m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00160
 [1], [2], [3], [4]
m6A modification ADAR1 ADAR1 METTL3 Methylation : m6A sites Direct Enhancement RNA modification CYP3A4 CYP3A4 ADAR Methylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Interferon-inducible protein 4 (ADAR1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) View Details
Crosstalk Relationship m6A  →  A-to-I Enhancement
Crosstalk Mechanism m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) transcript.
Responsed Drug Curcumin
 Drug Info 
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model
 MGG8 Glioblastoma Homo sapiens CVCL_D1H4
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-118MG Astrocytoma Homo sapiens CVCL_0633
HepaRG Hepatitis C infection Homo sapiens CVCL_9720
Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) 67 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Curcumin Phase 3 [5]
Synonyms
458-37-7; Diferuloylmethane; Natural yellow 3; Turmeric yellow; Turmeric; Curcuma; Kacha haldi; Gelbwurz; Indian saffron; Curcumin I; Souchet; Halud; Halad; Haidr; Haldar; Merita earth; Yellow Ginger; Terra Merita; Yellow Root; Safran d'Inde; Yo-Kin; Golden seal; Curcuma oil; Orange Root; Oils, curcuma; CI Natural Yellow 3; Curcumine; Hydrastis; Indian turmeric; Yellow puccoon; Turmeric extract; Diferaloylmethane; Kurkumin [Czech]; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; Tumeric yellow; Turmeric oil
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MOA Inhibitor
External Link
CID: 969516
TTD: D07SDQ
DrugBank: DB11672
 Compound Name PMX-53 Phase 2 [6]
Synonyms
YOKBGCTZYPOSQM-HPSWDUTRSA-N; PMX53; CHEMBL41547; (2S)-2-acetamido-N-[(3S,9S,12S,15R,18S)-15-(cyclohexylmethyl)-9-[3-(diaminomethylideneamino)propyl]-12-(1H-indol-3-ylmethyl)-2,8,11,14,17-pentaoxo-1,7,10,13,16-pentazabicyclo[1630]henicosan-3-yl]-3-phenylpropanamide; PMX 53; AcF-[OP(D-Cha)WR]; Ac-Phe-[Orn-Pro-cha-Trp-Arg]; C5aR-AP; AC1OCFH0; GTPL579; SCHEMBL16492460; SCHEMBL12971688; 219639-75-5; BDBM50111445; N-Acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-D-arginine N-52-C-16-lactam
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MOA Inhibitor
External Link
CID: 6918468
TTD: D0G2XE
 Compound Name Alpha-methylcubebin Investigative [7]
Synonyms
CHEMBL520915
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MOA Inhibitor
Activity IC50 = 7700 nM
External Link
CID: 44575384
TTD: D00GOQ
 Compound Name MEDIORESINOL Investigative [7]
Synonyms
CHEMBL513023; (-) Medioresinol; AC1L7B3T; BDBM50259877; NSC329245; NSC-329245
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MOA Inhibitor
External Link
CID: 181681
TTD: D00RGP
 Compound Name (-)-yatein Investigative [7]
Synonyms
Yatein; Dihydroanhydropodorhizol; 40456-50-6; (-)-deoxypodorhizone; Deoxypodorhizone; AC1L9DHE; CHEBI:4553; CHEMBL471067; C22H24O7; (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one; (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]tetrahydrofuran-2-one; 2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-, (3R,4R)-; Deoxypodorhizon; SCHEMBL1037807; DTXSID50193471; MolPort-035-706-087; GMLDZDDTZKXJLU-JKSUJKDBSA-N
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MOA Inhibitor
Activity Ki = 177 nM
External Link
CID: 442835
TTD: D01FBL
 Compound Name 3-(5-[1,3]dithiolan-2-yl-furan-2-yl)pyridine Investigative [8]
Synonyms
Pyridine, 3-[5-(1,3-dithiolan-2-yl)-2-furanyl]-; 859239-21-7; 3-[5-(1,3-dithiolan-2-yl)furan-2-yl]pyridine; CHEMBL215174; SCHEMBL3608709; CTK2I3856; BDBM12362; DTXSID40475410; nicotine 3-heteroaromatic analogue 17
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1100 nM
External Link
CID: 11993867
TTD: D02EAP
 Compound Name (-)-cubebinin Investigative [7]
