m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00492
 [1], [2], [3]
m6A modification GLUT1 GLUT1 LRPPRC : m6A sites Indirect Enhancement RNA modification MIR22 MIR22 FTO Demethylation : modification sites
m6A Modification:
m6A Regulator Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) READER
 Regulator Info 
m6A Target Glucose transporter type 1 (GLUT1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator Fat mass and obesity-associated protein (FTO) ERASER View Details
Regulated Target hsa-mir-22 View Details
Crosstalk Relationship m6Am  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Glucose transporter type 1 (GLUT1), which was regulated by LRPPRC-mediated m6A modification.
In-vitro Model
 Y-79 Retinoblastoma Homo sapiens CVCL_1893
WERI-Rb-1 Retinoblastoma Homo sapiens CVCL_1792
HEK293 Normal Homo sapiens CVCL_0045
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Solute carrier family 2 member 1 (SLC2A1) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name WZB-117 Preclinical [4]
Synonyms
WZB117; 1223397-11-2; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate); CHEMBL3092944; WZB 117; [3-fluoro-2-(3-hydroxybenzoyl)oxyphenyl] 3-hydroxybenzoate; WBZ117; SCHEMBL19183300; AOB5670; BCP24665; EX-A1492; BDBM50444088; NSC750937; s7927; AKOS032945159; ZINC103244507; CCG-268262; NSC-750937; AC-32898; AK685810; BS-14666; HY-19331; WZB-117, >=98% (HPLC); CS-0015243; Bis(3-hydroxybenzoic acid)3-fluoro-1,2-phenylene ester; Benzoic acid, 3-hydroxy-, 1,1'-(3-fluoro-1,2-phenylene) ester
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 46830365
TTD: DCL8J5
References
Ref 1 LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-alpha pathway in retinoblastoma. Mol Ther Oncolytics. 2021 Jun 24;22:582-591. doi: 10.1016/j.omto.2021.06.009. eCollection 2021 Sep 24.
Ref 2 N6-adenosine methylation in MiRNAs. PLoS One. 2015 Feb 27;10(2):e0118438. doi: 10.1371/journal.pone.0118438. eCollection 2015.
Ref 3 Dysregulated miRNAs contribute to altered placental glucose metabolism in patients with gestational diabetes via targeting GLUT1 and HK2. Placenta. 2021 Feb;105:14-22. doi: 10.1016/j.placenta.2021.01.015. Epub 2021 Jan 19.
Ref 4 Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. Biochimie. 2018 Aug;151:107-114.