m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00414
 [1], [2], [3], [4], [5], [6], [7], [8]
RNA modification MIR21 MIR21 ADAR Methylation : modification sites Indirect Enhancement m6A modification PTEN PTEN METTL14 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target MicroRNA 21 (MIR21) View Details
Crosstalk Relationship A-to-I  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with MicroRNA 21 (MIR21), increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL14-mediated m6A modification.
In-vitro Model
 HK2 Normal Acipenser baerii CVCL_YE28
HGC-27 Gastric carcinoma Homo sapiens CVCL_1279
AGS Gastric adenocarcinoma Homo sapiens CVCL_0139
HN4 Clear cell renal cell carcinoma Homo sapiens CVCL_IS30
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
References
Ref 1 METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease. Cell Death Dis. 2021 Jan 4;12(1):32. doi: 10.1038/s41419-020-03312-0.
Ref 2 The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma. Front Oncol. 2021 Aug 12;11:699749. doi: 10.3389/fonc.2021.699749. eCollection 2021.
Ref 3 The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis. Lung. 2018 Aug;196(4):393-400. doi: 10.1007/s00408-018-0115-9. Epub 2018 Apr 10.
Ref 4 ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 5 Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. J Cell Mol Med. 2021 Jan;25(1):61-72. doi: 10.1111/jcmm.15759. Epub 2020 Dec 17.
Ref 6 Long non?coding RNA MEG3 inhibits cell migration and invasion of non?small cell lung cancer cells by regulating the miR?21?5p/PTEN axis. Mol Med Rep. 2021 Mar;23(3):191. doi: 10.3892/mmr.2021.11830. Epub 2021 Jan 26.
Ref 7 lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia. Cancer Biother Radiopharm. 2021 Apr;36(3):268-272. doi: 10.1089/cbr.2019.3142. Epub 2020 May 15.
Ref 8 The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. Clin Sci (Lond). 2019 Jul 15;133(13):1439-1455. doi: 10.1042/CS20190156. Print 2019 Jul 15.