m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00452
 [1], [2], [3]
RNA modification MIR214 MIR214 ADARB1 Methylation : modification sites Indirect Inhibition m6A modification TFRC TFRC YTHDF1 : m6A sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 1 (YTHDF1) READER
 Regulator Info 
m6A Target Transferrin receptor protein 1 (TFRC)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Double-stranded RNA-specific editase 1 (ADARB1) WRITER View Details
Regulated Target MicroRNA 214 (MIR214) View Details
Crosstalk Relationship A-to-I  →  m6A Inhibition
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Transferrin receptor protein 1 (TFRC), which was regulated by YTHDF1-mediated m6A modification.
In-vitro Model
 FaDu Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
Detroit 562 Pharyngeal squamous cell carcinoma Homo sapiens CVCL_1171
Huh-7 Adult hepatocellular carcinoma Homo sapiens CVCL_0336
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Transferrin receptor protein 1 (TFRC) 2 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name CX2029 Phase 1/2 [4]
External Link
TTD: DZ1F3N
 Compound Name ABBV-CX-2029 Phase 1 [5]
External Link
TTD: D58AMF
References
Ref 1 YTHDF1-enhanced iron metabolism depends on TFRC m(6)A methylation. Theranostics. 2020 Oct 26;10(26):12072-12089. doi: 10.7150/thno.51231. eCollection 2020.
Ref 2 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. PLoS One. 2013 Dec 27;8(12):e81922. doi: 10.1371/journal.pone.0081922. eCollection 2013.
Ref 3 Comparison of pop-out responses to luminance and motion contrasting stimuli of tectal neurons in pigeons. Brain Res. 2020 Nov 15;1747:147068. doi: 10.1016/j.brainres.2020.147068. Epub 2020 Aug 19.
Ref 4 Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate. Mol Cancer Ther. 2022 Aug 2;21(8):1326-1336.
Ref 5 Clinical pipeline report, company report or official report of AbbVie.