Synonyms
CHEMBL480296; BDBM50259873
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MOA Inhibitor
Activity IC50 = 15000 nM
External Link
CID: 44575401
TTD: D02HSP
 Compound Name PALMATINE Investigative [9]
Synonyms
3486-67-7; Berbericinine; O,O-Dimethyldemethyleneberberine; Palmatin; Burasaine; UNII-G50C034217; 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium; Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-; BRN 1555498; GNF-PF-4086; CHEBI:16096; 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium; 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium; 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo(a,g)quinolizinium; Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-; G50C034217
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 900 nM
External Link
CID: 19009
TTD: D02SGJ
 Compound Name 1,2-Diacetoxylycorine Investigative [10]
Synonyms
1,2-Diacetyllycorine; CHEMBL465295; Lycorin diacetate; LYCORINE DIACETATE; 1,2-Di-O-acetyllycorine; SCHEMBL12319317; BDBM50293602; (1S,17S,18S,19S)-17-(acetyloxy)-5,7-dioxa-12-azapentacyclo[10.6.1.0^{2,10}.0^{4,8}.0^{15,19}]nonadeca-2,4(8),9,15-tetraen-18-yl acetate
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MOA Inhibitor
Activity Ki = 10000 nM
External Link
CID: 10429288
TTD: D02TKC
 Compound Name Geranylcoumarin Investigative [11]
Synonyms
CHEMBL241896
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 42930 nM
External Link
CID: 44429171
TTD: D03DMA
 Compound Name (-)-cubebininolide Investigative [7]
Synonyms
CHEMBL479314; Cordigerin; (-)-Cordigerine; VUNCHONBJWJYID-DLBZAZTESA-N; BDBM50259868; (3R,4R)-3,4-bis(3,4,5-Trimethoxybenzyl)dihydrofuran-2(3H)-one; 2(3H)-Furanone, dihydro-3,4-bis[(3,4,5-trimethoxyphenyl)methyl]-, (3R-trans)-; 2(3H)-Furanone, dihydro-3,4-bis[(3,4,5-trimethoxyphenyl)methyl]-, (3R,4R)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 14900 nM
External Link
CID: 13916150
TTD: D05KIF
 Compound Name (-)-dihydroclusin Investigative [7]
Synonyms
CHEMBL469916; 73149-51-6; AC1L7BWU; DTXSID10318502; BDBM50259874; NSC332042; NSC-332042
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MOA Inhibitor
Activity Ki = 54 nM
External Link
CID: 332806
TTD: D06MLU
 Compound Name 3-(3-methylthiophen-2-yl)pyridine Investigative [8]
Synonyms
CHEMBL179669; Pyridine, 3-(3-methyl-2-thienyl)-; 837376-35-9; SCHEMBL3606167; BDBM12351; CTK3D1375; DTXSID20635313; nicotine 3-heteroaromatic analogue 4; US8609708, 4
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3000 nM
External Link
CID: 23646069
TTD: D06TRS
 Compound Name (-)-thujaplicatintrimethyl ether Investigative [7]
Synonyms
Thujaplicatin methyl ether; UNII-2VJD5SJF7V; 2VJD5SJF7V; CHEMBL469917; 6512-67-0; 2(3H)-Furanone, dihydro-3-((4-hydroxy-3,5-dimethoxyphenyl)methyl)-4-((4-hydroxy-3-methoxyphenyl)methyl)-, (3S-trans)-; 3-O-Methylthujaplicatin; AC1Q6MJF; AC1L4V25; CTK2F4686; DTXSID40215434; BDBM50259876; 2(3h)-furanone, dihydro-3-((4-hydroxy-3,5-dimethoxyphenyl)methyl)-4-((4-hydroxy-3-methoxyphenyl)methyl)-,(3s-trans)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1100 nM
External Link
CID: 192827
TTD: D08BOH
 Compound Name DIETHOXYFLOURESCEIN Investigative [12]
Synonyms
CHEMBL1257567; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-diethoxy-; 21934-70-3; Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-diethoxy-; AC1Q6MMX; AC1L4PB7; 3',6'-Diethoxyfluorescein; SCHEMBL6404797; XAPFGEPPWZRGFN-UHFFFAOYSA-N; BDBM50328442; AKOS028111348
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MOA Inhibitor
Activity IC50 = 1000 nM
External Link
CID: 161373
TTD: D08FZC
 Compound Name 1-Acetoxy-2-tert-butyldimethylsilyl-oxylycorine Investigative [10]
Synonyms
