m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00481
|
[1], [2], [3] | |||
.png)
.png)
 : m6A sites
Indirect
Inhibition
RNA modification
MIR155
MIR155
ADAR
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Maternally expressed 3 (MEG3) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 155 (MIR155) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Inhibition | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | METTL3 interacts with Maternally expressed 3 (MEG3), increasing its m6A level and inhibiting its physical interaction with MicroRNA 155 (MIR155), which was regulated by ADAR1-mediated A-to-I modification. | ||||
In-vitro Model |
Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | |
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 | ||
| HN4 | Clear cell renal cell carcinoma | Homo sapiens | CVCL_IS30 | ||
| CAL-27 | Tongue squamous cell carcinoma | Homo sapiens | CVCL_1107 | ||
References