m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00652
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
PTEN
PTEN
TET1
Demethylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) | READER | |||
| m6A Target | hsa-mir-106b | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> 5-methylcytidine (m5C) | ||||
| Epigenetic Regulator | Methylcytosine dioxygenase TET1 (TET1) | ERASER | View Details | ||
| Regulated Target | Mutated in multiple advanced cancers 1 (PTEN) | View Details | |||
| Crosstalk Relationship | m6A → m5C | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | HNRNPA2B1 interacts with hsa-mir-106b, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification. | ||||
In-vitro Model |
Hep 3B2.1-7 | Childhood hepatocellular carcinoma | Homo sapiens | CVCL_0326 | |
| Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | ||
| A-549 | Lung adenocarcinoma | Homo sapiens | CVCL_0023 | ||
| SPC-A1 | Endocervical adenocarcinoma | Homo sapiens | CVCL_6955 | ||
|
TE1
|
N.A. | Mus musculus | CVCL_C6K3 | ||
References