link
CID: 49867936
TTD: D01MML
 Compound Name Melphalan flufenamide Approved [25]
Synonyms
J-1; Dipeptide-conjugated melphalan prodrug (iv formulation, ovary tumor), Oncopeptides
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CID: 9935639
TTD: D01HPY
 Compound Name Carfilzomib Approved [26]
Synonyms
868540-17-4; Kyprolis; Carfilzomib (PR-171); PR-171; UNII-72X6E3J5AR; 72X6E3J5AR; CHEMBL451887; CHEBI:65347; NCGC00249613-01; DSSTox_RID_82886; DSSTox_CID_28616; DSSTox_GSID_48690; (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide; N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
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CID: 11556711
TTD: D00UVA
DrugBank: DB08889
 Compound Name Nivolumab Approved [6]
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TTD: D00GOV
 Compound Name Melphalan Approved [27]
Synonyms
Alkeran; Levofalan; Levofolan; Levopholan; Melfalan; Melfalano; Melphalanum; Alanine Nitrogen Mustard; Phenylalanine mustard; Phenylalanine nitrogen mu stard; Phenylalanine nitrogen mustard; AY3360000; CB 3025; ALKERAN (TN); At-290; CB-3025; L-PAM; L-Phenylalanine mustard; L-Sarcolysin; L-Sarcolysine; L-Sarkolysin; Melfalano [INN-Spanish]; Melphalanum [INN-Latin]; SK-15673; TRANSGENIC MODEL EVALUATION (MELPHALAN); MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN)); P-L-Sarcolysin; P-L-sarcolysine; TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN); Melphalan (JP15/USP/INN); Melphalan [USAN:INN:BAN:JAN]; P-Bis(beta-chloroethyl)aminophenylalanine; P-N-Di(chloroethyl)aminophenylalanine; P-N-di(chloroethyl)aminophenylala nine; P-Di-(2-chloroethyl)amino-L-phenylalanine; P-N-Bis(2-chloroethyl)amino-L-phenylalanine; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine; P-N,N-bis(2-chloroethyl)amino-L-phenylalanine; (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid; 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine; 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine
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CID: 460612
TTD: D00FGO
DrugBank: DB01042
 Compound Name Trapidil Phase 4 [20]
Synonyms
Trapymin; Rocornal; 15421-84-8; Avantrin; Trapymine; N,N-diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; AR 12008; Trapidilum [INN-Latin]; UNII-EYG5Y6355E; EINECS 239-434-2; BRN 0186842; 7-Diethylamino-5-methyl-s-triazolo(1,5-a)pyrimidine; MLS000567667; EYG5Y6355E; N,N-Diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-7-amine; (1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-; 5-Methyl-7-diethylamino-s-triazolo-(1,5-a)-pyrimidine; NCGC00016715-01; AR-12008; SMR000154170; SU10991
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CID: 5531
TTD: D0U2CV
DrugBank: DB09283
 Compound Name Ciltacabtagene autoleucel Phase 3 [28]
Synonyms
JNJ-68284528
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TTD: DXV06E
 Compound Name ABC294640 Phase 3 [6]
Synonyms
915385-81-8; Opaganib; ABC-294640; CHEMBL2158685; ABC 294640; UNII-DRG21OQ517; DRG21OQ517; Yeliva; SCHEMBL1548333; GTPL6624; CHEBI:124965; MolPort-044-560-286; HMS3402P05; BCP08959; EX-A1962; BDBM50393642; 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide; AKOS027327311; CS-0877; SB17167; DB12764; API0017247; HY-16015; S7174; BRD-A70814879-003-01-8
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CID: 15604015
TTD: D0X6BX
DrugBank: DB12764
 Compound Name Tabalumab Phase 3 [29]
Synonyms
LY2127399
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TTD: D0U6UK
 Compound Name Marizomib Phase 1 [30]
Synonyms
salinosporamide A; 437742-34-2; (-)-Salinosporamide A; UNII-703P9YDP7F; NPI-0052; NPI 0052; ML 858; 703P9YDP7F; CHEBI:48045; (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Marizomib [USAN:INN]; marizomibum; Marizomib (USAN/INN); Salinosporamide A (NPI-0052, Marizomib); SCHEMBL151667; CHEMBL371405; NGWSFRIPKNWYAO-SHTIJGAHSA-N; ZINC3990364; BDBM50398608; 2531AH; AKOS027323566; DB11762; Z-3093; D09640; 855517-10-1
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CID: 11347535
TTD: D0N0RN
DrugBank: DB11762
 Compound Name Galinpepimut-S Phase 3 [6]
External Link
TTD: D0M9OO
 Compound Name Ulocuplumab Phase 3 [31]
External Link
TTD: D0C3LQ
 Compound Name Pelareorep Phase 2 [32]
External Link
TTD: D0BF8Y
 Compound Name NVP-LAQ824 Phase 3 [20]
Synonyms
Dacinostat; 404951-53-7; LAQ824; LAQ-824; LAQ824 (Dacinostat); UNII-V10P524501; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; CHEMBL356066; V10P524501; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Dacinostat [INN]; (E)-N-Hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide; (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide; NVP-LAQ 824; NVP-LAQ824, Dacinostat, LAQ824; LBH539
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CID: 6445533
TTD: D0B3FV
 Compound Name Plitidepsin Phase 3 [30]
Synonyms
Aplidin (TN)
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CID: 9812534
TTD: D07QJK
DrugBank: DB04977
 Compound Name Oblimersen Phase 3 [33]
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CID: 118984457
TTD: D05RJP
 Compound Name T89 Phase 3 [34]
Synonyms
