m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00467
|
[1], [2], [3] | |||
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.png)
 : modification sites
Indirect
Enhancement
m6A modification
HMGA2
HMGA2
METTL14
Methylation
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 14 (METTL14) | WRITER | |||
| m6A Target | High mobility group protein HMGI-C (HMGA2) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 149 (MIR149) | View Details | |||
| Crosstalk Relationship | A-to-I → m6A | Enhancement | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with High mobility group protein HMGI-C (HMGA2), which was regulated by METTL14-mediated m6A modification. | ||||
In-vitro Model |
MDA-MB-231 | Breast adenocarcinoma | Homo sapiens | CVCL_0062 | |
| BRO | Amelanotic melanoma | Homo sapiens | CVCL_7036 | ||
References