m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03044
 [1]
Histone modification H3K18la LDHA METTL3 Direct Enhancement m6A modification BMP2 BMP2 METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Bone morphogenetic protein 2 (BMP2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Lactate dehydrogenase A (LDHA) WRITER View Details
Regulated Target Histone H3 lysine 18 lactylation (H3K18la) View Details
Downstream Gene METTL3 View Details
Crosstalk Relationship Histone modification  →  m6A Enhancement
Crosstalk Mechanism Histone modification directly impacts m6A modification through modulating the level of m6A regulator
Crosstalk Summary LDHA knockdown-mediated inhibition of endogenous Histone H3 lysine 18 lactylation (H3K18la) suppressed osteogenic differentiation, a phenotype that was rescued by METTL3 overexpression. In conclusion, this study elucidates that histone lactylation-mediated upregulation of METTL3 promotes OLF progression through IGF2BP1-dependent m6A methylation of Bone morphogenetic protein 2 (BMP2), providing novel insights into potential therapeutic strategies for OLF management.
Responsed Disease Ossification of spinal ligaments ICD-11: FA83
 Disease Info 
In-vitro Model
OLF-136
 N.A. Oryzias latipes CVCL_3766
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Bone morphogenetic protein 2 (BMP2) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name DWP-431 Phase 3 [2]
Synonyms
Recombinant bone morphogenetic protein 2 (bone synthesis), Daewoong; RBMP-2 (bone synthesis), Daewoong
    Click to Show/Hide
MOA Modulator
External Link
TTD: D03HDV
Lactate dehydrogenase A (LDHA) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Nedosiran Approved [3]
Synonyms
nedosiran
    Click to Show/Hide
External Link
TTD: DZ8DF0
References
Ref 1 METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2. Mol Med. 2025 Mar 25;31(1):118. doi: 10.1186/s10020-025-01173-x.
Ref 2 Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery. Spine J. 2014 Mar 1;14(3):552-9. doi: 10.1016/j.spinee.2013.08.060. Epub 2014 Jan 8.
Ref 3 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.