2-Propanone, 1-(5-nitro-2H-tetrazol-2-yl)-; 131394-19-9; 1-(5-nitro-1,2,3,4-tetraazol-2-yl)acetone; ZERO/000247; AC1LOTQU; ACMC-20mu2z; 2-acetonyl-5-nitrotetrazole; CTK0C0970; DTXSID40361521; MolPort-001-904-996; ZINC1084291; STK760073; SBB000169; AKOS000558886; MCULE-5436124308; 1-(5-nitrotetrazol-2-yl)propan-2-one; 2-(2-Oxopropyl)-5-nitro-2H-tetrazole; ST026974; ST023819; BAS 01313849; 1-(5-Nitro-tetrazol-2-yl)-propan-2-one; EU-0085349; 1-(5-nitro-2H-tetrazol-2-yl)propan-2-one; SR-01000523987; SR-01000523987-1
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CID: 1270252
TTD: D05QUL
 Compound Name GMI-1271 Phase 3 [6]
Synonyms
Uproleselan
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CID: 71600085
TTD: D03PWD
DrugBank: DB14829
 Compound Name Selinexor Phase 3 [6]
Synonyms
Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
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CID: 71481097
TTD: D00LNW
DrugBank: DB11942
 Compound Name Imetelstat Phase 2 [35]
Synonyms
Motesanib diphosphate; 857876-30-3; Motesanib (Diphosphate); Motesanib Diphosphate (AMG-706); UNII-T6Q3060U91; Motesanib diphosphate [USAN]; T6Q3060U91; Motesanib diphosphate (USAN); AMG-706 diphosphate; Motesanib phosphate (JAN); bis(phosphoric acid); Motesanib Diphosphate/AMG-706; CHEMBL2107357; DTXSID30235080; C22H29N5O9P2; MolPort-016-633-170; HMS3654K07; AOB87339; ABP000867; AKOS026750408; CS-0193; API0006359; AN-5306; SB16584; RL05311; AS-17019; HY-10229; SW218300-2; FT-0672543; X7466; D08947; W-5527; A841448
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CID: 71587831
TTD: D04XEQ
 Compound Name CLR 131 Phase 1 [30]
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TTD: DNCA54
 Compound Name Descartes-11 Phase 2 [36]
External Link
TTD: DN28SH
 Compound Name DKN-01 Phase 2 [37]
External Link
TTD: DMF73Z
 Compound Name RAPA-201 Phase 2 [38]
External Link
TTD: DL7J8B
 Compound Name BHQ880 Phase 2 [39]
Synonyms
BHQ-880A; Anti-DKK1 monoclonal antibody (multiple myeloma), Novartis
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TTD: D62FLA
 Compound Name INCB00928 Phase 2 [40]
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TTD: D50OLM
 Compound Name Descartes-08 Phase 2 [41]
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TTD: D0Z6AR
 Compound Name GSK2857916 Phase 2 [6]
External Link
TTD: D0YV0N
 Compound Name Delanzomib Phase 2 [42]
Synonyms
((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutan-2-yl)boronic acid; s1157; ZINC202536926; SB16695; SW219161-1; boronic acid, b-[(1r)-1-[[(2s,3r)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]-
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CID: 24800541
TTD: D0VO0T
DrugBank: DB11956
 Compound Name Myeloma cancer vaccine Phase 2 [43]
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TTD: D0U0NS
 Compound Name CJM112 Phase 2 [6]
External Link
TTD: D0T5TN
 Compound Name Tanespimycin Discontinued in Phase 3 [44]
Synonyms
CNF-101; [(3S,5S,6R,7S,8E,10R,11S,12E,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; 17AAG, Tanespimycin, Geldanamycin, NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin, CP 127374
    Click to Show/Hide
External Link
CID: 6505803
TTD: D0SC2J
DrugBank: DB05134
 Compound Name CLR-131 Phase 2 [6]
External Link
TTD: D0RX6F
 Compound Name CDX-301 Phase 2 [6]
External Link
TTD: D0Q8CV
 Compound Name BI-505 Phase 2 [30]
External Link
TTD: D0Q7OE
 Compound Name SurVaxM Phase 2 [45]
External Link
TTD: D0KQ8W
 Compound Name LCAR-B38M CAR-T Cell Phase 2 [46]
External Link
TTD: D0K1AK
 Compound Name CART-19 cells Phase 2 [47]
External Link
TTD: D0I0NJ
 Compound Name ALT-803 Phase 2 [6]
Synonyms
IL-15 agonist/ IL-15R alpha-Fc fusion complex (cancer), Altor BioScience
    Click to Show/Hide
External Link
TTD: D0FD7H
 Compound Name LCL161 Phase 2 [6]
External Link
CID: 24737642
TTD: D09MIN
DrugBank: DB12085
 Compound Name mab 1-7F9 Phase 2 [48]
External Link
TTD: D08XPN
 Compound Name JNJ 63723283 Phase 2 [6]
External Link
TTD: D08UGS
 Compound Name GSK3377794 Phase 2 [6]
External Link
TTD: D08FWJ
 Compound Name GL-0817 Phase 2 [49]
Synonyms
912762-70-0; MolPort-002-506-765; tert-butyl N-[(2Z)-2-(2,4-dimethoxyphenyl)-2-(hydroxyimino)ethyl]carbamate; ZINC103473003; AKOS005256100; [2-(2,4-DIMETHOXY-PHENYL)-2-HYDROXYIMINO-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
    Click to Show/Hide
External Link
CID: 122706930
TTD: D08DUF
 Compound Name ONC201 Phase 2 [6]
Synonyms
Onc-201; TIC10; 1616632-77-9; UNII-9U35A31JAI; 9U35A31JAI; TIC10(ONC-201); 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5(4H)-one; TIC 10 active isomer; ONC201(TIC10 isomer); TIC 10; GTPL9978; SCHEMBL16227974; EX-A669; ONC 201; AOB2892; MolPort-039-137-731; HY-15615A; 3388AH; s7963; ZINC169620396; AKOS025404904; NSC 350625; CS-3564; AS-16735; AK174891; KB-335104; FT-0700231; J-690224; 1342897-86-2; 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimid
    Click to Show/Hide
External Link
CID: 73777259
TTD: D07XQS
DrugBank: DB14844
 Compound Name Selinexor Approved [19]
External Link
CID: 71481097
TTD: D07KVV
DrugBank: DB11942
 Compound Name Thalidomide Approved [50]
External Link
CID: 5426
TTD: D07ISX
DrugBank: DB01041
 Compound Name Bb2121 Phase 2 [6]
External Link
