m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00125
 [1], [2], [3]
m6A modification ADAR1 ADAR1 METTL3 Methylation : m6A sites Direct Enhancement RNA modification ICAM1 ICAM1 ADAR Methylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Interferon-inducible protein 4 (ADAR1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target Intercellular adhesion molecule 1 (ICAM1) View Details
Crosstalk Relationship m6A  →  A-to-I Enhancement
Crosstalk Mechanism m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Intercellular adhesion molecule 1 (ICAM1) transcript.
Responsed Drug ISIS 1570
 Drug Info 
Pathway Response mRNA surveillance pathway hsa03015
RNA degradation hsa03018
Cell Process RNA stability
In-vitro Model
 MGG8 Glioblastoma Homo sapiens CVCL_D1H4
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-118MG Astrocytoma Homo sapiens CVCL_0633
HUVEC-C Normal Homo sapiens CVCL_2959
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Intercellular adhesion molecule 1 (ICAM1) 24 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ISIS 1570 Approved [4]
External Link
TTD: D00OTT
 Compound Name Alicaforsen Phase 3 [5]
Synonyms
Alicaforsen [INN]; ISIS 2302; ISIS-2302; Intercellular adhesion molecule-1 antisense oligodeoxynucleotide; DNA, d((R)-P-thio)(G-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); Deoxyribonucleic acid, d((R)-P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A)
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External Link
CID: 16197725
TTD: D0P9BT
 Compound Name INXC-ICAM1 Terminated [6]
Synonyms
Antisense ICAM-1-TCS, Inex; ICAM-1 antisense (inflammation), INEX; Transmembrane carrier system (antisense ICAM-1), Inex; Antisense (ICAM-1, inflammation), INEX
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External Link
TTD: D0M0UV
 Compound Name ISIS 11159 Investigative [7]
External Link
TTD: D00FAL
 Compound Name ISIS 3224 Investigative [7]
External Link
TTD: D02TKV
 Compound Name ISIS 1931 Investigative [4]
External Link
TTD: D02ZMH
 Compound Name PIPERROLEIN B Investigative [8]
Synonyms
Piperolein B; Piperoleine B; 30505-89-6; CHEMBL256214; MEGxp0_000205; SCHEMBL15471329; ACon1_000259; FAXXHNWVMKTOFF-UXBLZVDNSA-N; MCULE-4025815326; NCGC00180733-01; BRD-K04771916-001-01-8; Piperidine, 1-[(8E)-9-(1,3-benzodioxol-5-yl)-1-oxo-8-nonenyl]-; (8E)-9-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)non-8-en-1-one; Piperidine, 1-[9-[3,4-(methylenedioxy)phenyl]-8-nonenoyl]-, (E)-; (E)-9-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)non-8-en-1-one; Piperidine, 1-[9-(1,3-benzodioxol-5-yl)-1-oxo-8-nonenyl]-, (
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MOA Inhibitor
External Link
CID: 21580213
TTD: D03YAG
 Compound Name ISIS 2974 Investigative [4]
External Link
TTD: D06SDT
 Compound Name Dehydropipernonaline Investigative [8]
Synonyms
107584-38-3; Dehydropipernoline; Piperidine, 1-[9-(1,3-benzodioxol-5-yl)-1-oxo-2,4,8-nonatrienyl]-, (E,E,E)-; Piperidine, 1-(9-(1,3-benzodioxol-5-yl)-1-oxo-2,4,8-nonatrienyl)-, (E,E,E)-; AC1O5SQM; CHEMBL483708; MolPort-039-101-180; KAYVDASZRFLFRZ-PQECNABGSA-N; N-(9-(3,4-Methylenedioxyphenyl)-2,4,8-nonatrienoyl)piperidine; ZINC14658239; 9-(3,4-Methylenedioxy)-2,4,8-nonatrienoic acid piperidide; (2E,4E,8E)-9-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylnona-2,4,8-trien-1-one; Piperidine, 1-[(2E,4E,8E)-9-(1
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MOA Inhibitor
External Link
CID: 6439947
TTD: D0H0FG
 Compound Name ISIS 3067 Investigative [7]
External Link
TTD: D0J1FW
 Compound Name ISIS 11665 Investigative [7]
External Link
TTD: D0K7HI
 Compound Name PIPERNONALINE Investigative [8]
Synonyms
CHEMBL450332; PKLGRWSJBLGIBF-JMQWPVDRSA-N; MolPort-006-668-470; ZINC14658236; Pipernonaline, > 9-(3,4-Methylenedioxyphenyl)-2,8-nonadienoic acid piperidide; 1-[9-(1,3-Benzodioxol-5-yl)-1-oxo-2,8-nonadienyl]piperidine, 9CI; (2E,8E)-9-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)nona-2,8-dien-1-one; (2E,8E)-9-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)nona-2,8-dien-1-one
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MOA Inhibitor
