m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00463
 [1], [2], [3], [4], [5], [6]
RNA modification MIR149 MIR149 ADAR Methylation : modification sites Indirect Enhancement m6A modification FOXM1 FOXM1 ALKBH5 Demethylation : m6A sites
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target Forkhead box protein M1 (FOXM1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 149 (MIR149) View Details
Crosstalk Relationship A-to-I  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with MicroRNA 149 (MIR149), increasing it's A-to-I level and promoting its physical interaction with Forkhead box protein M1 (FOXM1), which was regulated by ALKBH5-mediated m6A modification.
In-vitro Model
 GSC17 Glioblastoma Homo sapiens CVCL_DR57
GSC11 Glioblastoma Homo sapiens CVCL_DR55
A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
HEK293T Normal Homo sapiens CVCL_0063
C918 Uveal melanoma Homo sapiens CVCL_8471
BRO Amelanotic melanoma Homo sapiens CVCL_7036
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Forkhead box protein M1 (FOXM1) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name (D-Arg)(9)-p19(ARF) 26-44 peptide Investigative [7]
MOA Inhibitor
External Link
TTD: D01FSW
References
Ref 1 m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 Apr 10;31(4):591-606.e6. doi: 10.1016/j.ccell.2017.02.013. Epub 2017 Mar 23.
Ref 2 ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia. Biochem Biophys Res Commun. 2020 Jan 8;521(2):499-506. doi: 10.1016/j.bbrc.2019.10.145. Epub 2019 Oct 31.
Ref 3 DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m(6)A-demethylation of FOXM1 and NANOG. Apoptosis. 2020 Apr;25(3-4):233-246. doi: 10.1007/s10495-020-01591-8.
Ref 4 ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma. Aging (Albany NY). 2021 Jan 10;13(3):4045-4062. doi: 10.18632/aging.202371. Epub 2021 Jan 10.
Ref 5 ADAR1p150 regulates the biosynthesis and function of miRNA-149* in human melanoma. Biochem Biophys Res Commun. 2020 Mar 19;523(4):900-907. doi: 10.1016/j.bbrc.2019.12.110. Epub 2020 Jan 17.
Ref 6 Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149. Cancer Biol Ther. 2020;21(2):113-121. doi: 10.1080/15384047.2019.1669995. Epub 2019 Oct 10.
Ref 7 Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev. 2004 Apr 1;18(7):830-50. doi: 10.1101/gad.1200704.