TTD: D07CUR
 Compound Name PVX-410 Phase 2 [45]
External Link
TTD: D06DUS
 Compound Name Rocilinostat Phase 2 [51]
Synonyms
1316214-52-4; Rocilinostat (ACY-1215); 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-WKT909C62B; ACY-63; WKT909C62B; 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; AK151416; N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide; 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide; Ricolinostat [USAN:INN]; AH4; Ricolinostat (USAN/INN); MLS006011181; SCHEMBL574580; GTPL7010
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External Link
CID: 53340666
TTD: D05KED
DrugBank: DB12376
 Compound Name NVP-AUY922 Phase 2 [52]
Synonyms
Luminespib; 747412-49-3; AUY922; VER-52296; AUY-922; UNII-C6V1DAR5EB; AUY922 (NVP-AUY922); Luminespib (NVP-AUY922); NVP-AUY 922; 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide; C6V1DAR5EB; Luminespib (AUY-922, NVP-AUY922); CHEBI:83656; 5-[2,4-DIHYDROXY-5-ISOPROPYLPHENYL]-N-ETHYL-4-[4-(4-MORPHOLINYLMETHYL)PHENYL]-3-ISOXAZOLECARBOXAMIDE; AK174786; 5-[2,4-Dihydroxy-5-(1-Methylethyl)phenyl]-N-Ethyl-4-[4-(Morpholin-4-Ylmethyl)phenyl]isoxazole-3-Carboxamide
    Click to Show/Hide
External Link
CID: 135539077
TTD: D05BYA
 Compound Name ARRY-520 Phase 2 [30]
Synonyms
Filanesib; 885060-09-3; UNII-8A49OSO368; Arry520; CHEMBL2347655; ARRY 520 trifluoroacetate; 8A49OSO368; ARRY 520; (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide; Filanesib [INN]; Filanesib [USAN:INN]; C20H22F2N4O2S; 1385020-40-5; Filanesib(ARRY-520); SCHEMBL368043; DTXSID50237086; EX-A678; BCP07442; ZINC43204022; 3452AH; BDBM50431893; AKOS030526964; SB19209; RL05514; CS-0867; NCGC00381751-02; NCGC00381751-04
    Click to Show/Hide
External Link
CID: 44224257
TTD: D04VWJ
DrugBank: DB06040
 Compound Name BT-062 Phase 2 [6]
External Link
TTD: D04PUI
 Compound Name Captisol-enabled Melphalan Phase 2 [53]
External Link
TTD: D04LXB
 Compound Name IPH-2101 Phase 2 [54]
External Link
TTD: D04IXD
 Compound Name Darinaparsin Phase 2 [55]
Synonyms
ZIO-101
    Click to Show/Hide
External Link
CID: 11683005
TTD: D03ZME
DrugBank: DB06179
 Compound Name Ficlatuzumab Phase 2 [56]
Synonyms
AV-299
    Click to Show/Hide
External Link
TTD: D03UBW
 Compound Name GVAX Phase 2 [57]
External Link
TTD: D03OSE
 Compound Name INK128 Phase 2 [58]
Synonyms
1224844-38-5; Sapanisertib; INK-128; INK 128; INK 128 (MLN0128); TAK-228; UNII-JGH0DF1U03; JGH0DF1U03; 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine; INK-0128; 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H15N7O; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine; 5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]-pyrimidin-3-yl)benzo[d]oxazol-2-amine; Sapanisertib (USAN/INN)
    Click to Show/Hide
External Link
CID: 45375953
TTD: D03DPZ
DrugBank: DB11836
 Compound Name GSK2110183 Phase 2 [59]
External Link
CID: 46843057
TTD: D02NXM
DrugBank: DB11648
 Compound Name Oprozomib Phase 1 [6]
External Link
CID: 25067547
TTD: D02BLD
DrugBank: DB11991
 Compound Name CC-220 Phase 1 [6]
Synonyms
AC1OEW2H; NPD6561; MCULE-9299015048; BCP9000573; BCP0726000266
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External Link
CID: 67335295
TTD: D01XVX
DrugBank: DB12101
 Compound Name Ygalo Phase 2 [6]
External Link
TTD: D01CBE
 Compound Name Indatuximab ravtansine Phase 2 [60]
External Link
TTD: D00CQI
 Compound Name REGN5459 Phase 1/2 [61]
External Link
TTD: DY9G1D
 Compound Name REGN5458 Phase 1/2 [62]
External Link
TTD: DR7Q5N
 Compound Name ISB 1342 Phase 1/2 [63]
Synonyms
GBR1342
    Click to Show/Hide
External Link
TTD: DE0L6O
 Compound Name PBCAR269A Phase 1/2 [64]
External Link
TTD: D7LU8R
 Compound Name NEXI-002 Phase 1/2 [65]
External Link
TTD: D6EI9F
 Compound Name Tinostamustine Phase 1/2 [66]
Synonyms
1236199-60-2; 1H-Benzimidazole-2-heptanamide, 5-(bis(2-chloroethyl)amino)-N-hydroxy-1-methyl-; 1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl-; 29DKI2H2NY; 7-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)-N-hydroxyheptanamide; 7-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]-N-hydroxyheptanamide; 7-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}-N-hydroxyheptanamide; AKOS030526024; BCP20331; BDBM50569838; BE170657; CHEMBL3989941; CS-6484; D11182; DB15147; E76854; EDO-S 101; EDO-S101; EDO-S-101; EX-A1322; HY-101780; Minomustine; MS-27198; S8769; SB19172; SCHEMBL7915449; starbld0018955; Tinostamustine; Tinostamustine (USAN/INN); TINOSTAMUSTINE [INN]; Tinostamustine [USAN]; TINOSTAMUSTINE [WHO-DD]; Tinostamustine(EDO-S101); UNII-29DKI2H2NY
    Click to Show/Hide
External Link
CID: 46836227
TTD: D39TVC
DrugBank: DB15147
 Compound Name Modakafusp alfa Phase 1/2 [67]
Synonyms
TAK-573
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External Link
TTD: D1B3VP
 Compound Name SL-401 Phase 1/2 [6]
External Link
TTD: D0Z2ZY
 Compound Name Milatuzumab-doxorubicin conjugate Phase 1/2 [68]
External Link
TTD: D0Y6BO
 Compound Name CART-138 cells Phase 1/2 [69]
External Link
TTD: D0Y4MA
 Compound Name CAR-T cells targeting CD30 Phase 1/2 [70]
External Link
TTD: D0UA0U
 Compound Name CD56 CAR T cells Phase 1/2 [71]
External Link
TTD: D0U1GP