CHEMBL564408; 1-Acetoxy-2-TBS-lycorine; BDBM50293601; (1S,2S,3a1S,12bS)-2-(tert-butyldimethylsilyloxy)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl acetate
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MOA Inhibitor
Activity Ki = 158.49 nM
External Link
CID: 44191463
TTD: D08TSE
 Compound Name 1-Acetoxylycorine Investigative [10]
Synonyms
1-O-Acetyllycorine; 1-Acetyllycorine; CHEMBL251077; CHEBI:31045; C12166; AC1L9EZ8; SCHEMBL12319390; BDBM50221063; acetic acid (1S,2S,12bS,12cS)-2-hydroxy-1,2,4,5,12b,12c-hexahydro-7H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl ester; (1S,2S,12bS,12cS)-1,2-Diol-2,4,5,7, 12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1-acetate
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MOA Inhibitor
Activity Ki = 7600 nM
External Link
CID: 443672
TTD: D09REF
 Compound Name (-)-clusin Investigative [7]
Synonyms
CHEMBL479701; BDBM50259867
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MOA Inhibitor
Activity Ki = 82 nM
External Link
CID: 44575398
TTD: D09VMS
 Compound Name ETHOXYCLUSIN Investigative [7]
Synonyms
CHEMBL480295
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MOA Inhibitor
Activity IC50 = 440 nM
External Link
CID: 44575400
TTD: D0A1SJ
 Compound Name (8R,8'R)-4-hydroxycubebinone Investigative [7]
Synonyms
CHEMBL482034; AC1MHYPL; (8R,8''R)-4-hydroxycubebinone; BDBM50259848; 2(3H)-furanone, dihydro-4-[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-, (3R,4R)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7400 nM
External Link
CID: 3013841
TTD: D0B2ZB
 Compound Name 5-Pyridin-3-yl-thiophene-2-carbaldehyde oxime Investigative [13]
Synonyms
SCHEMBL3649264; 2-Thiophenecarboxaldehyde, 5-(3-pyridinyl)-, oxime
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MOA Inhibitor
External Link
CID: 91196339
TTD: D0C7JC
 Compound Name BERGAPTOL Investigative [11]
Synonyms
486-60-2; 5-Hydroxypsoralen; 4-Hydroxy-7H-furo[3,2-g]chromen-7-one; 5-Hydroxyfuranocoumarin; Psoralin, 5-hydroxy-; UNII-KTC8ANI30F; 4-Hydroxybergapten; 7H-Furo[3,2-g][1]benzopyran-7-one, 4-hydroxy-; NSC341958; KTC8ANI30F; 4-oxidanylfuro[3,2-g]chromen-7-one; NSC 341958; 5-Hydroxy-6,7-furanocoumarin; CHEMBL242711; CHEBI:17377; GIJHDGJRTUSBJR-UHFFFAOYSA-N; 4-hydroxyfuro[3,2-g]chromen-7-one; AK158894; Bergaptols; 5-Hydroxy-Psoralen; 5-Hydroxyfurocoumarin; AC1NQWYH; 5-HYDROXY-PSORALIN; 7H-Furo[3, 4-hydroxy-; BSPBio_002390
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MOA Inhibitor
Activity IC50 = 24920 nM
External Link
CID: 5280371
TTD: D0D5YP
 Compound Name 2-tert-Butyldimethylsilyloxylycorine Investigative [10]
Synonyms
CHEMBL558873; SCHEMBL12270994; BDBM50293600
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MOA Inhibitor
Activity Ki = 251.19 nM
External Link
CID: 44191462
TTD: D0E2GV
 Compound Name 5-(2-phenethylpiperazin-1-yl)-1H-indazole Investigative [14]
Synonyms
CHEMBL1170373; SCHEMBL2944873
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MOA Inhibitor
External Link
CID: 49798218
TTD: D0F5AQ
 Compound Name GSK-8062 Investigative [15]
Synonyms
UNII-37IS6K16XE; 37IS6K16XE; 6-(4-{[3-(2,6-Dichlorophenyl)-5-(1-Methylethyl)isoxazol-4-Yl]methoxy}phenyl)naphthalene-1-Carboxylic Acid; TUOXXRMLFZBSTB-UHFFFAOYSA-N; 943549-47-1; SCHEMBL2115258; CHEMBL476302; Naphthoic acid-based analog, 1b; BDBM30329; GSK8062; 1-Naphthalenecarboxylic acid, 6-(4-((3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl)methoxy)phenyl)-; 6-[4-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-naphthalenecarboxylic acid
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MOA Inhibitor
Activity IC50 = 4600 nM
External Link
CID: 16214849
TTD: D0G9YL
 Compound Name TILIROSIDE Investigative [16]
Synonyms
