m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00488				[1], [2], [3]
m⁶A modification H19 H19 METTL3 Methylation : m⁶A sites Indirect Enhancement RNA modification MIR22 MIR22 FTO Demethylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	H19 imprinted maternally expressed transcript (H19)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	View Details
Regulated Target	hsa-mir-22				View Details
Crosstalk Relationship	m6A → m6Am			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL3 interacts with H19 imprinted maternally expressed transcript (H19), decreasing its m6A level and promoting its physical interaction with hsa-mir-22, which was regulated by FTO-mediated m6Am modification.
In-vitro Model	MGG8	Glioblastoma	Homo sapiens		CVCL_D1H4
In-vitro Model	HEK293	Normal	Homo sapiens		CVCL_0045

References

Ref 1	N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2	N6-adenosine methylation in MiRNAs. PLoS One. 2015 Feb 27;10(2):e0118438. doi: 10.1371/journal.pone.0118438. eCollection 2015.
Ref 3	Long non?coding RNA H19 regulates cell growth and metastasis via the miR?22?3p/Snail1 axis in gastric cancer. Int J Oncol. 2019 Jun;54(6):2157-2168. doi: 10.3892/ijo.2019.4773. Epub 2019 Apr 4.