m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00519
 [1], [2], [3]
RNA modification MIR221 MIR221 ADARB1 Methylation : modification sites Indirect Inhibition m6A modification FOS FOS FTO Demethylation : m6A sites
m6A Modification:
m6A Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
m6A Target Protein c-Fos (FOS)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Double-stranded RNA-specific editase 1 (ADARB1) WRITER View Details
Regulated Target MicroRNA 221 (MIR221) View Details
Crosstalk Relationship A-to-I  →  m6A Inhibition
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADARB1 interacts with MicroRNA 221 (MIR221), increasing it's A-to-I level and inhibiting its physical interaction with Protein c-Fos (FOS), which was regulated by FTO-mediated m6A modification.
In-vitro Model
 COV434 Ovarian small cell carcinoma, hypercalcemic type Homo sapiens CVCL_2010
KGN Ovarian granulosa cell tumor Homo sapiens CVCL_0375
U-118MG Astrocytoma Homo sapiens CVCL_0633
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Protein c-Fos (FOS) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ISIS 10639 Investigative [4]
External Link
TTD: D0Z2OW
References
Ref 1 The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging. Cell Death Dis. 2021 Jul 27;12(8):744. doi: 10.1038/s41419-021-04016-9.
Ref 2 Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. Genome Biol. 2015 Jan 13;16(1):5. doi: 10.1186/s13059-014-0575-z.
Ref 3 Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microRNA-221 through upregulation of FOS. J Cell Physiol. 2019 Nov;234(11):21113-21125. doi: 10.1002/jcp.28714. Epub 2019 May 12.
Ref 4 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.