m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00116
|
[1], [2], [3] | |||
.png)
.png)
 : m6A sites
Direct
Enhancement
RNA modification
COL1A1
COL1A1
ADAR
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Interferon-inducible protein 4 (ADAR1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | Collagen alpha-1 (COL1A1) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Enhancement | |||
| Crosstalk Mechanism | m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator | ||||
| Crosstalk Summary | METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Collagen alpha-1 (COL1A1) transcript. | ||||
| Pathway Response | mRNA surveillance pathway | hsa03015 | |||
| RNA degradation | hsa03018 | ||||
| Cell Process | RNA stability | ||||
In-vitro Model |
MGG8 | Glioblastoma | Homo sapiens | CVCL_D1H4 | |
| U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 | ||
| U-118MG | Astrocytoma | Homo sapiens | CVCL_0633 | ||
| Hep-G2 | Hepatoblastoma | Homo sapiens | CVCL_0027 | ||
References