m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00480
 [1], [2], [3]
RNA modification MIR155 MIR155 ADAR Methylation : modification sites Indirect Enhancement m6A modification CASP2 CASP2 ELAVL1 : m6A sites
m6A Modification:
m6A Regulator ELAV-like protein 1 (ELAVL1) READER
 Regulator Info 
m6A Target Caspase-2 (CASP2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 155 (MIR155) View Details
Crosstalk Relationship A-to-I  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with MicroRNA 155 (MIR155), increasing it's A-to-I level and promoting its physical interaction with Caspase-2 (CASP2), which was regulated by ELAVL1-mediated m6A modification.
In-vitro Model
 DLD-1 Colon adenocarcinoma Homo sapiens CVCL_0248
HN4 Clear cell renal cell carcinoma Homo sapiens CVCL_IS30
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Caspase-2 (CASP2) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name QPI-1007 Phase 3 [4]
Synonyms
SiCASP2; SiRNA therapy (caspase-2, ocular injury), Quark Pharmaceuticals
    Click to Show/Hide
External Link
TTD: D06ZFV
References
Ref 1 Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. Cancer Lett. 2017 May 1;393:103-112. doi: 10.1016/j.canlet.2017.02.010. Epub 2017 Feb 20.
Ref 2 ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 3 LncDBH-AS1 knockdown enhances proliferation of non-small cell lung cancer cells by activating the Wnt signaling pathway via the miR-155/AXIN1 axis. Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):139-144. doi: 10.26355/eurrev_202101_24377.
Ref 4 Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014 Aug;24(4):258-66.