20316-62-5; Tribuloside; Trans-Tiliroside; UNII-15M04TXR9M; CHEMBL266564; 15M04TXR9M; CHEBI:80944; 22153-44-2; 2-Propenoic acid, 3-(4-hydroxyphenyl)-, 6'-ester with 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; AC1NSZRJ; SCHEMBL23597; Tiliroside, analytical standard; MEGxp0_000169; MolPort-001-740-347; ZINC17654711; BDBM50241244; AKOS015896718; MCULE-6075035042; NCGC00163634-01; LS-123660; W1685; kaempferol 3-O-(6"-O-p-coumaroyl)-glucoside; C17140
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MOA Inhibitor
Activity IC50 = 700 nM
External Link
CID: 5320686
TTD: D0IB3K
 Compound Name 3-(5-((methylthio)methyl)furan-2-yl)pyridine Investigative [8]
Synonyms
859239-20-6; Pyridine, 3-[5-[(methylthio)methyl]-2-furanyl]-; SCHEMBL3611062; CHEMBL214990; CTK2I3857; BDBM12361; DTXSID60475412; QSLAHFFHHYZNQL-UHFFFAOYSA-N; nicotine 3-heteroaromatic analogue 15
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MOA Inhibitor
Activity Ki = 7400 nM
External Link
CID: 11993873
TTD: D0J1IE
 Compound Name Go-Y026 Investigative [5]
Synonyms
CHEMBL493001; SCHEMBL2743841; SCHEMBL2743839; GO-Y-026; BDBM50258200; 1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one; 1,5-Bis(3,5-dimethoxy-4-hydroxyphenyl)-1,4-pentadien-3-one
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MOA Inhibitor
Activity IC50 = 76032627.69 nM
External Link
CID: 10691533
TTD: D0K4LS
 Compound Name (-)-cubebin Investigative [7]
Synonyms
Cubebin; 18423-69-3; beta-cubebin; UNII-J237078S8A; (2s,3r,4r)-3,4-bis(1,3-benzodioxol-5-ylmethyl)tetrahydrofuran-2-ol; EINECS 242-300-6; Tetrahydro-3,4-dipiperonylfuran-2-ol; (8R,8'R,9S)-cubebin; AI3-62265; CHEMBL399831; CHEBI:65684; J237078S8A; 2-Furanol, 3,4-bis(1,3-benzodioxol-5-ylmethyl)tetrahydro-; Cubebine; 9-Hydroxy-3,4:3',4'-bis(methylenedioxy)-9,9'-epoxylignan; 3,4-bis(2H-1,3-benzodioxol-5-ylmethyl)oxolan-2-ol; .beta.-Cubebin; 2-Furanol, tetrahydro-3,4-dipiperonyl-; AC1Q59VI; AC1L3KW2; SCHEMBL4884683
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MOA Inhibitor
Activity IC50 = 9100 nM
External Link
CID: 117443
TTD: D0NC3P
 Compound Name 3-(pyridin-3-yl)prop-2-yn-1-amine Investigative [8]
Synonyms
777856-62-9; 2-PROPYN-1-AMINE, 3-(3-PYRIDINYL)-; CHEMBL360541; SCHEMBL3603698; CTK2G6074; BDBM12348; DTXSID90460412; MolPort-014-472-743; BGKUWZFWNZFRMO-UHFFFAOYSA-N; ZINC13607158; nicotine 3-heteroaromatic analogue 3a; AKOS010148504; MCULE-3042424640; NE58716; US8609708, 3; Z1333761438
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 15200 nM
External Link
CID: 11263510
TTD: D0O1HH
 Compound Name Alpha-Hydroxy-Midazolam Investigative [17]
Synonyms
1'-hydroxymidazolam; 1-Hydroxymidazolam; alpha-Hydroxymidazolam; 1-Hydroxymethylmidazolam; 59468-90-5; UNII-E5142BN92Z; CHEMBL1188; QHSMEGADRFZVNE-UHFFFAOYSA-N; E5142BN92Z; C18H13ClFN3O; 1-OH-Mdz; 8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol; [8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methanol; 8-Chloro-6-(2-fluorophenyl)-4H-imidazo(1,5-a)(1,4)benzodiazepine-1-methanol; 1'-Hydroxy Midazolam; AC1L32ZB; SCHEMBL7310758; DTXSID50208175
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MOA Inhibitor
Activity IC50 = 10000 nM
External Link
CID: 107917
TTD: D0Q7QU
 Compound Name 2,5-bis(4-hydroxybenzylidene)cyclopentanone Investigative [5]
Synonyms
NSC666766; CHEMBL452101; AC1LVVMV; SCHEMBL14473242; MolPort-000-640-539; ZINC5955757; BDBM50264922; AKOS001331259; NSC-666766; 2,5-Bis[(E)-4-hydroxybenzylidene]cyclopentanone; (2E,5E)-2,5-bis[(4-hydroxyphenyl)methylene]cyclopentanone
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MOA Inhibitor
Activity IC50 = 5105050 nM
External Link
CID: 1712706
TTD: D0S0QN
 Compound Name (8R,8'R,9'S)-5-methoxyclusin Investigative [7]
Synonyms
CHEMBL482233; BDBM50259849
