m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00640
 [1], [2], [3], [4], [5]
RNA modification GAS5 GAS5 YBX1 : modification sites Indirect Enhancement m6A modification MIR18A MIR18A METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target hsa-mir-18a
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> 5-methylcytidine (m5C)
Epigenetic Regulator Y-box-binding protein 1 (YBX1) READER View Details
Regulated Target Growth arrest specific 5 (GAS5) View Details
Crosstalk Relationship m5C  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary YBX1 interacts with Growth arrest specific 5 (GAS5), reading its m5C sites and promoting its physical interaction with hsa-mir-18a, which was regulated by METTL3-mediated m6A modification.
In-vitro Model
 HGC-27 Gastric carcinoma Homo sapiens CVCL_1279
MKN45 Gastric adenocarcinoma Homo sapiens CVCL_0434
References
Ref 1 lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer. Sci Rep. 2015 May 11;5:10159. doi: 10.1038/srep10159.
Ref 2 Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis. Theranostics. 2019 Jul 28;9(19):5558-5576. doi: 10.7150/thno.34463. eCollection 2019.
Ref 3 N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w.
Ref 4 Long non-coding RNA GAS5 promotes natural killer cell cytotoxicity against gastric cancer by regulating miR-18a. Neoplasma. 2020 Sep;67(5):1085-1093. doi: 10.4149/neo_2020_191014N1034. Epub 2020 Jun 16.
Ref 5 lncRNA GAS5, as a ceRNA, inhibits the proliferation of diffuse large B?cell lymphoma cells by regulating the miR?18a?5p/RUNX1 axis. Int J Oncol. 2021 Nov;59(5):94. doi: 10.3892/ijo.2021.5274. Epub 2021 Oct 26.