m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00145				[1], [2]
m⁶A modification ADARB1 ADARB1 YTHDF2 : m⁶A sites Direct Inhibition RNA modification HNRNPLL HNRNPLL ADARB1 Methylation : modification sites
m6A Regulator	YTH domain-containing family protein 2 (YTHDF2)			READER	Regulator Info
m6A Target	Double-stranded RNA-specific editase 1 (ADARB1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)			WRITER	View Details
Regulated Target	Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL)				View Details
Crosstalk Relationship	m6A → A-to-I			Inhibition
Crosstalk Mechanism	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary	YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL).
In-vitro Model	A-172	Glioblastoma	Homo sapiens		CVCL_0131
In-vitro Model	HeLa	Endocervical adenocarcinoma	Homo sapiens		CVCL_0030

References

Ref 1	N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses. PLoS Biol. 2021 Jul 29;19(7):e3001292. doi: 10.1371/journal.pbio.3001292. eCollection 2021 Jul.
Ref 2	Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation. J Biol Chem. 2018 Jun 29;293(26):10158-10171. doi: 10.1074/jbc.RA117.001197. Epub 2018 May 16.