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MOA Inhibitor
Activity IC50 = 830 nM
External Link
CID: 11259008
TTD: D0T4AC
 Compound Name JATRORRHIZINE Investigative [9]
Synonyms
3621-38-3; neprotin; jateorrhizine; Yatrorizine; UNII-091S1F8V5Q; CHEMBL251055; CHEBI:6087; GNF-PF-220; 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium; 091S1F8V5Q; 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol; Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino-[3,2-a]isoquinolin-7-ium; NSC645313; NSC150445; NSC209410
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MOA Inhibitor
Activity IC50 = 2100 nM
External Link
CID: 72323
TTD: D0V0NM
 Compound Name 2-fluoro-5-(3-methylthiophen-2-yl)pyridine Investigative [8]
Synonyms
CHEMBL179621; 837376-37-1; Pyridine, 2-fluoro-5-(3-methyl-2-thienyl)-; SCHEMBL957977; BDBM12354; CTK3D1374; DTXSID90456895; RYGQGRAICBWYPW-UHFFFAOYSA-N; nicotine 3-heteroaromatic analogue 7; US8609708,10
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MOA Inhibitor
Activity Ki = 19600 nM
External Link
CID: 11148236
TTD: D0VD5O
 Compound Name HINOKININ Investigative [7]
Synonyms
(-)-Hinokinin; 26543-89-5; CHEBI:5722; CHEMBL242011; (3R,4R)-3,4-Bis(benzo[d][1,3]dioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R-trans)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; hinoquinin; (-)-hinoquinin; AC1L9DKH; Epitope ID:116880; SCHEMBL1121862; MolPort-039-338-821; ZINC1872258; BDBM50218812; AKOS027324070; LS-190466; C10627; (2r,3r)-2,3-di-(3,4-methylenedioxybenzyl)-butyrolactone
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MOA Inhibitor
Activity Ki = 373 nM
External Link
CID: 442879
TTD: D0X3CF
 Compound Name 4-[2-(4-Imidazol-1-yl-phenoxy)-ethyl]-morpholine Investigative [18]
Synonyms
CHEMBL113018; SCHEMBL14129876; BDBM50138231
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MOA Inhibitor
Activity IC50 = 5670 nM
External Link
CID: 44341256
TTD: D00PYW
 Compound Name DIHYDROCUBEBIN Investigative [7]
Synonyms
(-)-Dihydrocubebin; 24563-03-9; (2R,3R)-2,3-bis(1,3-benzodioxol-5-ylmethyl)butane-1,4-diol; CHEMBL486597; CHEBI:543841; 1,4-Butanediol, 2,3-bis(1,3-benzodioxol-5-ylmethyl)-, (R-(R*,R*))-; 1,4-Butanediol, 2,3-bis(1,3-benzodioxol-5-ylmethyl)-, [R-(R*,R*)]-; Cubebin, dihydro-; AC1Q6ZWV; AC1L4VHK; SCHEMBL15775181; CTK4F3896; DTXSID00179301; JKCVMTYNARDGET-HOTGVXAUSA-N; ZINC899938; BDBM50241937; 1,4-Butanediol, 2,3-bis(1,3-benzodioxol-5-ylmethyl)-, (R*,R*)-(-)-; 1,4-Butanediol, 2,3-dipiperonyl-, (-)-; C10558
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MOA Inhibitor
Activity Ki = 142 nM
External Link
CID: 193042
TTD: D00TOF
 Compound Name 3,3-(1,3-Thiazole-2,5-diyl)diphenol Investigative [19]
Synonyms
CHEMBL456379; SCHEMBL1181184; BDBM25832; hydroxyphenyl substituted thiazole, 4
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 800 nM
External Link
CID: 25093374
TTD: D00YNA
 Compound Name Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine Investigative [13]
Synonyms
CHEMBL179529
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MOA Inhibitor
Activity IC50 = 6300 nM
External Link
CID: 44388719
TTD: D01ARE
 Compound Name 3-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine Investigative [18]
Synonyms
CHEMBL262968; SCHEMBL14130000; BDBM50138237
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MOA Inhibitor
Activity IC50 = 417 nM
External Link
CID: 44341278
TTD: D02DTR
 Compound Name 4-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine Investigative [18]
Synonyms
CHEMBL113227; SCHEMBL14130001; BDBM50138238
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MOA Inhibitor
Activity IC50 = 344 nM
External Link
CID: 44341260
TTD: D03KXT
 Compound Name 4-(6-Methoxynaphthalen-2-yl)isoquinoline Investigative [20]
