m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00416
 [1], [2], [3], [4], [5], [6], [7]
RNA modification MIR21 MIR21 ADAR Methylation : modification sites Indirect Enhancement m6A modification PTEN PTEN ALKBH5 Demethylation : m6A sites
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 21 (MIR21) View Details
Crosstalk Relationship A-to-I  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by ALKBH5-mediated m6A modification.
In-vitro Model
 BEAS-2B Normal Homo sapiens CVCL_0168
HN4 Clear cell renal cell carcinoma Homo sapiens CVCL_IS30
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
References
Ref 1 ALKBH5 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating PTEN expression in an m6A-dependent manner. Ecotoxicol Environ Saf. 2021 Aug 23;224:112686. doi: 10.1016/j.ecoenv.2021.112686. Online ahead of print.
Ref 2 The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis. Lung. 2018 Aug;196(4):393-400. doi: 10.1007/s00408-018-0115-9. Epub 2018 Apr 10.
Ref 3 ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 4 Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. J Cell Mol Med. 2021 Jan;25(1):61-72. doi: 10.1111/jcmm.15759. Epub 2020 Dec 17.
Ref 5 Long non?coding RNA MEG3 inhibits cell migration and invasion of non?small cell lung cancer cells by regulating the miR?21?5p/PTEN axis. Mol Med Rep. 2021 Mar;23(3):191. doi: 10.3892/mmr.2021.11830. Epub 2021 Jan 26.
Ref 6 lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia. Cancer Biother Radiopharm. 2021 Apr;36(3):268-272. doi: 10.1089/cbr.2019.3142. Epub 2020 May 15.
Ref 7 The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clin Sci (Lond). 2019 Jul 15;133(13):1439-1455. doi: 10.1042/CS20190156. Print 2019 Jul 15.