 Compound Name NY-ESO-TCR Phase 1/2 [32]
External Link
TTD: D0TN1N
 Compound Name CAR-T cells targeting CD22 Phase 1/2 [70]
External Link
TTD: D0PD4C
 Compound Name Anti-CD38 CAR-T cells Phase 1/2 [72]
External Link
TTD: D0OO1S
 Compound Name MOR-202 Phase 1/2 [73]
Synonyms
Anti-CD38 antibodies, MorphoSys; HuCAL-mAb1, MorphoSys; HuCAL-mAb2, MorphoSys; HuCAL-mAb3, MorphoSys
    Click to Show/Hide
External Link
TTD: D0O4IN
 Compound Name BIW-8962 Phase 1/2 [74]
External Link
TTD: D0N6TD
 Compound Name Anti-BCMA CAR-T cells Phase 1/2 [72]
External Link
TTD: D0MK7H
 Compound Name CART-138 cells Phase 1/2 [75]
External Link
TTD: D0M3RI
 Compound Name Anti-NY-ESO-1 CAR-T cells Phase 1/2 [72]
External Link
TTD: D0LJ2S
 Compound Name CC-92480 Phase 1/2 [76]
Synonyms
CELMoD
    Click to Show/Hide
External Link
TTD: D0HT4Y
 Compound Name CD38 and BCMA CAR-T Cells Phase 1/2 [77]
External Link
TTD: D0G0PI
 Compound Name JCARH125 Phase 1/2 [78]
External Link
TTD: D0EQ6D
 Compound Name CAR-T cells targeting CLL1 Phase 1/2 [70]
External Link
TTD: D0DO8E
 Compound Name BION-1301 Phase 1/2 [6]
External Link
TTD: D0DJ2H
 Compound Name Atiprimod Phase 1/2 [20]
Synonyms
Atiprimod [INN]; SKF 106615; SKF-106615; N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine; 3-(8,8-dipropyl-3-azaspiro[4.5]decan-3-yl)-N,N-diethylpropan-1-amine
    Click to Show/Hide
External Link
CID: 129869
TTD: D0D9LJ
DrugBank: DB05513
 Compound Name CAR-T cells targeting BCMA Phase 1/2 [70]
External Link
TTD: D0D4ZN
 Compound Name AUTO2 Phase 1/2 [79]
External Link
TTD: D0B8UW
 Compound Name CART-19/BCMA Phase 1/2 [80]
External Link
TTD: D0AC9S
 Compound Name CD38 CAR T cells Phase 1/2 [71]
External Link
TTD: D09UFZ
 Compound Name P-BCMA-101 Phase 1/2 [81]
External Link
TTD: D09JKN
 Compound Name JCAR017 Phase 1 [78]
External Link
TTD: D08BPS
 Compound Name Anti-BCMA-CAR-transduced T cells Phase 1/2 [82]
External Link
TTD: D07QIQ
 Compound Name JNJ-68284528 Phase 1/2 [83]
External Link
TTD: D07PJS
 Compound Name AR-42 Phase 1/2 [84]
Synonyms
935881-37-1; OSU-HDAC42; AR 42; (S)-HDAC-42; (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide; UNII-E0GG29V0AQ; (S)-HDAC 42; E0GG29V0AQ; AR42; HDAC-42; AR-42 (HDAC-42); N-hydroxy-4-{[(2S)-3-methyl-2-phenylbutanoyl]amino}benzamide; N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide; AR-42 (OSU-HDAC42); AC1OCFYN; cc-20; OSU-HDAC 42; MLS006011089; CHEMBL191482; SCHEMBL2348844; OSU-42; DTXSID4042678; NOCAS_42678; CTK8C1969; AOB3995; N-Hydroxy-4-(3-methyl-2-(S)phenyl-butyrylamino)benzamide; MolPort-009-019-571
    Click to Show/Hide
External Link
CID: 6918848
TTD: D07KDI
DrugBank: DB12707
 Compound Name LGH-447 Phase 1/2 [85]
External Link
CID: 44814409
TTD: D07EHV
DrugBank: DB14943
 Compound Name CWP232291 Phase 1/2 [6]
External Link
TTD: D07AYI
 Compound Name CD138 CAR T cells Phase 1/2 [71]
External Link
TTD: D05CTQ
 Compound Name ImMucin Phase 1/2 [86]
Synonyms
MUC-1 peptide vaccine (cancer), Vaxil BioTherapeutics/Hadassah Medical
    Click to Show/Hide
External Link
TTD: D04UFI
 Compound Name CART-BCMA cells Phase 1/2 [69]
External Link
TTD: D04PIU
 Compound Name CAR-T cells targeting CD19 Phase 1/2 [70]
External Link
TTD: D04JHH
 Compound Name BCMA CAR-T Phase 1/2 [87]
External Link
TTD: D02JNC
 Compound Name BCMA CAR T cells Phase 1/2 [71]
External Link
TTD: D01CUC
 Compound Name CC-98633 Phase 1 [88]
External Link
TTD: DX6J8M
 Compound Name BCMA-CS1 cCAR Phase 1 [89]
External Link
TTD: DX1LD3
 Compound Name TNB-383B Phase 1 [90]
External Link
TTD: DW1H9O
 Compound Name 131I-labelled CLR1404 Phase 1 [91]
External Link
TTD: DVR84A
 Compound Name GPRC5D CAR-T cell therapy Phase 1 [92]
External Link
TTD: DV9M0Y
 Compound Name AMG 420 Phase 1 [6]
External Link
TTD: DUZ0F7
 Compound Name BCMA-CD19 cCAR Phase 1 [93]
External Link
TTD: DTR05Z
 Compound Name CD38 CAR-T Phase 1 [94]
External Link
TTD: DSWZ60
 Compound Name RG6538 Phase 1 [95]
External Link
TTD: DS86KN
 Compound Name UCARTCS1 Phase 1 [96]
External Link
TTD: DS6W8Z
 Compound Name MB-104 Phase 1 [97]
External Link
TTD: DRU0M6
 Compound Name JNJ-79635322 Phase 1 [98]
Synonyms
JNJ-5322
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External Link
TTD: DRFS19
 Compound Name VOB560 Phase 1 [99]
Synonyms
S 65487
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External Link
TTD: DP63FS
 Compound Name CC-93269 Phase 1 [6]
Synonyms
BCMA TCE
    Click to Show/Hide
External Link
TTD: DOQ13X
 Compound Name AMG 424 Phase 1 [100]
External Link
TTD: DLY65X
 Compound Name 225Ac-labelled aCD38 Phase 1 [101]
External Link
TTD: DK1PA2
 Compound Name CC-99712 Phase 1 [102]
External Link
TTD: DH5BX2
 Compound Name MEDI2228 Phase 1 [103]
External Link
TTD: DG80IS
 Compound Name AMG 701 Phase 1 [6]
External Link
TTD: DF43EH
 Compound Name KP1237 Phase 1 [104]
Synonyms
BHV-1100
    Click to Show/Hide
External Link
TTD: DECJ17
 Compound Name CTX120 Phase 1 [105]
External Link
TTD: DE49RW
 Compound Name RG6296 Phase 1 [106]
Synonyms
AFM-26
    Click to Show/Hide
External Link
TTD: DC3Y7O
 Compound Name WVT078 Phase 1 [107]
External Link
TTD: D81YIK
 Compound Name M3258 Phase 1 [108]
Synonyms
