m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00624
|
[1], [2], [3] | |||
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 : modification sites
Indirect
Enhancement
m6A modification
MIR126
MIR126
METTL14
Methylation
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | microRNA 126 (MIR126) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | Nuclear paraspeckle assembly transcript 1 (NEAT1) | View Details | |||
| Crosstalk Relationship | A-to-I → m6A | Enhancement | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | ADAR1 interacts with Nuclear paraspeckle assembly transcript 1 (NEAT1), increasing it's A-to-I level and promoting its physical interaction with microRNA 126 (MIR126), which was regulated by METTL14-mediated m6A modification. | ||||
In-vitro Model |
HUVEC-C | Normal | Homo sapiens | CVCL_2959 | |
| Hep 3B2.1-7 | Childhood hepatocellular carcinoma | Homo sapiens | CVCL_0326 | ||
| SMMC-7721 | Endocervical adenocarcinoma | Homo sapiens | CVCL_0534 | ||
References