Synonyms
CHEMBL500394; BDBM50272368
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MOA Inhibitor
Activity IC50 = 3540 nM
External Link
CID: 24754344
TTD: D06CWR
 Compound Name 3-[3-(4-Methoxybenzyl)naphthalen-2-yl]pyridine Investigative [21]
Synonyms
CHEMBL493082
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MOA Inhibitor
External Link
CID: 25130848
TTD: D06JYY
 Compound Name 1H-1,2,3-benzotriazol-1-amine Investigative [22]
Synonyms
1-aminobenzotriazole; 1614-12-6; 1H-Benzotriazol-1-amine; 1H-benzo[d][1,2,3]triazol-1-amine; 1-Benzotriazolamine; benzotriazol-1-amine; 1-Abtz; 1H-1,2,3-Benzotriazol-1-ylamine; UNII-9EFF75BJ1O; NSC 114498; 9EFF75BJ1O; CHEMBL101168; benzotriazolylamine; MFCD00132902; NSC656987; 1-Aminobenzotriazole, 98%; AK-830/25033013; Q-102063; 1-benzotriazolylamine; benzotriazol-1-ylamine; PubChem19954; rarechem aq nn 0550; ACMC-1BVFA; AC1L1BBK; timtec-bb sbb004208; Lopac-A-3940; ABT
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MOA Inhibitor
Activity IC50 = 450 nM
External Link
CID: 1367
TTD: D07ANY
 Compound Name 1,1':4',1''-terphenyl-3,3''-diol Investigative [19]
Synonyms
[1,1':4',1'']Terphenyl-3,3''-diol
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MOA Inhibitor
External Link
CID: 44542195
TTD: D07JOZ
 Compound Name 1-(4-Butoxy-phenyl)-1H-imidazole Investigative [18]
Synonyms
CHEMBL112532; SCHEMBL14129854; 1-(4-Butoxyphenyl)-1H-imidazole; ZINC13530153
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MOA Inhibitor
Activity IC50 = 348 nM
External Link
CID: 11321889
TTD: D07VHB
 Compound Name 6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one Investigative [23]
Synonyms
CHEMBL462093; 2(1H)-Naphthalenone,3,4-dihydro-6-(3-pyridinyl)-; BDBM50273703
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MOA Inhibitor
Activity IC50 = 6210 nM
External Link
CID: 25180108
TTD: D07WLT
 Compound Name 3-methoxy-5-(6-methoxynaphthalen-2-yl)pyridine Investigative [20]
Synonyms
CHEMBL447591; SCHEMBL3004402; SEXSHORPOJSDHK-UHFFFAOYSA-N; BDBM50272250; ZINC40979781
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MOA Inhibitor
Activity IC50 = 1913 nM
External Link
CID: 24827305
TTD: D08IDC
 Compound Name 2-(4-Imidazol-1-yl-phenoxymethyl)-pyridine Investigative [18]
Synonyms
CHEMBL112592; SCHEMBL14129997; BDBM50138232
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MOA Inhibitor
Activity IC50 = 630 nM
External Link
CID: 44341428
TTD: D0B0LC
 Compound Name 1-(3,4-DICHLOROPHENYL)-6-(METHOXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) Investigative [24]
Synonyms
SCHEMBL3194096; CHEMBL1173532; BDBM50322698; rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptane
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10000 nM
External Link
CID: 24802842
TTD: D0G6BJ
 Compound Name 1-(METHOXYMETHYL)-6-(NAPHTHALEN-2-YL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) Investigative [24]
Synonyms
SCHEMBL3260073; CHEMBL1172744; BDBM50322697
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MOA Inhibitor
Activity IC50 = 8000 nM
External Link
CID: 24803184
TTD: D0J4CB
 Compound Name 6-(3,4-DICHLOROPHENYL)-1-[1-(METHYLOXY)-3-BUTEN-1-YL]-3-AZABICYCLO[4.1.0]HEPTANE (DIASTEREOMERIC MIX) Investigative [24]
Synonyms
CHEMBL1173087; BDBM50322696; rac-6-(3,4-dichlorophenyl)-5-methoxy-1-1-methoxybut-3-enyl)-3-azabicyclo[4.1.0]heptane
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MOA Inhibitor
Activity IC50 = 3000 nM
External Link
CID: 49799108
TTD: D0K3EW
 Compound Name 3-[5-(4-Hydroxyphenyl)-3-thienyl]phenol Investigative [19]
Synonyms
CHEMBL462513; SCHEMBL1180467; BDBM25853; ZINC40393334; 4,3'-(2,4-Thiophenediyl)bisphenol; hydroxyphenyl substituted thiophene, 25