LMP7-IN-1; 2285330-15-4; NSC818432; NSC-818432; HY-111790; CS-0091883; ((R)-2-(Benzofuran-3-yl)-1-((1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carboxamido)ethyl)boronic acid
    Click to Show/Hide
External Link
CID: 138319683
TTD: D7X8AQ
 Compound Name FT538 Phase 1 [109]
External Link
TTD: D79JZU
 Compound Name RG6234 Phase 1 [95]
External Link
TTD: D6RT9L
 Compound Name NAM-NK cells Phase 1 [110]
External Link
TTD: D6N8UJ
 Compound Name PHE885 Phase 1 [111]
External Link
TTD: D67ZDJ
 Compound Name ABBV-467 Phase 1 [112]
External Link
TTD: D63QIY
 Compound Name ALLO-715 Phase 1 [113]
External Link
TTD: D5YN8U
 Compound Name TTI-622 Phase 1 [114]
External Link
TTD: D5FCP1
 Compound Name SEA-BCMA Phase 1 [115]
External Link
TTD: D4QZ3O
 Compound Name FOR46 Phase 1 [116]
External Link
TTD: D48ZBO
 Compound Name CART-ddBCMA Phase 1 [117]
External Link
TTD: D3T7NY
 Compound Name TAK-169 Phase 1 [118]
External Link
TTD: D2HE9I
 Compound Name CT053 Phase 1 [119]
External Link
TTD: D1WOX4
 Compound Name RO6870810 Phase 1 [120]
Synonyms
JQ-35, (S)-; (S)-JQ-35; 1349719-98-7; (S)-JQ35; Bet inhibitor TEN-010; UNII-TA3QN7788D; TA3QN7788D; TEN-010; Ro-6870810; (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)acetamide; SCHEMBL881288; TEN010; CHEMBL4297423; Rg 6146; EX-A3890; NSC816555; DB15151; NSC-816555; SB19675; HY-117286; CS-0064969; Q27896195; C1CN(C)CCN1CCCNC(=O)C[C@H]1C2=NN=C(C)N2C(SC(C)=C2C)=C2C(C=2C=CC(Cl)=CC=2)=N1; 6H-Thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-N-(3-(4-methyl-1-piperazinyl)propyl)-, (6S)-
    Click to Show/Hide
External Link
CID: 54670351
TTD: D15ZUR
DrugBank: DB15151
 Compound Name HPN217 Phase 1 [121]
External Link
TTD: D12DYT
 Compound Name TAK-573 Phase 1 [6]
External Link
TTD: D0ZDP2
 Compound Name PT-112 Phase 1 [6]
External Link
TTD: D0YJ5F
 Compound Name Anti-CD38 CAR-T cell therapy Phase 1 [6]
External Link
TTD: D0Y7LV
 Compound Name Actimab-M Phase 1 [32]
Synonyms
Actinium-225; Actinium, isotope of mass 225; 225Ac; AC1L4Z7V; 14265-85-1
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External Link
CID: 167045
TTD: D0XE4W
 Compound Name Anti-BCMA CAR T cells Phase 1 [122]
External Link
TTD: D0W7AB
 Compound Name BB-MPI-03 Phase 1 [45]
External Link
TTD: D0W1TL
 Compound Name Anti-FGFR3 Phase 1 [123]
External Link
TTD: D0V0BO
 Compound Name Anti-CD19/BCMA CAR-T cells Phase 1 [124]
External Link
TTD: D0U7WY
 Compound Name MTV273 Phase 1 [6]
External Link
TTD: D0U4KJ
 Compound Name Anti-BCMA CAR T cells Phase 1 [125]
External Link
TTD: D0U2PU
 Compound Name BCMA nanobody CAR-T cells Phase 1 [126]
External Link
TTD: D0T9CE
 Compound Name BCMA CART and huCART19 Phase 1 [127]
External Link
TTD: D0T8RV
 Compound Name SGN-CD48A Phase 1 [6]
External Link
TTD: D0S5CY
 Compound Name BCMA CART Phase 1 [127]
External Link
TTD: D0RD0D
 Compound Name Anti-BCMA CART Cells Phase 1 [128]
External Link
TTD: D0RA7L
 Compound Name APO-010 Phase 1 [129]
Synonyms
MegaFasL; Anticancer therapeutics (FasL), APoxis; Cancer therapeutics (FasL), Apoxis; Soluble FasL (Mega-Ligand), Apoxis; Soluble FasL (Mega-Ligand), TopoTarget
    Click to Show/Hide
External Link
TTD: D0Q6SF
 Compound Name Anti-BCMA CAR-T cell therapy Phase 1 [32]
External Link
TTD: D0O7XA
 Compound Name CC-115 Phase 1 [130]
Synonyms
CC-115 (hydrochloride); CC-115 hydrochloride; 1300118-55-1; SCHEMBL1767621; BCP20709; HY-16962A; AKOS030526389
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External Link
CID: 58298318
TTD: D0O1IM
DrugBank: DB12740
 Compound Name P-BCMA-101 CAR-T cells Phase 1 [131]
External Link
TTD: D0NK6K
 Compound Name BCMA CAR-T Cells Phase 1 [132]
External Link
TTD: D0NG3T
 Compound Name CM-CS1 T-cell Phase 1 [133]
External Link
TTD: D0NC9M
 Compound Name Mivebresib Phase 1 [6]
Synonyms
ABBV-075; 1445993-26-9; UNII-VR86R11J7J; VR86R11J7J; N-[4-(2,4-Difluorophenoxy)-3-(6-Methyl-7-Oxo-6,7-Dihydro-1h-Pyrrolo[2,3-C]pyridin-4-Yl)phenyl]ethanesulfonamide; N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide; 8NG; Mivebresib [INN]; ABBV-075 (Mivebresib); ABBV075; GTPL9117; SCHEMBL15068241; CHEMBL3987016; Mivebresib(ABBV-075 pound(c); MolPort-044-561-801; RDONXGFGWSSFMY-UHFFFAOYSA-N; BDBM220447; EX-A1082; s8400; ZINC146486516; AKOS030628486; CS-5815
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External Link
CID: 71600087
TTD: D0M2TS
 Compound Name PF-06688992 Phase 1 [32]
External Link
TTD: D0JB9C
 Compound Name DFRF4539A Phase 1 [134]
External Link
TTD: D0J9YS
 Compound Name C-CAR088 Phase 1 [135]
External Link
TTD: D0J7OU
 Compound Name AMG 176 Phase 1 [6]
Synonyms
JQNINBDKGLWYMU-GEAQBIRJSA-N; AMG-176; 1883727-34-1; AMG176; SCHEMBL17550216; EX-A2666; HY-101565; CS-0021721; Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-
    Click to Show/Hide
External Link
CID: 118910268
TTD: D0I5DP
 Compound Name LCAR-B4822M CAR-T Cell Phase 1 [136]
External Link
TTD: D0I1PF
 Compound Name Natural killer cell therapy Phase 1 [137]
Synonyms
Killer cell therapy; Natural killer cell therapy (autologous, multiple myeloma)
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External Link
TTD: D0H6FY
 Compound Name VLX1570 Phase 1 [30]
Synonyms
