m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00094
 [1], [2]
m6A modification ADARB1 ADARB1 YTHDF2 : m6A sites Direct Inhibition RNA modification GLI1 GLI1 ADARB1 Methylation : modification sites
m6A Modification:
m6A Regulator YTH domain-containing family protein 2 (YTHDF2) READER
 Regulator Info 
m6A Target Double-stranded RNA-specific editase 1 (ADARB1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Double-stranded RNA-specific editase 1 (ADARB1) WRITER View Details
Regulated Target Zinc finger protein GLI1 (GLI1) View Details
Crosstalk Relationship m6A  →  A-to-I Inhibition
Crosstalk Mechanism m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary YTHDF2 recognizes the m6A methylation sites and prevents Double-stranded RNA-specific editase 1 (ADARB1) dependent A-to-I RNA editing of Zinc finger protein GLI1 (GLI1).
Responsed Drug PMID26666870-Compound-16
 Drug Info 
In-vitro Model
 A-172 Glioblastoma Homo sapiens CVCL_0131
SH-SY5Y Neuroblastoma Homo sapiens CVCL_0019
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Zinc finger protein GLI1 (GLI1) 12 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PMID26666870-Compound-16 Patented [3]
MOA Inhibitor
External Link
TTD: D00KXJ
 Compound Name Imidazo bicyclic iminium derivative 1 Patented [3]
Synonyms
PMID26666870-Compound-17
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MOA Inhibitor
External Link
TTD: D0FL0T
 Compound Name Imidazo bicyclic iminium derivative 2 Patented [3]
Synonyms
PMID26666870-Compound-18
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MOA Inhibitor
External Link
TTD: D0II7X
 Compound Name Isoflavone derivative 1 Patented [3]
Synonyms
PMID26666870-Compound-19
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MOA Inhibitor
External Link
TTD: D00RRB
 Compound Name Isoflavone derivative 5 Patented [3]
Synonyms
PMID26666870-Compound-23
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MOA Inhibitor
External Link
TTD: D01BGG
 Compound Name Isoflavone derivative 7 Patented [3]
Synonyms
PMID26666870-Compound-25
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MOA Inhibitor
External Link
TTD: D04IFL
 Compound Name Isoflavone derivative 8 Patented [3]
Synonyms
PMID26666870-Compound-26
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MOA Inhibitor
External Link
TTD: D05NRG
 Compound Name Isoflavone derivative 9 Patented [3]
Synonyms
PMID26666870-Compound-27
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MOA Inhibitor
External Link
TTD: D09VIE
 Compound Name Isoflavone derivative 6 Patented [3]
Synonyms
PMID26666870-Compound-24
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MOA Inhibitor
External Link
TTD: D0J1RB
 Compound Name Isoflavone derivative 3 Patented [3]
Synonyms
PMID26666870-Compound-21
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MOA Inhibitor
External Link
TTD: D0TP0S
 Compound Name Isoflavone derivative 2 Patented [3]
Synonyms
PMID26666870-Compound-20
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MOA Inhibitor
External Link
TTD: D0WI1G
 Compound Name Isoflavone derivative 4 Patented [3]
Synonyms
PMID26666870-Compound-22
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MOA Inhibitor
External Link
TTD: D0Z6IS
References
Ref 1 N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses. PLoS Biol. 2021 Jul 29;19(7):e3001292. doi: 10.1371/journal.pbio.3001292. eCollection 2021 Jul.
Ref 2 RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling. RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.
Ref 3 Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35.