m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00553				[1], [2], [3]
RNA modification MIR122 MIR122 ADARB1 Methylation : modification sites Indirect Inhibition m⁶A modification SOX6 SOX6 METTL3 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Transcription factor SOX-6 (SOX6)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)			WRITER	View Details
Regulated Target	MicroRNA 122 (MIR122)				View Details
Crosstalk Relationship	A-to-I → m6A			Inhibition
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	ADARB1 interacts with MicroRNA 122 (MIR122), increasing it's A-to-I level and inhibiting its physical interaction with Transcription factor SOX-6 (SOX6), which was regulated by METTL3-mediated m6A modification.
In-vitro Model	SK-ChA-1	Cholangiocarcinoma	Homo sapiens		CVCL_6952
In-vitro Model	Huh-7	Adult hepatocellular carcinoma	Homo sapiens		CVCL_0336

References

Ref 1	The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma. Cancer Biol Med. 2021 Aug 4;19(3):343-57. doi: 10.20892/j.issn.2095-3941.2020.0661. Online ahead of print.
Ref 2	ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. PLoS One. 2013 Dec 27;8(12):e81922. doi: 10.1371/journal.pone.0081922. eCollection 2013.
Ref 3	Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis. Eur J Cancer Prev. 2020 Mar;29(2):165-173. doi: 10.1097/CEJ.0000000000000535.