SCKXBVLYWLLALY-ZSIIYVIPSA-N; VLX-1570; 1431280-51-1; BCP18900
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External Link
CID: 71523377
TTD: D0G7IF
 Compound Name STRO-001 Phase 1 [6]
External Link
TTD: D0E7FC
 Compound Name JNJ-64407564 Phase 1 [6]
External Link
TTD: D0DA4B
 Compound Name KITE-585 Phase 1 [6]
External Link
TTD: D0C8QA
 Compound Name ABBV-838 Phase 1 [32]
External Link
TTD: D0BB2V
 Compound Name CAR-T cells targeting BCMA Phase 1 [138]
External Link
TTD: D0B2WU
 Compound Name CAR138 T Cells Phase 1 [139]
External Link
TTD: D09ZDY
 Compound Name SGN-CD352A Phase 1 [6]
External Link
TTD: D09RUO
 Compound Name CB-5083 Phase 1 [140]
External Link
CID: 73051434
TTD: D08OOJ
 Compound Name AEW-541 Phase 1 [141]
Synonyms
AECDBHGVIIRMOI-UHFFFAOYSA-N; NVP-AEW541; 475489-16-8; 475488-34-7; AEW541; NVP-AEW 541; UNII-97QB5037VR; AEW 541; AVP-AEW541; 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; CHEMBL1614712; 97QB5037VR; 7-[TRANS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE; C27H29N5O; 7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, 7-[CIS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-
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External Link
CID: 11476171
TTD: D07HPJ
 Compound Name Anti-BCMA CAR-T cells Phase 1 [142]
External Link
TTD: D07HJS
 Compound Name IM21 CART Phase 1 [143]
External Link
TTD: D05XNF
 Compound Name Anti-CD38 CAR-T cells Phase 1 [144]
External Link
TTD: D05WET
 Compound Name ATA520 Phase 1 [32]
External Link
TTD: D05MVX
 Compound Name GRN163 Phase 1 [20]
External Link
CID: 56603713
TTD: D04HDZ
 Compound Name GBR 1342 Phase 1 [6]
External Link
TTD: D04GAG
 Compound Name ACTR-BCMA Phase 1 [6]
Synonyms
ACTR087 + SEA-BCMA
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External Link
TTD: D03XFH
 Compound Name CC-122 Phase 1 [6]
Synonyms
1015474-32-4; Avadomide; 3-(5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; CC122; CC 122; 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione; 2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-;2,6-Piperidinedione, 3-(5-amino-2-methyl-4-oxo-3(4H)-quinazolinyl)-; Avadomide [USAN]; Avadomide(CC-122); Avadomide (USAN/INN); SCHEMBL282749; US9694015, Compound A; CHEMBL3989934; BDBM76986; RSNPAKAFCAAMBH-UHFFFAOYSA-N; EX-A1191; BCP15938; s7892; AKOS025399378; SB18829; CS-5995
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External Link
CID: 24967599
TTD: D03QZJ
DrugBank: DB14857
 Compound Name PNK-007 Phase 1 [6]
External Link
TTD: D03IRG
 Compound Name Anti-CD19 CART Cells Phase 1 [128]
External Link
TTD: D02NFE
 Compound Name BFCR4350A Phase 1 [6]
Synonyms
RG6160
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External Link
TTD: D02HFN
 Compound Name CART-BCMA Phase 1 [145]
External Link
TTD: D01YZF
 Compound Name Citarinostat Phase 1 [6]
Synonyms
ACY-241; 1316215-12-9; HDAC-IN-2; 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-441P620G3P; 441P620G3P; Citarinostat [USAN]; Citarinostat (USAN); 2-(N-(2-chlorophenyl)anilino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide; 2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide; 2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; Citarinostat (ACY-241); SCHEMBL2225863; GTPL942
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External Link
CID: 53340426
TTD: D01WKZ
DrugBank: DB15449
 Compound Name NAM-NK cells + IL-2 Phase 1 [6]
External Link
TTD: D01PXH
 Compound Name PF-06863135 Phase 1 [6]
External Link
TTD: D01JSI
 Compound Name AMG 224 Phase 1 [6]
External Link
TTD: D01EXG
 Compound Name CART-19 T cells Phase 1 [146]
External Link
TTD: D00YUQ
 Compound Name Bb21217 Phase 1 [147]
External Link
TTD: D00OXP
 Compound Name CAR-T cells targeting CD56 Clinical trial [148]
External Link
TTD: D0V6WW
 Compound Name CAR-T cells targeting CD38 Clinical trial [148]
External Link
TTD: D0V6WU
 Compound Name CAR-T cells targeting CD138 Clinical trial [148]
External Link
TTD: D0T6NG
 Compound Name CAR-BCMA T cell Clinical trial [149]
External Link
TTD: D0PF1A
 Compound Name BCMA-UCART Clinical trial [150]
External Link
TTD: D0N8NT
 Compound Name CAR-T cells targeting BCMA Clinical trial [148]
External Link
TTD: D0LP1L
 Compound Name BCMA-CART Clinical trial [151]
External Link
TTD: D09ZGK
 Compound Name RG7598 Discontinued in Phase 1 [152]
External Link
TTD: D0S3BR
 Compound Name AS602868 Discontinued in Phase 1 [153]
Synonyms
Angelicin; ISOPSORALEN; 523-50-2; 2H-Furo[2,3-H]chromen-2-one; Angecin; furo[2,3-h]chromen-2-one; Isopsoralin; Furo(2,3-h)coumarin; Angelecin; Angelicin (coumarin derivative); 2H-Furo[2,3-H]-1-benzopyran-2-one; 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran; UNII-CZZ080D7BD; Angelicin (coumarin deriv); NSC 404563; Furo(5',4':7,8)coumarin; CCRIS 4276; HSDB 3554; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; BRN 0153970; CZZ080D7BD; 2H-Furo(2,3-H)-1-benzopyran-2-one; CHEMBL53569; Furo[5',4':7,8]coumarin
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External Link
CID: 9820526
TTD: D01OLO
 Compound Name UCART-CLL1 Preclinical [154]
External Link
TTD: DIW58H
 Compound Name 211At-labelled aLAT-1 Preclinical [155]
External Link
TTD: D2J4YT
