m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00672
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Inhibition
RNA modification
MALAT1
MALAT1
FTO
Demethylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | READER | |||
| m6A Target | hsa-mir-20a | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> N6,2'-O-dimethyladenosine (m6Am) | ||||
| Epigenetic Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | View Details | ||
| Regulated Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | View Details | |||
| Crosstalk Relationship | m6Am → m6A | Inhibition | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-20a, which was regulated by HNRNPA2B1-mediated m6A modification. | ||||
In-vitro Model |
253J | Bladder carcinoma | Homo sapiens | CVCL_7935 | |
| HT-1197 | Recurrent bladder carcinoma | Homo sapiens | CVCL_1291 | ||
| HT-1376 | Bladder carcinoma | Homo sapiens | CVCL_1292 | ||
|
TE1
|
N.A. | Mus musculus | CVCL_C6K3 | ||
References