m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00468				[1], [2], [3]
RNA modification MIR149 MIR149 METTL1 Methylation : modification sites Indirect Enhancement m⁶A modification HMGA2 HMGA2 METTL14 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 14 (METTL14)			WRITER	Regulator Info
m6A Target	High mobility group protein HMGI-C (HMGA2)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N7-methylguanosine (m7G)
Epigenetic Regulator	Methyltransferase-like protein 1 (METTL1)			WRITER	View Details
Regulated Target	MicroRNA 149 (MIR149)				View Details
Crosstalk Relationship	m7G → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	METTL1 interacts with MicroRNA 149 (MIR149), increasing it's m7G level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by METTL14-mediated m6A modification.
In-vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens		CVCL_0062
	SW480	Colon adenocarcinoma	Homo sapiens		CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens		CVCL_0547
	HCT 116	Colon carcinoma	Homo sapiens		CVCL_0291

References

Ref 1	Cross-talk among writers, readers, and erasers of m(6)A regulates cancer growth and progression. Sci Adv. 2018 Oct 3;4(10):eaar8263. doi: 10.1126/sciadv.aar8263. eCollection 2018 Oct.
Ref 2	Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis. Aging (Albany NY). 2019 Dec 20;11(24):12328-12344. doi: 10.18632/aging.102575. Epub 2019 Dec 20.
Ref 3	Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis. Mol Cell Biol. 2021 Jan 25;41(2):e00445-20. doi: 10.1128/MCB.00445-20. Print 2021 Jan 25.