m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00487				[1], [2], [3]
m⁶A modification SNAI1 SNAI1 LRPPRC : m⁶A sites Indirect Enhancement RNA modification MIR22 MIR22 FTO Demethylation : modification sites
m6A Regulator	Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)			READER	Regulator Info
m6A Target	Zinc finger protein SNAI1 (SNAI1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	View Details
Regulated Target	hsa-mir-22				View Details
Crosstalk Relationship	m6Am → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by LRPPRC-mediated m6A modification.
In-vitro Model	WERI-Rb-1	Retinoblastoma	Homo sapiens		CVCL_1792
	Y-79	Retinoblastoma	Homo sapiens		CVCL_1893
	HEK293	Normal	Homo sapiens		CVCL_0045

References

Ref 1	LRPPRC regulates metastasis and glycolysis by modulating autophagy and the ROS/HIF1-alpha pathway in retinoblastoma. Mol Ther Oncolytics. 2021 Jun 24;22:582-591. doi: 10.1016/j.omto.2021.06.009. eCollection 2021 Sep 24.
Ref 2	N6-adenosine methylation in MiRNAs. PLoS One. 2015 Feb 27;10(2):e0118438. doi: 10.1371/journal.pone.0118438. eCollection 2015.
Ref 3	Long non?coding RNA H19 regulates cell growth and metastasis via the miR?22?3p/Snail1 axis in gastric cancer. Int J Oncol. 2019 Jun;54(6):2157-2168. doi: 10.3892/ijo.2019.4773. Epub 2019 Apr 4.