m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00642				[1], [2], [3]
m⁶A modification MIR18A MIR18A METTL3 Methylation : m⁶A sites Indirect Enhancement RNA modification PTEN PTEN TET1 Demethylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	hsa-mir-18a				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	Methylcytosine dioxygenase TET1 (TET1)			ERASER	View Details
Regulated Target	Mutated in multiple advanced cancers 1 (PTEN)				View Details
Crosstalk Relationship	m6A → m5C			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL3 interacts with hsa-mir-18a, decreasing its m6A level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by TET1-mediated m5C modification.
In-vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens		CVCL_0326
	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027
	MKN45	Gastric adenocarcinoma	Homo sapiens		CVCL_0434

References

Ref 1	Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth. Mol Cancer. 2019 Oct 27;18(1):148. doi: 10.1186/s12943-019-1075-2.
Ref 2	N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w.
Ref 3	Long Noncoding RNA WDFY3-AS2 Represses the Progression of Esophageal Cancer through miR-18a/PTEN Axis. J Oncol. 2021 Jun 5;2021:9951010. doi: 10.1155/2021/9951010. eCollection 2021.