m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00651
 [1], [2], [3], [4], [5]
RNA modification GAS5 GAS5 YBX1 : modification sites Indirect Enhancement m6A modification MIR106B MIR106B HNRNPA2B1 : m6A sites
m6A Modification:
m6A Regulator Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) READER
 Regulator Info 
m6A Target hsa-mir-106b
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> 5-methylcytidine (m5C)
Epigenetic Regulator Y-box-binding protein 1 (YBX1) READER View Details
Regulated Target Growth arrest specific 5 (GAS5) View Details
Crosstalk Relationship m5C  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with hsa-mir-106b, which was regulated by HNRNPA2B1-mediated m6A modification.
In-vitro Model
 HGC-27 Gastric carcinoma Homo sapiens CVCL_1279
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
SPC-A1 Endocervical adenocarcinoma Homo sapiens CVCL_6955
TE1
 N.A. Mus musculus CVCL_C6K3
References
Ref 1 lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer. Sci Rep. 2015 May 11;5:10159. doi: 10.1038/srep10159.
Ref 2 Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics. 2019 Jul 28;9(19):5558-5576. doi: 10.7150/thno.34463. eCollection 2019.
Ref 3 Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis. Mol Ther. 2020 Jun 3;28(6):1479-1493. doi: 10.1016/j.ymthe.2020.03.010. Epub 2020 Mar 19.
Ref 4 HNRNPA2B1 Affects the Prognosis of Esophageal Cancer by Regulating the miR-17-92 Cluster. Front Cell Dev Biol. 2021 Jun 30;9:658642. doi: 10.3389/fcell.2021.658642. eCollection 2021.
Ref 5 LncRNA GAS5 regulates epithelial-mesenchymal transition and viability of glioma cells by targeting microRNA-106b and regulating PTEN expression. Neurosci Res. 2021 Sep;170:32-40. doi: 10.1016/j.neures.2020.08.009. Epub 2020 Sep 28.