m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00152
 [1], [2]
m6A modification ADARB1 ADARB1 METTL3 Methylation : m6A sites Direct Enhancement RNA modification GRIK2 GRIK2 ADARB1 Methylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Double-stranded RNA-specific editase 1 (ADARB1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Double-stranded RNA-specific editase 1 (ADARB1) WRITER View Details
Regulated Target Glutamate ionotropic receptor kainate type subunit 2 (GRIK2) View Details
Crosstalk Relationship m6A  →  A-to-I Enhancement
Crosstalk Mechanism m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Glutamate ionotropic receptor kainate type subunit 2 (GRIK2) transcript.
Responsed Drug 2,4-epi-neodysiherbaine
 Drug Info 
Cell Process RNA editing
In-vitro Model
 MGG8 Glioblastoma Homo sapiens CVCL_D1H4
HEK293T Normal Homo sapiens CVCL_0063
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Glutamate ionotropic receptor kainate type subunit 2 (GRIK2) 5 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name 2,4-epi-neodysiherbaine Investigative [3]
Synonyms
2,4-epi-neoDH
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MOA Antagonist
External Link
CID: 73755077
TTD: D00VEZ
 Compound Name domoic acid Investigative [3]
Synonyms
domoate; NSC 288031
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MOA Agonist
External Link
CID: 5282253
TTD: D09KRH
DrugBank: DB02852
 Compound Name dysiherbaine Investigative [3]
Synonyms
(2r,3ar,6s,7r,7ar)-2-[(2s)-2-Amino-2-Carboxyethyl]-6-Hydroxy-7-(Methylamino)hexahydro-2h-Furo[3,2-B]pyran-2-Carboxylic Acid; DYH; CHEMBL221142; GTPL4185; SCHEMBL12409079; BDBM85740; (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid (non-preferred name); (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)-hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid
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MOA Agonist
Activity Ki = 1.2 nM
External Link
CID: 9839436
TTD: D0K6AF
 Compound Name SYM2081 Investigative [3]
Synonyms
KRKRAOXTGDJWNI-DMTCNVIQSA-L; (2S,4R)-2-amino-4-methylpentanedioate; [3H](2S,4R)-4-methylglutamate; [3H]SYM2081; [(3)H]4MG; (2S,4R)-Me-Glu; GTPL4317; GTPL4075; compound 52 [PMID:
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MOA Agonist
External Link
CID: 21117106
TTD: D0S8AN
 Compound Name [3H]kainate Investigative [3]
Synonyms
(2S,3S,4S)-3-(Carboxylatomethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylate; GTPL4231; GTPL4085; KAINATE
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MOA Agonist
External Link
CID: 73755076
TTD: D04PFN
References
Ref 1 N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2 ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity. J Cell Sci. 2018 Dec 17;131(24):jcs222273. doi: 10.1242/jcs.222273.
Ref 3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451).