 Compound Name P-BCMA-ALL01 Preclinical [156]
External Link
TTD: D01SNU
 Compound Name zoxazolamine Terminated [157]
Synonyms
61-80-3; 2-Amino-5-chlorobenzoxazole; 5-chlorobenzo[d]oxazol-2-amine; 5-Chloro-1,3-benzoxazol-2-amine; Flexin; 2-Benzoxazolamine, 5-chloro-; Contrazole; Deflexol; Flexilon; Zoxamin; Zoxine; USAF MA-12; McN-485; 5-Chloro-2-benzoxazolamine; Zossazolamina [DCIT]; C7H5ClN2O; Zoxazolaminum [INN-Latin]; Zoxazolamina [INN-Spanish]; NSC 24995; UNII-9DOW362Q29; BENZOXAZOLE, 2-AMINO-5-CHLORO-; CHEBI:35053; EINECS 200-519-4; MLS002639033; AI3-63120; YGCODSQDUUUKIV-UHFFFAOYSA-N; 9DOW362Q29; 2-Amino-5-chlorobenzoxazole, 97%
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External Link
CID: 6103
TTD: D0N0LB
 Compound Name AG490 Terminated [158]
Synonyms
(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 133550-30-8; AG-490; Tyrphostin B42; Tyrphostin AG 490; AG 490; Tyrphostin AG490; tyrphostin AG-490; AG-490 (Tyrphostin B42); alpha-Cyano-(3,4-dihydroxy)-N-benzylcinnamide; N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 134036-52-5; (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; CHEMBL56543; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; (2E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE; SMR001230665
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External Link
CID: 5328779
TTD: D0GZ7B
 Compound Name G3139 + Dexamethasone Investigative [159]
External Link
CID: 91865905
TTD: D0W8ZE
 Compound Name GNE-652 Investigative [160]
Synonyms
PIM kinase inhibitor (multiple myeloma), Genentech
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External Link
TTD: D0U2OS
 Compound Name CCX-721 Investigative [160]
Synonyms
CCR1 antagonist (myeloma), ChemoCentryx
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External Link
TTD: D0P8HU
 Compound Name JB-1 Investigative [20]
Synonyms
JB1
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External Link
CID: 25150849
TTD: D0O0RY
 Compound Name BIBF100 Investigative [20]
External Link
TTD: D0N1RE
 Compound Name BAY11-7082 Investigative [161]
Synonyms
bay 11-7082; 19542-67-7; (E)-3-Tosylacrylonitrile; Bay 11-7821; (E)-3-(p-Toluenesulfonyl)acrylonitrile; BAY-11-7082; UNII-4Y5G2A4F6O; BAY-11-7821; (E)-3-(4-Methylphenyl)sulfonylprop-2-enenitrile; BAY-117082; BAY-117821; CHEMBL403183; 4Y5G2A4F6O; 3-(4-methylphenylsulfonyl)-2-propenenitrile; CHEBI:85928; 3-[(4-methylphenyl)sulfonyl]prop-2-enenitrile; AK129348; (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile; (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; J-501956; (2E)-3-[(4-methylphenyl)sulfonyl]prop-2-enenitrile
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External Link
CID: 5353431
TTD: D0L2XO
 Compound Name UCL-67022 Investigative [162]
Synonyms
HDAC inhibitor (multiple myeloma), ST Barts/UCL
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External Link
TTD: D0L0LR
 Compound Name AbGn-150 Investigative [160]
Synonyms
Antibody-150
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External Link
TTD: D0I6UN
 Compound Name ACHP Investigative [20]
External Link
CID: 135465539
TTD: D0F0VD
 Compound Name SU5402 Investigative [20]
Synonyms
215543-92-3; SU 5402; SU-5402; 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone; (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid; CHEMBL89363; 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE; J-502595; 3-{[3-(2-carboxyethyl)-4-methylpyrrol-2-yl]methylene}-2-indolinone; 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; (Z)-3-(4-Methyl-2-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoic acid
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External Link
CID: 5289418
TTD: D0A4XJ
DrugBank: DB08577
 Compound Name TP-110 Investigative [160]
Synonyms
Tyropeptin A derivatives, Microbial Chemistry Research Foundation; Proteasome inhibitors (cancer), Microbial Chemistry Research Foundation
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External Link
CID: 11592579
TTD: D0A4VW
 Compound Name TMPyP4 Investigative [20]
Synonyms
TMPP; AC1L1HPJ; N-Methylpyridylylporphyrin; AC1Q29RK; CHEMBL65606; ABCGFHPGHXSVKI-UHFFFAOYSA-O; BDBM50107609; 4,4',4'',4'''-(5,10,15,20-porphyrintetrayl)tetrakis(1-methylpyridinium); J2.096.016G; 5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin; 5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,22-dihydroporphyrin
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External Link
CID: 135398505
TTD: D08UZL
 Compound Name Sant7 Investigative [20]
Synonyms
beta-Methylene tad; BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE; 102977-57-1; beta-Tad; NSC617998; 1lrt; NSC 617998; beta-Methylene thiazole-4-carboxamide adenine dinucleotide; .beta.-Methylene TAD; AC1L2TER; Adenosine, 5'-(hydrogen (phosphonomethyl)phosphonate), 5'-ester with 2-beta-D-ribofuranosyl-4-thiazolecarboxamide
    Click to Show/Hide
External Link
CID: 128225
TTD: D07VQW
 Compound Name PS-1145 Investigative [20]
Synonyms
