m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00538
 [1], [2], [3], [4]
RNA modification MIR432 MIR432 ADAR Methylation : modification sites Indirect Inhibition m6A modification IGF2 IGF2 IGF2BP3 : m6A sites
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) READER
 Regulator Info 
m6A Target Insulin-like growth factor 2 (IGF2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 432 (MIR432) View Details
Crosstalk Relationship A-to-I  →  m6A Inhibition
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with MicroRNA 432 (MIR432), increasing it's A-to-I level and inhibiting its physical interaction with Insulin-like growth factor 2 (IGF2), which was regulated by IGF2BP3-mediated m6A modification.
In-vitro Model
 HTR-8/SVneo Normal Homo sapiens CVCL_7162
HEK293 Normal Homo sapiens CVCL_0045
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Insulin-like growth factor 2 (IGF2) 2 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Dusigitumab Phase 2 [5]
MOA Inhibitor
External Link
TTD: D09TQY
 Compound Name Xentuzumab Phase 2 [5]
External Link
TTD: D04DNB
References
Ref 1 Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis. 2014 Jan 23;5(1):e1025. doi: 10.1038/cddis.2013.545.
Ref 2 THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2307-2312. doi: 10.1073/pnas.1614265114. Epub 2017 Feb 13.
Ref 3 The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432. Behav Brain Res. 2021 Mar 26;402:113087. doi: 10.1016/j.bbr.2020.113087. Epub 2021 Jan 4.
Ref 4 MicroRNA?432 inhibits the aggressiveness of glioblastoma multiforme by directly targeting IGF?1R. Int J Mol Med. 2020 Feb;45(2):597-606. doi: 10.3892/ijmm.2019.4429. Epub 2019 Dec 16.
Ref 5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)