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MOA Inhibitor
Activity IC50 = 1900 nM
External Link
CID: 25093389
TTD: D0NM0P
 Compound Name 2-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine Investigative [18]
Synonyms
CHEMBL115876; SCHEMBL14129965; BDBM50138233
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MOA Inhibitor
Activity IC50 = 252 nM
External Link
CID: 44341234
TTD: D0U7BJ
 Compound Name (5-pyridin-3-yl-furan-2-yl)methanethiol Investigative [8]
Synonyms
2-Furanmethanethiol, 5-(3-pyridinyl)-; 859239-19-3; CHEMBL214784; SCHEMBL3611340; CTK2I3858; BDBM12360; DTXSID30475409; GLMNDKCXHHOKIQ-UHFFFAOYSA-N; nicotine 3-heteroaromatic analogue 14; [5-(pyridin-3-yl)furan-2-yl]methanethiol
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MOA Inhibitor
Activity Ki = 3100 nM
External Link
CID: 11993866
TTD: D0YP4A
 Compound Name 4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol Investigative [25]
Synonyms
CHEMBL569862; SCHEMBL1180208
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MOA Inhibitor
Activity IC50 = 1500 nM
External Link
CID: 25192621
TTD: D01RZP
 Compound Name 2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol Investigative [25]
Synonyms
CHEMBL577338; SCHEMBL1180589
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MOA Inhibitor
Activity IC50 = 820 nM
External Link
CID: 25192477
TTD: D0M0KX
 Compound Name 4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol Investigative [25]
Synonyms
1122660-25-6; 4-(5-(3-Hydroxyphenyl)thiophen-2-yl)-2-methylphenol; 3-(5-(4-hydroxy-3-methylphenyl)thiophen-2-yl)phenol; CHEMBL570596; AK160974; 3-(5-(4-Hydroxy-3-methylphenyl)-thiophen-2-yl)phenol; SCHEMBL1180399; MolPort-028-616-334; ZINC45254284; BDBM50299633; AKOS024463871; DS-9818; QC-10086; AJ-110394; AX8293985
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MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 25192475
TTD: D0Y2RL
 Compound Name 2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole Investigative [26]
Synonyms
4-(2-(4-tert-butylphenylthio)ethyl)-1H-imidazole; 4-(2-(40-tert-butylphenylthio)ethyl)-1H-imidazole
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MOA Inhibitor
Activity IC50 = 470 nM
External Link
CID: 46222048
TTD: D01JXM
 Compound Name ML-3375 Investigative [27]
Synonyms
CHEMBL113419; SCHEMBL4460547; SCHEMBL13712659; ZINC13491685; BDBM50119524; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridine; 2-(Methylthio)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole
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MOA Inhibitor
External Link
CID: 9795838
TTD: D09HBZ
 Compound Name ML-3403 Investigative [27]
Synonyms
p38 MAP Kinase Inhibitor III; ML3403; 549505-65-9; ML 3403; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine; CHEMBL111364; (RS)-{4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}-(1-phenylethyl)amine]; K00568a; AC1O4WCF; SCHEMBL2896072; GTPL6014; ml-3043; SCHEMBL15013352; MolPort-023-278-904; HMS3229M04; {4-[5-(4-Fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amine
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MOA Inhibitor
External Link
CID: 6419739
TTD: D0W4FF
 Compound Name ML-3163 Investigative [27]
Synonyms
ML 3163; CHEMBL111456; 4-[5-(4-Fluorophenyl)-2-(4-methanesulfinyl-benzylsulfanyl)-3H-imidazol-4-yl]pyridine; SCHEMBL4106398; BDBM50114690; IN1229; 4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfinyl-benzylsulfanyl)-1H-imidazol-4-yl]-pyridine; 4-(2-(4-(methylsulfinyl)benzylthio)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9845197
TTD: D08DSJ
 Compound Name 6-(3-Hydroxy-phenyl)-naphthalen-2-ol Investigative [28]
Synonyms
6-(3-hydroxyphenyl)-2-naphthol; 6-(3-hydroxyphenyl)naphthalen-2-ol
