m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00671				[1], [2], [3], [4], [5]
m⁶A modification MIR20A MIR20A METTL3 Methylation : m⁶A sites Indirect Inhibition RNA modification MALAT1 MALAT1 FTO Demethylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	hsa-mir-20a				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	View Details
Regulated Target	Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)				View Details
Crosstalk Relationship	m6Am → m6A			Inhibition
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), decreasing it's m6Am level and inhibiting its physical interaction with hsa-mir-20a, which was regulated by METTL3-mediated m6A modification.
In-vitro Model	253J	Bladder carcinoma	Homo sapiens		CVCL_7935
	HT-1197	Recurrent bladder carcinoma	Homo sapiens		CVCL_1291
	HT-1376	Bladder carcinoma	Homo sapiens		CVCL_1292
	MKN45	Gastric adenocarcinoma	Homo sapiens		CVCL_0434
	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens		CVCL_6898
	TE1	N.A.	Mus musculus		CVCL_C6K3

References

Ref 1	FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med. 2021 Feb;11(2):e310. doi: 10.1002/ctm2.310.
Ref 2	The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients. Bioengineered. 2021 Dec;12(1):5323-5333. doi: 10.1080/21655979.2021.1964893.
Ref 3	N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w.
Ref 4	Mechanism of methyltransferase like 3 in epithelial-mesenchymal transition process, invasion, and metastasis in esophageal cancer. Bioengineered. 2021 Dec;12(2):10023-10036. doi: 10.1080/21655979.2021.1994721.
Ref 5	LncRNA MALAT1 regulates inflammatory cytokine production in lipopolysaccharide-stimulated human gingival fibroblasts through sponging miR-20a and activating TLR4 pathway. J Periodontal Res. 2020 Apr;55(2):182-190. doi: 10.1111/jre.12700. Epub 2019 Sep 25.