External Link
CID: 9974595
TTD: D0S2UZ
 Compound Name ISIS 11158 Investigative [7]
External Link
TTD: D0V8KH
 Compound Name Pellitorin Investigative [8]
Synonyms
Pellitorine; 18836-52-7; trans-Pellitorin; (E,E)-N-(2-Methylpropyl)-2,4-decadienamide; (E,E)-N-Isobutyl-2,4-decadienamide; N-Isobutyldeca-trans-2,trans-4-dienamide; UNII-8IS5231171; 2,4-DECADIENAMIDE, N-ISOBUTYL-, (E,E)-; 2,4-Decadienamide, N-(2-methylpropyl)-, (E,E)-; BRN 1725967; AI3-19560; CHEBI:69686; MAGQQZHFHJDIRE-BNFZFUHLSA-N; Pellitorine (6CI); 2,4-Decadienamide, N-(2-methylpropyl)-, (2E,4E)-; 8IS5231171; (2E,4E)-N-(2-methylpropyl)deca-2,4-dienamide; N-(2-Methylpropyl)-2,4-Decadienamide; Optaflow A
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MOA Inhibitor
External Link
CID: 5318516
TTD: D0ZH9W
 Compound Name A-286982 Investigative [9]
Synonyms
280749-17-9; UNII-5I8WFS075A; A 286982; CHEMBL19677; 5I8WFS075A; C24H27N3O4S; (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one; SCHEMBL5829786; GTPL6592; SCHEMBL12063498; AOB1772; SYN5060; MolPort-023-277-110; ZINC602716; BDBM50092956; AKOS024458044; API0010263; Piperazine, 1-acetyl-4-((2E)-3-(4-((2-(1-methylethyl)phenyl)thio)-3-nitrophenyl)-1-oxo-2-propenyl)-; (E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one; AS-16426
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MOA Inhibitor
External Link
CID: 9846729
TTD: D07XCA
 Compound Name lifitegrast Approved [10]
Synonyms
Xiidra; 1025967-78-5; SAR-1118; SAR 1118; UNII-038E5L962W; CHEMBL2048028; 038E5L962W; (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid; (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid;(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid; SAR-1119; SHP606; SPD606
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External Link
CID: 11965427
TTD: D0Q9EV
DrugBank: DB11611
 Compound Name Alicaforsen Phase 3 [5]
Synonyms
Alicaforsen [INN]; ISIS 2302; ISIS-2302; Intercellular adhesion molecule-1 antisense oligodeoxynucleotide; DNA, d((R)-P-thio)(G-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A); Deoxyribonucleic acid, d((R)-P-thio)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A)
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External Link
CID: 16197725
TTD: D0P9BT
 Compound Name APC-8015F Phase 2 [10]
Synonyms
CD54-postive autologous cell immunotherapy (hormone refractory prostate cancer), Dendreon
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External Link
TTD: D0XH8X
 Compound Name BI-505 Phase 2 [10]
External Link
TTD: D0Q7OE
 Compound Name AIC100 Phase 1 [10]
External Link
TTD: DP0NU9
 Compound Name A-252444.0 Terminated [10]
Synonyms
A-155918; A-205804; A-241548
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External Link
TTD: D09GGO
 Compound Name MOR-102 Terminated [10]
Synonyms
MOR-101; MOR-101); ICAM-1 antibody (inflammation), MorphoSys
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External Link
TTD: D0M8JF
 Compound Name GI-270384X Terminated [10]
External Link
TTD: D0RR4T
 Compound Name ISIS-1939 Investigative [10]
Synonyms
136216-59-6
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External Link
TTD: D02BRA
References
Ref 1 N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2 ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism. Genome Biol. 2021 Jan 28;22(1):51. doi: 10.1186/s13059-021-02271-9.
Ref 3 ADAR1 is targeted by miR-143 to regulate IL-1beta-induced endothelial activation through the NFkappaB pathway. Int J Biochem Cell Biol. 2017 Aug;89:25-33. doi: 10.1016/j.biocel.2017.05.021. Epub 2017 May 17.
Ref 4 US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
Ref 5 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
Ref 6 ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6. doi: 10.2165/00126839-199901010-00028.
Ref 7 US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.
Ref 8 Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6. doi: 10.1016/j.bmcl.2008.07.045. Epub 2008 Jul 15.
Ref 9 Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73. doi: 10.1016/j.bmcl.2010.06.145. Epub 2010 Jul 23.
Ref 10 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.