m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00539
|
[1], [2], [3] | |||
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.png)
 : modification sites
Indirect
Inhibition
m6A modification
IGF2
IGF2
IGF2BP2
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | |||
| m6A Target | Insulin-like growth factor 2 (IGF2) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 432 (MIR432) | View Details | |||
| Crosstalk Relationship | A-to-I → m6A | Inhibition | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | ADAR1 interacts with MicroRNA 432 (MIR432), increasing it's A-to-I level and inhibiting its physical interaction with Insulin-like growth factor 2 (IGF2), which was regulated by IGF2BP2-mediated m6A modification. | ||||
In-vitro Model |
SW480 | Colon adenocarcinoma | Homo sapiens | CVCL_0546 | |
| SH-SY5Y | Neuroblastoma | Homo sapiens | CVCL_0019 | ||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Compound Name
References