431898-65-6; PS 1145; CHEMBL79004; N-(6-Chloro-9H-beta-carbolin-8-yl)-nicotinamide; MLS006010310; ZINC9090; SCHEMBL1420453; CTK1D2755; KS-00000TTM; CHEBI:94801; DTXSID00433238; EX-A786; MolPort-042-665-715; JZRMBDHPALEPDM-UHFFFAOYSA-N; HMS3229F21; BCP24095; s7691; BDBM50130248; AKOS030526812; CS-5415; ACN-053038; NCGC00165873-02; NCGC00165873-01; SMR004701376; HY-18008; AK547800; FT-0700478; J-690297; BRD-K93023739-001-02-9; N-{6-chloro-9H-pyrido[3,4-b]indol-8-yl}pyridine-3-carboxamide
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External Link
CID: 9949093
TTD: D07MQC
 Compound Name FM-101 Investigative [163]
External Link
TTD: D07CIX
 Compound Name NVP-ADW742 Investigative [20]
Synonyms
475488-23-4; ADW-742; 475489-15-7; UNII-MXS2N5862L; ADW742; MXS2N5862L; CHEMBL399021; 5-(3-(Benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-(Benzyloxy)phenyl)-7-(cis-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; C28H31N5O; 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    Click to Show/Hide
External Link
CID: 9825149
TTD: D06NMZ
 Compound Name CGEN-928 Investigative [160]
Synonyms
Anti-CGEN-928 polyclonal antibody (multiple myeloma treatment); Anti-TM21 polyclonal antibody (multiple myeloma treatment), Compugen; CGEN-928 (multiple myeloma treatment), Compugen; Anti-CGEN-928 polyclonal antibody (multiple myeloma treatment), Compugen
    Click to Show/Hide
External Link
TTD: D04VUM
 Compound Name Tubacin Investigative [164]
Synonyms
537049-40-4; AC1O7Y2P; CHEMBL356769; 1350555-93-9; N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide; Tubacin (BML-GR362); Octanediamide, N1-(4-((2R,4R,6S)-4-(((4,5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy-, rel-; N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide; SCHEMBL4741166
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External Link
CID: 6675804
TTD: D04KQF
 Compound Name Anti-HM1.24 Investigative [160]
External Link
TTD: D01LZB
 Compound Name Telomestatin Investigative [20]
Synonyms
YVSQVYZBDXIXCC-UHFFFAOYSA-N; AC1L9EVW; CHEMBL443683; CHEBI:29689; Telomestatin (TMS); gm95; SureCN10025441; SCHEMBL10025441; CHEBI:601758; BDBM213233; DCL000983
    Click to Show/Hide
External Link
CID: 443590
TTD: D01GEO
 Compound Name G3139 + Thalidomide Investigative [159]
External Link
CID: 91865905
TTD: D00DDR
References
Ref 1 ALKHB5-demethylated lncRNA SNHG15 promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting H3K36me3 modifier SETD2. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C684-C697. doi: 10.1152/ajpcell.00348.2023. Epub 2023 Dec 25.
Ref 2 ClinicalTrials.gov (NCT05461209) A Phase 3 Study Comparing Talquetamab to Belantamab Mafodotin in Participants With Relapsed/Refractory Multiple Myeloma Who Have Received at Least 4 Prior Therapies Including an Immunomodulatory Drug, a Proteasome Inhibitor, and an Anti-CD38 Antibody. U.S.National Institutes of Health.
Ref 3 ClinicalTrials.gov (NCT04126200) Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 5). U.S. National Institutes of Health.
Ref 4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
Ref 5 ClinicalTrials.gov (NCT05014412) A PHASE 1/2, OPEN-LABEL, MULTICENTER STUDY TO EVALUATE A DOSING REGIMEN WITH TWO STEP-UP PRIMING DOSES AND LONGER DOSING INTERVALS OF ELRANATAMAB (PF-06863135) MONOTHERAPY IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA. U.S.National Institutes of Health.
Ref 6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 7 ClinicalTrials.gov (NCT02051842) Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis. U.S. National Institutes of Health.
Ref 8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2015
Ref 9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7327).
Ref 10 ClinicalTrials.gov (NCT03246529) A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and G-GSF as Compared to Placebo and G-CSF for thE MobilizatioN of HematopoiEtic Stem Cells for Autologous TransplantatIon in SubjectS With MM (GENESIS). U.S. National Institutes of Health.
Ref 11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6391).
Ref 12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7395).
Ref 13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7331).
Ref 14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
Ref 15 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5678).
Ref 16 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 17 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8361).
Ref 18 ClinicalTrials.gov (NCT03651128) Efficacy and Safety Study of bb2121 Versus Standard Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM) (KarMMa-3). U.S. National Institutes of Health.
Ref 19 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 20 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. doi: 10.1517/14728210802676278.
Ref 21 ClinicalTrials.gov (NCT04557098) A Study of Teclistamab, in Participants With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health.
Ref 22 ClinicalTrials.gov (NCT02052778) A Dose Finding Study Followed by a Safety and Efficacy Study in Patients With Advanced Solid Tumors or Multiple Myeloma With FGF/FGFR-Related Abnormalities. U.S. National Institutes of Health.
Ref 23 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5056).
Ref 24 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8450).
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