m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00515				[1], [2], [3]
m⁶A modification MEG3 MEG3 METTL3 Methylation : m⁶A sites Indirect Inhibition RNA modification MIR18A MIR18A ADAR Methylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Maternally expressed 3 (MEG3)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)			WRITER	View Details
Regulated Target	hsa-mir-18a				View Details
Crosstalk Relationship	m6A → A-to-I			Inhibition
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL3 interacts with Maternally expressed 3 (MEG3), increasing its m6A level and inhibiting its physical interaction with hsa-mir-18a, which was regulated by ADAR1-mediated A-to-I modification.
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens		CVCL_0336
	CAL-27	Tongue squamous cell carcinoma	Homo sapiens		CVCL_1107
	HN4	Clear cell renal cell carcinoma	Homo sapiens		CVCL_IS30

References

Ref 1	m6A-Induced LncRNA MEG3 Suppresses the Proliferation, Migration and Invasion of Hepatocellular Carcinoma Cell Through miR-544b/BTG2 Signaling. Onco Targets Ther. 2021 Jun 15;14:3745-3755. doi: 10.2147/OTT.S289198. eCollection 2021.
Ref 2	ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 3	Knockdown of Long Noncoding RNAs of Maternally Expressed 3 Alleviates Hyperoxia-Induced Lung Injury via Inhibiting Thioredoxin-Interacting Protein-Mediated Pyroptosis by Binding to miR-18a. Am J Pathol. 2020 May;190(5):994-1005. doi: 10.1016/j.ajpath.2019.12.013. Epub 2020 Feb 19.