m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00537
 [1], [2], [3], [4], [5]
RNA modification MIR432 MIR432 ADAR Methylation : modification sites Indirect Inhibition m6A modification IGF2 IGF2 IGF2BP1 : m6A sites
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) READER
 Regulator Info 
m6A Target Insulin-like growth factor 2 (IGF2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 432 (MIR432) View Details
Crosstalk Relationship A-to-I  →  m6A Inhibition
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with MicroRNA 432 (MIR432), increasing it's A-to-I level and inhibiting its physical interaction with Insulin-like growth factor 2 (IGF2), which was regulated by IGF2BP1-mediated m6A modification.
In-vitro Model
 MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
U2OS Osteosarcoma Homo sapiens CVCL_0042
HONE-1 Nasopharyngeal carcinoma Homo sapiens CVCL_8706
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Insulin-like growth factor 2 (IGF2) 2 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Dusigitumab Phase 2 [6]
MOA Inhibitor
External Link
TTD: D09TQY
 Compound Name Xentuzumab Phase 2 [6]
External Link
TTD: D04DNB
References
Ref 1 MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells. Cell Prolif. 2012 Feb;45(1):32-8. doi: 10.1111/j.1365-2184.2011.00798.x. Epub 2011 Dec 13.
Ref 2 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012 Jan 15;26(2):176-89. doi: 10.1101/gad.177642.111.
Ref 3 Triptonide inhibits human nasopharyngeal carcinoma cell growth via disrupting Lnc-RNA THOR-IGF2BP1 signaling. Cancer Lett. 2019 Feb 28;443:13-24. doi: 10.1016/j.canlet.2018.11.028. Epub 2018 Nov 29.
Ref 4 The involvement of ADAR1 in antidepressant action by regulating BDNF via miR-432. Behav Brain Res. 2021 Mar 26;402:113087. doi: 10.1016/j.bbr.2020.113087. Epub 2021 Jan 4.
Ref 5 MicroRNA?432 inhibits the aggressiveness of glioblastoma multiforme by directly targeting IGF?1R. Int J Mol Med. 2020 Feb;45(2):597-606. doi: 10.3892/ijmm.2019.4429. Epub 2019 Dec 16.
Ref 6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)