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MOA Inhibitor
Activity IC50 = 1580 nM
External Link
CID: 10192730
TTD: D0P8PK
 Compound Name BMS-536924 Investigative [29]
MOA Inhibitor
Activity IC50 = 500 nM
External Link
CID: 135440466
TTD: D0M4SY
 Compound Name Heme Investigative [30]
Synonyms
protoheme; Haem; ferroprotoporphyrin; UNII-42VZT0U6YR; Iron protoporphyrin ix; Protohaem; Ferroheme; Reduced hematin; Ferrous protoheme; Iron protoporphyrin; Ferrous protoheme IX; Ferroprotoporphyrin IX; 14875-96-8; 42VZT0U6YR; Iron(II) protoporphyrin IX; Protoheme IX (VAN); Ferroheme (VAN); Heme (VAN); 85758-EP2305825A1; 85758-EP2305243A1; 85758-EP2270505A1; 85758-EP2270016A1; 3-[18-(2-carboxyethyl)-7,12-bis(ethenyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; iron(2+); NSC 16669; NSC 267100; AC1L9FPJ; Hemin
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MOA Inhibitor
External Link
CID: 26945
TTD: D0UU1I
 Compound Name AVI-4557 Phase 2 [31]
External Link
TTD: D0J6FE
References
Ref 1 N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2 ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism. Genome Biol. 2021 Jan 28;22(1):51. doi: 10.1186/s13059-021-02271-9.
Ref 3 RNA Editing Enzymes Modulate the Expression of Hepatic CYP2B6, CYP2C8, and Other Cytochrome P450 Isoforms. Drug Metab Dispos. 2019 Jun;47(6):639-647. doi: 10.1124/dmd.119.086702. Epub 2019 Apr 15.
Ref 4 Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing. J Pharmacol Exp Ther. 2019 Sep;370(3):408-415. doi: 10.1124/jpet.119.260109. Epub 2019 Jul 3.
Ref 5 Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31.
Ref 6 Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. doi: 10.1016/j.bmcl.2006.07.036. Epub 2006 Jul 28.
Ref 7 Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8.
Ref 8 Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001.
Ref 9 Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007 Dec;70(12):1930-3.
Ref 10 Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7.
Ref 11 Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem. 2007 Jun 1;15(11):3684-91.
Ref 12 Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. J Med Chem. 2010 Oct 14;53(19):7129-39.
Ref 13 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39.
Ref 14 2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression, Bioorg. Med. Chem. Lett. 20(13):3941-3945 (2010).
Ref 15 Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43.
Ref 16 Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa. J Nat Prod. 2004 Nov;67(11):1839-41.
Ref 17 Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4). Bioorg Med Chem Lett. 2003 Nov 3;13(21):3643-5.
Ref 18 Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6.
Ref 19 Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39.
Ref 20 Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74.
Ref 21 Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49.
Ref 22 Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5.
Ref 23 In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. J Med Chem. 2008 Dec 25;51(24):8077-87. doi: 10.1021/jm800888q.
Ref 24 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001.
Ref 25 New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43.
Ref 26 Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4.
Ref 27 Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. doi: 10.1021/jm030766k.
Ref 28 Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69.
Ref 29 Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity. J Med Chem. 2008 Oct 9;51(19):5897-900. doi: 10.1021/jm800832q. Epub 2008 Sep 3.
Ref 30 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. doi: 10.1093/nar/28.1.235.
Ref 31 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.